The University of Queensland

Monocytes, macrophages, and dendritic cells

Collin, Matthew and Hill, Geoffrey R. (2018). Monocytes, macrophages, and dendritic cells. Wintrobe's Clinical Hematology: Fourteenth Edition. (pp. 616-683) Philadelphia, PA United States: Wolters Kluwer.

Cytokines in Graft-versus-host Disease and Graft-versus-leukemia

Markey, K.A., MacDonald, K.P.A. and Hill, G.R. (2013). Cytokines in Graft-versus-host Disease and Graft-versus-leukemia. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. (pp. 357-391) New York, NY, U.S.A.: Elsevier Inc.. doi: 10.1016/B978-0-12-416004-0.00016-1

IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation

Zhang, Ping, Fleming, Peter, Andoniou, Christopher E., Waltner, Olivia G., Bhise, Shruti S., Martins, Jose Paulo, McEnroe, Benjamin A., Voigt, Valentina, Daly, Sheridan, Kuns, Rachel D., Ekwe, Adaeze P., Henden, Andrea S., Saldan, Alda, Olver, Stuart, Varelias, Antiopi, Smith, Corey, Schmidt, Christine R., Ensbey, Kathleen S., Legg, Samuel R.W., Sekiguchi, Tomoko, Minnie, Simone A., Gradwell, Mark, Wagenaar, Irma, Clouston, Andrew D., Koyama, Motoko, Furlan, Scott N., Kennedy, Glen A., Ward, E Sally, Degli-Esposti, Mariapia A. ... Tey, Siok-Keen (2024). IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation. Journal of Clinical Investigation, 134 (7) e174184. doi: 10.1172/jci174184

Clinical grade multiparametric cell sorting and gene-marking of regulatory T cells

Ekwe, Adaeze Precious, Au, Raymond, Zhang, Ping, McEnroe, Benjamin, Tan, Mei Ling, Saldan, Alda, Henden, Andrea S., Hutchins, Cheryl, Henderson, Ashleigh, Mudie, Kari, Kerr, Keri, Fuery, Madonna, Kennedy, Glen A., Hill, Geoffrey R. and Tey, Siok-Keen (2024). Clinical grade multiparametric cell sorting and gene-marking of regulatory T cells. Cytotherapy, 26 (7), 719-728. doi: 10.1016/j.jcyt.2024.02.023

Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Ng, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2024). Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 25 (4), 716-716. doi: 10.1038/s41590-024-01770-8

Autophagy prevents graft failure during murine Graft versus Host Disease

Lineburg, Katie E, Leveque-El Mouttie, Lucie, Hunter, Christopher R., Le Texier, Laeitia, McGirr, Crystal, Teal, Bianca, Blazar, Bruce R., Lane, Steven W, Hill, Geoffrey R, Levesque, Jean-Pierre and MacDonald, Kelli P.A. (2024). Autophagy prevents graft failure during murine Graft versus Host Disease. Blood Advances, 8 (8), 2032-2043. doi: 10.1182/bloodadvances.2023010972

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice

Adams, Rachael C, Carter-Cusack, Dylan, Llanes, Genesis T, Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc J, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R, Furlan, Scott N, Zeiser, Robert and MacDonald, Kelli P.A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice. Blood Journal, 142 (Supplement 1), 2052-2052. doi: 10.1182/blood.2023022040

Chronic GvHD NIH consensus project biology task force: evolving path to personalized treatment of chronic GvHD

Buxbaum, Nataliya Prokopenko, Socié, Gerard, Hill, Geoffrey R, MacDonald, Kelli PA, Tkachev, Victor, Teshima, Takanori, Lee, Stephanie J, Ritz, Jerome, Sarantopoulos, Stefanie, Luznik, Leo, Zeng, Defu, Paczesny, Sophie, Martin, Paul J., Pavletic, Steven Z, Schultz, Kirk R and Blazar, Bruce R. (2023). Chronic GvHD NIH consensus project biology task force: evolving path to personalized treatment of chronic GvHD. Blood Advances, 7 (17), 4886-4902. doi: 10.1182/bloodadvances.2022007611

Treg amelioration of GVHD following allo/xeno-HSCT using mobilized mouse and human peripheral blood donors

Barreras, Henry, Copsel, Sabrina N., Bader, Cameron S., Ding, Ying, Wolf, Dietlinde, Cash, Charles, Stacey, Caleb J., Benjamin, Cara, Seavey, Mathew M, Wolf, Jeffrey, Jasuja, Rahul R, Pfeiffer, Brent, Hill, Geoffrey R., Komanduri, Krishna V., Jurecic, Roland, Malek, Thomas R. and Levy, Robert B. (2023). Treg amelioration of GVHD following allo/xeno-HSCT using mobilized mouse and human peripheral blood donors. Transplantation and Cellular Therapy, 29 (5), 341.e1-341.e9. doi: 10.1016/j.jtct.2023.02.015

Impact of GVHD prophylaxis on CMV reactivation and disease after HLA-matched peripheral blood stem cell transplantation

