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Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools (2019–2022)

Abstract:
Communication between neurons relies on the fusion of synaptic vesicles containing neurotransmitters with the presynaptic plasma membrane. The addition of vesicular membrane is transient as the vesicles quickly reform from the plasma membrane and refill with neurotransmitter ready for subsequent rounds of fusion. This recycling process ensures that neurons communicate highly efficiently, however the underpinning mechanism is unknown. In this grant, we aim to use our recently developed single synaptic vesicle super-resolution tracking method to establish how Myosin-VI and Synapsin-IIa orchestrate this recycling in central and peripheral neurons. We will explain how neurons manage to preserve their astonishing ability to communicate.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Frederic Meunier

    Professor and Academic Senior Group
    Queensland Brain Institute
    of Clem Jones Centre for Ageing and
    Clem Jones Centre for Ageing Dementia Research
    Queensland Brain Institute
    of Clem Jones Centre for Ageing and
    Clem Jones Centre for Ageing Dementia Research
    Queensland Brain Institute
    Affiliate Professor of Institute fo
    Institute for Molecular Bioscience
Funded by:
Australian Research Council