The University of Queensland

Understanding sub-cellular systems at the atomic level (2011–2013)

Abstract:

Living cells are the ultimate example of a self-organised molecular system. Proteins fold spontaneously and further assemble into functional complexes; essentially biological machines. Understanding what gives rise to this emergent complexity is of fundamental theoretical importance with widespread practical implications. My aim is to develop the capacity to simulate processes such as the assembly of membrane-protein complexes in detail by integrating atomic level models and low-resolution structural data into a novel computational framework. Using these tools we will go beyond what can be observed experimentally to shed new light on processes such as hormone signal transduction, membrane trafficking and how viruses gain entry into cells.

Grant type:

ARC Discovery Projects

Researchers:

• 

  Professor Alan Mark

  Professor
  

  School of Chemistry and Molecular Biosciences

  Faculty of Science

  Affiliate of ARC COE for Innovation
  

  ARC Centre of Excellence for Innovations in Peptide and Protein Science

  Institute for Molecular Bioscience

  Affiliate of ARC COE in Quantum Bio
  

  ARC Centre of Excellence in Quantum Biotechnology

  Faculty of Science

Funded by:

Australian Research Council