Ueda Oshima, Masumi, Xie, Hu, Zamora, Danniel, Flowers, Mary E., Hill, Geoffrey R, Mielcarek, Marco, Sandmaier, Brenda M, Gooley, Theodore A and Boeckh, Michael J. (2023). Impact of GVHD prophylaxis on CMV reactivation and disease after HLA-matched peripheral blood stem cell transplantation. Blood Advances, 7 (8), 1394-1403. doi: 10.1182/bloodadvances.2022009112

Oncogenic drivers dictate immune control of acute myeloid leukemia

Austin, Rebecca J., Straube, Jasmin, Halder, Rohit, Janardhanan, Yashaswini, Bruedigam, Claudia, Witkowski, Matthew, Cooper, Leanne, Porter, Amy, Braun, Matthias, Souza-Fonseca-Guimaraes, Fernando, Minnie, Simone A., Cooper, Emily, Jacquelin, Sebastien, Song, Axia, Bald, Tobias, Nakamura, Kyohei, Hill, Geoffrey R., Aifantis, Iannis, Lane, Steven W. and Bywater, Megan J. (2023). Oncogenic drivers dictate immune control of acute myeloid leukemia. Nature Communications, 14 (1) 2155, 1-14. doi: 10.1038/s41467-023-37592-9

Infection induces tissue-resident memory NK cells that safeguard tissue health

Schuster, Iona S., Sng, Xavier Y. X., Lau, Colleen M., Powell, David R., Weizman, Orr-El, Fleming, Peter, Neate, Georgia E. G., Voigt, Valentina, Sheppard, Sam, Maraskovsky, Andreas I., Daly, Sheridan, Koyama, Motoko, Hill, Geoffrey R., Turner, Stephen J., O’Sullivan, Timothy E., Sun, Joseph C., Andoniou, Christopher E. and Degli-Esposti, Mariapia A. (2023). Infection induces tissue-resident memory NK cells that safeguard tissue health. Immunity, 56 (3), 531-546.e6. doi: 10.1016/j.immuni.2023.01.016

A novel RIPK1 inhibitor attenuates GVHD

Hill, Geoffrey R. and Koyama, Motoko (2023). A novel RIPK1 inhibitor attenuates GVHD. Blood, 141 (9), 969-970. doi: 10.1182/blood.2022019019

Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity

Larson, Jemma H., Jin, Sujeong, Loschi, Michael, Wagers, Sara Bolivar, Thangavelu, Govindarajan, Zaiken, Michael C., McDonald-Hyman, Cameron, Saha, Asim, Aguilar, Ethan G., Koehn, Brent, Osborn, Mark J., Panoskaltsis-Mortari, Angela, Macdonald, Kelli P.A., Hill, Geoffrey R., Murphy, William J., Serody, Jonathan S, Maillard, Ivan, Kean, Leslie S., Kim, Sangwon V., Littman, Dan R. and Blazar, Bruce R. (2023). Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity. American Journal of Transplantation, 23 (8), 1102-1115. doi: 10.1016/j.ajt.2023.01.030

Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche

Koyama, Motoko, Samson, Luke, Ensbey, Kathleen S., Takahashi, Shuichiro, Clouston, Andrew D., Martin, Paul J. and Hill, Geoffrey R. (2023). Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche. Blood, 141 (3), 315-319. doi: 10.1182/blood.2022015808

Supporting family members requested to donate hematopoietic stem cells to a relative: development and pilot testing of a psycho-educational resource

Zomerdijk, Nienke, Turner, Jane, Gottlieb, David, Barnes, Annette, Butler, Jason P., Markey, Kate A. and Hill, Geoffrey R. (2023). Supporting family members requested to donate hematopoietic stem cells to a relative: development and pilot testing of a psycho-educational resource. Journal of Psychosocial Oncology Research & Practice, 5 (1). doi: 10.1097/or9.0000000000000095

TIGIT inhibition and lenalidomide synergistically promote anti-myeloma immune responses after stem cell transplantation in mice

Minnie, Simone A., Waltner, Olivia G., Ensbey, Kathleen S., Olver, Stuart D., Collinge, Alika D., Sester, David P., Schmidt, Christine R., Legg, Samuel R.W., Takahashi, Shuichiro, Nemychenkov, Nicole S., Sekiguchi, Tomoko, Driessens, Gregory, Zhang, Ping, Koyama, Motoko, Spencer, Andrew, Holmberg, Leona A., Furlan, Scott N., Varelias, Antiopi and Hill, Geoffrey R. (2022). TIGIT inhibition and lenalidomide synergistically promote anti-myeloma immune responses after stem cell transplantation in mice. Journal of Clinical Investigation, 133 (4) e157907, 1-11. doi: 10.1172/jci157907

Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity

Minnie, Simone A., Waltner, Olivia G., Ensbey, Kathleen S., Nemychenkov, Nicole S., Schmidt, Christine R., Bhise, Shruti S., Legg, Samuel R. W., Campoy, Gabriela, Samson, Luke D., Kuns, Rachel D., Zhou, Ting, Huck, John D., Vuckovic, Slavica, Zamora, Danniel, Yeh, Albert, Spencer, Andrew, Koyama, Motoko, Markey, Kate A., Lane, Steven W., Boeckh, Michael, Ring, Aaron M., Furlan, Scott N. and Hill, Geoffrey R. (2022). Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity. Science Immunology, 7 (76) eabo3420, 1-18. doi: 10.1126/sciimmunol.abo3420

Multiplex microsphere PCR (mmPCR) allows simultaneous gram typing, detection of fungal DNA, and antibiotic resistance genes

Browne, Daniel J., Liang, Fang, Gartlan, Kate H., Harris, Patrick N. A., Hill, Geoffrey R., Corrie, Simon R. and Markey, Kate A. (2022). Multiplex microsphere PCR (mmPCR) allows simultaneous gram typing, detection of fungal DNA, and antibiotic resistance genes. Laboratory Medicine, 53 (5), 459-464. doi: 10.1093/labmed/lmac023

IFN-λ diminishes the severity of viral bronchiolitis in neonatal mice by limiting NADPH oxidase–induced PAD4-independent NETosis

Sebina, Ismail, Rashid, Ridwan B., Sikder, Md. Al Amin, Rahman, Muhammed Mahfuzur, Ahmed, Tufael, Radford-Smith, Daniel E., Kotenko, Sergei V., Hill, Geoffrey R., Bald, Tobias and Phipps, Simon (2022). IFN-λ diminishes the severity of viral bronchiolitis in neonatal mice by limiting NADPH oxidase–induced PAD4-independent NETosis. The Journal of Immunology, 208 (12), 2806-2816. doi: 10.4049/jimmunol.2100876

Retinoic acid signaling acts as a rheostat to balance Treg function

Thangavelu, Govindarajan, Andrejeva, Gabriela, Bolivar-Wagers, Sara, Jin, Sujeong, Zaiken, Michael C., Loschi, Michael, Aguilar, Ethan G., Furlan, Scott N., Brown, Chrysothemis C., Lee, Yu-Chi, Hyman, Cameron McDonald, Feser, Colby J., Panoskaltsis-Mortari, Angela, Hippen, Keli L., MacDonald, Kelli P., Murphy, William J., Maillard, Ivan, Hill, Geoffrey R., Munn, David H., Zeiser, Robert, Kean, Leslie S., Rathmell, Jeffrey C., Chi, Hongbo, Noelle, Randolph J. and Blazar, Bruce R. (2022). Retinoic acid signaling acts as a rheostat to balance Treg function. Cellular and Molecular Immunology, 19 (7), 820-833. doi: 10.1038/s41423-022-00869-y

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Zaiken, Michael C., Flynn, Ryan, Paz, Katelyn G., Rhee, Stephanie Y., Jin, Sujeong, Mohamed, Fathima A., Saha, Asim, Thangavelu, Govindarajan, Park, Paul M.C., Hemming, Matthew L., Sage, Peter T., Sharpe, Arlene H., DuPage, Michel, Bluestone, Jeffrey A., Panoskaltsis-Mortari, Angela, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Luznik, Leo, Maillard, Ivan, Hill, Geoffrey R., MacDonald, Kelli P.A., Munn, David H., Serody, Jonathan S., Murphy, William J., Kean, Leslie S., Zhang, Yi ... Blazar, Bruce R. (2022). BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Blood, 139 (19), 2983-2997. doi: 10.1182/blood.2021014557

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

Nalkurthi, Christina, Schroder, Wayne A., Melino, Michelle, Irvine, Katharine M., Nyuydzefe, Melanie, Chen, Wei, Liu, Jing, Teng, Michele WL., Hill, Geoffrey R., Bertolino, Patrick, Blazar, Bruce R., Miller, Gregory C., Clouston, Andrew D., Zanin-Zhorov, Alexandra and MacDonald, Kelli PA. (2022). ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis. JHEP Reports, 4 (1) 100386, 1-14. doi: 10.1016/j.jhepr.2021.100386

CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant

Yeh, Albert C., Varelias, Antiopi, Reddy, Anupama, Barone, Sierra M., Olver, Stuart D., Chilson, Kate, Onstad, Lynn E., Ensbey, Kathleen S., Henden, Andrea S, Samson, Luke, Jaeger, Carla A, Bi, Timothy, Dahlman, Kimberly B., Kim, Tae Kon, Zhang, Ping, Degli-Esposti, Mariapia A., Newell, Evan W., Jagasia, Madan H., Irish, Jonathan M., Lee, Stephanie J. and Hill, Geoffrey R. (2021). CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant. Blood, 138 (26), 2874-2885. doi: 10.1182/blood.2020009492

Peritransplant glucocorticoids redistribute donor T cells to the bone marrow and prevent relapse after haploidentical SCT

