The University of Queensland

Genetic manipulation of Group A Streptococcus - gene deletion by allelic replacement

Barnett, Timothy C., Daw, Jessica N., Walker, Mark J. and Brouwer, Stephan (2020). Genetic manipulation of Group A Streptococcus - gene deletion by allelic replacement. Group A Streptococcus: methods and protocols. (pp. 59-69) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0467-0_5

Humanized plasminogen mouse model to Study Group A Streptococcus invasive disease

Rivera-Hernandez, Tania and Walker, Mark J. (2020). Humanized plasminogen mouse model to Study Group A Streptococcus invasive disease. Group A Streptococcus: methods and protocols. (pp. 309-316) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-0467-0_24

Investigation of Group A Streptococcal interactions with host glycan structures using high-throughput techniques: glycan microarray analysis using recombinant protein and whole cells

Indraratna, Anuk, De Oliveira, David M. P., Hartley-Tassell, Lauren E., Day, Christopher J., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2020). Investigation of Group A Streptococcal interactions with host glycan structures using high-throughput techniques: glycan microarray analysis using recombinant protein and whole cells. Group A Streptococcus: methods and protocols. (pp. 145-151) edited by Thomas Proft and Jacelyn M. S. Loh. New York, NY USA: Springer Nature. doi: 10.1007/978-1-0716-0467-0_10

Group A streptococcal vaccine candidates: potential for the development of a human vaccine

Henningham, Anna, Gillen, Christine M. and Walker, Mark J. (2013). Group A streptococcal vaccine candidates: potential for the development of a human vaccine. Host-pathogen interactions in streptococcal diseases. (pp. 207-242) edited by G. Singh Chhatwal. New York, NY, United States: Springer. doi: 10.1007/82_2012_284

Gene expression and tagging of streptococcal proteins

Cole, J. N., Sanderson-Smith, M. L., Cork, A. J., Henningham, A., Conlan, F., Ranson, M., McArthur, J. D. and Walker, M. J. (2007). Gene expression and tagging of streptococcal proteins. Molecular Biology of Streptococci. (pp. 359-378) edited by Regine Hakenbeck and Singh Chhatwal. Norfold, United Kingdom: Horizon Bioscience.

Conserved molecular chaperone PrsA stimulates protective immunity against group A Streptococcus

Lai, Chien-Yu, Xie, Jia-Xun, Lai, Meng-Chih, Wu, Zhao-Yi, Lin, Jr-Shiuan, Huang, Yu-Tsung, Chi, Chia-Yu, Chiang-Ni, Chuan, Walker, Mark J. and Chang, Yung-Chi (2024). Conserved molecular chaperone PrsA stimulates protective immunity against group A Streptococcus. npj Vaccines, 9 (1) 46. doi: 10.1038/s41541-024-00839-7

Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model

Rivera-Hernandez, Tania, Carnathan, Diane G., Richter, Johanna, Marchant, Patrick, Cork, Amanda J., Elangovan, Gayathiri, Henningham, Anna, Cole, Jason N., Choudhury, Biswa, Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., Good, Michael F., Agarwal, Paresh, Kapoor, Neeraj, Nizet, Victor, Silvestri, Guido and Walker, Mark J. (2024). Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model. Vaccines, 12 (4) 382, 382. doi: 10.3390/vaccines12040382

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

Xie, Ouli, Morris, Jacqueline M., Hayes, Andrew J., Towers, Rebecca J., Jespersen, Magnus G., Lees, John A., Ben Zakour, Nouri L., Berking, Olga, Baines, Sarah L., Carter, Glen P., Tonkin-Hill, Gerry, Schrieber, Layla, McIntyre, Liam, Lacey, Jake A., James, Taylah B., Sriprakash, Kadaba S., Beatson, Scott A., Hasegawa, Tadao, Giffard, Phil, Steer, Andrew C., Batzloff, Michael R., Beall, Bernard W., Pinho, Marcos D., Ramirez, Mario, Bessen, Debra E., Dougan, Gordon, Bentley, Stephen D., Walker, Mark J., Currie, Bart J. ... Davies, Mark R. (2024). Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis. Nature Communications, 15 (1) 2286, 1-14. doi: 10.1038/s41467-024-46530-2

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w

Pathogenesis, epidemiology and control of Group A Streptococcus infection

Brouwer, Stephan, Rivera-Hernandez, Tania, Curren, Bodie F., Harbison-Price, Nichaela, De Oliveira, David M. P., Jespersen, Magnus G., Davies, Mark R. and Walker, Mark J. (2023). Pathogenesis, epidemiology and control of Group A Streptococcus infection. Nature Reviews Microbiology, 21 (7), 431-447. doi: 10.1038/s41579-023-00865-7

Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA

Davies, Mark R., Keller, Nadia, Brouwer, Stephan, Jespersen, Magnus G., Cork, Amanda J., Hayes, Andrew J., Pitt, Miranda E., De Oliveira, David M. P., Harbison-Price, Nichaela, Bertolla, Olivia M., Mediati, Daniel G., Curren, Bodie F., Taiaroa, George, Lacey, Jake A., Smith, Helen V., Fang, Ning-Xia, Coin, Lachlan J. M., Stevens, Kerrie, Tong, Steven Y. C., Sanderson-Smith, Martina, Tree, Jai J., Irwin, Adam D., Grimwood, Keith, Howden, Benjamin P., Jennison, Amy V. and Walker, Mark J. (2023). Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA. Nature Communications, 14 (1) 1051, 1-12. doi: 10.1038/s41467-023-36717-4

Streptolysin O deficiency in Streptococcus pyogenes M1T1 covR/S mutant strain attenuates virulence in In Vitro and In Vivo infection models

Langshaw, Emma L., Reynolds, Simone, Ozberk, Victoria, Dooley, Jessica, Calcutt, Ainslie, Zaman, Mehfuz, Walker, Mark J., Batzloff, Michael R., Davies, Mark R., Good, Michael F. and Pandey, Manisha (2023). Streptolysin O deficiency in Streptococcus pyogenes M1T1 covR/S mutant strain attenuates virulence in In Vitro and In Vivo infection models. mBio, 14 (1) e03488-22, e0348822. doi: 10.1128/mbio.03488-22

Promiscuous evolution of Group A Streptococcal M and M-like proteins

Frost, Hannah R., Guglielmini, Julien, Duchêne, Sebastian, Lacey, Jake A., Sanderson-Smith, Martina, Steer, Andrew C., Walker, Mark J., Botteaux, Anne, Davies, Mark R. and Smeesters, Pierre R. (2023). Promiscuous evolution of Group A Streptococcal M and M-like proteins. Microbiology, 169 (1) 001280, 1-10. doi: 10.1099/mic.0.001280

Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection (Nature Reviews Microbiology, (2023), 21, 7, (431-447), 10.1038/s41579-023-00865-7)

Brouwer, Stephan, Rivera-Hernandez, Tania, Curren, Bodie F., Harbison-Price, Nichaela, De Oliveira, David M. P., Jespersen, Magnus G., Davies, Mark R. and Walker, Mark J. (2023). Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection (Nature Reviews Microbiology, (2023), 21, 7, (431-447), 10.1038/s41579-023-00865-7). Nature Reviews Microbiology, 21 (9), 619-619. doi: 10.1038/s41579-023-00939-6

Vancomycin resistance in Enterococcus and Staphylococcus aureus

Li, Gen, Walker, Mark J. and De Oliveira, David M. P. (2022). Vancomycin resistance in Enterococcus and Staphylococcus aureus. Microorganisms, 11 (1) 24, 1-51. doi: 10.3390/microorganisms11010024

Repurposing the ionophore, PBT2, for treatment of multidrug-resistant Neisseria gonorrhoeae infections

Jen, Freda E-C, Edwards, Jennifer L., El-Deeb, Ibrahim M., Walker, Mark J., von Itzstein, Mark and Jennings, Michael P. (2022). Repurposing the ionophore, PBT2, for treatment of multidrug-resistant Neisseria gonorrhoeae infections. Antimicrobial Agents and Chemotherapy, 66 (9), 1-4. doi: 10.1128/aac.02318-21

Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion

Brouwer, Stephan, Jespersen, Magnus G., Ong, Cheryl-lynn Y., De Oliveira, David M. P., Keller, Bernhard, Cork, Amanda J., Djoko, Karrera Y., Davies, Mark R. and Walker, Mark J. (2022). Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion. mBio, 13 (3), e0067622. doi: 10.1128/mbio.00676-22

Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria

De Oliveira, David M. P., Keller, Bernhard, Hayes, Andrew J., Ong, Cheryl-Lynn Y., Harbison-Price, Nichaela, El-Deeb, Ibrahim M., Li, Gen, Keller, Nadia, Bohlmann, Lisa, Brouwer, Stephan, Turner, Andrew G., Cork, Amanda J., Jones, Thomas R., Paterson, David L., McEwan, Alastair G., Davies, Mark R., McDevitt, Christopher A., Itzstein, Mark von and Walker, Mark J. (2022). Neurodegenerative disease treatment drug PBT2 breaks intrinsic polymyxin resistance in Gram-positive bacteria. Antibiotics, 11 (4) 449, 449. doi: 10.3390/antibiotics11040449

An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii

De Oliveira, David M.P. and Walker, Mark J. (2022). An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii. Microbial Cell, 9 (3), 69-71. doi: 10.15698/MIC2022.03.772

The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection

Li, Gen, De Oliveira, David M.P. and Walker, Mark J. (2022). The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection. Journal of Inorganic Biochemistry, 227 111661, 111661. doi: 10.1016/j.jinorgbio.2021.111661

Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection

De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Brazel, Erin B., Tan, Aimee, Neville, Stephanie L., Iverson, Amy R., Udagedara, Saumya R., Cunningham, Bliss A., Sikanyika, Mwilye, De Oliveira, David M.P., Keller, Bernhard, Bohlmann, Lisa, El-Deeb, Ibrahim M., Ganio, Katherine, Eijkelkamp, Bart A., McEwan, Alastair G., von Itzstein, Mark, Maher, Megan J., Walker, Mark J., Rosch, Jason W. and McDevitt, Christopher A. (2022). Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model. Cell Reports, 38 (2) 110202, 1-18. doi: 10.1016/j.celrep.2021.110202

Streptococcal superantigens and the return of scarlet fever

Hurst, Jacklyn R., Brouwer, Stephan, Walker, Mark J. and McCormick, John K. (2021). Streptococcal superantigens and the return of scarlet fever. PLOS Pathogens, 17 (12) e1010097, e1010097. doi: 10.1371/journal.ppat.1010097

A drug candidate for Alzheimer's and Huntington's disease, PBT2, can be repurposed to render Neisseria gonorrhoeae susceptible to natural cationic antimicrobial peptides

Jen, Freda E. -C., El-Deeb, Ibrahim M., Zalucki, Yaramah M., Edwards, Jennifer L., Walker, Mark J., Von Itzstein, Mark and Jennings, Michael P. (2021). A drug candidate for Alzheimer's and Huntington's disease, PBT2, can be repurposed to render Neisseria gonorrhoeae susceptible to natural cationic antimicrobial peptides. Journal of Antimicrobial Chemotherapy, 76 (11), 2850-2853. doi: 10.1093/jac/dkab291

Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection

Richter, Johanna, Monteleone, Mercedes M, Cork, Amanda J., Barnett, Timothy C., Nizet, Victor, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology and Cell Biology, 99 (10), 1-13. doi: 10.1111/imcb.12499

Inflammasome activation and IL ‐1β signalling in Group A Streptococcus disease

Richter, Johanna, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Inflammasome activation and IL ‐1β signalling in Group A Streptococcus disease. Cellular Microbiology, 23 (9) e13373, 1-9. doi: 10.1111/cmi.13373

A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study

Osowicki, Joshua, Azzopardi, Kristy I, Fabri, Loraine, Frost, Hannah R, Rivera-Hernandez, Tania, Neeland, Melanie R, Whitcombe, Alana L, Grobler, Anneke, Gutman, Sarah J, Baker, Ciara, Wong, Janet M F, Lickliter, Jason D, Waddington, Claire S, Pandey, Manisha, Schuster, Tibor, Cheng, Allen C, Pollard, Andrew J, McCarthy, James S, Good, Michael F, Dale, James B, Batzloff, Michael, Moreland, Nicole J, Walker, Mark J, Carapetis, Jonathan R, Smeesters, Pierre R and Steer, Andrew C (2021). A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study. The Lancet Microbe, 2 (7), e291-e299. doi: 10.1016/S2666-5247(20)30240-8

A multivalent T-antigen-based vaccine for Group A Streptococcus

Loh, Jacelyn M. S., Rivera-Hernandez, Tania, McGregor, Reuben, Khemlani, Adrina Hema J., Tay, Mei Lin, Cork, Amanda J., M. Raynes, Jeremy, Moreland, Nicole J., Walker, Mark J. and Proft, Thomas (2021). A multivalent T-antigen-based vaccine for Group A Streptococcus. Scientific Reports, 11 (1) 4353, 1-10. doi: 10.1038/s41598-021-83673-4

