The University of Queensland

Structure and bioactivity of an insecticidal trans-defensin from assassin bug venom

Walker, Andrew A., Chin, Yanni K.-Y., Guo, Shaodong, Jin, Jiayi, Wilbrink, Evienne, Goudarzi, Mohaddeseh Hedayati, Wirth, Hayden, Gordon, Eric, Weirauch, Christiane and King, Glenn F. (2024). Structure and bioactivity of an insecticidal trans-defensin from assassin bug venom. Structure. doi: 10.1016/j.str.2024.05.016

Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation

Jia, Xinying, Chin, Yanni K.-Y., Zhang, Alan H., Crawford, Theo, Zhu, Yifei, Fletcher, Nicholas L., Zhou, Zihan, Hamilton, Brett R., Stroet, Martin, Thurecht, Kristofer J. and Mobli, Mehdi (2023). Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation. Communications Chemistry, 6 (1) 48, 1-10. doi: 10.1038/s42004-023-00841-5

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2

Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

Kuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w

Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2

Bartling, Christian R. O., Alexopoulou, Flora, Kuschert, Sarah, Chin, Yanni K.-Y., Jia, Xinying, Sereikaite, Vita, Özcelik, Dennis, Jensen, Thomas M., Jain, Palash, Nygaard, Mads M., Harpsøe, Kasper, Gloriam, David E., Mobli, Mehdi and Strømgaard, Kristian (2023). Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2. Journal of Medicinal Chemistry, 66 (4), 3045-3057. doi: 10.1021/acs.jmedchem.2c02017

The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF ^V600E

Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923

The tarantula toxin ω-Avsp1a specifically inhibits human CaV3.1 and CaV3.3 via the extracellular S3-S4 loop of the domain 1 voltage-sensor

Herzig, Volker, Chen, Yong-Cyuan, Chin, Yanni K.-Y., Dekan, Zoltan, Chang, Yu-Wang, Yu, Hui-Ming, Alewood, Paul F., Chen, Chien-Chang and King, Glenn F. (2022). The tarantula toxin ω-Avsp1a specifically inhibits human CaV3.1 and CaV3.3 via the extracellular S3-S4 loop of the domain 1 voltage-sensor. Biomedicines, 10 (5) 1066. doi: 10.3390/biomedicines10051066

Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor

Wilhelm, Patrick, Luna-Ramirez, Karen, Chin, Yanni K.-Y., Dekan, Zoltan, Abraham, Nikita, Tae, Han-Shen, Chow, Chun Yuen, Eagles, David A., King, Glenn F., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2022). Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor. ACS Chemical Neuroscience, 13 (8), 1245-1250. doi: 10.1021/acschemneuro.1c00857

A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals

Eagles, David A., Saez, Natalie J., Krishnarjuna, Bankala, Bradford, Julia J., Chin, Yanni K.-Y., Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E., Undheim, Eivind A. B., Norton, Raymond S., Thomas, Walter G., Vetter, Irina, King, Glenn F. and Robinson, Samuel D. (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences, 119 (7) e2112630119. doi: 10.1073/pnas.2112630119

Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider

Finol-Urdaneta, Rocio K., Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R., Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K.-Y., Wingerd, Joshua S., Undheim, Eivind A. B., Cristofori-Armstrong, Ben, Hill, Adam P., Herzig, Volker, King, Glenn F., Vetter, Irina, Rash, Lachlan D., Adams, David J. and Alewood, Paul F. (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences, 119 (5) e2110932119. doi: 10.1073/pnas.2110932119

Selective binding of small molecules to Vibrio cholerae DsbA offers a starting point for the design of novel antibacterials

Wang, Geqing, Mohanty, Biswaranjan, Williams, Martin L., Doak, Bradley C., Dhouib, Rabeb, Totsika, Makrina, McMahon, Róisín M., Sharma, Gaurav, Zheng, Dan, Bentley, Matthew R., Ka-Yan Chin, Yanni, Horne, James, Chalmers, David K., Heras, Begoña and Scanlon, Martin J. (2022). Selective binding of small molecules to Vibrio cholerae DsbA offers a starting point for the design of novel antibacterials. ChemMedChem, 17 (6) e202100673, e202100673. doi: 10.1002/cmdc.202100673

