The University of Queensland

Biologic and clinical analysis of childhood gamma delta T-ALL identifies LMO2/STAG2 rearrangements as extremely high-risk

Kimura, Shunsuke, Park, Chun Shik, Montefiori, Lindsey E., Iacobucci, Ilaria, Polonen, Petri, Gao, Qingsong, Arnold, Elizabeth D., Attarbaschi, Andishe, Brown, Anthony, Buldini, Barbara, Caldwell, Kenneth J., Chang, Yunchao, Chen, Chelsey, Cheng, Cheng, Cheng, Zhongshan, Choi, John, Conter, Valentino, Crews, Kristine R., de Groot-Kruseman, Hester A., Deguchi, Takao, Eguchi, Mariko, Muhle, Hannah Elisa., Elitzur, Sarah, Escherich, Gabriele, Freeman, Burgess B., Gu, Zhaohui, Han, Katie, Horibe, Keizo, Imamura, Toshihiko ... Mullighan, Charles G. (2024). Biologic and clinical analysis of childhood gamma delta T-ALL identifies LMO2/STAG2 rearrangements as extremely high-risk. Cancer Discovery. doi: 10.1158/2159-8290.cd-23-1452

Precision-guided treatment in high-risk pediatric cancers

Lau, Loretta M. S., Khuong-Quang, Dong-Anh, Mayoh, Chelsea, Wong, Marie, Barahona, Paulette, Ajuyah, Pamela, Senapati, Akanksha, Nagabushan, Sumanth, Sherstyuk, Alexandra, Altekoester, Ann-Kristin, Fuentes-Bolanos, Noemi A., Yeung, Veronica, Sullivan, Ashleigh, Omer, Natacha, Diamond, Yonatan, Jessop, Sophie, Battaglia, Lauren, Zhukova, Nataliya, Cui, Louise, Lin, Angela, Gifford, Andrew J., Fleuren, Emmy D. G., Dalla-Pozza, Luciano, Moore, Andrew S., Khaw, Seong-Lin, Eisenstat, David D., Gottardo, Nicholas G., Wood, Paul J., Tapp, Heather ... Ziegler, David S. (2024). Precision-guided treatment in high-risk pediatric cancers. Nature Medicine. doi: 10.1038/s41591-024-03044-0

Incidence and survival for childhood cancer by endorsed non‐stage prognostic indicators in Australia

Youlden, Danny R., Gupta, Sumit, Frazier, A. Lindsay, Moore, Andrew S., Gottardo, Nicholas G. and Aitken, Joanne F. (2024). Incidence and survival for childhood cancer by endorsed non‐stage prognostic indicators in Australia. Pediatric Blood & Cancer, 71 (4) e30889, e30889. doi: 10.1002/pbc.30889

Providing Australian children and adolescents with equitable access to new and emerging therapies through clinical trials: a call to action

Lorentzos, Michelle S., Metz, David, Moore, Andrew S., Fawcett, Laura K., Bray, Paula, Attwood, Lani, Munns, Craig F. and Davidson, Andrew (2023). Providing Australian children and adolescents with equitable access to new and emerging therapies through clinical trials: a call to action. Medical Journal of Australia, 220 (3), 121-125. doi: 10.5694/mja2.52191

Late effects in survivors of infant acute lymphoblastic leukaemia—a study of the Australian and New Zealand Children’s Haematology/Oncology Group

Mironova, Denitza, Saraswati, Chitra M., Downie, Peter, Lai, Chow Yee, Cook, Eleanor, Carruthers, Vickyanne, Moukhaiber, Perla, Molloy, Fiona, Serov, Joshua, McKinnon, Elizabeth, Alvaro, Frank, Osborn, Michael, Revesz, Tamas, Prestidge, Tim, Cross, Siobhan, Bateman, Caroline M., Moore, Andrew S., Khaw, Seong Lin, Mateos, Marion K. and Kotecha, Rishi S. (2023). Late effects in survivors of infant acute lymphoblastic leukaemia—a study of the Australian and New Zealand Children’s Haematology/Oncology Group. Blood Cancer Journal, 13 (1) 150, 150. doi: 10.1038/s41408-023-00924-5

Paediatric B lymphoblastic leukaemia with hyperdiploidy and a false-positive KMT2A fluorescence in situ hybridization result

Nunn, Jenna, Adayapalam, Nandini, Riyat, Sarbjit, Seymour, Louise, Williams, Bronwyn, Rehn, Jacqueline, White, Deborah, Moore, Andrew S. and Tsuchiya, Karen (2023). Paediatric B lymphoblastic leukaemia with hyperdiploidy and a false-positive KMT2A fluorescence in situ hybridization result. Cancer Genetics, 278-279, 80-83. doi: 10.1016/j.cancergen.2023.09.002

Reproducible bioinformatics analysis workflows for detecting IGH gene fusions in B-cell acute lymphoblastic leukaemia patients

Thomson, Ashlee J., Rehn, Jacqueline A., Heatley, Susan L., Eadie, Laura N., Page, Elyse C., Schutz, Caitlin, McClure, Barbara J., Sutton, Rosemary, Dalla-Pozza, Luciano, Moore, Andrew S., Greenwood, Matthew, Kotecha, Rishi S., Fong, Chun Y., Yong, Agnes S. M., Yeung, David T., Breen, James and White, Deborah L. (2023). Reproducible bioinformatics analysis workflows for detecting IGH gene fusions in B-cell acute lymphoblastic leukaemia patients. Cancers, 15 (19) 4731, 1-13. doi: 10.3390/cancers15194731

Temporal changes in childhood cancer incidence and survival by stage at diagnosis in Australia, 2000–2017

Youlden, Danny R., Baade, Peter D., Frazier, A. Lindsay, Gupta, Sumit, Gottardo, Nicolas G., Moore, Andrew S. and Aitken, Joanne F. (2023). Temporal changes in childhood cancer incidence and survival by stage at diagnosis in Australia, 2000–2017. Acta Oncologica, 62 (10), 1256-1264. doi: 10.1080/0284186X.2023.2251668

Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia

Conn, Vanessa M., Gabryelska, Marta, Toubia, John, Kirk, Kirsty, Gantley, Laura, Powell, Jason A., Cildir, Gökhan, Marri, Shashikanth, Liu, Ryan, Stringer, Brett W., Townley, Scott, Webb, Stuart T., Lin, He, Samaraweera, Saumya E., Bailey, Sheree, Moore, Andrew S., Maybury, Mellissa, Liu, Dawei, Colella, Alex D., Chataway, Timothy, Wallington-Gates, Craig T., Walters, Lucie, Sibbons, Jane, Selth, Luke A., Tergaonkar, Vinay, D’Andrea, Richard J., Pitson, Stuart M., Goodall, Gregory J. and Conn, Simon J. (2023). Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia. Cancer Cell, 41 (7), 1309-1326.e10. doi: 10.1016/j.ccell.2023.05.002

