NHMRC Emerging Leadership Fellow
Overview
Dr Kevin M. Koo is currently a National Health and Medical Research Council (NHMRC) Investigator Fellow at The University of Queensland Centre for Clinical Research (UQCCR). Dr Koo was awarded his PhD (Dean’s Award for Outstanding Thesis) from the Australian Institute for Bioengineering & Nanotechnology (AIBN), UQ in 2018. His PhD research was on the molecular analysis of nucleic acid biomarkers in prostate cancer liquid biopsies (with a particular interest in fusion genes), and the development of associated nanotechnology-based biosensors to facilitate precision cancer treatment.
Post-PhD, he begun a productive postdoctoral career with dual industry/academia appointments: as the Head of Assay Development/Lab Director in XING Technologies Pty Ltd (a Brisbane-based biotech start-up) to undertake product development projects for commercialization of disease in vitro diagnostics, and as an Honorary Fellow/Principal Research Scientist at UQCCR to continue his academic research in precision cancer nanodiagnostics. His research skills and experiences are honed through dedicated career time spent in both academic research and regulated industry environments.
Dr Koo's research encompasses multi-disciplinary fields of molecular biomarker and nanobiosensor development, translation, and commercialization for precision disease management applications. Presently, he is working on the design and development of integrated multi-bioanalyte sensing technologies to resolve the various challenges around holistic disease biomarker pathway understanding and disease detection.
Dr Koo's research endeavours have been recognized by a Metrohm Australia-New Zealand Young Chemist Award (2018), Springer Thesis Award (2019) and Queensland Young Tall Poppy Science Award (2023).
Research Interests
- Molecular Diagnostics/In Vitro Diagnostics
- Nanobiosensors
- Liquid Biopsy
- Photonics
- Electrochemistry
Research Impacts
To date, Dr Koo's research has contributed Knowledge Impact by:
- Developing point-of-need nanobiosensors for prostate cancer-specific urinary biomarkers (Koo KM et al., Nature Reviews Urology, 2019)
- Progressing nanobiosensor clinical translation for precision cancer management (Koo KM et al., ACS Nano, 2018)
- Addressing key assay challenges around circulating biomarker detection in cancer liquid biopsies (Koo KM & Trau M, ACS Sensors, 2020)
Dr Koo's specialist knowledge in his fields of research expertise has led to global invitations for scientific evaluation. He is an Associate Editor for Frontiers in Nanotechnology (2022-present) and regular Peer Reviewer (30+ reviews/yr) for 20+ leading journals of worldwide publishers American Chemical Society, Royal Society of Chemistry, Wiley-VCH, and Elsevier. He is an international Assessor for external quality assessment (EQA) organizations European Molecular Genetics Quality Network (EMQN) and Genomics Quality Assessment (GenQA) (2022-Present), evaluating 20+ clinical sequencing labs/yr worldwide participating in EQA schemes for technical and regulatory compliance.
Dr Koo is passionate about science communication and outreach activities to impact the broader community, especially by leveraging his unique academic/industry track record to champion diverse STEM career pathways. He volunteers as an Industry Mentoring Networking in STEM (IMNIS) Mentor to motivated early- and mid-career researchers (3 to date) for career and professional development mentoring.
