Is SPINT1 a key regulator of placental development? (ARC Discovery Project administered by the University of Melbourne) (2022–2025)
Abstract:
The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate
the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the
spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and
human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and
expansion of the placental exchange interface which is critical for offspring survival.
The project will increase understanding of placental development, enhance collaboration and research knowhow,
and promote future applied projects in all species that reproduce via placental support.