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, Daniel J., Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H., Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E., Adeli, Khosrow, Adolph, Timon E., Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B., Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N., Agrotis, Alexander, Aguilar, Patricia V., Ahmad, S. Tariq, Ahmed, Zubair M., Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus ... Tong, Chun-Kit (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17 (1), 1-382. doi: 10.1080/15548627.2020.1797280

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

Brouwer, Stephan, Barnett, Timothy C., Ly, Diane, Kasper, Katherine J., De Oliveira, David M. P., Rivera-Hernandez, Tania, Cork, Amanda J., McIntyre, Liam, Jespersen, Magnus G., Richter, Johanna, Schulz, Benjamin L., Dougan, Gordon, Nizet, Victor, Yuen, Kwok-Yung, You, Yuanhai, McCormick, John K., Sanderson-Smith, Martina L., Davies, Mark R. and Walker, Mark J. (2020). Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. Nature Communications, 11 (1) 5018, 5018. doi: 10.1038/s41467-020-18700-5

Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes

Stewart, Louisa J., Ong, Cheryl-Lynn Y., Zhang, May M., Brouwer, Stephan, McIntyre, Liam, Davies, Mark R., Walker, Mark J., McEwan, Alastair G., Waldron, Kevin J. and Djoko, Karrera Y. (2020). Role of glutathione in buffering excess intracellular copper in Streptococcus pyogenes. mBio, 11 (6) e02804-20, 1-19. doi: 10.1128/mBio.02804-20

Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis

De Oliveira, David M. P., Bohlmann, Lisa, Conroy, Trent, Jen, Freda E.-C., Everest-Dass, Arun, Hansford, Karl A., Bolisetti, Raghu, El-Deeb, Ibrahim M., Forde, Brian M., Phan, Minh-Duy, Lacey, Jake A., Tan, Aimee, Rivera-Hernandez, Tania, Brouwer, Stephan, Keller, Nadia, Kidd, Timothy J., Cork, Amanda J., Bauer, Michelle J., Cook, Gregory M., Davies, Mark R., Beatson, Scott A., Paterson, David L., McEwan, Alastair G., Li, Jian, Schembri, Mark A., Blaskovich, Mark A. T., Jennings, Michael P., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2020). Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. Science Translational Medicine, 12 (570) abb3791, eabb3791. doi: 10.1126/scitranslmed.abb3791

Erratum for: An experimental group a Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model (mBio, (2019) 10, 2, 10.1128/mBio.00693-19)

Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2020). Erratum for: An experimental group a Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model (mBio, (2019) 10, 2, 10.1128/mBio.00693-19). mBio, 11 (6) e02995-20, 1-1. doi: 10.1128/mBio.02995-20

Antimicrobial resistance in ESKAPE pathogens

De Oliveira, David M. P., Forde, Brian M., Kidd, Timothy J., Harris, Patrick N. A., Schembri, Mark A., Beatson, Scott A., Paterson, David L. and Walker, Mark J. (2020). Antimicrobial resistance in ESKAPE pathogens. Clinical Microbiology Reviews, 33 (3) e00181-19, e00181-19. doi: 10.1128/cmr.00181-19

Update on group A streptococcal vaccine development

Dale, James B. and Walker, Mark J. (2020). Update on group A streptococcal vaccine development. Current Opinion in Infectious Diseases, 33 (3), 244-250. doi: 10.1097/QCO.0000000000000644

All major cholesterol-dependent cytolysins use glycans as cellular receptors

Shewell, Lucy K., Day, Christopher J., Jen, Freda E.-C., Haselhorst, Thomas, Atack, John M., Reijneveld, Josephine F., Everest-Dass, Arun, James, David B. A., Boguslawski, Kristina M., Brouwer, Stephan, Gillen, Christine M., Luo, Zhenyao, Kobe, Bostjan, Nizet, Victor, von Itzstein, Mark, Walker, Mark J., Paton, Adrienne W., Paton, James C., Torres, Victor J. and Jennings, Michael P. (2020). All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances, 6 (21) EAAZ4926, eaaz4926. doi: 10.1126/sciadv.aaz4926

Multiple bactericidal mechanisms of the zinc ionophore PBT2

Harbison-Price, Nichaela, Ferguson, Scott A., Heikal, Adam, Taiaroa, George, Hards, Kiel, Nakatani, Yoshio, Rennison, David, Brimble, Margaret A., El-Deeb, Ibrahim M., Bohlmann, Lisa, McDevitt, Christopher A., von Itzstein, Mark, Walker, Mark J. and Cook, Gregory M. (2020). Multiple bactericidal mechanisms of the zinc ionophore PBT2. mSphere, 5 (2) e00157-20. doi: 10.1128/msphere.00157-20

Vaccine-induced Th1-type response protects against invasive group A Streptococcus infection in the absence of opsonizing antibodies

Rivera-Hernandez, Tania, Rhyme, Mira Syahira, Cork, Amanda J., Jones, Scott, Segui-Perez, Celia, Brunner, Livia, Richter, Johanna, Petrovsky, Nikolai, Lawrenz, Maria, Goldblatt, David, Collin, Nicolas and Walker, Mark J. (2020). Vaccine-induced Th1-type response protects against invasive group A Streptococcus infection in the absence of opsonizing antibodies. mBio, 11 (2) e00122-20. doi: 10.1128/mbio.00122-20

Updated emm-typing protocol for Streptococcus pyogenes

Frost, H. R., Davies, M. R., Velusamy, S., Delforge, V., Erhart, A., Darboe, S., Steer, A., Walker, M. J., Beall, B., Botteaux, A. and Smeesters, P. R. (2020). Updated emm-typing protocol for Streptococcus pyogenes. Clinical Microbiology and Infection, 26 (7), 946.e5-946.e8. doi: 10.1016/j.cmi.2020.02.026

Semisynthetic, self-adjuvanting vaccine development: efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine

Xu, Zhenghui, Rivera-Hernandez, Tania, Chatterjee, Oishee, Walker, Mark J. and Moyle, Peter M. (2020). Semisynthetic, self-adjuvanting vaccine development: efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine. Journal of Controlled Release, 317, 96-108. doi: 10.1016/j.jconrel.2019.11.018

Analysis of global collection of group A Streptococcus genomes reveals that the majority encode a trio of M and M-like proteins

Frost, Hannah R., Davies, Mark R., Delforge, Valérie, Lakhloufi, Dalila, Sanderson-Smith, Martina, Srinivasan, Velusamy, Steer, Andrew C., Walker, Mark J., Beall, Bernard, Botteaux, Anne and Smeesters, Pierre R. (2020). Analysis of global collection of group A Streptococcus genomes reveals that the majority encode a trio of M and M-like proteins. mSphere, 5 (1) e00806. doi: 10.1128/mSphere.00806-19

Neisseria gonorrhoeae becomes susceptible to polymyxin B and colistin in the presence of PBT2

Jen, Freda E.-C., Everest-Dass, Arun V., El-Deeb, Ibrahim M., Singh, Sanjesh, Haselhorst, Thomas, Walker, Mark J., Von Itzstein, Mark and Jennings, Michael P. (2020). Neisseria gonorrhoeae becomes susceptible to polymyxin B and colistin in the presence of PBT2. ACS Infectious Diseases, 6 (1), 50-55. doi: 10.1021/acsinfecdis.9b00307

Increased incidence of scarlet fever — China, 1999−2018

You, Yuanhai, Qin, Ying, Walker, Mark J., Feng, Luzhao and Zhang, Jianzhong (2019). Increased incidence of scarlet fever — China, 1999−2018. China CDC Weekly, 1 (5), 63-66. doi: 10.46234/ccdcw2019.019

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

Ly, Diane, Donahue, Deborah, Walker, Mark J., Ploplis, Victoria A., McArthur, Jason D., Ranson, Marie, Castellino, Francis J. and Sanderson-Smith, Martina L. (2019). Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes and Infection, 21 (8-9), 412-417. doi: 10.1016/j.micinf.2019.04.004

Scarlet fever changes its spots

Brouwer, Stephan, Lacey, Jake A., You, Yuanhai, Davies, Mark R. and Walker, Mark J. (2019). Scarlet fever changes its spots. Lancet Infectious Diseases, 19 (11), 1154-1155. doi: 10.1016/S1473-3099(19)30494-3

Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells

De Oliveira, David M. P., Everest-Dass, Arun, Hartley-Tassell, Lauren, Day, Christopher J., Indraratna, Anuk, Brouwer, Stephan, Cleary, Ailish, Kautto, Liisa, Gorman, Jody, Packer, Nicolle H., Jennings, Michael P., Walker, Mark J. and Sanderson-Smith, Martina L. (2019). Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells. FASEB Journal, 33 (10), 10808-10818. doi: 10.1096/fj.201900559R

The serotype-specific role of regulator of cov polymorphisms in the pathogenesis of invasive group a streptococcal infections

Brouwer, Stephan and Walker, Mark J. (2019). The serotype-specific role of regulator of cov polymorphisms in the pathogenesis of invasive group a streptococcal infections. American Journal of Pathology, 189 (10), 1913-1915. doi: 10.1016/j.ajpath.2019.07.005

Author correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Davies, Mark R., McIntyre, Liam, Mutreja, Ankur, Lacey, Jake A., Lees, John A., Towers, Rebecca J., Duchêne, Sebastián, Smeesters, Pierre R., Frost, Hannah R., Price, David J., Holden, Matthew T. G., David, Sophia, Giffard, Philip M., Worthing, Kate A., Seale, Anna C., Berkley, James A., Harris, Simon R., Rivera-Hernandez, Tania, Berking, Olga, Cork, Amanda J., Torres, Rosângela S. L. A., Lithgow, Trevor, Strugnell, Richard A., Bergmann, Rene, Nitsche-Schmitz, Patric, Chhatwal, Gusharan S., Bentley, Stephen D., Fraser, John D., Moreland, Nicole J. ... Walker, Mark J. (2019). Author correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics. Nature Genetics, 51 (8), 1295-1295. doi: 10.1038/s41588-019-0482-z

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Davies, Mark R., McIntyre, Liam, Mutreja, Ankur, Lacey, Jake A., Lees, John A., Towers, Rebecca J., Duchêne, Sebastián, Smeesters, Pierre R., Frost, Hannah R., Price, David J., Holden, Matthew T. G., David, Sophia, Giffard, Philip M., Worthing, Kate A., Seale, Anna C., Berkley, James A., Harris, Simon R., Rivera-Hernandez, Tania, Berking, Olga, Cork, Amanda J., Torres, Rosângela S. L. A., Lithgow, Trevor, Strugnell, Richard A., Bergmann, Rene, Nitsche-Schmitz, Patric, Chhatwal, Gusharan S., Bentley, Stephen D., Fraser, John D., Moreland, Nicole J. ... Walker, Mark J. (2019). Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics. Nature Genetics, 51 (6), 1035-1043. doi: 10.1038/s41588-019-0417-8

Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study

Osowicki, Joshua, Azzopardi, Kristy I., Baker, Ciara, Waddington, Claire S., Pandey, Manisha, Schuster, Tibor, Grobler, Anneke, Cheng, Allen C., Pollard, Andrew J., McCarthy, James S., Good, Michael F., Walker, Mark J., Dale, James B., Batzloff, Michael R., Carapetis, Jonathan R., Smeesters, Pierre R. and Steer, Andrew C. (2019). Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study. Vaccine, 37 (26), 3485-3494. doi: 10.1016/j.vaccine.2019.03.059

An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model

Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2019). An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model. mBio, 10 (2) e00693-19. doi: 10.1128/mBio.00693-19

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

Edgar, Rebecca J., van Hensbergen, Vincent P., Ruda, Alessandro, Turner, Andrew G., Deng, Pan, Le Breton, Yoann, El-Sayed, Najib M., Belew, Ashton T., McIver, Kevin S., McEwan, Alastair G., Morris, Andrew J., Lambeau, Gérard, Walker, Mark J., Rush, Jeffrey S., Korotkov, Konstantin V., Widmalm, Göran, van Sorge, Nina M. and Korotkova, Natalia (2019). Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides. Nature Chemical Biology, 15 (5), 463-471. doi: 10.1038/s41589-019-0251-4

Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress

Turner, Andrew G., Djoko, Karrera Y., Ong, Cheryl-Lynn Y., Barnett, Timothy C., Walker, Mark J. and McEwan, Alastair G. (2019). Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress. Biochemical Journal, 476 (3), 595-611. doi: 10.1042/BCJ20180902

A controlled human infection model of Group A Streptococcus pharyngitis: which strain and why?

