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Understanding biological membranes in atomic detail (2016–2018)

Abstract:
The aim is to develop the capacity to represent specific mammalian, fungal and bacterial membranes in atomic detail and to use such models to understand the role of membrane composition in the structure and dynamics of membrane proteins at an atomic level. Membrane protein assemblies are the ultimate nano-scale machines. Understanding these sub-cellular components is both a fundamental theoretical challenge and of widespread practical importance in biochemistry, structural biology and medicine. By representing in detail the complexity of biological membranes we will elucidate the role played by specific membrane components in determining the mechanism of action of proteins involved in transport and signal transduction in context.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Alan Mark

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    Affiliate of ARC COE in Quantum Bio
    ARC Centre of Excellence in Quantum Biotechnology
    Faculty of Science
Funded by:
Australian Research Council