Qualifications
- Doctor of Philosophy, The University of Queensland
- Bachelor (Honours) of Biochemistry, The University of Queensland
- Bachelor of Biophysics, The University of Queensland
Publications
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Journal Article: Point-of-need mastitis pathogen biosensing in bovine milk: From academic sample preparation novelty to industry prototype field testing
Fitzpatrick, Kira J., Rohlf, Hayden J., Phillips, Grant, Macaulay, R. Bruce, Anderson, Will, Price, Rochelle, Wood, Caitlin, James, Ameh, Langhorne, Charlotte, te Brake, Bill, Gibson, Justine S. and Koo, Kevin M. (2024). Point-of-need mastitis pathogen biosensing in bovine milk: From academic sample preparation novelty to industry prototype field testing. Talanta, 277 126424, 126424. doi: 10.1016/j.talanta.2024.126424
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Journal Article: Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis
Lin, Xuan, Vasanth, Arya, Ashok, Aditya, Phan, Hoang-Phuong, Koo, Kevin M., Amin, Mohammed A., Kaneti, Yusuf Valentino, Salomon, Carlos, Hossain, Md Shahriar A., Yamauchi, Yusuke and Masud, Mostafa Kamal (2024). Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis. Nano Materials Science. doi: 10.1016/j.nanoms.2024.01.010
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Journal Article: Cancer‐on‐Chip and Integrative Tumor Microenvironment Sensor Technologies for Progressing Precision Radiotherapy
Dey, Shuvashis, Kinoshita, Masaki, Puttick, Simon, Rose, Stephen, Trau, Matt, Roberts, Matthew J. and Koo, Kevin M. (2024). Cancer‐on‐Chip and Integrative Tumor Microenvironment Sensor Technologies for Progressing Precision Radiotherapy. Advanced Sensor Research. doi: 10.1002/adsr.202300193
Grants
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Integrated biosensor for multi-omics profiling of cancer biomarkers via molecular manipulation
(2024–2028) NHMRC Investigator Grants
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(2024–2026) Prostate Cancer Foundation of Australia
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(2020–2023) Xing Group Holdings Pty Ltd
Available Projects
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Development of a Novel Molecular Manipulation Technique for Multi-Bioanalyte Cancer Profiling
At present, DNA/RNA and protein detection require different assay workflows to be performed. This demands multiple assay workflows to be performed for multi-bioanalyte analysis, leading to prolonged analysis time for results and high assay running costs. In particular, the typical enzyme-linked immunosorbent assay (ELISA) for protein detection generally requires at least a two-day workflow and has limited detection sensitivity.
The core concept of this PhD research project is to develop an innovative molecular manipulation method to rapidly transform a single immunological interaction into an amplified molecular signal, as equivalent to polymerase chain reaction (PCR) method for DNA/RNA detection. Successful project outcomes will enable a single workflow for multi-bioanalyte prostate cancer analysis.
The Advisory Team aims to provide a supportive high-level research environment for the prospective PhD candidate to flourish. This PhD project will provide opportunities to achieve significant research outputs and skills for a scientific career in academia/industry upon graduating.
Publications
Book
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Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics
Koo, Kevin M. (2019). Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-31000-4
Book Chapter
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Wuethrich, Alain, Dey, Shuvashis, Koo, Kevin M, Sina, Abu A. I. and Trau, Matt (2021). Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor. Melanoma. (pp. 265-276) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1205-7_20
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Interfacial biosensing: direct biosensing of biomolecules at the bare metal interface
Ibn Sina, A. A., Koo, K. M., Ahmed, M., Carrascosa, L. G. and Trau, M. (2018). Interfacial biosensing: direct biosensing of biomolecules at the bare metal interface. Encyclopedia of interfacial chemistry: surface science and electrochemistry. (pp. 269-277) Amsterdam: Elsevier. doi: 10.1016/b978-0-12-409547-2.14188-5
Journal Article
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Fitzpatrick, Kira J., Rohlf, Hayden J., Phillips, Grant, Macaulay, R. Bruce, Anderson, Will, Price, Rochelle, Wood, Caitlin, James, Ameh, Langhorne, Charlotte, te Brake, Bill, Gibson, Justine S. and Koo, Kevin M. (2024). Point-of-need mastitis pathogen biosensing in bovine milk: From academic sample preparation novelty to industry prototype field testing. Talanta, 277 126424, 126424. doi: 10.1016/j.talanta.2024.126424
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Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis
Lin, Xuan, Vasanth, Arya, Ashok, Aditya, Phan, Hoang-Phuong, Koo, Kevin M., Amin, Mohammed A., Kaneti, Yusuf Valentino, Salomon, Carlos, Hossain, Md Shahriar A., Yamauchi, Yusuke and Masud, Mostafa Kamal (2024). Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis. Nano Materials Science. doi: 10.1016/j.nanoms.2024.01.010
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Dey, Shuvashis, Kinoshita, Masaki, Puttick, Simon, Rose, Stephen, Trau, Matt, Roberts, Matthew J. and Koo, Kevin M. (2024). Cancer‐on‐Chip and Integrative Tumor Microenvironment Sensor Technologies for Progressing Precision Radiotherapy. Advanced Sensor Research. doi: 10.1002/adsr.202300193
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Jaradi, Binny, Das, Tulika and Koo, Kevin M. (2023). Design and analytical evaluation of a rapid plasma screening assay for circulating human papillomavirus DNA via thermostable enzyme chemistries. Analytical Chemistry, 95 (29), 11172-11180. doi: 10.1021/acs.analchem.3c02528
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Koo, Kevin M. (2023). Multifunctional hybrid nanozymes for magnetic enrichment and bioelectrocatalytic sensing of circulating tumor RNA during minimal residual disease monitoring. Catalysts, 13 (1) 178, 1-10. doi: 10.3390/catal13010178
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Dey, Shuvashis, Koo, Kevin M., Ahmed, Emtiaz and Trau, Matt (2023). Nanophotonic immunoarray with electrochemically roughened surfaces for handheld detection of secreted PD-L1 to predict immuno-oncology efficacy. Lab on a Chip, 23 (15), 3443-3452. doi: 10.1039/d3lc00523b
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Exquisitely platinum-sensitive triple-negative breast cancer, time for BRCA methylation testing?