Inoue, Takayuki, Koyama, Motoko, Kaida, Katsuji, Ikegame, Kazuhiro, Ensbey, Kathleen S., Samson, Luke, Takahashi, Shuichiro, Zhang, Ping, Minnie, Simone A., Maruyama, Satoshi, Ishii, Shinichi, Daimon, Takashi, Fukuda, Takahiro, Nakamae, Hirohisa, Ara, Takahide, Maruyama, Yumiko, Ishiyama, Ken, Ichinohe, Tatsuo, Atsuta, Yoshiko, Blazar, Bruce R., Furlan, Scott N., Ogawa, Hiroyasu and Hill, Geoffrey R. (2021). Peritransplant glucocorticoids redistribute donor T cells to the bone marrow and prevent relapse after haploidentical SCT. JCI Insight, 6 (22) e153551. doi: 10.1172/jci.insight.153551

Mouse models of antigen presentation in hematopoietic stem cell transplantation

Koyama, Motoko and Hill, Geoffrey R. (2021). Mouse models of antigen presentation in hematopoietic stem cell transplantation. Frontiers in Immunology, 12 715893. doi: 10.3389/fimmu.2021.715893

The pathophysiology and treatment of graft-versus-host disease: Lessons learnt from animal models

Teshima, Takanori and Hill, Geoffrey R. (2021). The pathophysiology and treatment of graft-versus-host disease: Lessons learnt from animal models. Frontiers in Immunology, 12 715424. doi: 10.3389/fimmu.2021.715424

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

Current Concepts and Advances in Graft-Versus-Host Disease Immunology

Hill, Geoffrey R., Betts, Brian C., Tkachev, Victor, Kean, Leslie S. and Blazar, Bruce R. (2021). Current Concepts and Advances in Graft-Versus-Host Disease Immunology. Annual Review of Immunology, 39 (1), 19-49. doi: 10.1146/annurev-immunol-102119-073227

Autologous stem cell transplantation for myeloma: Cytoreduction or an immunotherapy?

Minnie, Simone A. and Hill, Geoffrey R. (2021). Autologous stem cell transplantation for myeloma: Cytoreduction or an immunotherapy?. Frontiers in Immunology, 12 651288. doi: 10.3389/fimmu.2021.651288

Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach

Ueda Oshima, Masumi, Sandmaier, Brenda M., Petersdorf, Effie, Flowers, Mary E., Hill, Geoffrey R., Lee, Stephanie J., Appelbaum, Frederick R., Carpenter, Paul A., Baker, K. Scott, Connelly-Smith, Laura, McCool, Andrea, Elgar, Suni, Pergam, Steven A., Liu, Catherine, Stewart, F. Marc and Mielcarek, Marco (2021). Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach. Bone Marrow Transplantation, 56 (2), 305-313. doi: 10.1038/s41409-020-01068-x

A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis

Kennedy, Glen, Tey, Siok-Keen, Buizen, Luke, Varelias, Antiopi, Gartlan, Kate H., Curley, Cameron, Olver, Stuart, Chang, Karshing, Butler, Jason, Misra, Ashish, Subramoniapillai, Elango, Morton, Anthony, Durrant, Simon, Henden, Andrea S, Moore, John, Ritchie, David S, Gottlieb, David, Cooney, Julian P, Paul, Sanjoy K and Hill, Geoffrey R. (2021). A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis. Blood, 137 (14), 1970-1979. doi: 10.1182/blood.2020009050

IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection

Montes de Oca, Marcela, de Labastida Rivera, Fabian, Winterford, Clay, Frame, Teija C. M., Ng, Susanna S., Amante, Fiona H., Edwards, Chelsea L., Bukali, Luzia, Wang, Yulin, Uzonna, Jude E., Kuns, Rachel D., Zhang, Ping, Kabat, Agnieszka, Klein Geltink, Ramon I., Pearce, Edward J., Hill, Geoffrey R. and Engwerda, Christian R. (2020). IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. PLoS Pathogens, 16 (10) e1008994, e1008994. doi: 10.1371/journal.ppat.1008994

The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

Ng, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2020). The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 21 (10), 1205-1218. doi: 10.1038/s41590-020-0758-6

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD

Blazar, Bruce R., Hill, Geoffrey R. and Murphy, William J. (2020). Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD. Nature Reviews Clinical Oncology, 17 (8), 475-492. doi: 10.1038/s41571-020-0356-4

Cytokines and costimulation in acute graft-versus-host disease

Hill, Geoffrey R. and Koyama, Motoko (2020). Cytokines and costimulation in acute graft-versus-host disease. Blood, 136 (4), 418-428. doi: 10.1182/blood.2019000952

Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease

Engel, Jessica A., Lee, Hyun Jae, Williams, Cameron G., Kuns, Rachel, Olver, Stuart, Lansink, Lianne Im, Soon, Megan Sf, Andersen, Stacey B., Powell, Joseph E., Svensson, Valentine, Teichmann, Sarah A., Hill, Geoffrey R., Varelias, Antiopi, Koyama, Motoko and Haque, Ashraful (2020). Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease. JCI Insight, 5 (13) 137990. doi: 10.1172/jci.insight.137990

ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome

Cheong, Melody, Gartlan, Kate H., Lee, Jason S., Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D., Andoniou, Christopher E., Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R., Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A., Boyle, Glen M., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Trapani, Joseph A., Degli-Esposti, Mariapia A., Koyama, Motoko and Hill, Geoffrey R. (2020). ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome. Cancer Immunology Research, 8 (8), 1085-1098. doi: 10.1158/2326-6066.cir-19-0653

Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre study

Zomerdijk, Nienke, Turner, Jane, Hill, Geoffrey R. and Gottlieb, David (2020). Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre study. Supportive Care in Cancer, 29 (2), 635-644. doi: 10.1007/s00520-020-05520-y

Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation

Gartlan, Kate H, Wilkinson, Andrew, Chang, Karshing, Kuns, Rachel D, Henden, Andrea, Minnie, Simone A, Ensbey, Kathleen S, Clouston, Andrew, Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica and Hill, Geoffrey R (2020). Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation. The Journal of Immunology, 204 (1_Supplement), 87.33-87.33. doi: 10.4049/jimmunol.204.supp.87.33

Inhibiting fatty acid synthesis (FAS) can prevent and treat chronic graft versus host disease (cGVHD)

Aguilar, Ethan George, Rhee, Stephanie, Thangavelu, Govindarajan, Loschi, Michael, Paz, Katelyn, Saha, Asim, Ly, Joanna, Sage, Peter, Sharpe, Arlene H, Maillard, Ivan, Murphy, William J, Serody, Jonathan S, Jin, Suji, Wagers, Sara Bolivar, Nicholls, Jemma, Hill, Geoffrey, MacDonald, Kelli PA, Compeer, Ewoud, Dustin, Michael, O’Connor, Roddy, Sparwasser, Tim and Blazar, Bruce R (2020). Inhibiting fatty acid synthesis (FAS) can prevent and treat chronic graft versus host disease (cGVHD). The Journal of Immunology, 204 (1_Supplement), 87.2-87.2. doi: 10.4049/jimmunol.204.supp.87.2

Posttransplant cyclophosphamide as a platform for immunotherapy after allogeneic stem cell transplantation for multiple myeloma

Minnie, Simone A, Kuns, Rachel D, Ensbey, Kathleen S, Samson, Luke D, Chesi, Marta, Gartlan, Kate H, Smyth, Mark J, Vuckovic, Slavica and Hill, Geoffrey R (2020). Posttransplant cyclophosphamide as a platform for immunotherapy after allogeneic stem cell transplantation for multiple myeloma. The Journal of Immunology, 204 (1_Supplement), 87.30-87.30. doi: 10.4049/jimmunol.204.supp.87.30

Immunotherapy of multiple myeloma

Minnie, Simone A. and Hill, Geoffrey R. (2020). Immunotherapy of multiple myeloma. The Journal of Clinical Investigation, 130 (4), 1565-1575. doi: 10.1172/JCI129205

Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis

Kumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., Montes de Oca, Marcela, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude ... Engwerda, Christian R. (2020). Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Reports, 30 (8), 2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099

Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma

Lynch, Jason P., Werder, Rhiannon B., Curren, Bodie F., Sikder, Md. Al Amin, Ullah, Ashik, Sebina, Ismail, Rashid, Ridwan B., Zhang, Vivian, Upham, John W., Hill, Geoff R., Steptoe, Raymond J. and Phipps, Simon (2020). Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunology, 13 (4), 652-664. doi: 10.1038/s41385-020-0268-8

Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice

Bowerman, Kate L., Varelias, Antiopi, Lachner, Nancy, Kuns, Rachel D., Hill, Geoffrey R. and Hugenholtz, Philip (2020). Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice. Gut Microbes, 11 (4), 1-17. doi: 10.1080/19490976.2019.1705729

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Thangavelu, Govindarajan, Du, Jing, Paz, Katelyn G., Loschi, Michael, Zaiken, Michael C., Flynn, Ryan, Taylor, Patricia A., Kirchmeier, Andrew Kemal, Panoskaltsis-Mortari, Angela, Luznik, Leo, MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Munn, David H., Serody, Jonathan S., Murphy, William J., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Dahlberg, Carol, Miller, Andrew T. and Blazar, Bruce R. (2020). Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease. Blood, 135 (1), 28-40. doi: 10.1182/blood.2019000032

MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota

Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce B., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota. Immunity, 51 (5), 885-898. doi: 10.1016/j.immuni.2019.08.011

Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

Austin, Rebecca J., Straube, Jasmin, Bruedigam, Claudia, Pali, Gabor, Jacquelin, Sebastien, Vu, Therese, Green, Joanne, Gräsel, Julius, Lansink, Lianne, Cooper, Leanne, Lee, Shin-Jye, Chen, Nien-Tsu, Lee, Chung-Wei, Haque, Ashraful, Heidel, Florian H., D’Andrea, Richard, Hill, Geoff R., Mullally, Ann, Milsom, Michael D., Bywater, Megan and Lane, Steven W. (2019). Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations. Leukemia, 34 (4), 1075-1089. doi: 10.1038/s41375-019-0638-y

