OR

Browse By

Membrane proteins: Understanding biological switches, motors and triggers. (2013–2015)

Abstract:
Our aim is to develop the capacity to represent in detail specific mammalian, fugal and bacterial membranes and to use these models to understand the role of membrane composition in the structure and dynamics of membrane proteins at an atomic level. Membrane proteins are the ultimate nano-scale biological machines. Understanding these sub-cellular components is both a fundamental theoretical challenge and of widespread practical importance in biochemistry, structural biology and medicine. By representing in detail the the complexity of biological membranes we will elucidate the role played by specific membrane components in determining the mechanism of action of proteins involved in active transport and signal transduction in context.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Alan Mark

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    Affiliate of ARC COE in Quantum Bio
    ARC Centre of Excellence in Quantum Biotechnology
    Faculty of Science

  • Professor Megan O'Mara

    Professorial Research Fellow and Gr
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Professor of School of Ch
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
Funded by:
Australian Research Council