Tan, Tira J., Fink, J. Lynn, Tay, Timothy K., Jaradi, Binny, Stone, Nathan, Waring, Paul, Koo, Kevin M., Tan, Puay Hoon, Tan, Daniel S. and Dent, Rebecca A. (2022). Exquisitely platinum-sensitive triple-negative breast cancer, time for BRCA methylation testing?. JCO Precision Oncology, 6 (6) e2200309, e2200309. doi: 10.1200/po.22.00309
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Wang, Jing, Koo, Kevin M. and Trau, Matt (2022). Tetraplex immunophenotyping of cell surface proteomes via synthesized plasmonic nanotags and portable raman spectroscopy. Analytical Chemistry, 94 (43), 14906-14916. doi: 10.1021/acs.analchem.2c02262
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Harnessing gene fusion-derived neoantigens for ‘cold’ breast and prostate tumor immunotherapy
Velaga, Ravi, Koo, Kevin M. and Mainwaring, Paul N. (2022). Harnessing gene fusion-derived neoantigens for ‘cold’ breast and prostate tumor immunotherapy. Immunotherapy, 14 (14), 1165-1179. doi: 10.2217/imt-2022-0081
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Koo, Kevin M. and Trau, Matt (2022). Molecular locker probe enrichment of gene fusion variants from matched patient liquid biopsy specimens for magneto-bioelectrocatalytic nanosensing. Nanoscale, 14 (11), 4225-4233. doi: 10.1039/d1nr07845c
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Fitzpatrick, Kira J., Rohlf, Hayden J., Sutherland, Tara D., Koo, Kevin M., Beckett, Sam, Okelo, Walter O., Keyburn, Anthony L., Morgan, Branwen S., Drigo, Barbara, Trau, Matt, Donner, Erica, Djordjevic, Steven P. and De Barro, Paul J. (2021). Progressing antimicrobial resistance sensing technologies across human, animal, and environmental health domains. ACS Sensors, 6 (12) acssensors.1c01973, 4283-4296. doi: 10.1021/acssensors.1c01973
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Bioengineered Polymer Nanobeads for Isolation and Electrochemical Detection of Cancer Biomarkers
Soda, Narshone, Gonzaga, Zennia Jean, Chen, Shuxiong, Koo, Kevin M., Nguyen, Nam-Trung, Shiddiky, Muhammad J. A. and Rehm, Bernd H. A. (2021). Bioengineered Polymer Nanobeads for Isolation and Electrochemical Detection of Cancer Biomarkers. ACS applied materials & interfaces, 13 (27) acsami.1c05355, 31418-31430. doi: 10.1021/acsami.1c05355
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Singh, Karishma, Nalabotala, Ruchika, Koo, Kevin M., Bose, Sudeep, Nayak, Ranu and Shiddiky, Muhammad J. A. (2021). Separation of distinct exosome subpopulations: isolation and characterization approaches and their associated challenges. Analyst, 146 (12), 3731-3749. doi: 10.1039/d1an00024a
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Koo, Kevin M., Soda, Narshone and Shiddiky, Muhammad J.A. (2021). Magnetic nanomaterial–based electrochemical biosensors for the detection of diverse circulating cancer biomarkers. Current Opinion in Electrochemistry, 25 100645, 100645. doi: 10.1016/j.coelec.2020.100645
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Zeng, Yi, Koo, Kevin M., Shen, Ai-Guo, Hu, Ji-Ming and Trau, Matt (2021). Nucleic acid hybridization-based noise suppression for ultraselective multiplexed amplification of mutant variants. Small, 17 (2) 2006370, e2006370. doi: 10.1002/smll.202006370
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Koo, Kevin M. and Trau, Matt (2020). Direct enhanced detection of multiple circulating tumor dna variants in unprocessed plasma by magnetic-assisted bioelectrocatalytic cycling. ACS Sensors, 5 (10), 3217-3225. doi: 10.1021/acssensors.0c01512
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Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020). Advanced Functional Materials, 30 (37) 2070248. doi: 10.1002/adfm.202070248
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Dey, Shuvashis, Trau, Matt and Koo, Kevin M. (2020). Surface-enhanced Raman spectroscopy for cancer immunotherapy applications: opportunities, challenges, and current progress in nanomaterial strategies. Nanomaterials, 10 (6) 1145, 1-15. doi: 10.3390/nano10061145
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Koo, Kevin M. and Mainwaring, Paul N. (2020). The role of circulating tumor DNA testing in breast cancer liquid biopsies: getting ready for prime time. Breast Cancer Management, 9 (1), BMT34. doi: 10.2217/bmt-2020-0003