Osowicki, Joshua, Azzopardi, Kristy I., McIntyre, Liam, Rivera-Hernandez, Tania, Ong, Cheryl-Lynn Y., Baker, Ciara, Gillen, Christine M., Walker, Mark J., Smeesters, Pierre R., Davies, Mark R. and Steer, Andrew C. (2019). A controlled human infection model of Group A Streptococcus pharyngitis: which strain and why?. mSphere, 4 (1) e00647-18, e00647-18. doi: 10.1128/mSphere.00647-18

Detection of epidemic scarlet fever group A Streptococcus in Australia

Walker, Mark J., Brouwer, Stephan, Forde, Brian M., Worthing, Kate A., McIntyre, Liam, Sundac, Lana, Maloney, Sam, Roberts, Leah W., Barnett, Timothy C., Richter, Johanna, Cork, Amanda J., Irwin, Adam D., You, Yuanhai, Zhang, Jianzhong, Dougan, Gordon, Yuen, K. Y., Nizet, Victor, Beatson, Scott A., Grimwood, Keith and Davies, Mark R. (2019). Detection of epidemic scarlet fever group A Streptococcus in Australia. Clinical Infectious Diseases, 69 (7), 1232-1234. doi: 10.1093/cid/ciz099

Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance

Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18, 1-12. doi: 10.1128/mBio.02391-18

Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance

Bohlmann, Lisa, De Oliveira, David M. P., El-Deeb, Ibrahim M., Brazel, Erin B., Harbison-Price, Nichaela, Ong, Cheryl-lynn Y., Rivera-Hernandez, Tania, Ferguson, Scott A., Cork, Amanda J., Phan, Minh-Duy, Soderholm, Amelia T., Davies, Mark R., Nimmo, Graeme R., Dougan, Gordon, Schembri, Mark A., Cook, Gregory M., McEwan, Alastair G., von Itzstein, Mark, McDevitt, Christopher A. and Walker, Mark J. (2018). Chemical synergy between ionophore PBT2 and zinc reverses antibiotic resistance. mBio, 9 (6) e02391-18. doi: 10.1128/mbio.02391-18

Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection

Imai, Takashi, Matsumura, Takayuki, Mayer-Lambertz, Sabine, Wells, Christine A., Ishikawa, Eri, Butcher, Suzanne K., Barnett, Timothy C., Walker, Mark J., Imamura, Akihiro, Ishida, Hideharu, Ikebe, Tadayoshi, Miyamoto, Tomofumi, Ato, Manabu, Ohga, Shouichi, Lepenies, Bernd, van Sorge, Nina M. and Yamasaki, Sho (2018). Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection. Proceedings of the National Academy of Sciences of the United States of America, 115 (45), E10662-E10671. doi: 10.1073/pnas.1809100115

Hypotheses for the resurgence of scarlet fever in China

You, Yuanhai, Davies, Mark R, Walker, Mark J and Zhang, Jianzhong (2018). Hypotheses for the resurgence of scarlet fever in China. The Lancet Infectious Diseases, 18 (9), 942-943. doi: 10.1016/S1473-3099(18)30470-5

Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment

Kawasaki, Minami, Delamare-Deboutteville, Jerome, Bowater, Rachel O, Walker, Mark J., Beatson, Scott, Ben Zakour, Nouri L. and Barnes, Andrew C. (2018). Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment. Applied and Environmental Microbiology, 84 (16) e00859-18, AEM.00859-18. doi: 10.1128/aem.00859-18

A host proteome atlas of Streptococcus pyogenes infection

Soderholm, Amelia T. and Walker, Mark J. (2018). A host proteome atlas of Streptococcus pyogenes infection. Cell Systems, 6 (5), 536-538. doi: 10.1016/j.cels.2018.05.003

Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP

Soderholm, Amelia T., Barnett, Timothy C., Korn, Othmar, Rivera-Hernandez, Tania, Seymour, Lisa M., Schulz, Benjamin L., Nizet, Victor, Wells, Christine A., Sweet, Matthew J. and Walker, Mark J. (2018). Group A Streptococcus M1T1 intracellular infection of primary tonsil epithelial cells dampens levels of secreted IL-8 through the action of SpyCEP. Frontiers in Cellular and Infection Microbiology, 8 (MAY) 160, 160. doi: 10.3389/fcimb.2018.00160

Complete genome sequence of a Streptococcus pyogenes serotype M12 scarlet fever outbreak isolate from China, compiled using Oxford nanopore and illumina sequencing

You, Yuanhai, Kou, Yongjun, Niu, Longfei, Jia, Qiong, Liu, Yahui, Davies, Mark R., Walker, Mark J., Zhu, Jiaqiang and Zhang, Jianzhong (2018). Complete genome sequence of a Streptococcus pyogenes serotype M12 scarlet fever outbreak isolate from China, compiled using Oxford nanopore and illumina sequencing. Genome Announcements, 6 (18) e00389-18, e00389-18. doi: 10.1128/genomeA.00389-18

The role of zinc acquisition and zinc tolerance in group A streptococcal infection

Ong, Cheryl-Lynn Y., Berking, Olga, Walker, Mark J. and McEwan, Alastair G. (2018). The role of zinc acquisition and zinc tolerance in group A streptococcal infection. Infection and Immunity, 86 (6) e00048-18, e00048-18. doi: 10.1128/IAI.00048-18

Scarlet fever epidemic in China caused by Streptococcus pyogenes serotype M12: epidemiologic and molecular analysis

You, Yuanhai, Davies, Mark R, Protani, Melinda, McIntyre, Liam, Walker, Mark J and Zhang, Jianzhong (2018). Scarlet fever epidemic in China caused by Streptococcus pyogenes serotype M12: epidemiologic and molecular analysis. EBioMedicine, 28, 128-135. doi: 10.1016/j.ebiom.2018.01.010

Scarlet fever makes a comeback

Walker, Mark J. and Brouwer, Stephan (2018). Scarlet fever makes a comeback. The Lancet Infectious Diseases, 18 (2), 128-129. doi: 10.1016/S1473-3099(17)30694-1

Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus

Henningham, Anna, Davies, Mark R., Uchiyama, Satoshi, van Sorge, Nina M., Lund, Sean, Chen, Kelsey T., Walker, Mark J., Cole, Jason N. and Nizet, Victor (2018). Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus. mBio, 9 (1) e02294-17, 1-12. doi: 10.1128/mBio.02294-17

The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes

Brouwer, Stephan, Cork, Amanda J., Ong, Cheryl-Lynn Y., Barnett, Timothy C., West, Nicholas P., McIver, Kevin S. and Walker, Mark J. (2018). The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology, 200 (8) e00654-17, e00654-17. doi: 10.1128/JB.00654-17

Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies

Soderholm, Amelia T., Barnett, Timothy C., Sweet, Matthew J. and Walker, Mark J. (2017). Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies. Journal of Leukocyte Biology, 103 (2), 193-213. doi: 10.1189/jlb.4MR0617-227RR

group A streptococcal M-Like Proteins: From pathogenesis to Vaccine POTENTIAL

Frost, Hannah, Sanderson-Smith, Martina, Walker, Mark, Botteaux, Anne and Smeesters, Pierre (2017). group A streptococcal M-Like Proteins: From pathogenesis to Vaccine POTENTIAL. FEMS microbiology reviews, 42 (2), 193-204. doi: 10.1093/femsre/fux057

Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli

Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Achard, Maud E. S., Forde, Brian M., Hong, Kar Wai, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, West, Nicholas P., Walker, Mark J., Paterson, David L., Beatson, Scott A. and Schembri, Mark A. (2017). Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli. Journal of Antimicrobial Chemotherapy, 72 (10), 2729-2736. doi: 10.1093/jac/dkx204

Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection

Rox, Katharina, Jansen, Rolf, Loof, Torsten G., Gillen, Christine M., Bernecker, Steffen, Walker, Mark J., Chhatwal, Gursharan Singh and Müller, Rolf (2017). Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection. Scientific Reports, 7 (1) 11798, 1-12. doi: 10.1038/s41598-017-11276-z

Caveolin 1 restricts Group A Streptococcus invasion of nonphagocytic host cells

Lim, Jin Yan, Barnett, Timothy C., Bastiani, Michele, McMahon, Kerrie-Ann, Ferguson, Charles, Webb, Richard I., Parton, Robert G. and Walker, Mark J. (2017). Caveolin 1 restricts Group A Streptococcus invasion of nonphagocytic host cells. Cellular microbiology, 19 (12) e12772, 1-16. doi: 10.1111/cmi.12772

Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli

Djoko, Karrera Y., Phan, Minh-Duy, Peters, Kate M., Walker, Mark J. , Schembri, Mark A. and McEwan, Alastair G. (2017). Interplay between tolerance mechanisms to copper and acid stress in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), 6818-6823. doi: 10.1073/pnas.1620232114

The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes

Turner, Andrew G., Ong, Cheryl-lynn Y., Djoko, Karrera Y., West, Nicholas P., Davies, Mark R., McEwan, Alastair G. and Walker, Mark J. (2017). The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes. Infection and Immunity, 85 (6) e00140-17, e00140-17.1-e00140-17.13. doi: 10.1128/IAI.00140-17

Transition metal homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae

Turner, Andrew G., Ong, Cheryl-lynn Y., Walker, Mark J., Djoko, Karrera Y. and McEwan, Alastair G. (2017). Transition metal homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae. Advances in Microbial Physiology, 70, 123-191. doi: 10.1016/bs.ampbs.2017.01.002

Blood group antigen recognition via the group A Streptococcal M protein mediates host colonization

De Oliveira, David M. P., Hartley-Tassell, Lauren, Everest-Dass, Arun, Day, Christopher J., Dabbs, Rebecca A., Ve, Thomas, Kobe, Bostjan, Nizet, Victor, Packer, Nicolle H., Walker, Mark J., Jennings, Michael P. and Sanderson-Smith, Martina L. (2017). Blood group antigen recognition via the group A Streptococcal M protein mediates host colonization. MBio, 8 (1) e02237-16, e02237-16. doi: 10.1128/mBio.02237-16

Tribute to professor Gursharan Singh Chhatwal

Walker, Mark J. (2016). Tribute to professor Gursharan Singh Chhatwal. Environmental Microbiology Reports, 8 (5), 553-553. doi: 10.1111/1758-2229.12460

Streptococcus iniae cpsG alters capsular carbohydrate composition and is a cause of serotype switching in vaccinated fish

Heath, Candice, Gillen, Christine M., Chrysanthopoulos, Panagiotis, Walker, Mark J. and Barnes, Andrew C. (2016). Streptococcus iniae cpsG alters capsular carbohydrate composition and is a cause of serotype switching in vaccinated fish. Veterinary Microbiology, 193, 116-124. doi: 10.1016/j.vetmic.2016.08.011

Streptococcus pyogenes adhesion and colonization

Brouwer, Stephan, Barnett, Timothy C., Rivera-Hernandez, Tania, Rohde, Manfred and Walker, Mark J. (2016). Streptococcus pyogenes adhesion and colonization. FEBS Letters, 590 (21), 3739-3757. doi: 10.1002/1873-3468.12254

Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models

Rivera-Hernandez, Tania, Pandey, Manisha, Henningham, Anna, Cole, Jason, Choudhury, Biswa, Cork, Amanda J., Gillen, Christine M., Ghaffar, Khairunnisa Abdul, West, Nicholas P., Silvestri, Guido, Good, Michael F., Moyle, Peter M., Toth, Istvan, Nizet, Victor, Batzloff, Michael R. and Walker, Mark J. (2016). Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models. mBio, 7 (3) e00618-16, e00618-16.1-e00618-16.9. doi: 10.1128/mBio.00618-16

Meet our editorial board member

Walker, Mark J. (2016). Meet our editorial board member. Current Drug Targets, 17 (8), 851-851. doi: 10.2174/138945011708160504105536

Interleukin-17A contributes to the control of Streptococcus pyogenes colonization and inflammation of the female genital tract

Carey, Alison J., Weinberg, Jason B., Dawid, Suzanne R., Venturini, Carola, Lam, Alfred K., Nizet, Victor, Caparon, Michael G., Walker, Mark J., Watson, Michael E. and Ulett, Glen C. (2016). Interleukin-17A contributes to the control of Streptococcus pyogenes colonization and inflammation of the female genital tract. Scientific Reports, 6 (1) 26836, 26836. doi: 10.1038/srep26836

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, Daniel J., et al., Wolvetang, Ernst and Walker, Mark J. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1), 1-222. doi: 10.1080/15548627.2015.1100356

Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015)

Kliosnky, D., Ernst Wolvetang and Mark J. Walker (2016). Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015). Autophagy, 12 (2), 443-443. doi: 10.1080/15548627.2016.1147886

Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?