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Koehn, Brent H., Saha, Asim, McDonald-Hyman, Cameron, Loschi, Michael, Thangavelu, Govindarajan, Ma, Lie, Zaiken, Michael, Dysthe, Josh, Krepps, Walker, Panthera, Jamie, Hippen, Keli, Jameson, Stephen C., Miller, Jeffrey S., Cooper, Matthew A., Farady, Christopher J., Iwawaki, Takao, Ting, Jenny P-Y, Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Murray, Peter J., Bronte, Vincenzo, Munn, David H., Zeiser, Robert and Blazar, Bruce R. (2019). Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD. Blood, 134 (19), 1670-1682. doi: 10.1182/blood.2019001950

Pegylated interferon-2 alpha invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation

Henden, Andrea S., Varelias, Antiopi, Leach, Justine, Sturgeon, Elise, Avery, Judy, Kelly, Jessica, Olver, Stuart, Samson, Luke, Hartel, Gunter, Durrant, Simon, Butler, Jason, Morton, Anthony J., Misra, Ashish, Tey, Siok-Keen, Subramoniapillai, Elango, Curley, Cameron, Kennedy, Glen and Hill, Geoffrey R. (2019). Pegylated interferon-2 alpha invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation. Blood Advances, 3 (20), 3013-3019. doi: 10.1182/bloodadvances.2019000453

Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

Gartlan, Kate H., Koyama, Motoko, Lineburg, Katie E., Chang, Karshing, Ensbey, Kathleen S., Kuns, Rachel D., Henden, Andrea S., Samson, Luke D., Clouston, Andrew D., Lopez, Angel F., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2019). Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract. Blood Advances, 3 (19), 2859-2865. doi: 10.1182/bloodadvances.2019000053

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, Asim, Taylor, Patricia A., Lees, Christopher J., Panoskaltsis-Mortari, Angela, Osborn, Mark J., Feser, Colby J., Thangavelu, Govindarajan, Melchinger, Wolfgang, Refaeli, Yosef, Hill, Geoffrey R., Munn, David H., Murphy, William J., Serody, Jonathan S., Maillard, Ivan, Kreymborg, Katharina, van den Brink, Marcel, Dong, Chen, Huang, Shuyu, Zang, Xingxing, Allison, James P., Zeiser, Robert and Blazar, Bruce R. (2019). Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality. JCI insight, 4 (19) e127716. doi: 10.1172/jci.insight.127716

IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling

Wilkinson, Andrew N., Chang, Karshing, Kuns, Rachel D., Henden, Andrea S., Minnie, Simone A., Ensbey, Kathleen S., Clouston, Andrew D., Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Gartlan, Kate H. and Hill, Geoffrey R. (2019). IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling. Blood, 134 (23), 2092-2106. doi: 10.1182/blood.2019000396

Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivo

Spicer, Julie A., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Giddens, Anna C., Jaiswal, Jagdish K., Jamieson, Stephen M. F., Bull, Matthew R., Denny, William A., Akhlaghi, Hedieh, Trapani, Joseph A., Hill, Geoff R., Chang, Karshing and Gartlan, Kate H. (2019). Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivo. Journal of Medicinal Chemistry, 63 (5) acs.jmedchem.9b00881, 2229-2239. doi: 10.1021/acs.jmedchem.9b00881

Adult related haematopoietic stem cell donor care: views of transplant nurses

Zomerdijk, Nienke, Turner, Jane, Hill, Geoffrey R. and Gottlieb, David (2019). Adult related haematopoietic stem cell donor care: views of transplant nurses. European Journal of Oncology Nursing, 41, 56-63. doi: 10.1016/j.ejon.2019.05.012

Interleukin-10 mediated immune regulation after stem cell transplantation: mechanisms and implications for therapeutic intervention

Zhang, Ping and Hill, Geoffrey R. (2019). Interleukin-10 mediated immune regulation after stem cell transplantation: mechanisms and implications for therapeutic intervention. Seminars in Immunology, 44 101322, 101322. doi: 10.1016/j.smim.2019.101322

Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model

Guillerey, Camille, Nakamura, Kyohei, Pichler, Andrea C., Barkauskas, Deborah, Krumeich, Sophie, Stannard, Kimberley, Miles, Kim, Harjunpää, Heidi, Yu, Yuan, Casey, Mika, Doban, Alina I., Lazar, Mircea, Hartel, Gunter, Smith, David, Vuckovic, Slavica, Teng, Michele W.L., Bergsagel, P. Leif, Chesi, Marta, Hill, Geoffrey R., Martinet, Ludovic and Smyth, Mark J. (2019). Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model. JCI Insight, 4 (14) :e125932. doi: 10.1172/jci.insight.125932

Adult-related haematopoietic stem cell donor experiences and the provision of information and psychosocial support: a systematic literature review