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Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies. Advanced Functional Materials, 30 (37) 1909306, 1909306. doi: 10.1002/adfm.201909306
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Li, Junrong, Koo, Kevin M., Wang, Yuling and Trau, Matt (2019). Native MicroRNA targets trigger self‐assembly of nanozyme‐patterned hollowed nanocuboids with optimal interparticle gaps for plasmonic‐activated cancer detection. Small, 15 (50) 1904689, 1904689. doi: 10.1002/smll.201904689
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Wang, Jing, Koo, Kevin M., Wang, Yuling and Trau, Matt (2019). Engineering state-of-the-art plasmonic nanomaterials for SERS-based clinical liquid biopsy applications. Advanced Science, 6 (23) 1900730, 1900730. doi: 10.1002/advs.201900730
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Watching SERS glow for multiplex biomolecular analysis in the clinic: A review
Zeng, Yi, Koo, Kevin M., Trau, Matt, Shen, Ai-Guo and Hu, Ji-Ming (2019). Watching SERS glow for multiplex biomolecular analysis in the clinic: A review. Applied Materials Today, 15, 431-444. doi: 10.1016/j.apmt.2019.03.005
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Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management
Koo, Kevin M., Mainwaring, Paul N., Tomlins, Scott A. and Trau, Matt (2019). Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management. Nature Reviews Urology, 16 (5), 302-317. doi: 10.1038/s41585-019-0178-2
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Phosphoprotein biosensors for monitoring pathological protein structural changes
Ahmed, Mostak, Koo, Kevin M., Mainwaring, Paul N., Carrascosa, Laura G. and Trau, Matt (2019). Phosphoprotein biosensors for monitoring pathological protein structural changes. Trends in Biotechnology, 38 (5), 519-531. doi: 10.1016/j.tibtech.2019.11.006
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Dey, Shuvashis, Koo, Kevin, Wang, Zhaoran, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2018). An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells. Lab on a Chip, 19 (5), 738-748. doi: 10.1039/c8lc00991k
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Koo, Kevin M., Dey, Shuvashis and Trau, Matt (2018). A sample-to-targeted gene analysis biochip for nanofluidic manipulation of solid-phase circulating tumor nucleic acid amplification in liquid biopsies. ACS Sensors, 3 (12) acssensors.8b01011, 2597-2603. doi: 10.1021/acssensors.8b01011
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"Mix-to-go" silver colloidal strategy for prostate cancer molecular profiling and risk prediction
Wang, Jing, Koo, Kevin M., Wang, Yuling and Trau, Matt (2018). "Mix-to-go" silver colloidal strategy for prostate cancer molecular profiling and risk prediction. Analytical Chemistry, 90 (21), 12698-12705. doi: 10.1021/acs.analchem.8b02959
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Koo, Kevin M., Wang, Jing, Richards, Renée S., Farrell, Aine, Yaxley, John W., Samaratunga, Hema, Teloken, Patrick E., Roberts, Matthew J., Coughlin, Geoffrey D., Lavin, Martin F., Mainwaring, Paul N., Wang, Yuling, Gardiner, Robert A. and Trau, Matt (2018). Design and clinical verification of surface-enhanced Raman spectroscopy diagnostic technology for individual cancer risk prediction. ACS Nano, 12 (8), 8362-8371. doi: 10.1021/acsnano.8b03698
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Koo, Kevin M., Dey, Shuvashis and Trau, Matt (2018). Amplification-free multi-RNA-type profiling for cancer risk stratification via alternating current electrohydrodynamic nanomixing. Small, 14 (17) 1704025, e1704025. doi: 10.1002/smll.201704025
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Koo, Kevin M., Dey, Shuvashis and Trau, Matt (2018). Adjustable fluidic nanomixing: amplification-free multi-RNA-type profiling for cancer risk stratification via alternating current electrohydrodynamic nanomixing (Small 17/2018). Small, 14 (17) 1870075. doi: 10.1002/smll.201870075
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Enabling miniaturised personalised diagnostics: from lab-on-a-chip to lab-in-a-drop
Koo, Kevin M., Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2017). Enabling miniaturised personalised diagnostics: from lab-on-a-chip to lab-in-a-drop. Lab On a Chip, 17 (19), 3200-3220. doi: 10.1039/c7lc00587c