Zhang, May M., Ong, Cheryl-lynn, Walker, Mark J. and McEwan, Alastair G. (2015). Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?. Pathogens and Disease, 74 (2) ARTN ftv122, ftv122. doi: 10.1093/femspd/ftv122

Streptococcal toxins: role in pathogenesis and disease

Barnett, Timothy C., Cole, Jason N., Rivera-Hernandez, Tania, Henningham, Anna, Paton, James C., Nizet, Victor and Walker, Mark J. (2015). Streptococcal toxins: role in pathogenesis and disease. Cellular Microbiology, 17 (12), 1721-1741. doi: 10.1111/cmi.12531

Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone

Ben Zakour, Nouri L., Davies, Mark R., You, Yuanhai, Chen, Jonathan H. K., Forde, Brian M., Stanton-Cook, Mitchell, Yang, Ruifu, Cui, Yujun, Barnett, Timothy C., Venturini, Carola, Ong, Cheryl-lynn Y., Tse, Herman, Dougan, Gordon, Zhang, Jianzhong, Yuen, Kwok-Yung, Beatson, Scott A. and Walker MJ (2015). Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone. Scientific Reports, 5 (1) 15877, 15877.1-15877.7. doi: 10.1038/srep15877

Meet our editorial board member

Walker, Mark J. (2015). Meet our editorial board member. Current Drug Targets, 16 (11).

Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses

Tsatsaronis, James A., Ly, Diane, Pupovac, Aleta, Goldmann, Oliver, Rohde, Manfred, Taylor, Jude M., Walker, Mark J., Medina, Eva and Sanderson-Smith, Martina L. (2015). Group A Streptococcus Modulates Host Inflammation by Manipulating Polymorphonuclear Leukocyte Cell Death Responses. Journal of Innate Immunity, 7 (6), 612-622. doi: 10.1159/000430498

Host-pathogen interaction during bacterial vaccination

Barnett, Timothy C., Lim, Jin Yan, Soderholm, Amelia T., Rivera-Hernandez, Tania, West, Nicholas P. and Walker, Mark J. (2015). Host-pathogen interaction during bacterial vaccination. Current Opinion in Immunology, 36, 1-7. doi: 10.1016/j.coi.2015.04.002

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.

Djoko, Karrera Y, Ong, Cheryl-lynn Y, Walker, Mark J and McEwan, Alastair G (2015). The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.. Journal of Biological Chemistry, 290 (31), 18954-18961. doi: 10.1074/jbc.R115.647099

Molecular typing of Chinese Streptococcus pyogenes isolates

You, Yuanhai, Wang, Haibin, Bi, Zhenwang, Walker, Mark, Peng, Xianhui, Hu, Bin, Zhou, Haijian, Song, Yanyan, Tao, Xiaoxia, Kou, Zengqiang, Meng, Fanliang, Zhang, Menghan, Bi, Zhenqiang, Luo, Fengji and Zhang, Jianzhong (2015). Molecular typing of Chinese Streptococcus pyogenes isolates. Molecular and Cellular Probes, 29 (3), 172-176. doi: 10.1016/j.mcp.2015.03.009

Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.

Ong, Cheryl-lynnY., Walker, Mark J. and McEwan, Alastair G. (2015). Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes.. Scientific Reports, 5 (Art No.: 10799) 10799, 10799. doi: 10.1038/srep10799.

Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase

Cork, Amanda J., Ericsson, Daniel J., Law, Ruby H. P., Casey, Lachlan W., Valkov, Eugene, Bertozzi, Carlo, Stamp, Anna, Jovcevski, Blagojce, Aquilina, J. Andrew, Whisstock, James C., Walker, Mark J. and Kobe, Bostjan (2015). Stability of the octameric structure affects plasminogen-binding capacity of Streptococcal enolase. PLoS One, 10 (3) e0121764, 1-18. doi: 10.1371/journal.pone.0121764

Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence

Turner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15

Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-José, Descorps-Declere, Stéphane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., Holden, Matthew T G., Poyart, Claire and Glaser, Philippe (2015). Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 6 (1) 6108. doi: 10.1038/ncomms7108

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance

Davies, Mark R., Holden, Matthew T., Coupland, Paul, Chen, Jonathan H. K., Venturini, Carola, Barnett, Timothy C., Ben Zakour, Nouri L., Tse, Herman, Dougan, Gordon, Yuen, Kwok-Yung and Walker, Mark J. (2015). Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance. Nature Genetics, 47 (1), 84-87+. doi: 10.1038/ng.3147

Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak

Bartley, Paul B., Ben Zakour, Nouri L., Stanton-Cook, Mitchell, Muguli, Raghuram, Prado, Luis, Garnys, Vyt, Taylor, Katherine, Barnett, Timothy C., Pinna, Glen, Robson, Jennifer, Paterson, David L., Walker, Mark J., Schembri, Mark A. and Beatson, Scott A. (2015). Hospital-Wide Eradication of a Nosocomial Legionella pneumophila Serogroup 1 Outbreak. Clinical Infectious Diseases, 62 (3), 273-279. doi: 10.1093/cid/civ870

Meet our editorial board member

Walker, Mark J. (2015). Meet our editorial board member. Current Drug Targets, 16 (11)

The contribution of non-human primate models to the development of human vaccines

Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.

Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus

Henningham, Anna, Yamaguchi, Masaya, Aziz, Ramy K., Kuipers, Kirsten, Buffalo,Cosmo Z., Dahesh, Samira, Choudhury, Biswa, Van Vleet, Jeremy, Yamaguchi, Yuka, Seymour, Lisa M., Ben Zakour, Nouri L., He, Lingjun, Smith, Helen V., Grimwood, Keith, Beatson, Scott A., Ghosh, Partho, Walker, Mark J., Nizet, Victor and Cole, Jason N. (2014). Mutual exclusivity of hyaluronan and hyaluronidase in invasive group a Streptococcus. Journal of Biological Chemistry, 289 (46), 32303-32315. doi: 10.1074/jbc.M114.602847

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.

Shewell, Lucy K., Harvey,Richard M., Higgins, Melanie A., Day, Christopher J., Hartley-Tassell, Lauren E., Chen, Austen Y., Gillen, Christine M., James, David B. A., Alonzo, Francis, Torres, Victor J., Walker, Mark J., Paton, Adrienne W., Paton, James C. and Jennings, Michael P. (2014). The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.. Proceedings of the National Academy of Sciences of the United State of America, 111 (49), E5312-E5320. doi: 10.1073/pnas.1412703111

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

Sanderson-Smith, Martina, De Oliveira, David M. P., Guglielmini, Julien, McMillan, David J., Vu, Therese, Holien, Jessica K., Henningham, Anna, Steer, Andrew C., Bessen, Debra E., Dale, James B., Curtis, Nigel, Beall, Bernard W., Walker, Mark J., Parker, Michael W., Carapetis, Jonathan R., Van Melderen, Laurence, Sriprakash, Kadaba S. and Smeesters, Pierre R. (2014). A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. The Journal of Infectious Diseases, 210 (8), 1325-1338. doi: 10.1093/infdis/jiu260

Tracking antibiotic resistance

Beatson, Scott A. and Walker, Mark J. (2014). Tracking antibiotic resistance. Science, 345 (6203), 1454-1455. doi: 10.1126/science.1260471

Host responses to group A Streptococcus: cell death and inflammation

Tsatsaronis, James A., Walker, Mark J. and Sanderson-Smith, Martina L. (2014). Host responses to group A Streptococcus: cell death and inflammation. PLoS Pathogens, 10 (8) e1004266, e1004266.1-e1004266.7. doi: 10.1371/journal.ppat.1004266

Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-Jose, Descorps-Declere, Stephane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., The DEVANI Consortium, Holden, Matthew T. G. ... Glaser, Philippe (2014). Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 5 (1) 4544, 4544.1-4544.11. doi: 10.1038/ncomms5544

Evaluation of recombinant Mycoplasma hyopneumoniae P97/P102 paralogs formulated with selected adjuvants as vaccines against mycoplasmal pneumonia in pigs

Woolley, Lauren K., Fell, Shayne A., Gonsalves, Jocelyn R., Raymond, Benjamin B. A., Collins, Damian, Kuit, Tracey A., Walker, Mark J., Djordjevic, Steven P., Eamens, Graeme J. and Jenkins, Cheryl (2014). Evaluation of recombinant Mycoplasma hyopneumoniae P97/P102 paralogs formulated with selected adjuvants as vaccines against mycoplasmal pneumonia in pigs. Vaccine, 32 (34), 4333-4341. doi: 10.1016/j.vaccine.2014.06.008

Working towards a Group A Streptococcal vaccine: report of a collaborative Trans-Tasman workshop

Moreland, Nicole J., Waddington, Claire S., Williamson, Deborah A., Sriskandan, Shiranee, Smeesters, Pierre R., Proft, Thomas, Steer, Andrew C., Walker, Mark J., Baker, Edward N., Baker, Michael G., Lennon, Diana, Dunbar, Rod and Fraser, John D. (2014). Working towards a Group A Streptococcal vaccine: report of a collaborative Trans-Tasman workshop. Vaccine, 32 (30), 3713-3720. doi: 10.1016/j.vaccine.2014.05.017

The classical Lancefield antigen of Group A Streptococcus is a virulence determinant with implications for vaccine design

van Sorge, Nina M., Cole, Jason N., Kuipers, Kristen, Henningham, Anna, Aziz, Ramy K., Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien T. M., Davies, Mark R., Dougan, Gordon, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph A., Hutter, Julia, Lepenies, Bernd, Rooijakkers, Suzan H. M., Malley, Richard, Walker, Mark J., Shattil, Sanford J., Schlievert, Patrick M., Choudhury, Biswa and Nizet, Victor (2014). The classical Lancefield antigen of Group A Streptococcus is a virulence determinant with implications for vaccine design. Cell Host and Microbe, 15 (6), 729-740. doi: 10.1016/j.chom.2014.05.009.

An antimicrobial role for zinc in innate immune defence against group A streptococcus

Ong, Cheryl-lynn Y., Gillen, Christine M., Barnett, Timothy C., Walker, Mark J. and McEwan, Alastair G. (2014). An antimicrobial role for zinc in innate immune defence against group A streptococcus. Journal of Infectious Diseases, 209 (10), 1500-1508. doi: 10.1093/infdis/jiu053

Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants

Cook, Simon M., Skora, Amanda, Walker, Mark J., Sanderson-Smith, Martina L. and McArthur, Jason D. (2014). Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants. Biochemical Journal, 458 (1), 23-31. doi: 10.1042/BJ20131305

Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing

Ly, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754

Disease manifestations and pathogenic mechanisms of group A Streptococcus

Walker, Mark J., Barnett, Timothy C., McArthur, Jason D., Cole, Jason N., Gillen, Christine M., Henningham, Anna, Sriprakash, K. S., Sanderson-Smith, Martina L. and Nizet, Victor (2014). Disease manifestations and pathogenic mechanisms of group A Streptococcus. Clinical Microbiology Reviews, 27 (2), 264-301. doi: 10.1128/CMR.00101-13

The globally disseminated M1T1 clone of Group A Streptococcus evades autophagy for intracellular replication

Barnett, Timothy C., Liebl, David, Seymour, Lisa M., Gillen, Christine M., Lim, Jin Yan, LaRock, Christopher N., Davies, Mark R., Schulz, Benjamin L., Nizet, Victor, Teasdale, Rohan D. and Walker, Mark J. (2013). The globally disseminated M1T1 clone of Group A Streptococcus evades autophagy for intracellular replication. Cell Host and Microbe, 14 (6), 675-682. doi: 10.1016/j.chom.2013.11.003

Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts

Venturini, Carola, Hassan, Karl A., Chowdhury, Piklu Roy, Paulsen, Ian T., Walker, Mark J. and Djordjevic, Steven P. (2013). Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts. PLoS ONE, 8 (11) e78862, e78862.1-e78862.14. doi: 10.1371/journal.pone.0078862

Extensive diversity of Streptococcus pyogenes in a remote human population reflects global-scale transmission rather than localised diversification

Towers, Rebecca J., Carapetis, Jonathan R., Currie, Bart J., Davies, Mark R., Walker, Mark J., Dougan, Gordon and Giffard, Philip M. (2013). Extensive diversity of Streptococcus pyogenes in a remote human population reflects global-scale transmission rather than localised diversification. PLoS One, 8 (9) e73851, e73851.1-e73851.6. doi: 10.1371/journal.pone.0073851

Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus

Henningham, Anna, Ericsson, Daniel J., Langer, Karla, Casey, Lachlan W., Jovcevski, Blagojce, Singh Chhatwal, G., Aquilina, J. Andrew, Batzloff, Michael R., Kobe, Bostjan and Walker, Mark J. (2013). Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. mBio, 4 (4) e00509-13. doi: 10.1128/mBio.00509-13

A key role for the urokinase Plasminogen Activator (uPA) in invasive Group A streptococcal infection

