The University of Queensland

The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

McDonald, Tanya S., McCombe, Pamela A., Woodruff, Trent M. and Lee, John D. (2020). The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis. The FASEB Journal, 34 (6) fj.201901781, 7225-7233. doi: 10.1096/fj.201901781

Complement dysregulation in the central nervous system during development and disease

Lee, John D., Coulthard, Liam G. and Woodruff, Trent M. (2019). Complement dysregulation in the central nervous system during development and disease. Seminars in Immunology, 45 101340, 101340. doi: 10.1016/j.smim.2019.101340

Revisiting the role of the innate immune complement system in ALS

Parker, Sandra E., Hanton, Angela M., Stefanou, Stephen N., Noakes, Peter G., Woodruff, Trent M. and Lee, John D. (2019). Revisiting the role of the innate immune complement system in ALS. Neurobiology of Disease, 127, 223-232. doi: 10.1016/j.nbd.2019.03.003

Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosis

Lee, John D., Levin, Samantha C., Willis, Emily F., Li, Rui, Woodruff, Trent M. and Noakes, Peter G. (2018). Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 15 (1) 171, 171. doi: 10.1186/s12974-018-1217-2

Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Lee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730

Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis

Lee, John D., Kamaruzaman, Nur A., Fung, Jenny N. T., Taylor, Stephen M., Turner, Bradley J., Atkin, Julie D., Woodruff, Trent M. and Noakes, Peter G. (2013). Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 10 (1) 119, 119. doi: 10.1186/1742-2094-10-119

Neuroinflammation in Huntington’s

Lee, John D., Lo, Martin W., Fung, Jenny N. T. and Woodruff, Trent M. (2022). Neuroinflammation in Huntington’s. Neurodegenerative Diseases Biomarkers. (pp. 215-233) edited by Philip V. Peplow, Bridget Martinez and Thomas A. Gennarelli. New York, NY, United States: Springer US. doi: 10.1007/978-1-0716-1712-0_9

Innate immunity in ALS

Lee, John D., Lee, Jia Y., Taylor, Stephen M., Noakes, Peter G. and Woodruff, Trent M. (2012). Innate immunity in ALS. Amyotrophic lateral sclerosis. (pp. 393-412) edited by Martin H. Maurer. Croatia: InTech - Open Access Publisher. doi: 10.5772/30341

Complement(ing) long-COVID thromboinflammation and pathogenesis

Lee, John D. and Woodruff, Trent M. (2024). Complement(ing) long-COVID thromboinflammation and pathogenesis. Trends in Immunology, 45 (6), 397-399. doi: 10.1016/j.it.2024.04.001

Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure

Chen, Hsiao-Jou Cortina, Spiers, Jereme G., Lerskiatiphanich, Titaya, Parker, Sandra E., Lavidis, Nickolas A., Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2024). Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure. Biological Psychiatry: Global Open Science, 4 (3) 100306, 100306. doi: 10.1016/j.bpsgos.2024.100306

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9

A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral Sclerosis

Vassileff, Natasha, Spiers, Jereme G., Lee, John D., Woodruff, Trent M., Ebrahimie, Esmaeil, Mohammadi Dehcheshmeh, Manijeh, Hill, Andrew F. and Cheng, Lesley (2024). A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral Sclerosis. Molecular Neurobiology, 1-15. doi: 10.1007/s12035-023-03857-z

Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing

Li, Xaria X., Fung, Jenny N., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2024). Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. Proceedings of the National Academy of Sciences, 121 (5), e2314627121. doi: 10.1073/pnas.2314627121

The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Alexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Beck‐Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne ... Ye, Richard D. (2023). The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180 (S2), S23-S144. doi: 10.1111/bph.16177

Complement peptide receptors in GtoPdb v.2023.1

Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2023). Complement peptide receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). doi: 10.2218/gtopdb/f5/2023.1

TLQP-21 is a low potency partial C3aR activator on human primary macrophages

Li, Xaria X., Lee, John D., Lee, Han S., Clark, Richard J. and Woodruff, Trent M. (2023). TLQP-21 is a low potency partial C3aR activator on human primary macrophages. Frontiers in Immunology, 14 1086673, 1-10. doi: 10.3389/fimmu.2023.1086673

