The University of Queensland

Elucidating ATPase function during NLRP3 inflammasome assembly (2022–2024)

Abstract:

Humans and animals are constantly exposed to microbes, which inhabit their external environment as well as body surfaces such as the skin and gut. We are, however, able to co-exist with these microbes, because our immune system protects us from these everyday encounters. This proposal will reveal how an important immune protein called NLRP3 senses microbes and other physiological processes. When NLRP3 senses such factors and is activated, it induces the release of messenger substances to alert other immune cells. This research will deliver fundamental knowledge of how animals normally co-exist with microbes.

Grant type:

ARC Discovery Early Career Researcher Award

Researchers:

• 

  Dr Stefan Emming

  ARC DECRA Fellow
  

  Institute for Molecular Bioscience

Funded by:

Australian Research Council