The University of Queensland

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis

Sajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 4528. doi: 10.1038/s41467-024-48317-x

Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease

Kumarapperuma, Hirushi, Wang, Ran, Little, Peter J and Kamato, Danielle (2024). Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease. Trends in Cardiovascular Medicine, 34 (3), 203-211. doi: 10.1016/j.tcm.2023.01.002

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells

Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C. -H., Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Z. (2023). Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells. The Journal of Experimental Medicine, 220 (11) e20230106. doi: 10.1084/jem.20230106

GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection

Foo, Cheng Xiang, Bartlett, Stacey, Chew, Keng Yih, Ngo, Minh Dao, Bielefeldt-Ohmann, Helle, Jayakody Arachchige, Buddhika, Matthews, Benjamin, Reed, Sarah, Wang, Ran, Smith, Christian, Sweet, Matthew J., Burr, Lucy, Bisht, Kavita, Shatunova, Svetlana, Sinclair, Jane E., Parry, Rhys, Yang, Yuanhao, Lévesque, Jean-Pierre, Khromykh, Alexander, Rosenkilde, Mette Marie, Short, Kirsty R. and Ronacher, Katharina (2023). GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection. European Respiratory Journal, 61 (3) 2201306, 1-15. doi: 10.1183/13993003.01306-2022

IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis

Moniruzzaman, Md., Wong, Kuan Yau, Wang, Ran, Symon, Hamish, Mueller, Alexandra, Rahman, M. Arifur and Hasnain, Sumaira Z. (2022). IL-20 activates ERK1/2 and suppresses splicing of X-box protein-1 in intestinal epithelial cells but does not improve pathology in acute or chronic models of colitis. International Journal of Molecular Sciences, 24 (1) 174, 174. doi: 10.3390/ijms24010174

Building a case for pancreas and liver targeted intereukin-22 therapy in fatty liver disease

Sajiir, Haressh, Wong, Kuan Yau, Mueller, Alexandra, Keshvari, Sahar, Wang, Ran, Wiid, Percival, Ramm, Grant, Macdonald, Graeme, Prins, John, McGuckin, Michael and Hasnain, Sumaira (2022). Building a case for pancreas and liver targeted intereukin-22 therapy in fatty liver disease. Journal of Hepatology, 77 (Supplement 1), S190-S191. doi: 10.1016/s0168-8278(22)00756-5

MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis

Sheng, Yong H., Davies, Julie M., Wang, Ran, Wong, Kuan Yau, Giri, Rabina, Yang, Yuanhao, Begun, Jakob, Florin, Timothy H., Hasnain, Sumaira Z. and McGuckin, Michael A. (2022). MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis. Cellular and Molecular Gastroenterology and Hepatology, 14 (4), 789-811. doi: 10.1016/j.jcmgh.2022.06.010

A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells

Moniruzzaman, Md, Rahman, M. Arifur, Wang, Ran, Wong, Kuan Yau, Chen, Alice C-H, Mueller, Alexandra, Taylor, Steven, Harding, Alexa, Illankoon, Thishan, Wiid, Percival, Sajiir, Haressh, Schreiber, Veronika, Martin, Megan L., Burr, Lucy D., McGuckin, Michael A., Phipps, Simon and Hasnain, Sumaira Zia (2022). A novel role for Interleukin-22 in suppressing major histocompatibility complex II in mucosal epithelial cells. SSRN Electronic Journal. doi: 10.2139/ssrn.4185134

Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders

Wang, Ran, Campbell, Sean, Amir, Mohammed, Mosure, Sarah A., Bassette, Molly A., Eliason, Amber, Sundrud, Mark S., Kamenecka, Theodore M. and Solt, Laura A. (2021). Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disorders. Nature Communications, 12 (1) 76, 1-18. doi: 10.1038/s41467-020-20385-9