Zomerdijk, Nienke, Turner, Jane M. and Hill, Geoffrey R. (2019). Adult-related haematopoietic stem cell donor experiences and the provision of information and psychosocial support: a systematic literature review. European Journal of Cancer Care, 28 (3) e12932, 1-15. doi: 10.1111/ecc.12932

B7-H4 expression in donor T cells and host cells negatively regulates acute graftversus- host disease lethality

Saha, Asim, Taylor, Patricia A., Lees, Christopher J., Panoskaltsis-Mortari, Angela, Osborn, Mark J., Feser, Colby J., Thangavelu, Govindarajan, Melchinger, Wolfgang, Refaeli, Yosef, Hill, Geoffrey R., Munn, David H., Serody, Jonathan S., Maillard, Ivan, Kreymborg, Katharina, van den Brink, Marcel, Dong, Chen, Huang, Shuyu, Zang, Xingxing, Allison, James P, Zeiser, Robert and Blazar, Bruce R. (2019). B7-H4 expression in donor T cells and host cells negatively regulates acute graftversus- host disease lethality. The Journal of Immunology, 202 (1_Supplement), 69.10-69.10. doi: 10.4049/jimmunol.202.supp.69.10

Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology

Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S, Henden, Andrea S, Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D, Robb, Renee J, Zhang, Ping, Blazar, Bruce R., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D, Degli-Esposti, Mariapia A and Hill, Geoffrey R. (2019). Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology. The Journal of Immunology, 202 (1_Supplement), 69.38-69.38. doi: 10.4049/jimmunol.202.supp.69.38

Inhibiting EZH2 function prevents and treats chronic graft vs host disease (cGVHD) by disrupting germinal center formation and plasma cell maturation

Zaiken, Michael C, Flynn, Ryan, Paz, Katelyn, Rhee, Stephanie, Park, Paul, Hemming, Matthew, Sage, Peter, Sharpe, Arlene, Luznik, Leonard, Mailard, Ivan, Hill, Geoffrey R., MacDonald, Kelli, Serody, Jonathon, Cutler, Corey, Koreth, John, Miklos, David, Antin, Joseph, Soiffer, Robert, Ritz, Jerome, Bradner, Jay, Qi, Jun and Blazar, Bruce R. (2019). Inhibiting EZH2 function prevents and treats chronic graft vs host disease (cGVHD) by disrupting germinal center formation and plasma cell maturation. The Journal of Immunology, 202 (1_Supplement), 69.42-69.42. doi: 10.4049/jimmunol.202.supp.69.42

Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer

Zhang, Ping, Curley, Cameron I., Mudie, Kari, Nakagaki, Midori, Hill, Geoffrey R., Roberts, Jason A. and Tey, Siok-Keen (2019). Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer. Bone Marrow Transplantation, 54 (12), 2110-2116. doi: 10.1038/s41409-019-0505-5

Expansion of IL-17A-secreting CD8 + mucosa-associated invariant T cells in peripheral blood following stem cell mobilization

Varelias, Antiopi, Gartlan, Kate H., Wilkinson, Andrew N., Olver, Stuart D., Samson, Luke D., Tey, Siok-Keen, MacDonald, Kelli P. A. and Hill, Geoffrey R. (2019). Expansion of IL-17A-secreting CD8 + mucosa-associated invariant T cells in peripheral blood following stem cell mobilization. Blood Advances, 3 (5), 718-723. doi: 10.1182/bloodadvances.2018025601

Phase I trial of inducible caspase 9 T cells in adult stem cell transplant demonstrates massive clonotypic proliferative potential and long-term persistence of transgenic T cells

Zhang, Ping, Raju, Jyothy, Ullah, Md Ashik, Au, Raymond, Varelias, Antiopi, Gartlan, Kate H, Olver, Stuart D., Samson, Luke D., Sturgeon, Elise, Zomerdijk, Nienke, Avery, Judy, Gargett, Tessa, Brown, Michael P., Coin, Lachlan J., Ganesamoorthy, Devika, Hutchins, Cheryl, Pratt, Gary R, Kennedy, Glen A., Morton, A. James, Curley, Cameron I., Hill, Geoffrey R. and Tey, Siok-Keen (2019). Phase I trial of inducible caspase 9 T cells in adult stem cell transplant demonstrates massive clonotypic proliferative potential and long-term persistence of transgenic T cells. Clinical Cancer Research, 25 (6), 1749-1755. doi: 10.1158/1078-0432.CCR-18-3069

Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

Martins, Jose Paulo, Andoniou, Christopher E., Fleming, Peter, Kuns, Rachel D., Schuster, Iona S., Voigt, Valentina, Daly, Sheridan, Varelias, Antiopi, Tey, Siok-Keen, Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation. Science, 363 (6424), 288-293. doi: 10.1126/science.aat0066

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Paz, Katelyn, Flynn, Ryan, Du, Jing, Qi, Jun, Luznik, Leo, Maillard, Ivan, MacDonald, Kelli P., Hill, Geoffrey R., Serody, Jonathan S., Murphy, William J., Sage, Peter T., Sharpe, Arlene H., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Bradner, James E., Melnick, Ari M. and Blazar, Bruce R. (2019). Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease. Blood, 133 (1), 94-99. doi: 10.1182/blood-2018-03-839993