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0

Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders

McDonald, Tanya S., Lerskiatiphanich, Titaya, Woodruff, Trent M., McCombe, Pamela A. and Lee, John D. (2022). Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders. Journal of Cerebral Blood Flow and Metabolism, 43 (1), 26-43. doi: 10.1177/0271678x221135061

Glucose metabolism in amyotrophic lateral sclerosis: It is bitter-sweet

Lerskiatiphanich, Titaya, Marallag, Jianina and Lee, John D. (2022). Glucose metabolism in amyotrophic lateral sclerosis: It is bitter-sweet. Neural Regeneration Research, 17 (9), 1975-1977. doi: 10.4103/1673-5374.335154

SARS-CoV-2 triggers complement activation through interactions with heparan sulfate

Lo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413

In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacy

Cui, Cedric S., Kumar, Vinod, Gorman, Declan M., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacy. ACS Pharmacology and Translational Science, 5 (1) acsptsci.1c00227, 41-51. doi: 10.1021/acsptsci.1c00227

Unexpected off-target activities for recombinant C5a in human macrophages

Li, Xaria X., Gorman, Declan M., Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2021). Unexpected off-target activities for recombinant C5a in human macrophages. Journal of Immunology, 208 (1), 133-142. doi: 10.4049/jimmunol.2100444

Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivo

Gorman, Declan M., Li, Xaria X., Payne, Colton D., Cui, Cedric S., Lee, John D., Rosengren, K. Johan, Woodruff, Trent M. and Clark, Richard J. (2021). Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivo. ACS Pharmacology and Translational Science, 4 (6) acsptsci.1c00199, 1808-1817. doi: 10.1021/acsptsci.1c00199

Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity

Gorman, Declan M., Li, Xaria X., Lee, John D., Fung, Jenny N., Cui, Cedric S., Lee, Han Siean, Rolfe, Barbara E., Woodruff, Trent M. and Clark, Richard J. (2021). Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. Journal of Medicinal Chemistry, 64 (22) acs.jmedchem.1c01174, 16598-16608. doi: 10.1021/acs.jmedchem.1c01174

Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

Pandey, Shubhi, Kumari, Punita, Baidya, Mithu, Kise, Ryoji, Cao, Yubo, Dwivedi-Agnihotri, Hemlata, Banerjee, Ramanuj, Li, Xaria X., Cui, Cedric S., Lee, John D., Kawakami, Kouki, Maharana, Jagannath, Ranjan, Ashutosh, Chaturvedi, Madhu, Jhingan, Gagan Deep, Laporte, Stéphane A., Woodruff, Trent M., Inoue, Asuka and Shukla, Arun K. (2021). Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Molecular Cell, 81 (22), 4605-4621.e11. doi: 10.1016/j.molcel.2021.09.007

The emerging role of complement in neuromuscular disorders

Lee, John D. and Woodruff, Trent M. (2021). The emerging role of complement in neuromuscular disorders. Seminars in Immunopathology, 43 (6), 817-828. doi: 10.1007/s00281-021-00895-4

The concise guide to pharmacology 2021/22: G protein‐coupled receptors

Alexander, Stephen PH, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Abbracchio, Maria Pia, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J.M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner‐Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo ... Ye, Richard D. (2021). The concise guide to pharmacology 2021/22: G protein‐coupled receptors. British Journal of Pharmacology, 178 (S1), S27-S156. doi: 10.1111/bph.15538

Complement peptide receptors in GtoPdb v.2021.3

Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2021). Complement peptide receptors in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE, 2021 (3). doi: 10.2218/gtopdb/f5/2021.3

Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism

McDonald, Tanya S., Kumar, Vinod, Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2021). Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism. The FASEB Journal, 35 (7) e21707, e21707. doi: 10.1096/fj.202002450r

Complement: a global immunometabolic regulator in amyotrophic lateral sclerosis

Lo, Martin W. and Lee, John D. (2021). Complement: a global immunometabolic regulator in amyotrophic lateral sclerosis. Neural Regeneration Research, 16 (6), 1210-1211. doi: 10.4103/1673-5374.300441