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

Mayoh, Chelsea, Gifford, Andrew J., Terry, Rachael, Lau, Loretta M S, Wong, Marie, Rao, Padmashree, Shai-Hee, Tyler, Saletta, Federica, Khuong-Quang, Dong-Anh, Qin, Vicky, Mateos, Marion K., Meyran, Deborah, Miller, Katherine E., Yuksel, Aysen, Mould, Emily V A, Bowen-James, Rachel, Govender, Dinisha, Senapati, Akanksha, Zhukova, Nataliya, Omer, Natacha, Dholaria, Hetal, Alvaro, Frank, Tapp, Heather, Diamond, Yonatan, Pozza, Luciano Dalla, Moore, Andrew S., Nicholls, Wayne, Gottardo, Nicholas G., McCowage, Geoffrey ... Ekert, Paul G. (2023). A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer. Genome Medicine, 15 (1) 20, 20. doi: 10.1186/s13073-023-01170-x

Childhood cancer survival and avoided deaths in Australia, 1983–2016

Youlden, Danny R., Baade, Peter D., Moore, Andrew S., Pole, Jason D., Valery, Patricia C. and Aitken, Joanne F. (2022). Childhood cancer survival and avoided deaths in Australia, 1983–2016. Paediatric and Perinatal Epidemiology, 37 (1), 81-91. doi: 10.1111/ppe.12895

Measurable residual disease analysis in paediatric acute lymphoblastic leukaemia patients with ABL-class fusions

Venn, Nicola C., Huang, Libby, Hovorková, Lenka, Muskovic, Walter, Wong, Marie, Law, Tamara, Heatley, Susan L., Khaw, Seong Lin, Revesz, Tom, Dalla Pozza, Luciano, Shaw, Peter J., Fraser, Chris, Moore, Andrew S., Cross, Siobhan, Bendak, Katerina, Norris, Murray D., Henderson, Michelle J., White, Deborah L., Cowley, Mark J., Trahair, Toby N., Zuna, Jan and Sutton, Rosemary (2022). Measurable residual disease analysis in paediatric acute lymphoblastic leukaemia patients with ABL-class fusions. British Journal of Cancer, 127 (5), 908-915. doi: 10.1038/s41416-022-01806-6

Changes in cancer incidence and survival among Aboriginal and Torres Strait Islander children in Australia, 1997–2016

Youlden, Danny R., Baade, Peter D., McBride, Craig A., Pole, Jason D., Moore, Andrew S., Valery, Patricia C., Young, Angela and Aitken, Joanne F. (2021). Changes in cancer incidence and survival among Aboriginal and Torres Strait Islander children in Australia, 1997–2016. Pediatric Blood and Cancer, 69 (4) e29492, e29492. doi: 10.1002/pbc.29492

Live-3d-cell immunocytochemistry assays of pediatric diffuse midline glioma

Pericoli, Giulia, Ferretti, Roberta, Moore, Andrew S. and Vinci, Maria (2021). Live-3d-cell immunocytochemistry assays of pediatric diffuse midline glioma. Journal of Visualized Experiments, 177 (177) e63091. doi: 10.3791/63091

Invasive fungal disease in children with acute myeloid leukaemia: an Australian multicentre 10‐year review

Yeoh, Daniel K., Moore, Andrew S., Kotecha, Rishi S., Bartlett, Adam W., Ryan, Anne L., Cann, Megan P., McMullan, Brendan J., Thursky, Karin, Slavin, Monica, Blyth, Christopher C., Haeusler, Gabrielle M. and Clark, Julia E. (2021). Invasive fungal disease in children with acute myeloid leukaemia: an Australian multicentre 10‐year review. Pediatric Blood and Cancer, 68 (11) e29275, 1-11. doi: 10.1002/pbc.29275

Childhood acute myeloid leukemia shows a high level of germline predisposition

Samaraweera, Saumya E, Wang, Paul Po-Shen, Li, Ka Leung, Casolari, Debora A., Feng, Jinghua, Pinese, Mark, Maung, Kyaw Ze Ya, Leo, Paul James, Cowley, Mark J., Perkins, Kelly, Smith, Amanda M., Ellis, Jonathan, Wee, Amilia, Hiwase, Devendra K., Scott, Hamish S., Schreiber, Andreas W., Brown, Anna L., Deans, Andrew J., Ross, David M., Moore, Andrew S., Gonda, Thomas, Hahn, Christopher N. and D'Andrea, Richard J. (2021). Childhood acute myeloid leukemia shows a high level of germline predisposition. Blood, 138 (22), 2293-2298. doi: 10.1182/blood.2021012666

Tumor cell invasion into Matrigel: optimized protocol for RNA extraction

Ferretti, Roberta, Baldassarre, Antonella, Billy, Emmanuel de, M Carcaboso, Angel, Moore, Andrew, Carai, Andrea, Mastronuzzi, Angela, Masotti, Andrea and Vinci, Maria (2021). Tumor cell invasion into Matrigel: optimized protocol for RNA extraction. BioTechniques, 70 (6), 327-335. doi: 10.2144/btn-2021-0001

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

Wong, Marie, Mayoh, Chelsea, Lau, Loretta M. S., Khuong-Quang, Dong-Anh, Pinese, Mark, Kumar, Amit, Barahona, Paulette, Wilkie, Emilie E., Sullivan, Patricia, Bowen-James, Rachel, Syed, Mustafa, Martincorena, Iñigo, Abascal, Federico, Sherstyuk, Alexandra, Bolanos, Noemi A., Baber, Jonathan, Priestley, Peter, Dolman, M. Emmy M., Fleuren, Emmy D. G., Gauthier, Marie-Emilie, Mould, Emily V. A., Gayevskiy, Velimir, Gifford, Andrew J., Grebert-Wade, Dylan, Strong, Patrick A., Manouvrier, Elodie, Warby, Meera, Thomas, David M., Kirk, Judy ... Cowley, Mark J. (2020). Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer. Nature Medicine, 26 (11), 1742-1753. doi: 10.1038/s41591-020-1072-4

Paediatric Strategy Forum for medicinal product development for acute myeloid leukaemia in children and adolescents

Pearson, Andrew. D. J., Zwaan, C. Michel, Kolb, E. Anders, Karres, Dominik, Guillot, Julie, Kim, Su Young, Marshall, Lynley, Tasian, Sarah K., Smith, Malcolm, Cooper, Todd, Adamson, Peter C., Barry, Elly, Benettaib, Bouchra, Binlich, Florence, Borgman, Anne, Brivio, Erica, Capdeville, Renaud, Delgado, David, Faller, Douglas V., Fogelstrand, Linda, Fraenkel, Paula Goodman, Hasle, Henrik, Heenen, Delphine, Kaspers, Gertjan, Kieran, Mark, Klusmann, Jan-Henning, Lesa, Giovanni, Ligas, Franca, Mappa, Silvia ... Vassal, Gilles (2020). Paediatric Strategy Forum for medicinal product development for acute myeloid leukaemia in children and adolescents. European Journal of Cancer, 136, 116-129. doi: 10.1016/j.ejca.2020.04.038