Nanocarriers for oral delivery of biologics: small carriers for big payloads

Cao, Yuxue, Rewatkar, Prarthana, Wang, Ran, Hasnain, Sumaira Z., Popat, Amirali and Kumeria, Tushar (2021). Nanocarriers for oral delivery of biologics: small carriers for big payloads. Trends in Pharmacological Sciences, 42 (11), 957-972. doi: 10.1016/j.tips.2021.08.005

Gut microbiota shape the inflammatory response in mice with an epithelial defect

Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720

Editorial: the response of mucosal epithelial cells to infections

Wang, Ran and Proud, David (2020). Editorial: the response of mucosal epithelial cells to infections. Frontiers in Cellular and Infection Microbiology, 10 602312, 602312. doi: 10.3389/fcimb.2020.602312

Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis

Pujara, Naisarg, Wong, Kuan Yau, Qu, Zhi, Wang, Ran, Moniruzzaman, Md., Rewatkar, Prarthana, Kumeria, Tushar, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2020). Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, 18 (2) acs.molpharmaceut.0c00048, 627-640. doi: 10.1021/acs.molpharmaceut.0c00048

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y

Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway

Moniruzzaman, Md., Wang, Ran, Jeet, Varinder, McGuckin, Michael A. and Hasnain, Sumaira Z. (2019). Interleukin (IL)-22 from IL-20 Subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway. International Journal of Molecular Sciences, 20 (14) 3468, 3468. doi: 10.3390/ijms20143468

Genetic and pharmacological modulation of RORα regulates TH17-driven inflammatory disorders

Solt, Laura A, Wang, Ran, Amir, Mohammed, Chaudhari, Sweena, Campbell, Sean, Bassette, Molly B, Eliason, Amber, Sundrud, Mark S and Kamenecka, Theodore (2019). Genetic and pharmacological modulation of RORα regulates TH17-driven inflammatory disorders. The Journal of Immunology, 202 (1_Supplement), 68.11-68.11. doi: 10.4049/jimmunol.202.supp.68.11

REV-ERBα regulates T(H)17 cell development and autoimmunity

Amir, Mohammed, Chaudhari, Sweena, Wang, Ran, Campbell, Sean, Mosure, Sarah A., Chopp, Laura B., Lu, Qun, Shang, Jinsai, Pelletier, Oliver B., He, Yuanjun, Doebelin, Christelle, Cameron, Michael D., Kojetin, Douglas J., Kamenecka, Theodore M. and Solt, Laura A. (2018). REV-ERBα regulates T(H)17 cell development and autoimmunity. Cell Reports, 25 (13), 3733-+. doi: 10.1016/j.celrep.2018.11.101

A non-redundant role for RORα in TH17 cell development and TH17-driven inflammatory disorders

Solt, Laura A., Wang, Ran, Amir, Mohammed, Chaudhari, Sweena M., Campbell, Sean, Bassette, Molly A. and Kamenecka, Theodore M. (2018). A non-redundant role for RORα in TH17 cell development and TH17-driven inflammatory disorders. The Journal of Immunology, 200 (1_Supplement), 121.3-121.3. doi: 10.4049/jimmunol.200.supp.121.3

The REV-ERBs: Negative Regulators of Th17 Cell Development and Autoimmunity

Amir, Mohammed, Chaudhari, Sweena M., Wang, Ran, Campbell, Sean, Kamenecka, Theodore M. and Solt, Laura A. (2018). The REV-ERBs: Negative Regulators of Th17 Cell Development and Autoimmunity. The Journal of Immunology, 200 (1_Supplement), 163.10-163.10. doi: 10.4049/jimmunol.200.supp.163.10

Immune regulation of the unfolded protein response at the mucosal barrier in viral infection

Wang, Ran, Moniruzzaman, Md., Shuffle, Eric, Lourie, Rohan and Hasnain, Sumaira Z. (2018). Immune regulation of the unfolded protein response at the mucosal barrier in viral infection. Clinical & Translational Immunology, 7 (4) e1014, e1014. doi: 10.1002/cti2.1014

