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Towards selective targeting of HDACs for anti-inflammatory applications (2009–2011)

Abstract:
HDAC inhibitors are anti-cancer drugs that kill rapidly growing cells (like cancer cells). These drugs also have anti-inflammatory properties and so may be beneficial in chronic inflammatory diseases such as as Rheumatoid Arthritis. However, it is unknown how they reduce inflammation. In this project we aim to understand how HDAC inhibitors act as anti-inflammatory agents and to design new HDAC inhibitors with reduced side effects for the treatment of inflammatory diseases.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor Matt Sweet

    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    Affiliate NHMRC Leadership Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor David Fairlie

    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience

  • Professor Allison Pettit

    Professor
    Mater Research Institute-UQ
    Faculty of Medicine

  • Dr Ian Ross

    Senior Biologist
    Institute for Molecular Bioscience
Funded by:
National Health and Medical Research Council