Sanderson-Smith, Martina L., Zhang, Yueling, Ly, Diane, Donahue, Deborah, Hollands, Andrew, Nizet, Victor, Ranson, Marie, Ploplis, Victoria A., Walker, Mark J. and Castellino, Francis J. (2013). A key role for the urokinase Plasminogen Activator (uPA) in invasive Group A streptococcal infection. PLoS Pathogens, 9 (7) e1003469, e1003469.1-e1003469.9. doi: 10.1371/journal.ppat.1003469

Molecular characterization of endocarditis-associated Staphylococcus aureus

Nethercott, Cara, Mabbett, Amanda N., Totsika, Makrina, Peters, Paul, Ortiz, Juan C., Nimmo, Graeme R., Coombs, Geoffrey W., Walker, Mark J. and Schembri, Mark A. (2013). Molecular characterization of endocarditis-associated Staphylococcus aureus. Journal of Clinical Microbiology, 51 (7), 2131-2138. doi: 10.1128/JCM.00651-13

Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370

Venturini, Carola, Ong, Cheryl-Iynn Y., Gillen, Christine M., Ben-Zakour, Nouri L., Maamary, Peter G., Nizet, Victor, Beatson, Scott A. and Walker, Mark J. (2013). Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370. Infection and Immunity, 81 (6), 2062-2069. doi: 10.1128/IAI.00192-13

Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR

Ong, Cheryl-lynn Y., Potter, Adam J., Trappetti, Claudia, Walker, Mark J., Jennings, Michael P., Paton, James C. and McEwan, Alastair G. (2013). Interplay between manganese and iron in pneumococcal pathogenesis: role of the orphan response regulator RitR. Infection and Immunity, 81 (2), 421-429. doi: 10.1128/IAI.00805-12

Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus

Tsatsaronis, James A., Hollands, Andrew, Cole, Jason N., Maamary, Peter G., Gillen, Christine M., Ben Zakour, Nouri L., Kotb, Malak, Nizet, Victor, Beatson, Scott A., Mark J. Walker and Sanderson-Smith, Martina L. (2013). Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus. FASEB Journal, 27 (7), 2633-2643. doi: 10.1096/fj.12-226662

Evaluation of clinical, histological and immunological changes and qPCR detection of Mycoplasma hyopneumoniae in tissues during the early stages of mycoplasmal pneumonia in pigs after experimental challenge with two field isolates

Woolley, Lauren K., Fell, Shayne, Gonsalves, Jocelyn R., Walker, Mark J., Djordjevic, Steven P., Jenkins, Cheryl and Eamens, Graeme J. (2012). Evaluation of clinical, histological and immunological changes and qPCR detection of Mycoplasma hyopneumoniae in tissues during the early stages of mycoplasmal pneumonia in pigs after experimental challenge with two field isolates. Veterinary Microbiology, 161 (1-2), 186-195. doi: 10.1016/j.vetmic.2012.07.025

Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics - implications for pathogenesis

Cook, Simon M., Skora, Amanda, Gillen, Christine M., Walker, Mark J. and McArthur, Jason D. (2012). Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics - implications for pathogenesis. Molecular Microbiology, 86 (5), 1052-1062. doi: 10.1111/mmi.12037

Outsmarting outbreaks

Walker, Mark J. and Beatson, Scott A. (2012). Outsmarting outbreaks. Science, 338 (6111), 1161-1162. doi: 10.1126/science.1232327

Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone

Maamary, Peter G., Ben Zakour, Nouri L., Cole, Jason N., Hollands, Andrew, Aziz, Ramy K., Barnett, Timothy C., Cork, Amanda J., Henningham, Anna, Sanderson-Smith, Martina, McArthur, Jason D., Venturini, Carola, Gillen, Christine M., Kirk, Joshua K., Johnson, Dwight R., Taylor, William L., Kaplan, Edward L., Kotb, Malak, Nizet, Victor, Beatson, Scott A. and Walker, Mark J. (2012). Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone. FASEB Journal, 26 (11), 4675-4684. doi: 10.1096/fj.12-212142

Molecular characterization of the 2011 Hong Kong scarlet fever outbreak

Tse, Herman, Bao, Jessie Y. J., Davies, Mark R., Maamary, Peter, Tsoi, Hoi-Wah, Tong, Amy H. Y., Ho, Tom C. C., Lin, Chi-Ho, Gillen, Christine M., Barnett, Timothy C., Chen, Jonathan H. K., Lee, Mianne, Yam, Wing-Cheong, Wong, Chi-Kin, Ong, Cheryl-lynn Y., Chan, Yee-Wai, Wu, Cheng-Wei, Ng, Tony, Lim, Wilina W. L., Tsang, Thomas H. F., Tse, Cindy W. S., Dougan, Gordon, Walker, Mark J., Lok, Si and Yuen, Kwok-Yung (2012). Molecular characterization of the 2011 Hong Kong scarlet fever outbreak. The Journal of Infectious Diseases, 206 (3), 341-351. doi: 10.1093/infdis/jis362

Pathogenesis of group A streptococcal infections

Henningham, Anna, Barnett, Timothy C., Maamary, Peter G. and Walker, Mark J. (2012). Pathogenesis of group A streptococcal infections. Discovery Medicine, 13 (72), 329-342.

Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates surface topography

Bogema, Daniel R., Deutscher, Ania T., Woolley, Lauren K., Seymour, Lisa M., Raymond, Benjamin B. A., Tacchi, Jessica L., Padula, Matthew P., Dixon, Nicholas E., Minion, F. Chris, Jenkins, Cheryl, Walker, Mark J. and Djordjevic, Steven P. (2012). Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates surface topography. mBio, 3 (2) e00282-11, e00282.1-e00282.11. doi: 10.1128/mBio.00282-11

Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an alpha-Hemolytic Escherichia coli O108:H- Human Clinical Isolate

Dawes, Fay E., Bulach, Dieter M., Kuzevski, Alexander, Bettelheim, Karl A., Venturini, Carola, Djordjevic, Steven P. and Walker, Mark J. (2012). Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an alpha-Hemolytic Escherichia coli O108:H- Human Clinical Isolate. Plos One, 7 (4) e34718, e34718.1-e34718.6. doi: 10.1371/journal.pone.0034718

Polyelectrolyte complex materials consisting of antibacterial and cell-supporting layers

Amin, Khairul Anuar Mat, Gilmore, Kerry J., Matic, Jake, Poon, Stephen, Walker, Mark J., Wilson, Mark R. and Panhuis, Marc In Het (2012). Polyelectrolyte complex materials consisting of antibacterial and cell-supporting layers. Macromolecular Bioscience, 12 (3), 374-382. doi: 10.1002/mabi.201100317

The role of streptokinase as a virulence determinant of Streptococcus pyogenes: Potential for therapeutic targeting

McArthur, Jason D., Cook, Simon M., Venturini, Carola and Walker, Mark J. (2012). The role of streptokinase as a virulence determinant of Streptococcus pyogenes: Potential for therapeutic targeting. Current Drug Targets, 13 (3), 297-307. doi: 10.2174/138945012799424589

Analysis of a Streptococcus pyogenes puerperal sepsis cluster using whole-genome sequencing

Ben Zakour, Nouri L., Venturini, Carola, Beatson, Scott A. and Walker, Mark J. (2012). Analysis of a Streptococcus pyogenes puerperal sepsis cluster using whole-genome sequencing. Journal of Clinical Microbiology, 50 (7), 2224-2228. doi: 10.1128/JCM.00675-12

Conserved anchorless surface proteins as group A streptococcal vaccine candidates

Henningham, Anna, Chiarot, Emiliano, Gillen, Christine M., Cole, Jason N., Rohde, Manfred, Fulde, Marcus, Ramachandran, Vidiya, Cork, Amanda J., Hartas, Jon, Magor, Graham, Djordjevic, Steven P., Cordwell, Stuart J., Kobe, Bostjan, Sriprakash, Kabada S., Nizet, Victor, Chhatwal, G. S., Margarit, Immaculada Y. R., Batzloff, Michael R. and Walker, Mark J. (2012). Conserved anchorless surface proteins as group A streptococcal vaccine candidates. Journal of Molecular Medicine, 90 (10), 1197-1207. doi: 10.1007/s00109-012-0897-9

Establishment of the Australian Infectious Diseases Research Centre

Walker, Mark (2012). Establishment of the Australian Infectious Diseases Research Centre. Current Drug Targets, 13 (11), 1347-1347. doi: 10.2174/138945012803530189

Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface

Seymour, Lisa M., Jenkins, Cheryl, Deutscher, Ania T., Raymond, Benjamin B. A., Padula, Matthew P., Tacchi, Jessica L., Bogema, Daniel R., Eamens, Graeme J., Woolley, Lauren K., Dixon, Nicholas E., Walker , Mark J. and Djordjevic, Steven P. (2012). Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface. Cellular Microbiology, 14 (1), 81-94. doi: 10.1111/j.1462-5822.2011.01702.x

Sequence TTKF (down arrow) QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae

Bogema, Daniel R., Scott, Nichollas E., Padula, Matthew P., Tacchi, Jessica L., Raymond, Benjamin B. A., Jenkins, Cheryl, Cordwell, Stuart J., Minion, F. Chris, Walker, Mark J. and Djordjevic, Steven P. (2011). Sequence TTKF (down arrow) QE defines the site of proteolytic cleavage in Mhp683 protein, a novel glycosaminoglycan and cilium adhesin of Mycoplasma hyopneumoniae. Journal of Biological Chemistry, 286 (48), 41217-41229. doi: 10.1074/jbc.M111.226084

Molecular insight into invasive group A streptococcal disease

Cole, Jason N., Barnett, Timothy C., Nizet, Victor and Walker, Mark J. (2011). Molecular insight into invasive group A streptococcal disease. Nature Reviews Microbiology, 9 (10), 724-736. doi: 10.1038/nrmicro2648

Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae

Seymour, Lisa M., Falconer, Linda, Deutscher, Ania T., Minion, F. Chris, Padula, Matthew P., Nicholas E. Dixon,, Djordjevic, Steven P. and Walker, Mark J. (2011). Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae. Journal of Biological Chemistry, 286 (12), 10097-10104. doi: 10.1074/jbc.M110.208140

A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, alpha A- and alpha B-crystallin

Treweek, TM, Rekas, A, Walker, MJ and Carver, JA (2010). A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, alpha A- and alpha B-crystallin. Experimental Eye Research, 91 (5), 691-699. doi: 10.1016/j.exer.2010.08.015

A processed Multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia

Seymour, Lisa M., Deutscher, Ania T., Jenkins, Cheryl, Kuit, Tracey A., Falconer, Linda, Minion, F. Chris, Crossett, Ben, Padula, Matthew, Dixon, Nicholas E., Djordjevic, Steven P. and Walker, Mark J. (2010). A processed Multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia. Journal of Biological Chemistry, 285 (44), 33971-33978. doi: 10.1074/jbc.M110.104463

Parameters governing invasive disease propensity of non-M1 serotype group A streptococci

Maamary, PG, Sanderson-Smith, ML, Aziz, RK, Hollands, A, Cole, JN, Mckay, FC, McArthur, JD, Kirk, JK, Cork, AJ, Keefe, RJ, Kansal, RG, Sun, H, Taylor, WL, Chhatwal, GS, Ginsburg, D, Nizet, V, Kotb, M and Walker, MJ (2010). Parameters governing invasive disease propensity of non-M1 serotype group A streptococci. Journal of Innate Immunology, 2 (6), 596-606. doi: 10.1159/000317640

Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia

Deutscher, Ania T., Jenkins, Cheryl, Minion, F. Chris, Seymour, Lisa M., Padula, Matthew P., Dixon, Nicholas E., Walker, Mark J. and Djordjevic, Steven P. (2010). Repeat regions R1 and R2 in the P97 paralogue Mhp271 of Mycoplasma hyopneumoniae bind heparin, fibronectin and porcine cilia. Molecular Microbiology, 78 (2), 444-458. doi: 10.1111/j.1365-2958.2010.07345.x

Distribution of class 1 integrons with IS26-mediated deletions in their 3 '-conserved segments in Escherichia coli of human and animal origin

Dawes, Faye E., Kuzevski, Alexander, Bettelheim, Karl A., Hornitzky, Michael A., Djordjevic, Steven P. and Walker, Mark J. (2010). Distribution of class 1 integrons with IS26-mediated deletions in their 3 '-conserved segments in Escherichia coli of human and animal origin. PLoS One, 5 (9) e12754, e12754-1-e12754-6. doi: 10.1371/journal.pone.0012754

M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus

Cole, JN, Pence, MA, von Kockritz-Blickwede, M, Hollands, A, Gallo, RL, Walker, MJ and Nizet, V (2010). M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus. mBio, 1 (4) e00191-10, e00191-10-1-e00191-10-8. doi: 10.1128/mBio.00191-10

Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone

Hollands, Andrew, Pence, Morgan A., Timmer, Anjuli M., Osvath, Sarah R., Turnbull, Lynne, Whitchurch, Cynthia B., Walker, Mark J. and Nizet, Victor (2010). Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A Streptococcus M1T1 clone. Journal of Infectious Diseases, 202 (1), 11-19. doi: 10.1086/653124

Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM)

Figuera-Losada, M., Ranson, M., Sanderson-Smith, M.L., Walker, M. J., Castellino, F. J. and Prorok, M. (2010). Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). BBA - Proteins and Proteomics, 1804 (6), 1342-1349. doi: 10.1016/j.bbapap.2010.01.019

Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence

Aziz, Ramy K., Kansal, Rita, Aronow, Bruce J., Taylor, William L., Rowe, Sarah L., Kubal, Michael, Chhatwal, Gursharan S., Walker, Mark J. and Kotb, Malak (2010). Microevolution of Group A streptococci in vivo: Capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence. PLoS One, 5 (4) e9798, e9798. doi: 10.1371/journal.pone.0009798

Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid

Venturini, C, Beatson, SA, Djordjevic, SP and Walker, MJ (2010). Multiple antibiotic resistance gene recruitment onto the enterohemorrhagic Escherichia coli virulence plasmid. The FASEB Journal, 24 (4), 1160-1166. doi: 10.1096/fj.09-144972

Defining the structural basis of human plasminogen binding by streptococcal surface enolase

Cork, A. J., Jergic, S., Hammerschmidt, S., Kobe, B., Pancholi, V., Benesch, J. L. P., Robinson, C. V., Dixon, N. E., Aquilina, J. A. and Walker, M. J. (2009). Defining the structural basis of human plasminogen binding by streptococcal surface enolase. Journal of Biological Chemistry, 284 (25), 17129-17137. doi: 10.1074/jbc.M109.004317

Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium

Matic, Jake N., Terry, Tamsin D., Van Bockel, David, Maddocks, Tracy, Tinworth, David, Jennings, Michael P., Djordjevic, Steven P. and Walker, Mark J. (2009). Development of non-antibiotic-resistant, chromosomally based, constitutive and inducible expression systems for aroA-attenuated Salmonella enterica serovar typhimurium. Infection and Immunity, 77 (5), 1817-1826. doi: 10.1128/IAI.01301-08

Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae

Wilton, Jody, Jenkins, Cheryl, Cordwell, Stuart J., Falconer, Linda, Minion, F. Chris, Oneal, David C., Djordjevic, Michael A., Connolly, Angela, Barchia, Idris, Walker, Mark J. and Djordjevic, Steven P. (2009). Mhp493 (P216) is a proteolytically processed, cilium and heparin binding protein of Mycoplasma hyopneumoniae. Molecular Microbiology, 71 (3), 566-582. doi: 10.1111/j.1365-2958.2008.06546.x

A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence

Hollands, Andrew, Aziz, Ramy K., Kansal, Rita, Kotb, Malak, Nizet, Victor and Walker, Mark J. (2008). A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One, 3 (12 Article # e4102) e4102, e4102. doi: 10.1371/journal.pone.0004102

Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity

Morris, Amie M., Treweek, Teresa M., Aquilina, J. A., Carver, John A. and Walker, Mark J. (2008). Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity. FEBS Journal, 275 (23), 5885-5898. doi: 10.1111/j.1742-4658.2008.06719.x

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation

McArthur, Jason D., McKay, Fiona C., Ramachandran, Vidiya, Shyam, Priya, Cork, Amanda J., Sanderson-Smith, Martina L., Cole, Jason N., Ringdahl, Ulrika, Sjobring, Ulf, Ranson, Marie and Walker, Mark J. (2008). Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation. Faseb Journal, 22 (9), 3146-3153. doi: 10.1096/fj.08-109348

M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate

Sanderson-Smith, M. L., Dinkla, K., Cole, J. N., Cork, A. J., Maamary, P. G., McArthur, J. D., Chhatwal, G. S. and Walker, M. J. (2008). M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate. The FASEB Journal, 22 (8), 2715-2722. doi: 10.1096/fj.07-105643

Human pathogenic streptococcal proteomics and vaccine development

Cole, Jason N., Henningham, Anna, Gillen, Christine M., Ramachandran, Vidiya and Walker, Mark J. (2008). Human pathogenic streptococcal proteomics and vaccine development. Proteomics Clinical Applications, 2 (3), 387-410. doi: 10.1002/prca.200780048

Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete

Gillen, Christine M., Courtney, Harry S., Schulze, Kai, Rohde, Manfred, Wilson, Mark R., Timmer, Anjulli M., Guzman, Carlos A., Nizet, Victor, Chhatwal, G. s. and Walker, Mark J. (2008). Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. Journal of Biological Chemistry, 283 (10), 6359-6366. doi: 10.1074/jbc.M706739200

Isolation and solubilization of gram-positive bacterial cell wall-associated proteins

Cole, Jason N, Djordjevic, Steven P and Walker, Mark J (2008). Isolation and solubilization of gram-positive bacterial cell wall-associated proteins. Methods in molecular biology (Clifton, N.J.), 425, 295-311.

Role of group A Streptococcus HtrA in the maturation of SpeB protease

Cole, Jason N., Aquilina, John A., Hains, Peter G., Henningham, Anna, Sriprakash, Kadaba S., Caparon, Michael G., Nizet, Victor, Kotb, Malak, Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2007). Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics, 7 (24), 4488-4498. doi: 10.1002/pmic.200700626

Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation

Treweek, Teresa M., Ecroyd, Heath, Williams, Danielle M., Meehan, Sarah, Carver, John A. and Walker, Mark J. (2007). Site-directed mutations in the C-terminal extension of human αB-crystallin affect chaperone function and block amyloid fibril formation. PLoS One, 2 (Article # e1046) e1046, e1046. doi: 10.1371/journal.pone.0001046

DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection

Walker, Mark J., Hollands, Andrew, Sanderson-Smith, Martina L., Cole, Jason N., Kirk, Joshua K., Henningham, Anna, McArthur, Jason D., Dinkla, Katrin, Aziz, Ramy K., Kansal, Rita G., Simpson, Amelia J., Buchanan, John T., Chhatwal, Gursharan S., Kotb, Malak and Nizet, Malak (2007). DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nature Medicine, 13 (8), 981-985. doi: 10.1038/nm1612

New understanding of the group A Streptococcus pathogenesis cycle

Tart, Anne H., Walker, Mark J. and Musser, James M. (2007). New understanding of the group A Streptococcus pathogenesis cycle. Trends in Microbiology, 15 (7), 318-325. doi: 10.1016/j.tim.2007.05.001

Characterization of mesophilic bacilli in faeces of feedlot cattle

Wu, X. -Y., Walker, M., Vanselow, B., Chao, R. -L. and Chin, J. (2007). Characterization of mesophilic bacilli in faeces of feedlot cattle. Journal of Applied Microbiology, 102 (3), 872-879. doi: 10.1111/j.1365-2672.2006.03106.x

Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs

Wu, Xi-Yang, Chapman, Toni, Trott, Darren J., Bettelheim, Karl, Do, Thuy N., Driesen, Steve, Walker, Mark J. and Chin, James (2007). Comparative analysis of virulence genes, genetic diversity, and phylogeny of commensal and enterotoxigenic Escherichia coli isolates from weaned pigs. Applied and Environmental Microbiology, 73 (1), 83-91. doi: 10.1128/AEM.00990-06

Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence

Timmer, Anjuli M., Kristian, Sascha A., Datta, Vivekanand, Jeng, Arthur, Gillen, Christine M., Walker, Mark J., Beall, Bernard and Nizet, Victor (2006). Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence. Molecular Microbiology, 62 (1), 15-25. doi: 10.1111/j.1365-2958.2006.05337.x

The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains

Sanderson-Smith, Martina L., Walker, Mark J. and Ranson, Marie (2006). The maintenance of high affinity plasminogen binding by group A streptococcal plasminogen-binding M-like protein is mediated by arginine and histidine residues within the a1 and a2 repeat domains. Journal of Biological Chemistry, 281 (36), 25965-25971. doi: 10.1074/jbc.M603846200

Trigger for group A streptococcal M1T1 invasive disease

Cole, Jason N., McArthur, Jason D., McKay, Fiona C., Sanderson-Smith, Martina L., Cork, Amanda J., Ranson, Marie, Rohde, Manfred, Itzek, Andreas, Sun, Hongmin, Ginsburg, David, Kotb, Malak, Nizet, Victor, Chhatwal, GS and Walker, Mark J. (2006). Trigger for group A streptococcal M1T1 invasive disease. FASEB Journal, 20 (10), E1139-E1145. doi: 10.1096/fj.06-5804fje

Inhibition of indoleamine 2,3 dioxygenase activity by H2O2

Poljak, Anne, Grant, Ross, Austin, Chris J. D., Jamie, Joanne F., Willows, Robert D., Takikawa, Osamu, Littlejohn, Tamantha K., Truscott, Roger J. W., Walker, Mark J., Sachdev, Perminder and Smythe, George A. (2006). Inhibition of indoleamine 2,3 dioxygenase activity by H2O2. Archives of Biochemistry and Biophysics, 450 (1), 9-19. doi: 10.1016/j.abb.2006.03.003

P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells

Burnett, Tracey A., Dinkla, Katrin, Rohde, Manfred, Chhatwal, Gursharan S., Uphoff, Cord, Srivastava, Mukesh, Cordwell, Stuart J., Geary, Steven, Liao, Xiaofen, Minion, F. Chris, Walker, Mark J. and Djordjevic, Steven P. (2006). P159 is a proteolytically processed, surface adhesin of Mycoplasma hyopneumoniae : Defined domains of P159 bind heparin and promote adherence to eukaryote cells. Molecular Microbiology, 60 (3), 669-686. doi: 10.1111/j.1365-2958.2006.05139.x

Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants

Sanderson-Smith, Martina, Batzloff, Michael, Sriprakash, Kabada S., Dowton, Mark, Ranson, Marie and Walker, Mark J. (2006). Divergence in the plasminogen-binding group A streptococcal M protein family : Functional conservation of binding site and potential role for immune selection of variants. Journal of Biological Chemistry, 281 (6), 3217-3226. doi: 10.1074/jbc.M508758200

Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance

Wu, Xi-Yang, Walker, Mark J., Hornitzky, Michael and Chin, James (2006). Development of a group-specific PCR combined with ARDRA for the identification of Bacillus species of environmental significance. Journal of Microbiological Methods, 64 (1), 107-119. doi: 10.1016/j.mimet.2005.04.021

Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development

McArthur, Jason D. and Walker, Mark J. (2006). Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection : Implications for vaccine development. Molecular Microbiology, 59 (1), 1-4. doi: 10.1111/j.1365-2958.2005.04967.x

Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin

Jenkins, Cheryl, Wilton, Jody L., Minion, F. Chris, Falconer, Linda, Walker, Mark J. and Djordjevic, Steven P. (2006). Two domains within the Mycoplasma hyopneumoniae cilium adhesin bind heparin. Infection and Immunity, 74 (1), 481-487. doi: 10.1128/IAI.74.1.481-487.2006

Is plasminogen deployed as a Streptococcus pyogenes virulence factor?

Walker, Mark J., McArthur, Jason D., McKay, Fiona and Ranson, Marie (2005). Is plasminogen deployed as a Streptococcus pyogenes virulence factor?. Trends in Microbiology, 13 (7), 308-313. doi: 10.1016/j.tim.2005.05.006

Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus

Cole, Jason N., Ramirez, Ruben D., Currie, Bart J., Cordwell, Stuart J., Djordjevic, Steven P. and Walker, Mark J. (2005). Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus. Infection and Immunity, 73 (5), 3137-3146. doi: 10.1128/IAI.73.5.3137-3146.2005

R120G alpha B-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable

Treweek, Teresa M., Rekas, Agata, Lindner, Robyn A., Walker, Mark J., Aquilina, J. Andrew, Robinson, Carol V., Horwitz, Joseph, Perng, Ming Der, Quinlan, Roy A. and Carver, John A. (2005). R120G alpha B-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable. FEBS Journal, 272 (3), 711-724. doi: 10.1111/j.1742-4658.2004.04507.x

Intranasal vaccination with streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model

McArthur, J., Medina, E., Mueller, A., Chin, J., Currie, B. J., Sriprakash, K. S., Talay, S. R., Chhatwal, G. S. and Walker, M. J. (2004). Intranasal vaccination with streptococcal fibronectin binding protein Sfb1 fails to prevent growth and dissemination of Streptococcus pyogenes in a murine skin infection model. Infection and Immunity, 72 (12), 7342-7345. doi: 10.1128/IAI.72.12.7342-7345.2004

Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci

Towers, Rebecca J., Gal, Daniel, McMillan, David, Sriprakash, Kadaba S., Currie, Bart J., Walker, Mark J., Chhatwal, Gursharan S. and Fagan, Peter K. (2004). Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci. Journal of Clinical Microbiology, 42 (11), 5357-5361. doi: 10.1128/JCM.42.11.5357-5361.2004

Two distinct genotypes of prtF2, encoding a fibronectin binding protein, and evolution of the gene family in Streptococcus pyogenes

Ramachandran, V., McArthur, J. D., Behm, C. E., Gutzeit, C., Dowton, M., Fagan, P. K., Towers, R., Currie, B., Sriprakash, K. S. and Walker, M. J. (2004). Two distinct genotypes of prtF2, encoding a fibronectin binding protein, and evolution of the gene family in Streptococcus pyogenes. Journal of Bacteriology, 186 (22), 7601-7609. doi: 10.1128/JB.186.22.7601-7609.2004

Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice

McArthur, J., Schulze, K., Chin, J., Currie, B. J., Sriprakash, K. S., Talay, S. R., Chhatwal, G. S., Guzmán, C. A. and Walker, M. J. (2004). Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice. Indian Journal of Medical Research, Supplement, 119 (MAY), 115-120.

Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection

McKay, Fiona C., McArthur, Jason D., Sanderson-Smith, Marina L., Gardam, Sandra, Currie, Bart J., Sriprakash, Kadaba S., Fagan, Peter K., Towers, Rebecca J., Batzloff, Michael R., Chhatwal, Gursharan S., Ranson, Marie and Walker, Mark J. (2004). Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection. Infection and Immunity, 72 (1), 364-370. doi: 10.1128/IAI.72.1.364-370.2004

Evolution of sfbI encoding streptococcal fibronectin-binding protein I: Horizontal genetic transfer and gene mosaic structure

Towers, R. J., Fagan, P. K., Talay, S. R., Currie, B. J., Sriprakash, K. S., Walker, M. J. and Chhatwal, G. S. (2003). Evolution of sfbI encoding streptococcal fibronectin-binding protein I: Horizontal genetic transfer and gene mosaic structure. Journal of Clinical Microbiology, 41 (12), 5398-5406. doi: 10.1128/JCM.41.12.5398-5406.2003

Distribution of intimin subtypes among Escherichia coli isolates from ruminant and human sources

Ramachandran, V., Brett, K., Hornitzky, M. A., Dowton, M., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). Distribution of intimin subtypes among Escherichia coli isolates from ruminant and human sources. Journal of Clinical Microbiology, 41 (11), 5022-5032. doi: 10.1128/JCM.41.11.5022-5032.2003

The pyruvate dehydrogenase complex of Mycoplasma hyopneumoniae contains a novel lipoyl domain arrangement

Matic, JN, Wilton, JL, Towers, RJ, Scarman, AL, Minion, FC, Walker, MJ and Djordjevic, SP (2003). The pyruvate dehydrogenase complex of Mycoplasma hyopneumoniae contains a novel lipoyl domain arrangement. Gene, 319, 99-106. doi: 10.1016/S0378-1119(03)000798-4

Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase

Littlejohn, TK, Takikawa, O, Truscott, RJW and Walker, MJ (2003). Asp(274) and His(346) are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. Journal of Biological Chemistry, 278 (32), 29525-29531. doi: 10.1074/jbc.M301700200

Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes

Brett, K. N., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). Bovine non-O157 Shiga toxin 2-containing Escherichia coli isolates commonly possess stx(2-EDL933) and/or stx(2vhb) subtypes. Journal of Clinical Microbiology, 41 (6), 2716-2722. doi: 10.1128/JCM.41.6.2716-2722.2003

An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection

McArthur, JD, West, NP, Cole, JN, Jungnitz, H, Guzman, CA, Chin, J, Lehrbach, PR, Djordjevic, SP and Walker, MJ (2003). An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection. Fems Microbiology Letters, 221 (1), 7-16. doi: 10.1016/S0378-1097(03)00162-9

stx(1c) is the most common Shiga toxin 1 subtype among Shiga toxin-producing Escherichia coli isolates from sheep but not among isolates from cattle

Brett, K. N., Ramachandran, V., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2003). stx(1c) is the most common Shiga toxin 1 subtype among Shiga toxin-producing Escherichia coli isolates from sheep but not among isolates from cattle. Journal of Clinical Microbiology, 41 (3), 926-936. doi: 10.1128/JCM.41.3.926-936.2003

Production of truncated enzymically active human indoleamine 2,3-dioxygenase using site-directed mutagenesis

Littlejohn, Tamantha K., Takikawa, Osamu, Jamie, Joanne F., Walker, Mark J. and Truscott, Roger J.W (2002). Production of truncated enzymically active human indoleamine 2,3-dioxygenase using site-directed mutagenesis. International Congress Series, 1233 (C), 157-160. doi: 10.1016/S0531-5131(02)00312-6

Molecular analysis of group B protective surface protein, a new cell surface protective antigen of group B streptococci

Erdogan, Sezgin, Fagan, Peter K., Talay, Susanne R., Rohde, Manfred, Ferrieri, Patricia, Flores, Aurea E., Guzman, Carlos A., Walker, Mark J. and Chhatwal, Gursharan S. (2002). Molecular analysis of group B protective surface protein, a new cell surface protective antigen of group B streptococci. Infection and Immunity, 70 (2), 803-811. doi: 10.1128/IAI.70.2.803-811.2002

Immunological response mounted by Aboriginal Australians living in the Northern Territory of Australia against Streptococcus pyogenes serum opacity factor

Gillen, Christine M., Towers, Rebecca J., McMillan, David J., Delvecchio, Armando, Sriprakash, Kadaba S., Currie, Bart, Kreikemeyer, Berndt, Chhatwal, Gurusharan S. and Walker, Mark J. (2002). Immunological response mounted by Aboriginal Australians living in the Northern Territory of Australia against Streptococcus pyogenes serum opacity factor. Microbiology, 148 (1), 169-178. doi: 10.1099/00221287-148-1-169

Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia

Delvecchio, A., Currie, B. J., McArthur, J. D., Walker, M. J. and Sriprakash, K. S. (2002). Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia. Epidemiology and Infection, 128 (3), 391-396. doi: 10.1017/S0950268802006787

The common ovine shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type

Ramachandran, V., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J. and Djordjevic, S. P. (2001). The common ovine shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type. Journal of Clinical Microbiology, 39 (5), 1932-1937. doi: 10.1128/JCM.39.5.1932-1937.2001

The virulence factors of Bordetella pertussis: a matter of control

Smith, AM, Guzman, CA and Walker, MJ (2001). The virulence factors of Bordetella pertussis: a matter of control. Fems Microbiology Reviews, 25 (3), 309-333. doi: 10.1111/j.1574-6976.2001.tb00580.x

Oral immunization of swine with attenuated Salmonella typhimurium aroA SL3261 expressing a recombinant antigen of Mycoplasma hyopneumoniae (NrdF) primes the immune system for a NrdF specific secretory IgA response in the lungs

Fagan, PK, Walker, MJ, Chin, J, Eamens, GJ and Djordjevic, SP (2001). Oral immunization of swine with attenuated Salmonella typhimurium aroA SL3261 expressing a recombinant antigen of Mycoplasma hyopneumoniae (NrdF) primes the immune system for a NrdF specific secretory IgA response in the lungs. Microbial Pathogenesis, 30 (2), 101-110. doi: 10.1006/mpat.2000.0412

Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli

Smith, AM, Yan, H, Groves, N, Dalla Pozza, T and Walker, MJ (2000). Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli. Fems Microbiology Letters, 191 (2), 177-182. doi: 10.1016/S0378-1097(00)00386-4

Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence

West, Nicholas P., Jungnitz, Heidrun, Fitter, John T., McArthur, Jason D., Guzman, Carlos A. and Walker, Mark J. (2000). Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infection and Immunity, 68 (8), 4673-4680. doi: 10.1128/IAI.68.8.4673-4680.2000

Expression and purification of recombinant human indoleamine 2,3-dioxygenase

Littlejohn, TK, Takikawa, O, Skylas, D, Jamie, JF, Walker, MJ and Truscott, RJW (2000). Expression and purification of recombinant human indoleamine 2,3-dioxygenase. Protein Expression and Purification, 19 (1), 22-29. doi: 10.1006/prep.2000.1214

Contribution of adjuvant to adaptive immune responses in mice against Actinobacillus pleuropneumoniae

San Gil, F, Turner, B, Walker, MJ, Djordjevic, SP and Chin, JC (1999). Contribution of adjuvant to adaptive immune responses in mice against Actinobacillus pleuropneumoniae. Microbiology-Uk, 145 (9), 2595-2603. doi: 10.1099/00221287-145-9-2595

Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract

McMillan, DJ, Medina, E, Guzman, CA and Walker, MJ (1999). Expression of urease does not affect the ability of Bordetella bronchiseptica to colonise and persist in the murine respiratory tract. Fems Microbiology Letters, 178 (1), 7-11. doi: 10.1111/j.1574-6968.1999.tb13752.x

A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence

Jungnitz, Heidrun, West, Nicholas P., Walker, Mark J., Chhatwal, Gursharan S. and Guzman, Carlos A. (1998). A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence. Infection and Immunity, 66 (10), 4640-4650.

Demonstration that Australian Pasteurella multocida isolates from sporadic outbreaks of porcine pneumonia are non-toxigenic (toxA(-)) and display heterogeneous DNA restriction endonuclease profiles compared with toxigenic isolates from herds with progress

Djordjevic, SP, Eamens, GJ, Ha, H, Walker, MJ and Chin, JC (1998). Demonstration that Australian Pasteurella multocida isolates from sporadic outbreaks of porcine pneumonia are non-toxigenic (toxA(-)) and display heterogeneous DNA restriction endonuclease profiles compared with toxigenic isolates from herds with progress. Journal of Medical Microbiology, 47 (8), 679-688. doi: 10.1099/00222615-47-8-679

Reiterated repeat region variability in the ciliary adhesin gene of Mycoplasma hyopneumoniae

Wilton, JL, Scarman, AL, Walker, MJ and Djordjevic, SP (1998). Reiterated repeat region variability in the ciliary adhesin gene of Mycoplasma hyopneumoniae. Microbiology-Uk, 144 (7), 1931-1943. doi: 10.1099/00221287-144-7-1931

Reiterated repeat region variability in the ciliary adhesin gene of Mycoplasma hyopneumoniae

Wilton, Jody L., Scarman, Anthony L., Walker, Mark J. and Djordjevic, Steven P. (1998). Reiterated repeat region variability in the ciliary adhesin gene of Mycoplasma hyopneumoniae. Microbiology, 144 (7), 1931-1942.

Construction and characterisation of Salmonella typhimurium aroA simultaneously expressing the five pertussis toxin subunits

Dalla Pozza, T, Yan, HR, Meek, D, Guzman, CA and Walker, MJ (1998). Construction and characterisation of Salmonella typhimurium aroA simultaneously expressing the five pertussis toxin subunits. Vaccine, 16 (5), 522-529. doi: 10.1016/S0264-410X(97)80006-0

Flow cytometric analysis of cellular changes in mice after intradermal inoculation with a liposome-iscom adjuvanted vaccine

San Gil, F, Turner, B, Mullbacher, A, Walker, MJ, Djordjevic, SP, Eamens, GJ and Chin, JC (1998). Flow cytometric analysis of cellular changes in mice after intradermal inoculation with a liposome-iscom adjuvanted vaccine. Scandinavian Journal of Immunology, 47 (3), 243-253. doi: 10.1046/j.1365-3083.1998.00304.x

Characterisation of the urease gene cluster in Bordetella bronchiseptica

McMillan, DJ, Mau, M and Walker, MJ (1998). Characterisation of the urease gene cluster in Bordetella bronchiseptica. Gene, 208 (2), 243-251. doi: 10.1016/S0378-1119(97)00651-3

Expression of a synthetic pertussis toxin operon in Escherichia coli

Pozza, TD, Yan, HR and Walker, MJ (1997). Expression of a synthetic pertussis toxin operon in Escherichia coli. Vaccine, 15 (9), 968-975. doi: 10.1016/S0264-410X(96)00306-4

Oral immunization of mice with attenuated Salmonella typhimurium aroA expressing a recombinant Mycoplasma hyopneumoniae antigen (NrdF)

Fagan, Peter K., Djordjevic, Steve P., Chin, James, Eamens, Graeme J. and Walker, Mark J. (1997). Oral immunization of mice with attenuated Salmonella typhimurium aroA expressing a recombinant Mycoplasma hyopneumoniae antigen (NrdF). Infection and Immunity, 65 (6), 2502-2507.

