The University of Queensland

Self Organisation In (Bio) Molecular Systems: Simulating The Folding And Aggregation Of Peptides, Proteins And Lipids (2005–2010)

Abstract:

Molecular self-assembly is a basic property of living systems. Most proteins fold spontaneously and then further self-organize into functional complexes, effectively biological machines. Understanding how this occurs is a fundamental theoretical challenge with widespread application. Work will focus on developing methodology to simulate, computationally, the folding and aggregation of peptides, proteins, and lipids. The aim is to accurately predict the structures of small peptides in solution and to refine crude models of larger molecules (complexes). This will facilitate the development of peptide based therapeutics and is essential in exploiting the growing volume of genetic information in biology and medicine.

Grant type:

ARC Federation Fellowships

Researchers:

• 

  Professor Alan Mark

  Professor
  

  School of Chemistry and Molecular Biosciences

  Faculty of Science

  Affiliate of ARC COE for Innovation
  

  ARC Centre of Excellence for Innovations in Peptide and Protein Science

  Institute for Molecular Bioscience

  Affiliate of ARC COE in Quantum Bio
  

  ARC Centre of Excellence in Quantum Biotechnology

  Faculty of Science

Funded by:

Australian Research Council