The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse

Borg, Danielle J., Wang, Ran, Murray, Lydia, Tong, Hui, Steptoe, Raymond J., McGuckin, Michael A. and Hasnain, Sumaira Z. (2017). The effect of interleukin-22 treatment on autoimmune diabetes in the NOD mouse. Diabetologia, 60 (11), 1-6. doi: 10.1007/s00125-017-4392-2

Analyzing the properties of murine intestinal mucins by electrophoresis and histology

Wang, Ran and Hasnain, Sumaira Z. (2017). Analyzing the properties of murine intestinal mucins by electrophoresis and histology. Bio-protocol, 7 (14). doi: 10.21769/BioProtoc.2394

Negative regulation of Th17 cell development and function by the REV-ERBs

Solt, Laura A, Amir, Mohammed, Chaudhari, Sweena M., Wang, Ran and Campbell, Sean (2017). Negative regulation of Th17 cell development and function by the REV-ERBs. The Journal of Immunology, 198 (1_Supplement), 127.15-127.15. doi: 10.4049/jimmunol.198.supp.127.15

Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism

Oancea, I., Movva, R., Das, I., Aguirre de Carcer, D., Schreiber, V., Yang, Y., Purdon, A., Harrington, B., Proctor, M., Wang, R., Sheng, Y., Lobb, M., Lourie, R., Cuiv, P.O., Duley, J.A., Begun, J. and Florin, T.H.J. (2016). Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism. Gut, 66 (1), 59-69. doi: 10.1136/gutjnl-2015-310874

High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22

Gulhane, Max, Murray, Lydia, Lourie, Rohan, Tong, Hui, Sheng, Yong H., Wang, Ran, Kang, Alicia, Schreiber, Veronika, Wong, Kuan Yau, Magor, Graham, Denman, Stuart, Begun, Jakob, Florin, Timothy H., Perkins, Andrew, Cuiv, Paraic O., McGuckin, Michael A. and Hasnain, Sumaira Z. (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. Scientific Reports, 6 (1) 28990, 28990. doi: 10.1038/srep28990

Metabolism of murine TH17 cells: impact on cell fate and function

Wang, Ran and Solt, Laura A. (2016). Metabolism of murine TH17 cells: impact on cell fate and function. European Journal of Immunology, 46 (4), 807-816. doi: 10.1002/eji.201545788

Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model

Wang, Ran, Hasnain, Sumaira Z., Tong, Hui, Das, Indrajit, Che-Hao Chen, Alice, Oancea, Iulia, Proctor, Martina, Florin, Timothy H., Eri, Rajaraman D. and McGuckin, Michael A. (2015). Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model. Inflammatory Bowel Diseases, 21 (5), 973-984. doi: 10.1097/MIB.0000000000000353

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonghua H., Ng, Choa Ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014). Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12), 1417-1426. doi: 10.1038/nm.3705

Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice

Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C., Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown, Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014). Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 (7), 1755-1767. doi: 10.1002/art.38638

MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

Sheng, Y. H., Triyana, S., Wang, R., Das, I., Gerloff, K., Florin, T. H., Sutton, P. and McGuckin, M. A. (2013). MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunology, 6 (3), 557-568. doi: 10.1038/mi.2012.98

A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease

Rahman, M. A., Moniruzzaman, M., Wang, R., Harding, A., Wiid, P., Sajiir, H., Yong, K. Y., Sheng, Y., Mueller, A., Symon, H., Varelias, A., McGuckin, M., Phipps, S. and Hasnain, S. (2022). A novel role for interleukin-22 signaling in modulating mucosal epithelial cell antigen presentation machinery to control disease. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW), Sydney, NSW, Australia, 9–11 September 2022. Richmond, VIC, Australia: John Wiley & Sons.