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

Clarke, Matthew, Mackay, Alan, Ismer, Britta, Pickles, Jessica Chiara, Tatevossian, Ruth G., Newman, Scott, Bale, Tejus A., Stoler, Iris, Izquierdo, Elisa, Temelso, Sara, Carvalho, Diana M., Molinari, Valeria, Burford, Anna, Howell, Louise, Virasami, Alex, Fairchild, Amy R., Avery, Aimee, Chalker, Jane, Kristiansen, Mark, Haupfear, Kelly, Dalton, James D., Orisme, Wilda, Wen, Ji, Hubank, Michael, Kurian, Kathreena M., Rowe, Catherine, Maybury, Mellissa, Crosier, Stephen, Knipstein, Jeffrey ... Jones, Chris (2020). Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes. Cancer Discovery, 10 (7), 942-963. doi: 10.1158/2159-8290.cd-19-1030

Pattern of relapse and treatment response in WNT-activated medulloblastoma

Nobre, Liana, Zapotocky, Michal, Khan, Sara, Fukuoka, Kohei, Fonseca, Adriana, McKeown, Tara, Sumerauer, David, Vicha, Ales, Grajkowska, Wieslawa A, Trubicka, Joanna, Li, Kay Ka Wai, Ng, Ho-Keung, Massimi, Luca, Lee, Ji Yeoun, Kim, Seung-Ki, Zelcer, Shayna, Vasiljevic, Alexandre, Faure-Conter, Cécile, Hauser, Peter, Lach, Boleslaw, van Veelen-Vincent, Marie-Lise, French, Pim J, Van Meir, Erwin G, Weiss, William A, Gupta, Nalin, Pollack, Ian F, Hamilton, Ronald L, Nageswara Rao, Amulya A, Giannini, Caterina ... Ramaswamy, Vijay (2020). Pattern of relapse and treatment response in WNT-activated medulloblastoma. Cell Reports Medicine, 1 (3) 100038, 100038. doi: 10.1016/j.xcrm.2020.100038

Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736

Moore, Andrew S., Faisal, Amir, Mak, Grace W. Y., Miraki-Moud, Farideh, Bavetsias, Vassilios, Valenti, Melanie, Box, Gary, Hallsworth, Albert, de Haven Brandon, Alexis, Xavier, Cristina P. R., Stronge, Randal, Pearson, Andrew D. J., Blagg, Julian, Raynaud, Florence I., Chopra, Rajesh, Eccles, Suzanne A., Taussig, David C. and Linardopoulos, Spiros (2020). Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736. Blood Advances, 4 (7), 1478-1491. doi: 10.1182/bloodadvances.2019000986

Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Uden, Theodor, Bertaina, Alice, Abrahamsson, Jonas, Ansari, Marc, Balduzzi, Adriana, Bourquin, JeanPierre, Gerhardt, Corinne, Bierings, Marc, Hasle, Henrik, Lankester, Arjan, Mischke, Kirsten, Moore, Andrew S., Nivison-Smith, Ian, Pieczonka, Anna, Peters, Christina, Sedlacek, Petr, Reinhardt, Dirk, Stein, Jerry, Versluys, Birgitta, Wachowiak, Jacek, Willems, Leen, Zimmermann, Martin, Locatelli, Franco and Sauer, Martin G. (2020). Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children. British Journal of Haematology, 189 (4) bjh.16441, 745-750. doi: 10.1111/bjh.16441

Second primary cancers in people who had cancer as children: an Australian Childhood Cancer Registry population-based study

Youlden, Danny R., Baade, Peter D., Green, Adèle C., Valery, Patricia C., Moore, Andrew S. and Aitken, Joanne F. (2020). Second primary cancers in people who had cancer as children: an Australian Childhood Cancer Registry population-based study. Medical Journal of Australia, 212 (3) mja2.50425, 121-125. doi: 10.5694/mja2.50425

Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors (Oncotarget (2019) 10 (5755-5767) DOI: 10.18632/oncotarget.27206)

Smith, Amanda M., Zhang, Christine R.C., Cristino, Alexandre S., Grady, John P., Lynn Fink, J. and Moore, Andrew S. (2020). Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors (Oncotarget (2019) 10 (5755-5767) DOI: 10.18632/oncotarget.27206). Oncotarget, 11 (3), 305-305. doi: 10.18632/oncotarget.27402

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors

Smith, Amanda M., Zhang, Christine R.C., Cristino, Alexandre S., Grady, John P., Fink, Lynn J. and Moore, Andrew S. (2019). PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors. Oncotarget, 10 (56), 5755-5767. doi: 10.18632/oncotarget.27206

Invasive fungal infections in children with acute lymphoblastic leukaemia: results from four Australian centres, 2003‐2013

Wang, Stacie S., Kotecha, Rishi S., Bernard, Anne, Blyth, Christopher C., McMullan, Brendan J., Cann, Megan P., Yeoh, Daniel K., Bartlett, Adam W., Ryan, Anne L., Moore, Andrew S., Bryant, Penelope A., Clark, Julia and Haeusler, Gabrielle M. (2019). Invasive fungal infections in children with acute lymphoblastic leukaemia: results from four Australian centres, 2003‐2013. Pediatric Blood and Cancer, 66 (10) e27915, e27915. doi: 10.1002/pbc.27915

Hematopoietic stem cell transplantation for children with acute myeloid leukemia in second remission: a report from the Australasian Bone Marrow Transplant Recipient Registry and the Australian and New Zealand Children's Haematology Oncology Group

Selim, Adrian, Alvaro, Frank, Cole, Catherine H., Fraser, Chris J., Mechinaud, Francoise, O'Brien, Tracey A., Shaw, Peter J., Tapp, Heather, Teague, Lochie, Nivison‐Smith, Ian and Moore, Andrew S. (2019). Hematopoietic stem cell transplantation for children with acute myeloid leukemia in second remission: a report from the Australasian Bone Marrow Transplant Recipient Registry and the Australian and New Zealand Children's Haematology Oncology Group. Pediatric Blood & Cancer, 66 (8) e27812, e27812. doi: 10.1002/pbc.27812

Stage at diagnosis for children with blood cancers in Australia: Application of the Toronto Paediatric Cancer Stage Guidelines in a population-based national childhood cancer registry

Youlden, Danny R., Gupta, Sumit, Frazier, A. Lindsay, Moore, Andrew S., Baade, Peter D., Valery, Patricia C., Green, Adèle C. and Aitken, Joanne F. (2019). Stage at diagnosis for children with blood cancers in Australia: Application of the Toronto Paediatric Cancer Stage Guidelines in a population-based national childhood cancer registry. Pediatric Blood and Cancer, 66 (6) e27683, e27683. doi: 10.1002/pbc.27683

ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma

Carvalho, Diana, Taylor, Kathryn R., Olaciregui, Nagore Gene, Molinari, Valeria, Clarke, Matthew, Mackay, Alan, Ruddle, Ruth, Henley, Alan, Valenti, Melanie, Hayes, Angela, Brandon, Alexis De Haven, Eccles, Suzanne A., Raynaud, Florence, Boudhar, Aicha, Monje, Michelle, Popov, Sergey, Moore, Andrew S., Mora, Jaume, Cruz, Ofelia, Vinci, Mara, Brennan, Paul E., Bullock, Alex N., Carcaboso, Angel Montero and Jones, Chris (2019). ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma. Communications Biology, 2 (1) 156, 156. doi: 10.1038/s42003-019-0420-8

The Australian and New Zealand Children's Haematology/Oncology Group Biobanking Network