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, Katelyn, Flynn, Ryan, Du, Jing, Tannheimer, Stacey, Johnson, Amy J., Dong, Shuai, Stark, Anne-Katrien, Okkenhaug, Klaus, Panoskaltsis-Mortari, Angela, Sage, Peter T., Sharpe, Arlene H., Luznik, Leo, Ritz, Jerome, Soiffer, Robert J., Cutler, Corey S., Koreth, John, Antin, Joseph H., Miklos, David B., MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Serody, Jonathan S., Murphy, William J., Munn, David H., Feser, Colby, Zaiken, Michael, Vanhaesebroeck, Bart, Turka, Laurence A., Byrd, John C. and Blazar, Bruce R. (2019). Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease. American Journal of Transplantation, 19 (6) ajt.15305, 1820-1830. doi: 10.1111/ajt.15305

Distinct roles for CD4+ Foxp3+ regulatory T cells and IL-10–mediated immunoregulatory mechanisms during experimental visceral Leishmaniasis caused by Leishmania donovani

Bunn, Patrick T., Montes de Oca, Marcela, de Labastida Rivera, Fabian, Kumar, Rajiv, Ng, Susanna S., Edwards, Chelsea L., Faleiro, Rebecca J., Sheel, Meru, Amante, Fiona H., Frame, Teija C. M., Muller, Werner, Haque, Ashraful, Uzonna, Jude E., Hill, Geoffrey R. and Engwerda, Christian R. (2018). Distinct roles for CD4+ Foxp3+ regulatory T cells and IL-10–mediated immunoregulatory mechanisms during experimental visceral Leishmaniasis caused by Leishmania donovani. The Journal of Immunology, 201 (11), 3362-3372. doi: 10.4049/jimmunol.1701582

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Jacquelin, Sebastien, Straube, Jasmin, Cooper, Leanne, Vu, Therese, Song, Axia, Bywater, Megan, Baxter, Eva, Heidecker, Matthew, Wackrow, Brad, Porter, Amy, Ling, Victoria, Green, Joanne, Austin, Rebecca, Kazakoff, Stephen, Waddell, Nicola, Hesson, Luke B., Pimanda, John E., Stegelmann, Frank, Bullinger, Lars, Döhner, Konstanze, Rampal, Raajit K., Heckl, Dirk, Hill, Geoffrey R. and Lane, Steven W. (2018). Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation. Blood, 132 (26), blood-2018. doi: 10.1182/blood-2018-04-846220

Myeloma escape after stem cell transplantation is a consequence of t-cell exhaustion and is prevented by tigit blockade

Minnie, Simone A., Kuns, Rachel D., Gartlan, Kate H., Zhang, Ping, Wilkinson, Andrew N., Samson, Luke, Guillerey, Camille, Engwerda, Christian, MacDonald, Kelli P. A., Smyth, Mark J., Markey, Kate A., Vuckovic, Slavica and Hill, Geoffrey R. (2018). Myeloma escape after stem cell transplantation is a consequence of t-cell exhaustion and is prevented by tigit blockade. Blood, 132 (16), 1675-1688. doi: 10.1182/blood-2018-01-825240

Bone marrow transplantation generates T cell–dependent control of myeloma in mice

Vuckovic, Slavica, Minnie, Simone A., Smith, David, Gartlan, Kate H., Watkins, Thomas S., Markey, Kate A., Mukhopadhyay, Pamela, Guillerey, Camille, Kuns, Rachel D., Locke, Kelly R., Pritchard, Antonia L., Johansson, Peter A., Varelias, Antiopi, Zhang, Ping, Huntington, Nicholas D., Waddell, Nicola, Chesi, Marta, Miles, John J., Smyth, Mark J. and Hill, Geoffrey R. (2018). Bone marrow transplantation generates T cell–dependent control of myeloma in mice. Journal of Clinical Investigation, 129 (1) CI98888, 106-121. doi: 10.1172/jci98888

TIGIT immune checkpoint blockade restores CD8 T cell immunity against multiple myeloma

Guillerey, Camille, Harjunpää, Heidi, Carrié, Nadège, Kassem, Sahar, Teo, Tricia, Miles, Kim, Krumeich, Sophie, Weulersse, Marianne, Cuisinier, Marine, Stannard, Kimberley, Yu, Yuan, Minnie, Simone A., Hill, Geoffrey R., Dougall, William C., Avet-Loiseau, Hervé, Teng, Michele W. L., Nakamura, Kyohei, Martinet, Ludovic and Smyth, Mark J. (2018). TIGIT immune checkpoint blockade restores CD8 T cell immunity against multiple myeloma. Blood, 132 (16), blood-2018. doi: 10.1182/blood-2018-01-825265

Immune regulatory cell infusion for graft-versus-host disease prevention and therapy

Blazar, Bruce R., MacDonald, Kelli P.A. and Hill, