The University of Queensland

Identification of ATM protein kinase phosphorylation sites by mass spectrometry

Graham, Mark E., Lavin, Martin F. and Kozlov, Sergei V. (2017). Identification of ATM protein kinase phosphorylation sites by mass spectrometry. In Sergei V. Kozlov (Ed.), ATM kinase: methods and protocols (pp. 127-144) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-6955-5_10

Lentiviral reprogramming of A-T patient fibroblasts to induced pluripotent stem cells

Nayler, Sam, Kozlov, Sergei V., Lavin, Martin F. and Wolvetang, Ernst (2017). Lentiviral reprogramming of A-T patient fibroblasts to induced pluripotent stem cells. In Sergei V. Kozlov (Ed.), ATM kinase: methods and protocols (pp. 401-418) New York, NY, United States: Humana Press; Springer Science+Business Media. doi:10.1007/978-1-4939-6955-5_29

Preface

Kozlov, Sergei V. (2017). Preface. ATM kinase: methods and protocols. (pp. v-v) edited by Sergei V. Kozlov. New York, NY, United States: Humana Press.

ATM mediated signaling defends the integrity of the genome

Lavin, Martin F., Gatei, Magtouf, Chen, Philip, Kijas, Amanda and Kozlov, Sergei (2010). ATM mediated signaling defends the integrity of the genome. Handbook of Cell Signaling. (pp. 2171-2183) edited by Ralph A. Bradshaw and Edward A. Dennis. Amsterdam, The Netherlands: Elsevier Inc.. doi: 10.1016/B978-0-12-374145-5.00263-1

ATM and cellular response to DNA damage

Lavin, Martin F., Kozlov, Sergei, Gueven, Nuri, Peng, Cheng, Birrell, Geoff, Chen, Phillip and Scott, Shaun (2005). ATM and cellular response to DNA damage. Genome instability in cancer development. (pp. 457-476) edited by Erich A. Nigg. New York, USA: Springer.

Role of ATM in Radiation Signal Transduction

Lavin, Martin F., Scott, Shaun, Chen, Philip, Kozlov, Sergei, Gueven, Nuri and Birrell, Geoff (2003). Role of ATM in Radiation Signal Transduction. Handbook of Cell Signaling. (pp. 225-236) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-012124546-7/50667-7

Role of ATM in radiation signal transduction

Lavin, M. F., Scott, S., Chen, P., Kozlov, S., Gueven, N. and Birrell, G. (2003). Role of ATM in radiation signal transduction. Handbook of Cell Signaling. (pp. 225-236) edited by R. A. Bradshaw and E. A. Dennis. New York: Elsevier Science.

Retrograde regulation by the viral protein kinase epigenetically sustains the Epstein-Barr virus latency-to-lytic switch to augment virus production

Li, Xiaofan, Kozlov, Sergei V., El-Guindy, Ayman and Bhaduri-McIntosh, Sumita (2019). Retrograde regulation by the viral protein kinase epigenetically sustains the Epstein-Barr virus latency-to-lytic switch to augment virus production. Journal of Virology, 93 (17). doi: 10.1128/JVI.00572-19

A Roberts syndrome individual with differential genotoxin sensitivity and a DNA damage response defect

McKay, Michael J., Craig, Jeffery, Kalitsis, Paul, Kozlov, Sergei, Verschoor, Sandra, Chen, Phillip, Lobachevsky, Pavel, Vasireddy, Raja, Yan, Yuqian, Ryan, Jacinta, McGillivray, George, Savarirayan, Ravi, Lavin, Martin F., Ramsay, Robert G. and Xu, Huiling (2019). A Roberts syndrome individual with differential genotoxin sensitivity and a DNA damage response defect. International Journal of Radiation Oncology Biology Physics, 103 (5), 1194-1202. doi: 10.1016/j.ijrobp.2018.11.047

Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage

Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C. Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Journal of Leukocyte Biology, 101 (4), 927-947. doi: 10.1189/jlb.4VMA0716-316R

A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype

Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Human Molecular Genetics, 26 (1), 109-123. doi: 10.1093/hmg/ddw371

ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor

Lavin, Martin F., Kozlov, Sergei, Gatei, Magtouf and Kijas, Amanda W. (2015). ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor. Biomolecules, 5 (4) A31, 2877-2902. doi: 10.3390/biom5042877

ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen

Kozlov, Sergei V., Waardenberg, Ashley J., Engholm-Keller, Kasper, Arthur, Jonathan W., Graham, Mark E. and Lavin, Martin (2015). ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen. Molecular and Cellular Proteomics, 15 (3), 1032-1047. doi: 10.1074/mcp.M115.055723

Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells

Lim, Yi Chieh, Roberts, Tara L., Day, Bryan W., Stringer, Brett W., Kozlov, Sergei, Fazry, Shazrul, Bruce, Zara C., Ensbey, Kathleen S., Walker, David G., Boyd, Andrew W. and Lavin, Martin F. (2014). Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells. Molecular Oncology, 8 (8), 1603-1615. doi: 10.1016/j.molonc.2014.06.012

A patient-derived olfactory stem cell disease model for ataxia-telangiectasia

Stewart, Romal, Kozlov, Sergei, Matigian, Nicholas, Wali, Gautam, Gatei, Magtouf, Sutharsan, Ratneswary, Bellette, Bernadette, Kijas, Amanda Wraith, Cochrane, Julie, Coulthard, Mark, Perry, Chris, Sinclair, Kate, Mackay-Sim, Alan and Lavin, Martin F. (2013). A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Human Molecular Genetics, 22 (12), 2495-2509. doi: 10.1093/hmg/ddt101

A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells

Lim, Yi Chieh, Roberts, Tara L., Day, Bryan W., Harding, Angus, Kozlov, Sergei, Kijas, Amanda W., Ensbey, Kathleen S., Walker, David G. and Lavin, Martin F. (2012). A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells. Molecular Cancer Therapeutics, 11 (9), 1863-1872. doi: 10.1158/1535-7163.MCT-11-1044

Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype

Nayler, Sam, Gatei, Magtouf, Kozlov, Sergei, Gatti, Richard, Mar, Jessica C., Wells, Christine A., Lavin, Martin and Wolvetang, Ernst (2012). Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype. Stem Cells Translational Medicine, 1 (7), 523-535. doi: 10.5966/sctm.2012-0024

ATM protein kinase: The linchpin of cellular defenses to stress

Bhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin and Khanna, Kum Kum (2011). ATM protein kinase: The linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences, 68 (18), 2977-3006. doi: 10.1007/s00018-011-0683-9

Autophosphorylation and ATM activation: Additional sites add to the complexity

Kozlov, Sergei V., Graham, Mark E., Jakob, Burkhard, Tobias, Frank, Kijas, Amanda W., Tanuji, Marcel, Chen, Philip, Robinson, Phillip J., Taucher-Scholz, Gisela, Suzuki, Keiji, So, Sairai, Chen, David and Lavin, Martin F. (2011). Autophosphorylation and ATM activation: Additional sites add to the complexity. The Journal of Biological Chemistry, 286 (11), 9107-9119. doi: 10.1074/jbc.M110.204065

Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis

Jurado, Sabine, Smyth, Ian, van Denderen, Bryce, Tenis, Nora, Hammet, Andrew, Hewitt, Kimberly, Ng, Jane-Lee, McNees, Carolyn J., Kozlov, Sergei V., Oka, Hayato, Kobayashi, Masahiko, Conlan, Lindus A., Cole, Timothy J., Yamamoto, Ken-ichi, Taniguchi, Yoshihito, Takeda, Shunichi, Lavin, Martin F. and Heierhorst, Jörg (2010). Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genetics, 6 (10) e1001170, e1001170-1-e1001170-13. doi: 10.1371/journal.pgen.1001170

ATM activation by oxidative stress

Guo, Zhi, Kozlov, Sergei, Lavin, Martin F., Person, Maria D. and Paull, Tanya T. (2010). ATM activation by oxidative stress. Science, 330 (6003), 517-521. doi: 10.1126/science.1192912

Low levels of ATM in breast cancer patients with clinical radiosensitivity

Fang, Zhiming, Kozlov, Sergei, McKay, Michael J., Woods, Rick, Birrell, Geoff, Sprung, Carl N., Murrell, Dédée F., Wangoo, Kiran, Teng, Linda, Lavin, Martin F., Kearsley, John H., Graham, Peter H. and Clarke, Raymond A. (2010). Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integrity, 1 (1) 9, 9-1-9-9. doi: 10.1186/2041-9414-1-9

Leveraging cell cycle analysis in anticancer drug discovery to identify novel plasmodial drug targets

Kozlov, Sergei, Waters, Norman C. and Chavchich, Marina (2010). Leveraging cell cycle analysis in anticancer drug discovery to identify novel plasmodial drug targets. Infectious Disorders - Drug Targets, 10 (3), 165-190.

Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein

Fang Z. M., Tse R. V., Marjoniemi V. M., Koslov, S., Lavin, M. F., Chen, H., Kearsley, J. H., Graham, P. H. and Clarke, R. A. (2009). Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein. Journal of Medical Imaging and Radiation Oncology, 53 (2), 234-239. doi: 10.1111/j.1754-9485.2009.02053.x

Low dose ionizing radiation responses and knockdown of ATM kinase activity in glioma stem cells

Lim, Yi Chieh, Roberts, Tara, Harding, Angus, Day, Bryan, Kozlov, Sergei, Walker, David and Lavin, Martin (2008). Low dose ionizing radiation responses and knockdown of ATM kinase activity in glioma stem cells. Acta Medica Nagasakiensia, 53 (Suppl.), 37-43. doi: 10.11343/amn.53.S37

ATM activation and DNA damage response

Lavin, MF and Kozlov, S (2007). ATM activation and DNA damage response. Cell Cycle, 6 (8), 931-942. doi: 10.4161/cc.6.8.4180

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly (ADP-ribose) dependent pathway in the early response to DNA-damaging agents

Haince, J. F., Kozlov, S., Dawson, V. L., Dawson, T. M., Hendzel, M. J., Lavin, M. F. and Poirier, G. G. (2007). Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly (ADP-ribose) dependent pathway in the early response to DNA-damaging agents. Journal of Biological Chemistry, 282 (22), 16441-16453. doi: 10.1074/jbc.M608406200

DNA damage-induced signalling in ataxia-telangiectasia and related syndromes

Lavin, MF and Kozlov, S (2007). DNA damage-induced signalling in ataxia-telangiectasia and related syndromes. Radiotherapy And Oncology, 83 (3), 231-237. doi: 10.1016/j.radonc.2007.04.032

Inhibition of transforming growth factor-beta 1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress

Kirshner, Julia, Jobling, Michael F., Pajares, Maria Jose, Ravani, Shraddha A., Glick, Adam B., Lavin, Martin J., Koslov, Sergei V., Shiloh, Yosef and Barcellos-Hoff, Mary Helen (2006). Inhibition of transforming growth factor-beta 1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Research, 66 (22), 10861-10869. doi: 10.1158/0008-5472.CAN-06-2565

Involvement of novel autophosphorylation sites in ATM activation

Kozlov, Sergei V., Graham, Mark E., Peng, Cheng, Chen, Philip, Robinson, Phillip J. and Lavin, Martin F. (2006). Involvement of novel autophosphorylation sites in ATM activation. Embo Journal, 25 (15), 3504-3514. doi: 10.1038/sj.emboj.7601231

ATM and cellular response to DNA damage

Lavin, Martin F., Kozlov, Sergei, Gueven, Nuri, Peng, Cheng, Birrell, Geoff, Chen, Phillip and Scott, Shaun (2005). ATM and cellular response to DNA damage. Advances in Experimental Medicine and Biology, 570, 457-476. doi: 10.1007/1-4020-3764-3_16

ATM signaling and genornic stability in response to DNA damage

Lavin, Martin F., Birrell, Geoff, Chen, Philip, Kozlov, Sergei, Scott, Shaun and Gueven, Nuri (2005). ATM signaling and genornic stability in response to DNA damage. Mutation Research-fundamental And Molecular Mechanisms of Mutagenesis, 569 (1-2), 123-132. doi: 10.1016/j.mrfmmm.2004.04.020

Functional consequences of sequence alterations in the ATM gene

Lavin, Martin F., Scott, Shaun, Gueven, Nuri, Kozlov, Sergei, Peng, Cheng and Chen, Philip (2004). Functional consequences of sequence alterations in the ATM gene. DNA Repair, 3 (8-9), 1197-1205. doi: 10.1016/j.dnarep.2004.03.011

Analyzing the regulation and function of ATM.

Lavin M.F., Scott S.P., Kozlov S. and Gueven N. (2004). Analyzing the regulation and function of ATM.. Methods in molecular biology (Clifton, N.J.), 281, 163-178.