Boutros, Rose, Catchpoole, Daniel, Collins, Kiri, Cross, Siobhan, Downie, Peter, Drinkwater, Caroline, Fletcher, Jamie, Gottardo, Nicholas, Hunter, Sarah, Kirby, Maria, Ludlow, Louise, Macnish, Marion, Maybury, Mellissa, Moore, Andrew, Morrin, Helen, Purdy, Sarah, Revesz, Tamas, Saffery, Richard, Strong, Robyn, Trahair, Toby, Wood, Andrew and Byrne, Jennifer (2019). The Australian and New Zealand Children's Haematology/Oncology Group Biobanking Network. Biopreservation and Biobanking, 17 (2), 95-97. doi: 10.1089/bio.2019.0013

Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10-year review

Bartlett, Adam W., Cann, Megan P., Yeoh, Daniel K., Bernard, Anne, Ryan, Anne L., Blyth, Christopher C., Kotecha, Rishi S., McMullan, Brendan J., Moore, Andrew S., Haeusler, Gabrielle M. and Clark, Julia E. (2019). Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10-year review. Pediatric Blood and Cancer, 66 (4) e27564, e27564. doi: 10.1002/pbc.27564

The incidence of childhood cancer in Australia, 1983–2015, and projections to 2035

Youlden, Danny R., Baade, Peter D., Green, Adèle C., Valery, Patricia C., Moore, Andrew S. and Aitken, Joanne F. (2019). The incidence of childhood cancer in Australia, 1983–2015, and projections to 2035. Medical Journal of Australia, 212 (3) mja2.50456, 113-120. doi: 10.5694/mja2.50456

Therapy-related acute myeloid leukemia following treatment for cancer in childhood: a population-based registry study

Brown, Catherine A., Youlden, Danny R., Aitken, Joanne F. and Moore, Andrew S. (2018). Therapy-related acute myeloid leukemia following treatment for cancer in childhood: a population-based registry study. Pediatric Blood & Cancer, 65 (12) e27410, e27410. doi: 10.1002/pbc.27410

The genetic basis and cell of origin of mixed phenotype acute leukaemia

Alexander, Thomas B., Gu, Zhaohui, Iacobucci, Ilaria, Dickerson, Kirsten, Choi, John K., Xu, Beisi, Payne-Turner, Debbie, Yoshihara, Hiroki, Loh, Mignon L., Horan, John, Buldini, Barbara, Basso, Giuseppe, Elitzur, Sarah, de Haas, Valerie, Zwaan, C. Michel, Yeoh, Allen, Reinhardt, Dirk, Tomizawa, Daisuke, Kiyokawa, Nobutaka, Lammens, Tim, De Moerloose, Barbara, Catchpoole, Daniel, Hori, Hiroki, Moorman, Anthony, Moore, Andrew S., Hrusak, Ondrej, Meshinchi, Soheil, Orgel, Etan, Devidas, Meenakshi ... Mullighan, Charles G. (2018). The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature, 562 (7727), 373-379. doi: 10.1038/s41586-018-0436-0

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells

Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R., Pemberton, Helen N., Lord, Christopher J., Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V., Qin, Elizabeth Y., Ingram, Wendy J., Moore, Andrew S., Ng, Ho-Keung, Trabelsi, Saoussen, H’mida-Ben Brahim, Dorra, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume ... Jones, Chris (2018). Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells. Nature Medicine, 24 (8), 1204-1215. doi: 10.1038/s41591-018-0086-7

Molecular minimal residual disease monitoring in acute myeloid leukemia: challenges and future directions

Selim, Adrian and Moore, Andrew S (2018). Molecular minimal residual disease monitoring in acute myeloid leukemia: challenges and future directions. The Journal of Molecular Diagnostics, 20 (4), 389-397. doi: 10.1016/j.jmoldx.2018.03.005

Assessing the feasibility and validity of the Toronto Childhood Cancer Stage Guidelines: a population-based registry study

Aitken, Joanne F, Youlden, Danny R, Moore, Andrew S, Baade, Peter D, Ward, Leisa J, Thursfield, Vicky J, Valery, Patricia C, Green, Adèle C, Gupta, Sumit and Frazier, A Lindsay (2018). Assessing the feasibility and validity of the Toronto Childhood Cancer Stage Guidelines: a population-based registry study. The Lancet Child and Adolescent Health, 2 (3), 173-179. doi: 10.1016/S2352-4642(18)30023-3

The MLL recombinome of acute leukemias in 2017

Meyer, C, Burmeister, T, Gröger, D, Tsaur, G, Fechina, L, Renneville, A, Sutton, R, Venn, N C, Emerenciano, M, Pombo-de-Oliveira, M S, Barbieri Blunck, C, Almeida Lopes, B, Zuna, J, Trka, J, Ballerini, P, Lapillonne, H, De Braekeleer, M, Cazzaniga, G, Corral Abascal, L, van der Velden, V H J, Delabesse, E, Park, T S, Oh, S H, Silva, M L M, Lund-Aho, T, Juvonen, V, Moore, A S, Heidenreich, O, Vormoor, J ... Marschalek, R (2018). The MLL recombinome of acute leukemias in 2017. Leukemia, 32 (2), 273-284. doi: 10.1038/leu.2017.213

The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion

Burford, Anna, Mackay, Alan, Popov, Sergey, Vinci, Maria, Carvalho, Diana, Clarke, Matthew, Izquierdo, Elisa, Avery, Aimee, Jacques, Thomas S., Ingram, Wendy J., Moore, Andrew S., Frawley, Kieran, Hassall, Timothy E., Robertson, Thomas and Jones, Chris (2018). The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion. Scientific Reports, 8 (1) 1032, 1-10. doi: 10.1038/s41598-018-19389-9

Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours

Izquierdo, Elisa, Yuan, Lina, George, Sally, Hubank, Michael, Jones, Chris, Proszek, Paula, Shipley, Janet, Gatz, Susanne A., Stinson, Caedyn, Moore, Andrew S., Clifford, Steven C., Hicks, Debbie, Lindsey, Janet C., Hill, Rebecca M., Jacques, Thomas S., Chalker, Jane, Thway, Khin, O'Connor, Simon, Marshall, Lynley, Moreno, Lucas, Pearson, Andrew, Chesler, Louis, Walker, Brian A. and De Castro, David Gonzalez (2017). Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours. Oncotarget, 8 (67), 112036-112050. doi: 10.18632/oncotarget.23000

High prevalence of relapse in children with Philadelphia-like acute lymphoblastic leukemia despite risk-adapted treatment

Heatley, Susan L., Sadras, Teresa, Kok, Chung H., Nievergall, Eva, Quek, Kelly, Dang, Phuong, McClure, Barbara, Venn, Nicola, Moore, Sarah, Suttle, Jeffrey, Law, Tamara, Ng, Anthea, Muskovic, Walter, Norris, Murray D., Revesz, Tamas, Osborn, Michael, Moore, Andrew S., Suppiah, Ram, Fraser, Chris, Alvaro, Frank, Hughes, Timothy P., Mullighan, Charles G., Marshall, Glenn M., Pozza, Luciano Dalla, Yeung, David T., Sutton, Rosemary and White, Deborah L. (2017). High prevalence of relapse in children with Philadelphia-like acute lymphoblastic leukemia despite risk-adapted treatment. Haematologica, 102 (12), 490-493. doi: 10.3324/haematol.2016.162925

Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions

Sadras, Teresa, Heatley, Susan L, Kok, Chung H., Dang, Phuong, Galbraith, Kate M., McClure, Barbara J., Muskovic, Walter, Venn, Nicola C., Moore, Sarah, Osborn, Michael, Revesz, Tamas, Moore, Andrew S., Hughes, Timothy P., Yeung, David, Sutton, Rosemary and White, Deborah L. (2017). Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions. Cancer Letters, 408, 92-101. doi: 10.1016/j.canlet.2017.08.034

Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma

Mackay, Alan, Burford, Anna, Carvalho, Diana, Izquierdo, Elisa, Fazal-Salom, Janat, Taylor, Kathryn R., Bjerke, Lynn, Clarke, Matthew, Vinci, Mara, Nandhabalan, Meera, Temelso, Sara, Popov, Sergey, Molinari, Valeria, Raman, Pichai, Waanders, Angela J., Han, Harry J., Gupta, Saumya, Marshall, Lynley, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Ng, Ho-Keung, Li, Xingang, Mu, Kun, Trabelsi, Saoussen ... Jones, Chris (2017). Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma. Cancer Cell, 32 (4), 520-+. doi: 10.1016/j.ccell.2017.08.017

Erratum to: Population pharmacokinetic modelling of doxorubicin and doxorubicinol in children with cancer: is there a relationship with cardiac troponin profiles? (Cancer Chemotherapy and Pharmacology, (2017), 80, 1, (15-25), 10.1007/s00280-017-3309-6)

Kunarajah, Kuhan, Hennig, Stefanie, Norris, Ross L. G., Lobb, Michael, Charles, Bruce G., Pinkerton, Ross and Moore, Andrew S. (2017). Erratum to: Population pharmacokinetic modelling of doxorubicin and doxorubicinol in children with cancer: is there a relationship with cardiac troponin profiles? (Cancer Chemotherapy and Pharmacology, (2017), 80, 1, (15-25), 10.1007/s00280-017-3309-6). Cancer Chemotherapy and Pharmacology, 80 (1), 27-28. doi: 10.1007/s00280-017-3338-1

Intertumoral heterogeneity within medulloblastoma subgroups

Cavalli, Florence M. G., Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David J. H., Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A. Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M., Farooq, Hamza, Isaev, Karen, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Kim, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A., Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Nageswara Rao, Anulya A., Li, Kay Ka Wai, Ng, Ho-Keung ... Taylor, Michael D. (2017). Intertumoral heterogeneity within medulloblastoma subgroups. Cancer Cell, 31 (6), 737-754.e6. doi: 10.1016/j.ccell.2017.05.005

Population pharmacokinetic modelling of doxorubicin and doxorubicinol in children with cancer: is there a relationship with cardiac troponin profiles?

Kunarajah, Kuhan, Hennig, Stefanie, Norris, Ross L. G., Lobb, Michael, Charles, Bruce G., Pinkerton, Ross and Moore, Andrew S. (2017). Population pharmacokinetic modelling of doxorubicin and doxorubicinol in children with cancer: is there a relationship with cardiac troponin profiles?. Cancer Chemotherapy and Pharmacology, 80 (1), 15-25. doi: 10.1007/s00280-017-3309-6

EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia

Charmsaz, S., Al-Ejeh, F., Yeadon, T. M., Miller, K. J., Smith, F. M., Stringer, B. W., Moore, A. S., Lee, F.-T., Cooper, L. T., Stylianou, C., Yarranton, G. T., Woronicz, J., Scott, A. M., Lackmann, M. and Boyd, A. W. (2017). EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia. Leukemia, 31 (8), 1779-1787. doi: 10.1038/leu.2016.371

Integrated (epi)-genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors

Torchia, Jonathon, Golbourn, Brian, Feng, Shengrui, Ho, King Ching, Sin-Chan, Patrick, Vasiljevic, Alexandre, Norman, Joseph D., Guilhamon, Paul, Garzia, Livia, Agamez, Natalia R., Lu, Mei, Chan, Tiffany S., Picard, Daniel, de Antonellis, Pasqualino, Khuong-Quang, Dong-Anh, Planello, Aline C., Zeller, Constanze, Barsyte-Lovejoy, Dalia, Lafay-Cousin, Lucie, Letourneau, Louis, Bourgey, Mathieu, Yu, Man, Gendoo, Deena M. A., Dzamba, Misko, Barszczyk, Mark, Medina, Tiago, Riemenschneider, Alexandra N., Morrissy, A. Sorana, Ra, Young-Shin ... Huang, Annie (2016). Integrated (epi)-genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors. Cancer Cell, 30 (6), 891-908. doi: 10.1016/j.ccell.2016.11.003

A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia

Vormoor, B., Veal, G. J., Griffin, M. J., Boddy, A. V., Irving, J., Minto, L., Case, M., Banerji, U., Swales, K. E., Tall, J. R., Moore, A. S., Toguchi, M., Acton, G., Dyer, K., Schwab, C., Harrison, C. J., Grainger, J. D., Lancaster, D., Kearns, P., Hargrave, D. and Vormoor, J. (2016). A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia. Pediatric Blood and Cancer, 64 (6) e26351, e26351. doi: 10.1002/pbc.26351

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Smith, Amanda M., Dun, Matthew D., Lee, Erwin M., Harrison, Celeste, Kahl, Richard, Flanagan, Hayley, Panicker, Nikita, Mashkani, Baratali, Don, Anthony S., Morris, Jonathan, Toop, Hamish, Lock, Richard B., Powell, Jason A., Thomas, Daniel, Guthridge, Mark A., Moore, Andrew, Ashman, Leonie K., Skelding, Kathryn A., Enjeti, Anoop and Verrills, Nicole M. (2016). Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors. Oncotarget, 7 (30), 47465-47478. doi: 10.18632/oncotarget.10167

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Nikbakht, Hamid, Panditharatna, Eshini, Mikael, Leonie G., Li, Rui, Gayden, Tenzin, Osmond, Matthew, Ho, Cheng-Ying, Kambhampati, Madhuri, Hwang, Eugene I., Faury, Damien, Siu, Alan, Papillon-Cavanagh, Simon, Bechet, Denise, Ligon, Keith L., Ellezam, Benjamin, Ingram, Wendy J., Stinson, Caedyn, Moore, Andrew S., Warren, Katherine E., Karamchandani, Jason, Packer, Roger J., Jabado, Nada, Majewski, Jacek and Nazarian, Javad (2016). Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma. Nature Communications, 7 (1) 11185, 11185. doi: 10.1038/ncomms11185

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Thompson, Eric M., Hielscher, Thomas, Bouffet, Eric, Remke, Marc, Luu, Betty, Gururangan, Sridharan, McLendon, Roger E., Bigner, Darell D., Lipp, Eric S., Perreault, Sebastien, Cho, Yoon-Jae, Grant, Gerald, Kim, Seung-Ki, Lee, Ji Yeoun, Rao, Amulya A. Nageswara, Giannini, Caterina, Li, Kay Ja Wai, Ng, Ho-Keung, Yao, Yu, Kumabe, Toshihiro, Tominaga, Teiji, Grajkowska, Wieslawa A., Perek-Polnik, Marta, Low, David C. Y., Seow, Wan Tew, Chang, Kenneth T. E., Mora, Jaume, Pollack, Ian F., Hamilton, Ronald L. ... Taylor, Michael D. (2016). Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. The Lancet Oncology, 17 (4), 484-495. doi: 10.1016/S1470-2045(15)00581-1

New brain tumor entities emerge from molecular classification of CNS-PNETs

Sturm, Dominik, Orr, Brent A., Toprak, Umut H., Hovestadt, Volker, Jones, David T. W., Capper, David, Sill, Martin, Buchhalter, Ivo, Northcott, Paul A., Leis, Irina, Ryzhova, Marina, Koelsche, Christian, Pfaff, Elke, Allen, Sariah J., Balasubramanian, Gnanaprakash, Worst, Babara C., Pajtler, Kristian W., Brabetz, Sebastian, Johann, Pascal D., Sahm, Felix, Reimand, Juri, Mackay, Alan, Carvalho, Diana M., Remke, Marc, Phillips, Joanna J., Perry, Arie, Cowdrey, Cynthia, Drissi, Rachid, Fouladi, Maryam ... Kool, Marcel (2016). New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell, 164 (5), 1060-1072. doi: 10.1016/j.cell.2016.01.015

EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.

Charmsaz, Sara, Beckett, Kirrilee, Smith, Fiona M., Bruedigam, Claudia, Moore, Andrew S., Al-Ejeh, Fares, Lane, Steven W. and Boyd, Andrew W. (2015). EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.. PLoS One, 10 (6) e0130692, e0130692-e0130692. doi: 10.1371/journal.pone.0130692

The outcomes and treatment burden of childhood acute myeloid leukaemia in Australia, 1997-2008: A report from the Australian Paediatric Cancer Registry.

Foresto, Steven A., Youlden, Danny R., Baader, Peter D., Hallahan, Andrew R., Aitken, Joanne F. and Moore, Andrew S. (2015). The outcomes and treatment burden of childhood acute myeloid leukaemia in Australia, 1997-2008: A report from the Australian Paediatric Cancer Registry.. Pediatric Blood and Cancer, 62 (9), 1664-1666. doi: 10.1002/pbc.25517

Targeting Survivin with YM155 (Sepantronium Bromide): A novel therapeutic strategy for paediatric acute myeloid leukaemia

Smith, Amanda M., Little, Erica B., Zivanovic, Andjelija, Hong, Priscilla, Liu, Alfred K. S., Burow, Rachel, Stinson, Caedyn, Hallahan, Andrew R. and Moore, Andrew S. (2015). Targeting Survivin with YM155 (Sepantronium Bromide): A novel therapeutic strategy for paediatric acute myeloid leukaemia. Leukemia Research, 39 (4), 435-444. doi: 10.1016/j.leukres.2015.01.005

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy

Bruedigam, C., Bagger, F.O., Heidel, F.H., Paine, Kuhn C., Guignes, S., Song, A., Austin, R., Vu, T., Lee, E., Riyat, S., Moore, A.S., Lock, R.B., Bullinger, L., Hill, G.R., Armstrong, S.A., Williams, D.A. and Lane, S.W. (2014). Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell, 15 (6), 775-790. doi: 10.1016/j.stem.2014.11.010

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

Roberts, K. G., Li, Y., Payne‑Turner, D., Harvey, R. C., Yang, Y.‑L., Pei, D., McCastlain, K., Ding, L., Lu, C., Song, G., Ma, J., Becksfort, J., Rusch, M., Chen, S.‑C., Easton, J., Cheng, J., Boggs, K., Santiago‑Morales, N., Iacobucci, I., Fulton, R. S., Wen, J., Valentine, M., Cheng, C., Paugh, S. W., Devidas, M., Chen, I.‑M., Reshmi, S., Smith, A., Hedlund, E. ... Mullighan, C. G. (2014). Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. New England Journal of Medicine, 371 (11), 1005-1015. doi: 10.1056/NEJMoa1403088

Vincristine sulfate liposomal injection for acute lymphoblastic leukemia

Soosay Raj, Trisha A., Smith, Amanda M. and Moore, Andrew S. (2013). Vincristine sulfate liposomal injection for acute lymphoblastic leukemia. International Journal of Nanomedicine, 8 (1), 4361-4369. doi: 10.2147/IJN.S54657

BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group

Moore, Andrew S., Alonzo, Todd A., Gerbing, Robert B., Lange, Beverly J., Heerema, Nyla A., Franklin, Janet, Raimondi, Susana C., Hirsch, Betsy A., Gamis, Alan S. and Meshinchi, Soheil (2013). BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Pediatric Blood and Cancer, 61 (4), 647-652. doi: 10.1002/pbc.24822

Novel therapies for children with acute myeloid leukaemia

Moore, A. S., Kearns, P. R., Knapper, S., Pearson, A. D. J. and Zwaan, C. M. (2013). Novel therapies for children with acute myeloid leukaemia. Leukemia, 27 (7), 1451-1460. doi: 10.1038/leu.2013.106

Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia

Bavetsias, Vassilios, Crumpler, Simon, Sun, Chongbo, Avery, Sian, Atrash, Butrus, Faisal, Amir, Moore, Andrew S., Kosmopoulou, Magda, Brown, Nathan, Sheldrake, Peter W., Bush, Katherine, Henley, Alan, Box, Gary, Valenti, Melanie, Brandon, Alexis de Haven, Raynaud, Florence I., Workman, Paul, Eccles, Suzanne A., Bayliss, Richard, Linardopoulos, Spiros and Blagg, Julian (2012). Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia. Journal of Medicinal Chemistry, 55 (20), 8721-8734. doi: 10.1021/jm300952s

Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: A model for emerging clinical resistance patterns

Moore, A. S., Faisal, A., Gonzalez de Castro, D., Bavetsias, V., Sun, C., Atrash, B., Valenti, M., de Haven Brandon, A., Avery, S., Mair, D., Mirabella, F., Swansbury, J., Pearson, A. D. J., Workman, P., Blagg, J., Raynaud, F. I., Eccles, S. A. and Linardopoulos, S. (2012). Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: A model for emerging clinical resistance patterns. Leukemia, 26 (7), 1462-1470. doi: 10.1038/leu.2012.52

A stable-isotope HPLC-MS/MS method to simplify storage of human whole blood samples for glutathione assay

Norris, R. L. G., Paul, M., George, R., Moore, A., Pinkerton, R., Haywood, A. and Charles, B. (2012). A stable-isotope HPLC-MS/MS method to simplify storage of human whole blood samples for glutathione assay. Journal of Chromatography B, 898, 136-140. doi: 10.1016/j.jchromb.2012.04.003

Vincristine pharmacodynamics and pharmacogenetics in children with cancer: A limited-sampling, population modelling approach

Moore, Andrew S., Norris, Ross, Price, Gareth, Nguyen, Thu, Ming, Ni, George, Rani, van Breda, Karin, Duley, John, Charles, Bruce and Pinkerton, Ross (2011). Vincristine pharmacodynamics and pharmacogenetics in children with cancer: A limited-sampling, population modelling approach. Journal of Paediatric and Child Health, 47 (12), 875-882. doi: 10.1111/j.1440-1754.2011.02103.x

Adaptation of the plasma inhibitory activity assay to detect Aurora, ABL and FLT3 kinase inhibition by AT9283 in pediatric leukemia

Podesta, Jennifer E., Sugar, Richard, Squires, Matt, Linardopoulos, Spiros, Pearson, Andrew D. J. and Moore, Andrew S. (2011). Adaptation of the plasma inhibitory activity assay to detect Aurora, ABL and FLT3 kinase inhibition by AT9283 in pediatric leukemia. Leukemia Research, 35 (9), 1273-1275. doi: 10.1016/j.leukres.2011.05.022

Aurora kinase inhibitors: Novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias

Moore, A. S., Blagg, J., Linardopoulos, S. and Pearson, A. D. J. (2010). Aurora kinase inhibitors: Novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias. Leukemia, 24 (4), 671-678. doi: 10.1038/leu.2010.15

Vincristine: Can its therapeutic index be enhanced?

Moore, Andrew and Pinkerton, Ross (2009). Vincristine: Can its therapeutic index be enhanced?. Pediatric Blood and Cancer, 53 (7), 1180-1187. doi: 10.1002/pbc.22161

Localised peripheral primitive neuroectodermal tumour (PNET) of the conjunctiva

Moore, Andrew S., Wilson, Peter G., McKelvie, Penny, La Nauze, Jamie and Hirst, Lawrence W. (2009). Localised peripheral primitive neuroectodermal tumour (PNET) of the conjunctiva. Pediatric Blood and Cancer, 53 (4), 669-671. doi: 10.1002/pbc.22062

Haemopoietic stem cell transplantation for children in Australia and New Zealand, 1998-2006: a report on behalf of the Australasian Bone Marrow Transplant Recipient Registry and the Australian and New Zealand Children's Haematology Oncology Group

Moore, A.S., Shaw, P.J., Hallahan, A.R., Carter, T, Kilo, T, Nivison-Smith, I, O'Brien, T.A., Tapp, H, Teague, L, Wilson, S.R. and Tiedemann, K (2009). Haemopoietic stem cell transplantation for children in Australia and New Zealand, 1998-2006: a report on behalf of the Australasian Bone Marrow Transplant Recipient Registry and the Australian and New Zealand Children's Haematology Oncology Group. Medical Journal of Australia, 190 (3), 121-125.

Re: Hyponatraemia and seizures in oncology patients associated with hypotonic intravenous fluids

Moore, A, Suppiah, R and Weier, S (2007). Re: Hyponatraemia and seizures in oncology patients associated with hypotonic intravenous fluids. Journal of Paediatrics And Child Health, 43 (5), 415-416. doi: 10.1111/j.1440-1754.2007.01094.x

A High-grade Gliomas Occurring In Teenagers And Young Adult Patients Comprise Novel Molecular Subgroups

Clarke, M. T., Pereira, R., Mackay, A., Grabovska, Y., Clarke, A., Nicoll, J., Procter, J., Moore, A., Schagen, J., Walker, L., Roncaroli, F., Ogunbigi, O., Jacques, T., Marshall, L., Carceller, F., Reisz, Z., Al-Sarraj, S., Vinci, M., Kurian, K., Ng, H., Brandner, S. and Jones, C. (2023). A High-grade Gliomas Occurring In Teenagers And Young Adult Patients Comprise Novel Molecular Subgroups. 18th Meeting of the European Association of Neuro-Oncology, Rotterdam, Netherlands, 21-24 September 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/neuonc/noad137.069

High-grade gliomas occurring in teenagers and young adult patients comprise novel molecular subgroups

Clarke, Matthew, Pereira, Rita, Mackay, Alan, Grabovska, Yura, Clarke, Amelia, Nicoll, James, Procter, John, Moore, Andrew, Schagen, Joanna, Walker, Liam, Roncaroli, Federico, Ogunbigi, Olumide, Jacques, Thomas, Marshall, Lynley, Carceller, Fernando, Reisz, Zita, Al-Sarraj, Safa, Vinci, Maria, Kurian, Kathreena, Ng, H K, Brandner, Sebastian and Jones, Chris (2023). High-grade gliomas occurring in teenagers and young adult patients comprise novel molecular subgroups. 2023 Pediatric Neuro-Oncology Research Conference, Washington, DC United States, 22-24 June 2023. Cary, NC United States: Oxford University Press. doi: 10.1093/neuonc/noad073.164

Diffuse intrinsic pontine glioma and pediatric glioblastoma derived-exosomes have specific oncogenic signatures

Pericoli, Giulia, Galardi, Angela, Petrilli, Lucia Lisa, Colletti, Marta, Ferretti, Roberta, Paolini, Alessandro, Masotti, Andrea, Mortera, Stefano Levi, Petrini, Stefania, de Billy, Emmanuel, Pascucci, Luisa, Court, Will, Cacchione, Antonella, Carai, Andrea, Camassei, Francesca Diomedi, Moore, Andrew, Carcaboso, Angel Montero, Jones, Chris, Mastronuzzi, Angela, Locatelli, Franco, Di Giannatale, Angela and Vinci, Maria (2018). Diffuse intrinsic pontine glioma and pediatric glioblastoma derived-exosomes have specific oncogenic signatures. 23rd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO) / 3rd CNS Anticancer Drug Discovery and Development Conference, New Orleans, LA, United States, 14-18 November 2018. Cary, NC, United States: Oxford University Press.

Targeting H3.3G34R/V re-wiring of the epigenome in paediatric glioblastoma of children and young adults

Bjerke, Lynn, Mackay, Alan, Carvalho, Diana, Pemberton, Helen, Molinari, Valeria, Vinci, Maria, Carceller, Fernando, Marshall, Lynley, Moore, Andrew, Montero Carcaboso, Angel, Lord, Chris, Hargrave, Darren and Jones, Chris (2018). Targeting H3.3G34R/V re-wiring of the epigenome in paediatric glioblastoma of children and young adults. 23rd Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO) / 3rd CNS Anticancer Drug Discovery and Development Conference, New Orleans, United States, 14-18 November, 2018. Cary, NC, United States: Oxford University Press.