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Koo, Kevin M. , Carrascosa, Laura G. and Trau, Matt (2017). DNA-directed assembly of copper nanoblocks with inbuilt fluorescent and electrochemical properties: Application in simultaneous amplification-free analysis of multiple RNA species. Nano Research, 11 (2), 1-13. doi: 10.1007/s12274-017-1706-0
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High-speed biosensing strategy for non-invasive profiling of multiple cancer fusion genes in urine
Koo, Kevin M., Wee, Eugene J. H. and Trau, Matt (2017). High-speed biosensing strategy for non-invasive profiling of multiple cancer fusion genes in urine. Biosensors and Bioelectronics, 89 (2), 715-720. doi: 10.1016/j.bios.2016.11.024
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Wang, Jing, Koo, Kevin M., Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2017). A nanoplasmonic label-free surface-enhanced Raman scattering strategy for non-invasive cancer genetic subtyping in patient samples. Nanoscale, 9 (10), 3496-3503. doi: 10.1039/c6nr09928a
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Koo, Kevin M., McNamara, Benjamin, Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2016). Rapid and sensitive fusion gene detection in prostate cancer urinary specimens by label-free surface-enhanced raman scattering. Journal of Biomedical Nanotechnology, 12 (9), 1798-1805. doi: 10.1166/jbn.2016.2294
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Koo, Kevin M., Wee, Eugene J. H., Mainwaring, Paul N. and Trau, Matt (2016). A simple, rapid, low-cost technique for naked-eye detection of urine-isolated TMPRSS2:ERG gene fusion RNA. Scientific reports, 6 (1) 30722, 30722. doi: 10.1038/srep30722
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Koo, Kevin M., Carrascosa, Laura G., Shiddiky, Muhammad J. A. and Trau, Matt (2016). Amplification-free detection of gene fusions in prostate cancer urinary samples using mRNA-gold affinity interactions. Analytical Chemistry, 88 (13), 6781-6788. doi: 10.1021/acs.analchem.6b01182
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Koo, Kevin, Wee, Eugene and Trau, Matt (2016). Colorimetric TMPRSS2-ERG gene fusion detection in prostate cancer urinary samples via recombinase polymerase amplification. Theranostics, 6 (9), 1415-1424. doi: 10.7150/thno.15250
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Koo, Kevin M., Carrascosa, Laura G., Shiddiky, Muhammad J. A. and Trau, Matt (2016). Poly(A) extensions of miRNAs for amplification-free electrochemical detection on screen-printed gold electrodes. Analytical Chemistry, 88 (4), 2000-2005. doi: 10.1021/acs.analchem.5b04795
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Koo, Kevin M., Wee, Eugene J. H., Mainwaring, Paul N., Wang, Yuling and Trau, Matt (2016). Toward precision medicine: a cancer molecular subtyping nano-trategy for RNA biomarkers in tumor and urine. Small, 12 (45), 6233-6242. doi: 10.1002/smll.201602161
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DNA-bare gold affinity interactions: mechanism and applications in biosensing
Koo, Kevin M., Sina, Abu A. I., Carrascosa, Laura G., Shiddiky, Muhammad J. A. and Trau, Matt (2015). DNA-bare gold affinity interactions: mechanism and applications in biosensing. Analytical Methods, 7 (17), 1-13. doi: 10.1039/c5ay01479d
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Wee, Eugene J.H., Koo, Kevin M, Mainwaring, Paul N. and Trau, Mattias (2015). Towards rapid and cost-effective point-of-care detection of TMPRSS2:ERG fusion transcripts in urine via a novel methodology. Journal of Clinical Oncology, 33 (15_suppl), 11063-11063. doi: 10.1200/jco.2015.33.15_suppl.11063
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Koo, Kevin M., Sina, Abu Ali Ibn, Carrascosa, Laura G., Shiddiky, Muhammad J. A. and Trau, Matt (2014). eMethylsorb: rapid quantification of DNA methylation in cancer cells on screen-printed gold electrodes. Analyst, 139 (23), 6178-6184. doi: 10.1039/c4an01641f
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Microdevices for detecting locus-specific DNA methylation at CpG resolution
Koo, Kevin M., Wee, Eugene, Rauf, Sakandar, Shiddiky, Muhammad J. A. and Trau, Matt (2014). Microdevices for detecting locus-specific DNA methylation at CpG resolution. Biosensors and Bioelectronics, 56, 278-285. doi: 10.1016/j.bios.2014.01.029