Temperature dependent expression of an acid phosphatase by Bordetella bronchiseptica: Role in intracellular survival

Chhatwal, GS, Walker, MJ, Yan, HR, Timmis, KN and Guzman, CA (1997). Temperature dependent expression of an acid phosphatase by Bordetella bronchiseptica: Role in intracellular survival. Microbial Pathogenesis, 22 (5), 257-264. doi: 10.1006/mpat.1996.0118

Non-motile mini-transposon mutants of Bordetella bronchiseptica exhibit altered abilities to invade and survive in eukaryotic cells

West, NP, Fitter, JT, Jakubzik, U, Rodhe, M, Guzman, CA and Walker, MJ (1997). Non-motile mini-transposon mutants of Bordetella bronchiseptica exhibit altered abilities to invade and survive in eukaryotic cells. Fems Microbiology Letters, 146 (2), 263-269. doi: 10.1111/j.1574-6968.1997.tb10203.x

Molecular analysis of the bvg-repressed urease of Bordetella bronchiseptica

McMillan, DJ, Shojaei, M, Chhatwal, GS, Guzman, CA and Walker, MJ (1996). Molecular analysis of the bvg-repressed urease of Bordetella bronchiseptica. Microbial Pathogenesis, 21 (5), 379-394. doi: 10.1006/mpat.1996.0069

Clusterin, a putative complement regulator, binds to the cell surface of Staphylococcus aureus clinical isolates

Partridge, Sally R., Baker, Mark S., Walker, Mark J. and Wilson, Mark R. (1996). Clusterin, a putative complement regulator, binds to the cell surface of Staphylococcus aureus clinical isolates. Infection and Immunity, 64 (10), 4324-4329.

Transfer of a pertussis toxin expression locus to isogenic bvg-positive and bvg-negative strains of Bordetella bronchiseptica using an in vivo technique

Smith, AM and Walker, MJ (1996). Transfer of a pertussis toxin expression locus to isogenic bvg-positive and bvg-negative strains of Bordetella bronchiseptica using an in vivo technique. Microbial Pathogenesis, 20 (5), 263-273. doi: 10.1006/mpat.1996.0025

Molecular characterization of a ribonucleotide reductase (nrdF) gene fragment of Mycoplasma hyopneumoniae and assessment of the recombinant product as an experimental vaccine for enzootic pneumonia

Fagan, Peter K., Djordjevic, Steven P., Eamens, Graeme J., Chin, James and Walker, Mark J. (1996). Molecular characterization of a ribonucleotide reductase (nrdF) gene fragment of Mycoplasma hyopneumoniae and assessment of the recombinant product as an experimental vaccine for enzootic pneumonia. Infection and Immunity, 64 (3), 1060-1064.

Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase

Southan, MD, Truscott, RJW, Jamie, JF, Pelosi, L, Walker, MJ, Maeda, H, Iwamoto, Y and Tone, S (1996). Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase. Medicinal Chemistry Research, 6 (5), 343-352.

A Novel Escherichia-Coli Expression-Export Vector Containing Alkaline Phosp Hatase as An Insertional Inactivation Screening System

Guzman, CA, Piatti, G, Walker, MJ, Guardati, MC and Pruzzo, C (1994). A Novel Escherichia-Coli Expression-Export Vector Containing Alkaline Phosp Hatase as An Insertional Inactivation Screening System. Gene, 148 (1), 171-172. doi: 10.1016/0378-1119(94)90254-2

Lipopolysaccharide O-Antigen Biosynthesis in Shigella-Dysenteriae Serotype 1 - Analysis of the Plasmid-Carried Rfp Determinant

Gohmann, S, Manning, PA, Alpert, CA, Walker, MJ and Timmis, KN (1994). Lipopolysaccharide O-Antigen Biosynthesis in Shigella-Dysenteriae Serotype 1 - Analysis of the Plasmid-Carried Rfp Determinant. Microbial Pathogenesis, 16 (1), 53-64. doi: 10.1006/mpat.1994.1005

Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid

Guzman, Carlos A., Molinari, Gabriella, Fountain, Michael W., Rohde, Manfred, Timmis, Kenneth N. and Walker, Mark J. (1993). Antibody-Responses in the Serum and Respiratory-Tract of Mice Following Oral Vaccination with Liposomes Coated with Filamentous Hemagglutinin and Pertussis Toxoid. Infection and Immunity, 61 (2), 573-579.

Specific Lung Mucosal and Systemic Immune-Responses After Oral Immunization of Mice with Salmonella-Typhimurium-Aroa, Salmonella-Typhi Ty21a, and Invasive Escherichia-Coli Expressing Recombinant Pertussis Toxin S1 Subunit

Walker, Mark J., Rohde, Manfred, Timmis, Kenneth N. and Guzman, Carlos A. (1992). Specific Lung Mucosal and Systemic Immune-Responses After Oral Immunization of Mice with Salmonella-Typhimurium-Aroa, Salmonella-Typhi Ty21a, and Invasive Escherichia-Coli Expressing Recombinant Pertussis Toxin S1 Subunit. Infection and Immunity, 60 (10), 4260-4268.

Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli Using a 2-Cistron System

Guzman, CA, Walker, MJ, Rohde, M and Timmis, KN (1992). Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli Using a 2-Cistron System. Microbial Pathogenesis, 12 (5), 383-389. doi: 10.1016/0882-4010(92)90101-S

Antibody-Responses in the Lungs of Mice Following Oral Immunization with Salmonella-Typhimurium Aroa and Invasive Escherichia-Coli Strains Expressing the Filamentous Hemagglutinin of Bordetella-Pertussis

Guzman, Carlos A., Brownlie, Robert M., Kadurugamuwa, Jagath, Walker, Mark J. and Timmis, Kenneth N. (1991). Antibody-Responses in the Lungs of Mice Following Oral Immunization with Salmonella-Typhimurium Aroa and Invasive Escherichia-Coli Strains Expressing the Filamentous Hemagglutinin of Bordetella-Pertussis. Infection and Immunity, 59 (12), 4391-4397.

Characterization of Murine Monoclonal-Antibodies That Recognize Defined Epitopes of Pertussis Toxin and Neutralize its Toxic Effect On Chinese-Hamster Ovary Cells

Walker, Mark J., Wehland, Jurgen, Timmis, Kenneth N., Raupach, Barbel and Schmidt, M. A. (1991). Characterization of Murine Monoclonal-Antibodies That Recognize Defined Epitopes of Pertussis Toxin and Neutralize its Toxic Effect On Chinese-Hamster Ovary Cells. Infection and Immunity, 59 (11), 4249-4251.

Construction of Minitransposons for Constitutive and Inducible Expression of Pertussis Toxin in Bvg-Negative Bordetella-Bronchiseptica

Walker, Mark J., Rohde, Manfred, Wehland, Jurgen and Timmis, Kenneth N. (1991). Construction of Minitransposons for Constitutive and Inducible Expression of Pertussis Toxin in Bvg-Negative Bordetella-Bronchiseptica. Infection and Immunity, 59 (11), 4238-4248.

Direct Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli and Salmonella-Typhimurium Aroa

Guzman, Carlos A., Walker, Mark J., Rohde, Manfred and Timmis, Kenneth N. (1991). Direct Expression of Bordetella-Pertussis Filamentous Hemagglutinin in Escherichia-Coli and Salmonella-Typhimurium Aroa. Infection and Immunity, 59 (10), 3787-3795.

Production of Recombinant Bordetella pertussis Serotype 2 Fimbriae in Bordetella parapertussis and Bordetella bronchiseptica: Utility of Escherichia coli Gene Expression Signals

Walker, Mark J., Guzman, Carlos A., Rohde, Manfred and Timmis, Kenneth N. (1991). Production of Recombinant Bordetella pertussis Serotype 2 Fimbriae in Bordetella parapertussis and Bordetella bronchiseptica: Utility of Escherichia coli Gene Expression Signals. Infection and Immunity, 59 (5), 1739-1746.

Engineering Upstream Transcriptional and Translational Signals of Bordetella-Pertussis Serotype-2 Fimbrial Subunit Protein for Efficient Expression in Escherichia-Coli - Invitro Autoassembly of the Expressed Product Into Filamentous Structures

Walker, MJ, Rohde, M, Brownlie, RM and Timmis, KN (1990). Engineering Upstream Transcriptional and Translational Signals of Bordetella-Pertussis Serotype-2 Fimbrial Subunit Protein for Efficient Expression in Escherichia-Coli - Invitro Autoassembly of the Expressed Product Into Filamentous Structures. Molecular Microbiology, 4 (1), 39-47. doi: 10.1111/j.1365-2958.1990.tb02013.x

Cloning and Characterization of An Albicidin Resistance Gene From Klebsiella-Oxytoca

Walker, MJ, Birch, RG and Pemberton, JM (1988). Cloning and Characterization of An Albicidin Resistance Gene From Klebsiella-Oxytoca. Molecular Microbiology, 2 (4), 443-454. doi: 10.1111/j.1365-2958.1988.tb00050.x

Construction of Transposons Encoding Genes for Beta-Glucosidase, Amylase and Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca and Their Expression in a Range of Gram-Negative Bacteria

Walker, MJ and Pemberton, JM (1988). Construction of Transposons Encoding Genes for Beta-Glucosidase, Amylase and Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca and Their Expression in a Range of Gram-Negative Bacteria. Current Microbiology, 17 (2), 69-75. doi: 10.1007/BF01568788

Construction of a Transposon Containing a Gene for Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca

Walker, MJ and Pemberton, JM (1987). Construction of a Transposon Containing a Gene for Polygalacturonate Trans-Eliminase From Klebsiella-Oxytoca. Archives of Microbiology, 146 (4), 390-395. doi: 10.1007/BF00410941

Genetics and virulence role of the classical group A Streptococcus Lancefield antigen

Cole, Jason, van Sorge, Nina, Kuipers, Kirsten, Henningham, Anna, Aziz, Ramy, Kasirer-Friede, Ana, Lin, Leo, Berends, Evelien, Davies, Mark, Dougan, Gordan, Zhang, Fan, Dahesh, Samira, Shaw, Laura, Gin, Jennifer, Cunningham, Madeleine, Merriman, Joseph, Rooijakkers, Suzan, Malley, Richard, Walker, Mark, Shattil, Sanford, Schlievert, Patrick, Choudhury, Biswa and Nizet, Victor (2014). Genetics and virulence role of the classical group A Streptococcus Lancefield antigen. Experimental Biology Meeting, San Diego Ca, 26-30 April 2014. Federation of American Societies for Experimental Biology.

Mycoplasma hyopneumoniae surface proteins Mhp385 and Mhp384 bind host cilia and glycosaminoglycans and are endoproteolytically processed by proteases that recognize different cleavage motifs

Deutscher, Ania T., Tacchi, Jessica L., Minion, F. Chris, Padula, Matthew P., Crossett, Ben, Bogema, Daniel R., Jenkins, Cheryl, Kuit, Tracey A., Walker, Mark J. and Djordjevic, Steven P. (2012). Mycoplasma hyopneumoniae surface proteins Mhp385 and Mhp384 bind host cilia and glycosaminoglycans and are endoproteolytically processed by proteases that recognize different cleavage motifs. Washington, DC, United States: American Chemical Society. doi: 10.1021/pr201115v

The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues

Sanderson-Smith, Martina L., Dowton, Mark, Ranson, Marie and Walker, Mark J. (2007). The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues. Washington, DC, United States: American Society for Microbiology. doi: 10.1128/JB.01218-06

Comparison of pig enterotoxigenic E. coli by pulsed-field gel electrophoresis (PFGE)

Wu, X.Y., Chapman, T., Tan, M.K., Trott, D. J., Walker, M. and Chin, J. (2003). Comparison of pig enterotoxigenic E. coli by pulsed-field gel electrophoresis (PFGE). Australasian Pig Science Assoc (Inc) Conference, Fremantle, WA, 23-26 November 2003. Fremantle, WA: Australasian Pig Science Assoc..

Molecular virulence gene typing of clinical E. coli isolates from pigs with post-weaning diarrhea

Wu, X. Y., Chapman, T., Gordon, D., Do, N. T., Driesen, S., Walker, M. and Chin, J. (2003). Molecular virulence gene typing of clinical E. coli isolates from pigs with post-weaning diarrhea. The Ninth Biennial Conference of the Australasian Pig Science Association, Fremantle, WA, 23 - 26 Nov 2003. Werribee, Victoria: Australian Pig Science Association.

Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: Relevance for senile nuclear cataract

Takikawa, O., Littlejohn, T., Jamie, J. F., Walker, M. J. and Truscott, R. J.W. (2000). Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: Relevance for senile nuclear cataract.

Use of Salmonella Spp Carrier Strains to Deliver Bordetella-Pertussis Antigens in Mice Using the Oral Route

Guzman, CA, Timmis, KN and Walker, MJ (1993). Use of Salmonella Spp Carrier Strains to Deliver Bordetella-Pertussis Antigens in Mice Using the Oral Route. NATO Advanced Research Workshop on Biology of Salmonella, Portorosa Italy, May 11-15, 1992. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.