Beyond structure - solving conformational dynamics for intractable proteins (2023–2026)
Abstract:
Proteins perform almost every task that enables the amazing complexity of cellular and whole organism
physiology. These molecular machines perform this incredible array of tasks due to their ability to dynamically
change shape. For the vast majority of these machines, we can only view a snapshot of the possible shapes they
can adopt and can¿t monitor how they change from one shape to another, which is critical for their functioning.
This project aims to develop and apply a completely new method to visualise dynamic changes in protein shape
which is not possible with current techniques. This will allow us to provide a new description and understanding of
the function of proteins, which is fundamental to all biology.