Venom composition of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae) and functional characterization of a major venom peptide

Pinto, Ciro P.G., Walker, Andrew A., Robinson, Samuel D., Chin, Yanni K.-Y, King, Glenn F. and Rossi, Guilherme D. (2021). Venom composition of the endoparasitoid wasp Cotesia flavipes (Hymenoptera: Braconidae) and functional characterization of a major venom peptide. Toxicon, 202, 1-12. doi: 10.1016/j.toxicon.2021.09.002

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

Pineda, Sandy S., Chin, Yanni K.-Y., Undheim, Eivind A. B., Senff, Sebastian, Mobli, Mehdi, Dauly, Claire, Escoubas, Pierre, Nicholson, Graham M., Kaas, Quentin, Guo, Shaodong, Herzig, Volker, Mattick, John S. and King, Glenn F. (2020). Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene. Proceedings of the National Academy of Sciences, 117 (21) A41, 201914536-11408. doi: 10.1073/pnas.1914536117

A selective naV1.1 activator with potential for treatment of dravet syndrome epilepsy

Chow, Chun Yuen, Chin, Yanni K.Y., Ma, Linlin, Undheim, Eivind A.B., Herzig, Volker and King, Glenn F. (2020). A selective naV1.1 activator with potential for treatment of dravet syndrome epilepsy. Biochemical Pharmacology, 181 113991, 113991. doi: 10.1016/j.bcp.2020.113991

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

Luna-Ramirez, Karen, Csoti, Agota, McArthur, Jeffrey R., Chin, Yanni K.Y., Anangi, Raveendra, Najera, Rosby del Carmen, Possani, Lourival D., King, Glenn F., Panyi, Gyorgy, Yu, Haibo, Adams, David J. and Finol-Urdaneta, Rocio K. (2020). Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochemical Pharmacology, 174 113782, 113782. doi: 10.1016/j.bcp.2019.113782

Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugs

Chow, Chun Yuen, Chin, Yanni K.-Y., Walker, Andrew A., Guo, Shaodong, Blomster, Linda V., Ward, Micaiah J., Herzig, Volker, Rokyta, Darin R. and King, Glenn F. (2019). Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugs. ACS Pharmacology & Translational Science, 3 (1) acsptsci.9b00079, 119-134. doi: 10.1021/acsptsci.9b00079

The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides

Deplazes, Evelyne, Chin, Yanni K.‐Y., King, Glenn F. and Mancera, Ricardo L. (2019). The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides. Proteins, 88 (3) prot.25828, 485-502. doi: 10.1002/prot.25828

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target

Ma, Linlin, Chin, Yanni K.Y., Dekan, Zoltan, Herzig, Volker, Chow, Chun Yuen, Heighway, Jacqueline, Lam, Sau Wing, Guillemin, Gilles J., Alewood, Paul F. and King, Glenn F. (2018). Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target. Biochemical Pharmacology, 158, 60-72. doi: 10.1016/j.bcp.2018.08.038

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Herzig, Volker, de Araujo, Aline, Greenwood, Kathryn, Chin, Yanni, Windley, Monique, Chong, Youmie, Muttenthaler, Markus, Mobli, Mehdi, Audsley, Neil, Nicholson, Graham, Alewood, Paul and King, Glenn (2018). Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides. Biomedicines, 6 (3) 90, 90. doi: 10.3390/biomedicines6030090

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold

Madio, Bruno, Peigneur, Steve, Chin, Yanni K. Y., Hamilton, Brett R., Henriques, Sónia Troeira, Smith, Jennifer J., Cristofori-Armstrong, Ben, Dekan, Zoltan, Boughton, Berin A., Alewood, Paul F., Tytgat, Jan, King, Glenn F. and Undheim, Eivind A. B. (2018). PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold. Cellular and Molecular Life Sciences, 75 (24), 4511-4524. doi: 10.1007/s00018-018-2897-6