Building a case for liver and pancreas targeted interleukin-22 therapy for use in non-alcoholic fatty liver disease

Sajiir, Haressh, Wong, Kuanyau, Mueller, Alexander, Keshvari, Sahar, Wang, Ran, Macdonald, Graeme A., Prins, John, Mcguckin, Michael and Hasnain, Sumaira Z. (2022). Building a case for liver and pancreas targeted interleukin-22 therapy for use in non-alcoholic fatty liver disease. Digestive Disease Week 2022, San Diego, CA United States, 21-24 May 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(22)60035-0

Pancreatic Interleukin-22 Receptor Signaling is Critical in Maintaining Beta-Cell Insulin Production and is Hepatoprotective

Sajiir, Haressh, Wong, Kuan Yau, Mueller, Alexandra, Keshvari, Sahar, Wang, Ran, Wiid, Percival, Macdonald, Graeme, Prins, John, McGuckin, Michael A. and Hasnain, Sumaira Z. (2022). Pancreatic Interleukin-22 Receptor Signaling is Critical in Maintaining Beta-Cell Insulin Production and is Hepatoprotective. Immunology 2022 Meeting, Portland, OR United States, 6-10 May 2022. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.208.supp.46.08

Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections

Wang, R., Moniruzzaman, M., Wang, K., Upham, J. W., McGuckin, M., Phipps, S. and Hasnain, S. Z. (2020). Blocking endogenous IL-22 is associated with reduced viral load and improved lung pathology in respiratory viral infections. International Conference of the American-Thoracic-Society (ATS), Online, 10 November 2020. New York, NY, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6530

Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection

Hasnain, S., Wang, R., Taylor, S., Wong, K. Y., Moniruzzaman, M., Upham, J., Spann, K., Mcguckin, M. A., Burr, L. and Phipps, S. (2020). Harnessing the therapeutic potential of interleukin-22 in neonatal respiratory viral infection. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC, Australia, 27–31 March 2020. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777

Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity

Moniruzzaman, M., Wang, R., Wong, K., Tong, H., McGuckin, M. and Hasnain, S. (2019). Interleukin-20 subfamily cytokines in controlling intestinal inflammation and epithelial barrier integrity. Congress of ECCO, Copenhagen, Denmark, 6-9 March 2019. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjy222.044

A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection

Wang, R., Taylor, S., Moniruzzaman, M., Wong, K., Upham, J., Spann, K., McGuckin, M., Phipps, S. and Hasnain, S. (2019). A novel role of IL-22 in regulating epithelial MHC molecule expression and antigen presentation during viral infection. 17th International Congress of Immunology (IUIS), Beijing, People's Republic of China, 9-23 October 2019. Weinheim, Germany: Wiley.

Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation

Wang, R., Giri, R., Moniruzzaman, M., Tong, H., Wong, K. Y., Begun, J., McGuckin, M. A. and Hasnain, S. Z. (2018). Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.

Interleukin-22: A potential therapy to control intestinal inflammation

Moniruzzaman, M., Wang, R., Wong, K. Y., Tong, H., McGuckin, M. A. and Hasnain, S. Z. (2018). Interleukin-22: A potential therapy to control intestinal inflammation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.

Ubiquitin Ligase MARCH8 attenuates Graft versus Host Disease via Regulation of Gut Epithelial Cell Surface MHC II Expression

Lineburg, Katie E., Le Texier, Laetitia, Melino, Michelle, Wang, Ran, Clouston, Andrew, Blazar, Bruce R., McGuckin, Michael A., Villadangos, Jose A., Mintern, Justine D. and MacDonald, Kelli P. A. (2018). Ubiquitin Ligase MARCH8 attenuates Graft versus Host Disease via Regulation of Gut Epithelial Cell Surface MHC II Expression. 27th International Congress of the Transplantation-Society (TTS), Madrid, Spain, 30 June - 5 July 2018. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/01.tp.0000543013.84163.3a

Targeting interleukin-23(p19) secretion from intestinal epithelial cells to improve intestinal barrier integrity in inflammatory bowel disease

Wang, R., Lourie, R., Tong, H., Giri, R., Schreiber, V., Begun, J., Florin, T., McGuckin, M. A. and Hasnain, S. Z. (2017). Targeting interleukin-23(p19) secretion from intestinal epithelial cells to improve intestinal barrier integrity in inflammatory bowel disease. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD Australia, 20–22 August 2017. Richmond, VIC Australia: Wiley.