ATP activates ataxia-telangiectasia mutated (ATM) in vitro - Importance of autophosphorylation

Kozlov, Sergei, Gueven, Nuri, Keating, Katherine, Ramsay, Jonathan and Lavin, Martin F. (2003). ATP activates ataxia-telangiectasia mutated (ATM) in vitro - Importance of autophosphorylation. Journal of Biological Chemistry, 278 (11), 9309-9317. doi: 10.1074/jbc.M300003200

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P. and Khanna, K. (2000). ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nature Genetics, 25 (1), 115-119. doi: 10.1038/75508

ATM associates with and phosphorylates p53: Mapping the region of interaction

Khanna K.K., Keating K.E., Kozlov S., Scott S., Gatei M., Hobson K., Taya Y., Gabrielli B., Chan D., Lees-Miller S.P. and Lavin M.F. (1998). ATM associates with and phosphorylates p53: Mapping the region of interaction. Nature Genetics, 20 (4), 398-400. doi: 10.1038/3882

Interaction between ATM protein and c-Abl in response to DNA damage

Shafman, T, Khanna, KK, Kedar, P, Spring, K, Kozlov, S, Yen, T, Hobson, K, Gatei, M, Zhang, N, Watters, D, Egerton, M, Shiloh, Y, Kharbanda, S, Kufe, D and Lavin, MF (1997). Interaction between ATM protein and c-Abl in response to DNA damage. Nature, 387 (6632), 520-523. doi: 10.1038/387520a0

Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

Watters, D, Khanna, KK, Beamish, H, Birrell, G, Spring, K, Kedar, P, Gatei, M, Stenzel, D, Hobson, K, Kozlov, S, Zhang, N, Farrell, A, Ramsay, J, Gatti, R and Lavin, M (1997). Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene, 14 (16), 1911-1921. doi: 10.1038/sj.onc.1201037

Isolation of full-length ATM cDNA and correction of the ataxia- telangiectasia cellular phenotype

Zhang, N, Chen, P, Khanna, KK, Scott, S, Gatei, M, Kozlov, S, Watters, D, Spring, K, Yen, T and Lavin, MF (1997). Isolation of full-length ATM cDNA and correction of the ataxia- telangiectasia cellular phenotype. Proceedings of the National Academy of Sciences of the United States of America, 94 (15), 8021-8026. doi: 10.1073/pnas.94.15.8021

Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia

Quek, H., Luff, J., Cheung, K., Kozlov, S., Gatei, M., Lee, C. S., Bellingham, M., Noakes, P., Lim, Y. C., Barnett, N., Dingwall, S., Wolvetang, E., Mashimo, T., Roberts, T. and Lavin, M. (2016). Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200

Clinical PKD1 sequencing in Queensland

Kozlov, S., Mallett, A., Woods, R., Healy, H., Rowell, J., Mcgaughran, J. and Hyland, V. (2012). Clinical PKD1 sequencing in Queensland. 48th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Auckland, New Zealand, 27-29 August 2012. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/j.1440-1797.2012.01632.x

Response of glioma initiating cells to ionising radiation

Lim, Y. C., Roberts, T., Day, B., Harding, A., Ensbey, K., Kozlov, S., Kijas, A., Walker, D. and Lavin, M. (2012). Response of glioma initiating cells to ionising radiation. Targeting Cancer from Diagnosis to Cure & 5th Annual COGNO Annual Scientific Meeting, Brisbane, QLD, Australia, 8-10 August 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1743-7563.2012.01586_2.x

Ataxia telangiectasia and the complexity of radiosensitivity

Lavin, MF, Scott, S, Gueven, N, Chen, P, Kozlov, S, Birrell, G and Ahangari, F (2002). Ataxia telangiectasia and the complexity of radiosensitivity. American-Statistical-Association Conference on Radiation and Health, Deerfield Beach Florida, Jun 23-26, 2002. OAK BROOK: RADIATION RESEARCH SOC.

Sensing damage in DNA: ATM and cellular signalling

Lavin, MF, Khanna, KK, Watters, D, Spring, K, Scott, S, Keating, K, Gatei, M, Kaneko, H and Kozlov, S (2000). Sensing damage in DNA: ATM and cellular signalling. 11th International Congress of Radiation Research, Dublin Ireland, Jul 18-23, 1999. LAWRENCE: ALLEN PRESS INC.