The University of Queensland

Regulation of mRNA translation by the microtubule-associated protein Tau (2019–2022)

Abstract:

Fundamental neuronal functions such as synaptic strengthening and memory formation are dependent on the tightly regulated process of protein translation. We discovered that the kinase Fyn (which is localized to dendritic spines where memories are formed) activates the ERK/S6 pathway leading to massive translation of the scaffolding protein Tau. More importantly, we found that the activation of this cascade is Tau-dependent. This project aims to determine how Tau activates this pathway, and to decipher the physiological role of the Tau/Fyn/Tau feedback loop. This will inform our understanding of the molecular regulation of learning and memory.

Grant type:

ARC Discovery Projects

Researchers:

• 

  Professor Jürgen Götz

  Director of CJCADR - GL
  

  Queensland Brain Institute

  Centre Director of Clem Jones Centr
  

  Clem Jones Centre for Ageing Dementia Research

  Queensland Brain Institute

Funded by:

Australian Research Council