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J., Chin, Yanni K. Y., Lei, Jianlin, Zhou, Qiang, King, Glenn F. and Yan, Nieng (2018). Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, 362 (6412) eaau2596, eaau2596-+. doi: 10.1126/science.aau2596

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017). Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 (14), 3750-3755. doi: 10.1073/pnas.1614728114

Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus

Touchard, Axel, Brust, Andreas, Cardoso, Fernanda C., Chin, K.-Y., Herzig, Volker, Jin, Ai-Hua, Dejean, Alain, Alewood, Paul F., King, Glenn F., Orivel, Jérôme and Escoubas, Pierre (2016). Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus. Biochimica et Biophysica Acta, 1860 (11 Part A), 2553-2562. doi: 10.1016/j.bbagen.2016.07.027

Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target na(v)1.7

Klint, Julie K., Chin, Yanni K. -Y. and Mobli, Mehdi (2015). Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target na(v)1.7. Molecular Pharmacology, 88 (6), 1002-1010. doi: 10.1124/mol.115.100784

Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ

Nogueira, Maria Luiza C., Sforca, Mauricio Luis, Chin, Yanni K. -Y., Mobli, Mehdi, Handler, Aaron, Gorbatyuk, Vitaliy Y., Robson, Scott A., King, Glenn F., Gueiros-Filho, Frederico J. and de Mattos Zeri, Ana Carolina (2015). Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ. Biomolecular NMR Assignments, 9 (2), 387-391. doi: 10.1007/s12104-015-9615-1

Assignments of human integrin α1I domain in the apo and Mg 2+ bound states

Chin, Yanni K. -Y., Headey, Stephen, Mohanty, Biswaranjan, Emsley, Jonas, Simpson, Jamie S. and Scanlon, Martin J. (2014). Assignments of human integrin α1I domain in the apo and Mg 2+ bound states. Biomolecular NMR Assignments, 8 (1), 117-121. doi: 10.1007/s12104-013-9465-7

The structure of integrin α1I domain in complex with a collagen-mimetic peptide

Chin, Yanni K. -Y., Headey, Stephen J., Mohanty, Biswaranjan, Patil, Rahul, McEwan, Paul A., Swarbrick, James D., Mulhern, Terrence D., Emsley, Jonas, Simpson, Jamie S. and Scanlon, Martin J. (2013). The structure of integrin α1I domain in complex with a collagen-mimetic peptide. Journal of Biological Chemistry, 288 (52), 36796-36809. doi: 10.1074/jbc.M113.480251

The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes

Paxman, Jason J., Borg, Natalie A., Horne, James, Thompson, Philip E., Chin, Yanni, Sharma, Pooja, Simpson, Jamie S., Wielens, Jerome, Piek, Susannah, Kahler, Charlene M., Sakellaris, Harry, Pearce, Mary, Bottomley, Stephen P., Rossjohn, Jamie and Scanlon, Martin J. (2009). The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes. Journal of Biological Chemistry, 284 (26), 17835-17845. doi: 10.1074/jbc.M109.011502

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from neisseria meningitidis

Vivian, Julian P., Scoullar, Jessica, Robertson, Amy L., Bottomley, Stephen P., Horne, James, Chin, Yanni, Wielens, Jerome, Thompson, Philip E., Velkov, Tony, Piek, Susannah, Byres, Emma, Beddoe, Travis, Wilce, Matthew C. J., Kahler, Charlene M., Rossjohn, Jamie and Scanlon, Martin J. (2008). Structural and biochemical characterization of the oxidoreductase NmDsbA3 from neisseria meningitidis. Journal of Biological Chemistry, 283 (47), 32452-32461. doi: 10.1074/jbc.M803990200

Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae—a 15N - 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA

Horne, James, d'Auvergne, Edward J., Coles, Murray, Velkov, Tony, Chin, Yanni, Charman, William N., Prankerd, Richard, Gooley, Paul R. and Scanlon, Martin J. (2007). Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae—a 15N - 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA. Journal of Molecular Biology, 371 (3), 703-716. doi: 10.1016/j.jmb.2007.05.067

The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation

Fernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014