The “C3aR Antagonist” SB290157 is a partial C5aR2 agonist

Li, Xaria X., Kumar, Vinod, Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). The “C3aR Antagonist” SB290157 is a partial C5aR2 agonist. Frontiers in Pharmacology, 11 591398, 591398. doi: 10.3389/fphar.2020.591398

Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan

Gorman, Declan M., Lee, John, Payne, Colton D., Woodruff, Trent M. and Clark, Richard J. (2021). Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan. Amino Acids, 53 (1), 143-147. doi: 10.1007/s00726-020-02921-5

Clinical and electrophysiological examination of pinch strength in patients with amyotrophic lateral sclerosis

Lee, John D., Heshmat, Saman, Heggie, Susan, Thorpe, Kathryn A., McCombe, Pamela A. and Henderson, Robert D. (2021). Clinical and electrophysiological examination of pinch strength in patients with amyotrophic lateral sclerosis. Muscle and Nerve, 63 (1) mus.27111, 108-113. doi: 10.1002/mus.27111

TDP-43 Puts the STING in ALS

Lee, John D. and Woodruff, Trent M. (2020). TDP-43 Puts the STING in ALS. Trends in Neurosciences, 44 (2), 81-82. doi: 10.1016/j.tins.2020.12.001

Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xiang X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2020). Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2020 (5). doi: 10.2218/gtopdb/f5/2020.5

Is the C3a receptor antagonist SB290157 a useful pharmacological tool?

Lee, John D., Taylor, Stephen M. and Woodruff, Trent M. (2020). Is the C3a receptor antagonist SB290157 a useful pharmacological tool?. British Journal of Pharmacology, 177 (24) bph.15264, 5677-5678. doi: 10.1111/bph.15264

Absence of the C5a receptor C5aR2 worsens ischemic tissue injury by increasing C5aR1-mediated neutrophil infiltration

Wu, Mike C. L., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2020). Absence of the C5a receptor C5aR2 worsens ischemic tissue injury by increasing C5aR1-mediated neutrophil infiltration. The Journal of Immunology, 205 (10), 1-6. doi: 10.4049/jimmunol.2000778

A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models

Kumar, Vinod, Lee, John D., Coulson, Elizabeth J. and Woodruff, Trent M. (2020). A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models. Journal of Neurochemistry, 158 (3) jnc.15119, 807-817. doi: 10.1111/jnc.15119

Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis

Lee, John D., McDonald, Tanya S., Fung, Jenny N. T. and Woodruff, Trent M. (2020). Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 Mouse Model of Amyotrophic Lateral Sclerosis. Molecular Neurobiology, 57 (10), 4143-4155. doi: 10.1007/s12035-020-02019-9

Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function

Li, Xaria X., Lee, John D., Massey, Nicholas L., Guan, Carolyn, Robertson, Avril A. B., Clark, Richard J. and Woodruff, Trent M. (2020). Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function. Biochemical Pharmacology, 180 114156, 114156. doi: 10.1016/j.bcp.2020.114156

The peripheral immune system and amyotrophic lateral sclerosis

McCombe, Pamela A., Lee, John D., Woodruff, Trent M. and Henderson, Robert D. (2020). The peripheral immune system and amyotrophic lateral sclerosis. Frontiers in Neurology, 11 279, 279. doi: 10.3389/fneur.2020.00279

The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis

McDonald, Tanya S., McCombe, Pamela A., Woodruff, Trent M. and Lee, John D. (2020). The potential interplay between energy metabolism and innate complement activation in amyotrophic lateral sclerosis. The FASEB Journal, 34 (6) fj.201901781, 7225-7233. doi: 10.1096/fj.201901781

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Deora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728

Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice

Kumar, Vinod, Lee, John D., Clark, Richard J., Noakes, Peter G., Taylor, Stephen M. and Woodruff, Trent M. (2020). Preclinical pharmacokinetics of complement C5a receptor antagonists PMX53 and PMX205 in mice. ACS Omega, 5 (5) acsomega.9b03735, 2345-2354. doi: 10.1021/acsomega.9b03735