Aberrant splicing of KMT2A as a potential molecular MRD marker in cytogenetically-normal AML

Zhang, Christine R. C., Afrin, Sadia, Maybury, Mellissa, Pham, Thy, Fink, Lynn and Moore, Andrew S. (2018). Aberrant splicing of KMT2A as a potential molecular MRD marker in cytogenetically-normal AML. 60th Annual Meeting of the American Society of Hematology (ASH), San Diego, CA USA, 1-4 December 2018. Washington, DC USA: American Society of Hematology. doi: 10.1182/blood-2018-99-117759

Quantitative analysis of MLL fusion transcripts by droplet digital PCR to monitor minimal residual disease in MLL-rearranged acute myeloid leukemia

Afrin, Sadia, Zhang, Christine R. C., Meyer, Claus, Maybury, Mellissa, Pham, Thy, Venn, Nicola, Trahair, Toby N., Sutton, Rosemary, Marschalek, Rolf, Fink, Lynn and Moore, Andrew S. (2018). Quantitative analysis of MLL fusion transcripts by droplet digital PCR to monitor minimal residual disease in MLL-rearranged acute myeloid leukemia. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA USA, 1-4 December 2018. Washington, DC USA: American Society of Hematology. doi: 10.1182/blood-2018-99-117761

The Molecular Pathology of Infant Gliomas

Clarke, M. T., Jones, D., Carvalho, D. M., Mackay, A., Izquierdo, E., Hargrave, D., Moore, A. S., Popov, S., Jacques, T. S. and Jones, C. (2018). The Molecular Pathology of Infant Gliomas. Winter Meeting on Epigenetics - Understanding Disease and Guiding Therapies / Joint Meeting of the Royal-Society-of-Medicine / 209th Scientific Meeting of the Pathological-Society-of-Great-Britain-and-Ireland, Marylebone England, 25-26 January 2018. Hoboken, NJ United States: Wiley.

The molecular pathology of infant gliomas

Clarke, M., Jones, D. T. W., Carvalho, D., Mackay, A., Izquierdo, E., Hargrave, D., Moore, A. S., Popov, S., Jacques, T. and Jones, C. (2018). The molecular pathology of infant gliomas. 119th Meeting of the British-Neuropathological-Society (BNS) / Epilepsy Neuropathology Symposium, London England, Feb 28-Mar 02 2018. Hoboken, NJ United States: Wiley.

A pilot study to investigate the relationship between doxorubicin and doxorubicinol pharmacokinetics and cardiotoxicity in children and adolescents with cancer.

Hennig, S., Kunarajah, K., Norris, R., Lobb, M., Charles, B., Pinkerton, R. and Moore, A. S. (2016). A pilot study to investigate the relationship between doxorubicin and doxorubicinol pharmacokinetics and cardiotoxicity in children and adolescents with cancer.. World Conference of Pharmacometrics, Brisbane / Brisbane Convention Centre, 21-24 August 2016.

Rare and Common Germline Variants Contribute to Occurrence of Myelodysplastic Syndrome

Hahn, Christopher N., Babic, Milena, Schreiber, Andreas W., Kutyna, Monika M., Wee, L. Amilia, Brown, Anna L., Perugini, Michelle, Singhal, Deepak, Hiwase, Smita, Feng, Jinghua, Parker, Wendy T., Moore, Sarah, Bardy, Peter G., Saal, Russell, Marlton, Paula, Moore, Andrew S., Gonda, Thomas J., Leo, Paul, Branford, Susan, DAndrea, Richard J., Lewis, Ian D., Bik, Luen, Scott, Harnish S. and Hiwase, Devendra (2015). Rare and Common Germline Variants Contribute to Occurrence of Myelodysplastic Syndrome. 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, United States, 5-8 December 2015. WASHINGTON: AMER SOC HEMATOLOGY. doi: 10.1182/blood.V126.23.1644.1644

Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)

Bruedigam, Claudia, Bagger, Frederik Otzen, Heidel, Florian H., Kuhn, Catherine, Guignes, Solene, Song, Axia, Austin, Rebecca, Vu, Therese, Lee, Erwin M., Moore, Andrew S., Lock, Richard B., Bullinger, Lars, Hill, Geoff R. and Lane, Steven W. (2014). Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML). 56th Annual Meeting of the American Society of Hematology, San Francisco CA, United States, 06-09 December 2014. Washington, DC United States: American Society of Hematology.

Blood collection technique for pharmacokinetic studies of doxorubicin in paediatric patients

Lobb, M., Norris, R. L. G., Charles, B., Gilshenan, K., Moore, A. and Pinkerton, R. (2011). Blood collection technique for pharmacokinetic studies of doxorubicin in paediatric patients. 12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Stuttgart, Germany, 2-6 October, 2011. Philadelphia PA, United States: Lippincott Wiliams & Wilkins. doi: 10.1097/01.ftd.0000400651.94145.ba

Resistance to Selective FLT3 Inhibitors, Driven by FLT3 Ligand and FLT3 Point Mutations, Can Be Overcome with the Dual FLT3-Aurora Kinase Inhibitor CCT241736

Moore, AS, Faisal, A, Bavetsias, V, de Castro, DG, Sun, CB, Atrash, B, Valenti, M, Brandon, AD, Avery, S, Pearson, ADJ, Workman, P, Blagg, J, Raynaud, FI, Eccles, SA and Linardopoulos, S (2011). Resistance to Selective FLT3 Inhibitors, Driven by FLT3 Ligand and FLT3 Point Mutations, Can Be Overcome with the Dual FLT3-Aurora Kinase Inhibitor CCT241736. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego CA, DEC 10-13, 2011.

Adaptation and Validation of the Plasma Inhibitory Activity (PIA) Assay to Detect Inhibition of Aurora, ABL and FLT3 kinases by AT9283 In Children and Adolescents with Leukaemia.

Podesta, JE, Griffin, MJ, Sugar, R, Squires, MS, Boddy, A, Linardopoulos, S, Pearson, ADJ and Moore, AS (2010). Adaptation and Validation of the Plasma Inhibitory Activity (PIA) Assay to Detect Inhibition of Aurora, ABL and FLT3 kinases by AT9283 In Children and Adolescents with Leukaemia.. 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Orlando FL, DEC 04-07, 2010.

Dual Inhibition of Aurora and FLT3 Kinases by CCT137690: A Novel Treatment Strategy Against FLT3-ITD Positive AML In Vitro and In Vivo

Moore, AS, Faisal, A, Bavetsias, V, Sun, CB, Atrash, B, Valenti, M, Brandon, AD, Avery, S, Raynaud, FI, Workman, P, Pearson, ADJ, Blagg, J, Eccles, SA and Linardopoulos, S (2010). Dual Inhibition of Aurora and FLT3 Kinases by CCT137690: A Novel Treatment Strategy Against FLT3-ITD Positive AML In Vitro and In Vivo. 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Orlando FL, DEC 04-07, 2010.

Use of etanercept in children following haematopoietic stem cell transplantation: a single institution experience

Moore, A.S. and Hallahan, A.R. (2008). Use of etanercept in children following haematopoietic stem cell transplantation: a single institution experience. 48th Annual Scientific Meeting of the British Society for Haematology, Glasgow, Scotland, 7-9 April 2008. United Kingdom: Wiley-Blackwell Publishing Ltd.. doi: 10.1111/j.1365-2141.2008.07061.x

Does myelosuppression during consolidation or high-dose methotrexate clearance correlate with tolerance of initial maintenance therapy in childhood acute lymphoblastic leukaemia?

Moore, Andrew, Charles, Bruce, Wilkinson, Catherine, Weier, Steven and Pinkerton, Ross (2007). Does myelosuppression during consolidation or high-dose methotrexate clearance correlate with tolerance of initial maintenance therapy in childhood acute lymphoblastic leukaemia?. 39th Annual Conference of the International Society of Paediatric Oncology SIOP 2007, Mumbai, India, 31 October-3 November 2007. Hoboken: Wiley-Liss, Inc. doi: 10.1002/pbc.21342