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Wee, Eugene J. H., Rauf, Sakandar, Koo, Kevin, Shiddiky, Muhammad J. A. and Trau, Matt (2013). mu-eLCR: a microfabricated device for electrochemical detection of DNA base changes in breast cancer cell lines. Lab on a Chip, 13 (22), 4385-4391-4385-4391. doi: 10.1039/C3LC50528F
Conference Publication
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Mainwaring, Paul N., Grewal, Yadveer S., Koo, Kevin M., Anderson, Will and Korbie, Darren J. (2019). Liquid biopsy in cancer—getting down to the nano level. Can nano-diagnostics lead to comprehensive, accurate, and affordable biomarkers to improve advanced breast (ABC) care?. Advanced Breast Cancer Fifth International Consensus Conference (ABC5), Lisbon, Portugal, 14 - 16 November, 2019. London, United Kingdom: Churchill Livingstone. doi: 10.1016/s0960-9776(19)30638-1
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Gardiner, F., Koo, K., Wang, J., Richards, R., Farrell, A., Yaxley, J., Samaratunga, H., Teloken, P., Roberts, M., Coughlin, G., Lavin, M., Mainwaring, P., Wang, Y., Gardiner, R. and Trau, M. (2019). Design and clinical validation of surface enhanced Raman spectroscopy nanodiagnostic technology for urinary prostate cancer risk prediction. Annual Scientific Meeting of the Urological Society of Australia and New-Zealand, Brisbane, Australia, 13-16 April 2019 . Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
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Koo, K., Wee, E., Mainwaring, P., Wang, Y. and Trau, M. (2016). Towards precision medicine: A cancer molecular subtyping nano-strategy for RNA biomarkers in tumor and urine. 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Munich Germany, November 29 - December 2 2016. United Kingdom: Pergamon. doi: 10.1016/S0959-8049(16)32680-6
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Wee, Eugene J. H., Koo, Kevin M., Mainwaring, Paul N. and Trau, Mattias (2015). Towards rapid and cost-effective point-of-care detection of TMPRSS2:ERG fusion transcripts in urine via a novel methodology. Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago, IL United States, 29 May-02 June 2015. Alexandria, VA United States: American Society of Clinical Oncology.
Other Outputs
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Advancing Gene Fusion Detection towards Personalized Cancer Nanodiagnostics
Koo, Maisheng (2018). Advancing Gene Fusion Detection towards Personalized Cancer Nanodiagnostics. PhD Thesis, The Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland. doi: 10.14264/uql.2018.716
Grants (Administered at UQ)
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Integrated biosensor for multi-omics profiling of cancer biomarkers via molecular manipulation
(2024–2028) NHMRC Investigator Grants
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(2024–2026) Prostate Cancer Foundation of Australia
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(2020–2023) Xing Group Holdings Pty Ltd
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(2019–2023) Royal Brisbane and Women's Hospital Foundation
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(2018) Metro North Hospital and Health Service
Possible Research Projects
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
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Development of a Novel Molecular Manipulation Technique for Multi-Bioanalyte Cancer Profiling
At present, DNA/RNA and protein detection require different assay workflows to be performed. This demands multiple assay workflows to be performed for multi-bioanalyte analysis, leading to prolonged analysis time for results and high assay running costs. In particular, the typical enzyme-linked immunosorbent assay (ELISA) for protein detection generally requires at least a two-day workflow and has limited detection sensitivity.
The core concept of this PhD research project is to develop an innovative molecular manipulation method to rapidly transform a single immunological interaction into an amplified molecular signal, as equivalent to polymerase chain reaction (PCR) method for DNA/RNA detection. Successful project outcomes will enable a single workflow for multi-bioanalyte prostate cancer analysis.
The Advisory Team aims to provide a supportive high-level research environment for the prospective PhD candidate to flourish. This PhD project will provide opportunities to achieve significant research outputs and skills for a scientific career in academia/industry upon graduating.