The Concise Guide to Pharmacology 2019/20: G protein‐coupled receptors

Alexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair, Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Davies, Jamie A., Abbracchio, Maria P., Alexander, Wayne, Al-hosaini, Khaled, Bäck, Magnus, Beaulieu, Jean‐Martin, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J.M., Blaho, Victoria, Bousquet, Corinne, Bräuner-Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P., Catt, Kevin J. ... Yao, Chengcan (2019). The Concise Guide to Pharmacology 2019/20: G protein‐coupled receptors. British Journal of Pharmacology, 176 (S1), S21-S141. doi: 10.1111/bph.14748

Complement dysregulation in the central nervous system during development and disease

Lee, John D., Coulthard, Liam G. and Woodruff, Trent M. (2019). Complement dysregulation in the central nervous system during development and disease. Seminars in Immunology, 45 101340, 101340. doi: 10.1016/j.smim.2019.101340

Complement peptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2019). Complement peptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019 (4). doi: 10.2218/gtopdb/f5/2019.4

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma

Nabizadeh, Jamileh A., Manthey, Helga D., Panagides, Nadya, Steyn, Frederik J., Lee, John D., Li, Xaria X., Akhir, Fazrena N. M., Chen, Weiyu, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2019). C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma. FASEB Journal, 33 (10), fj201800980RR-11071. doi: 10.1096/fj.201800980rr

Revisiting the role of the innate immune complement system in ALS

Parker, Sandra E., Hanton, Angela M., Stefanou, Stephen N., Noakes, Peter G., Woodruff, Trent M. and Lee, John D. (2019). Revisiting the role of the innate immune complement system in ALS. Neurobiology of Disease, 127, 223-232. doi: 10.1016/j.nbd.2019.03.003

The complement receptor C5aR2: a powerful modulator of innate and adaptive immunity

Li, Xaria X., Lee, John D., Kemper, Claudia and Woodruff, Trent M. (2019). The complement receptor C5aR2: a powerful modulator of innate and adaptive immunity. Journal of Immunology, 202 (12), 3339-3348. doi: 10.4049/jimmunol.1900371

Gut microbiota in ALS: possible role in pathogenesis?

McCombe, Pamela A., Henderson, Robert D., Lee, Aven, Lee, John D., Woodruff, Trent M., Restuadi, Restuadi, McRae, Allan, Wray, Naomi R., Ngo, Shyuan and Steyn, Frederik J. (2019). Gut microbiota in ALS: possible role in pathogenesis?. Expert Review of Neurotherapeutics, 19 (9), 1-21. doi: 10.1080/14737175.2019.1623026

Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Lee, John D., Liu, Ning, Levin, Samantha C., Ottosson, Lars, Andersson, Ulf, Harris, Helena E. and Woodruff, Trent M. (2019). Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 16 (1) 45, 45. doi: 10.1186/s12974-019-1435-2

Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance

Coulthard, Liam G., Hawksworth, Owen A., Conroy, Jacinta, Lee, John D. and Woodruff, Trent M. (2018). Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance. Molecular Immunology, 101, 176-181. doi: 10.1016/j.molimm.2018.06.271

Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosis

Lee, John D., Levin, Samantha C., Willis, Emily F., Li, Rui, Woodruff, Trent M. and Noakes, Peter G. (2018). Complement components are upregulated and correlate with disease progression in the TDP-43 mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 15 (1) 171, 171. doi: 10.1186/s12974-018-1217-2

Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice

Kumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4

Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis

Chand, Kirat K., Lee, Kah Meng, Lee, John D., Qiu, Hao, Willis, Emily F., Lavidis, Nickolas A., Hilliard, Massimo A. and Noakes, Peter G. (2018). Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 32 (5), fj201700835R-2689. doi: 10.1096/fj.201700835R

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Wang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M. and Noakes, Peter G. (2017). Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Skeletal Muscle, 7 (1) 10, 10. doi: 10.1186/s13395-017-0128-8

Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ

Coulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017). Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 (22), 5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017

Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Lee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730

Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system

Spiers, Jereme G., Chen, Hsiao-Jou Cortina, Steyn, Frederik J., Lavidis, Nickolas A., Woodruff, Trent M. and Lee, John D. (2017). Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system. Stress, 20 (1), 59-67. doi: 10.1080/10253890.2016.1276898

Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis

Fogarty, Matthew J., Klenowski, Paul M., Lee, John D., Drieberg-Thompson, Joy R., Bartlett, Selena E., Ngo, Shyuan T., Hilliard, Massimo A., Bellingham, Mark C. and Noakes, Peter G. (2016). Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis. Scientific Reports, 6 (1) 37968, 37968. doi: 10.1038/srep37968

Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions

Brennan, Faith H., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2016). Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions. Seminars in Immunology, 28 (3), 292-308. doi: 10.1016/j.smim.2016.03.015

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis

Lee, Jia Y., Lee, John D., Phipps, Simon, Noakes, Peter G. and Woodruff, Trent M. (2015). Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 12 (1) 90, 90. doi: 10.1186/s12974-015-0310-z

Role for terminal complement activation in amyotrophic lateral sclerosis disease progression

Woodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111

Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis

Lee, John D., Kamaruzaman, Nur A., Fung, Jenny N. T., Taylor, Stephen M., Turner, Bradley J., Atkin, Julie D., Woodruff, Trent M. and Noakes, Peter G. (2013). Dysregulation of the complement cascade in the hSOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 10 (1) 119, 119. doi: 10.1186/1742-2094-10-119

Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo

Fung, Jenny N. T., Jeffery, Penny L., Lee, John D., Seim, Inge, Roche, Deborah, Obermair, Andreas, Chopin, Lisa K. and Chen, Chen (2013). Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo. American Journal of Physiology-Endocrinology and Metabolism, 305 (2), E305-E313. doi: 10.1152/ajpendo.00156.2013

Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis

Steyn, F. J., Ngo, S. T, Lee, J. D., Leong, J. W., Buckley, A. J., Veldhuis, J. D., McCombe, P. A., Chen, C. and Bellingham, M. C. (2012). Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis. Endocrinology, 153 (8), 3735-3746. doi: 10.1210/en.2011-2171

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

Crane, James W., Baiquni, Gilang P., Sullivan, Robert K. P., Lee, John D, Sah, Pankaj, Taylor, Stephen M, Noakes, Peter G. and Woodruff, Trent (2009). The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres. Journal of Neuroinflammation, 6 (34) 34, 34.1-34.10. doi: 10.1186/1742-2094-6-34

Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma

Nabizadeh, J., Manthey, H., Panagides, N., Steyn, F., Lee, J., Li, X., Woodruff, T. and Rolfe, B. (2019). Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma. 17th International Congress of Immunology (IUIS), Beijing, China, 19-23 October 2019. Weinheim, Germany: Wiley.

Deciphering key roles for complement peptide receptors in brain development

Woodruff, T., Hawksworth, O., Lee, J. and Coulthard, L. (2019). Deciphering key roles for complement peptide receptors in brain development. Joint Meeting of the International Society for Neurochemistry and American Society for Neurochemistry (ISN-ASN), Montreal, Canada, 4-8 August 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Motor neuron disease proteins activate complement and generate C5a

Deora, Vandana, Mantovani, Susanna, Yerbury, Justin, Clark, Richard, Atkin, Julie, Lee, John, Gordon, Richard and Woodruff, Trent M. (2017). Motor neuron disease proteins activate complement and generate C5a. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen, Denmark, 8-12 September 2017. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.144

A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease

Li, Rui, Lee, John D., Levin, Samantha, Gordon, Richard and Woodruff, Trent M. (2016). A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.186

The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's disease

Li, R., Levin, S., Lee, J., Gordon, R. and Woodruff, T. (2016). The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's disease. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegeneration

Kumar, Vinod, Lee, John, Noakes, Peter and Woodruff, Trent (2015). Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegeneration. 8th International Conference on Complement Therapeutics, Chania, Crete, Greece, 1-6 January 2015.

Dysregulation of the complement system in neurodegenerative disease

Woodruff, T. M., Lee, J. D., Taylor, S. M. and Noakes, P. G. (2010). Dysregulation of the complement system in neurodegenerative disease. XXIII International Complement Workshop, New York, NY, U.S.A., 1-5 August 2010. Oxford, U.K.: Pergamon Press. doi: 10.1016/j.molimm.2010.05.215

The role of complement system in amyotrophic lateral sclerosis

Lee, John (2014). The role of complement system in amyotrophic lateral sclerosis. PhD Thesis, School of Biomedical Sciences, The University of Queensland. doi: 10.14264/uql.2015.156