971d Colonic microbiota can promote rapid improvement of murine colitis by thioguanine independently of T-lymphocytes and host metabolism

Oancea, Iulia, Das, Indrajit D., de Carcer, Daniel Aguirre, Schreiber, Veronika, Wang, Ran, Sheng, Yong, Movva, Ramya, Cuiv, Paraic O, Duley, John, Begun, Jakob and Florin, Timothy H. (2016). 971d Colonic microbiota can promote rapid improvement of murine colitis by thioguanine independently of T-lymphocytes and host metabolism. Digestive Disease Week 2016, San Diego, CA USA, 21-24 May 2016. Philadelphia, PA USA: Elsevier. doi: 10.1016/s0016-5085(16)30737-5

Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis

Oancea, I., Das, I., de Carcer, D. Aguirre, Movva, R., Schreiber, V., Yang, Y., Proctor, M., Wang, R., Sheng, Y., Lobb, M., Cuiv, P. O., Duley, J. A., Begun, J. and Florin, T. H. J. (2016). Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis. 11th Congress of ECCO - European Crohn’s and Colitis Organisation, Amsterdam, Netherlands, 16-19 March 2016. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjw019.177

MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target

Sheng, Yong H., He, Yaowu, Hasnain, Sumaira Z., Wang, Ran, Tong, Hui, Clarke, Daniel T., Lourie, Rohan, Oancea, Lulia, Wong, Kuanyau, Lumley, John W., Florin, Timothy H., Sutton, Philip, Hooper, John. D., Mcmillan, Nigel A. and Mcguckin, Michael A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target. AACR 107th Annual Meeting on Bioinformatics and Systems Biology, New Orleans, Los Angeles, 16-20 April 2016 . Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2016-3564

Unravelling a novel mechanism by which cytokines induce ER stress to halt viral protein synthesis in mucosal epithelial cells

Hasnain, S. Z., Taylor, S., Wang, R., Chen, A., Oancea, I, Das, I, Tong, H., Florin, T., Serisier, D., Coulson, B., Mcauley, J., Lourie, R., Phipps, S. and Mcguckin, M. (2016). Unravelling a novel mechanism by which cytokines induce ER stress to halt viral protein synthesis in mucosal epithelial cells. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200

High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease

Gulhane, M., Murray, L., Wang, R., Tong, H., Mcguckin, M. and Hasnain, S. (2015). High fat diet and the colonic mucus barrier: implications for obesity and inflammatory bowel disease. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13094

Direct Adverse Effects of IL-23 on Epithelial Cells Underline Greater Efficacy of Neutralizing IL-23 in Suppressing Murine Colitis

Wang, Ran, Hasnain, Sumaira Z., Tong, Hui, Lourie, Rohan, Florin, Timothy H. and McGuckin, Michael A. (2014). Direct Adverse Effects of IL-23 on Epithelial Cells Underline Greater Efficacy of Neutralizing IL-23 in Suppressing Murine Colitis. 55th Annual Meeting of the Society for Surgery of the Alimentary Tract (SSAT) / Digestive Disease Week (DDW), Chicago, Il, United States, May 03-06, 2014. Maryland Heights, MO, United States: W.B. Saunders Co.. doi: 10.1016/S0016-5085(14)62987-5

Immunoregulation of Human Myeloid Dendritic Cells and Monocytes by Vascular Endothelial Growth Factor

Sanchez, Washington Yamandu, Jr., Wang, Ran, Wilkinson, Andrew, Khalil, Dalia, Hart, Derek N. J., Catley, Laurence and Vuckovic, Slavica (2011). Immunoregulation of Human Myeloid Dendritic Cells and Monocytes by Vascular Endothelial Growth Factor. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego Ca, Dec 10-13, 2011.

Targeting IL-23/TH17 axis in suppressing intestinal inflammation

Wang, Ran (2015). Targeting IL-23/TH17 axis in suppressing intestinal inflammation. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2015.426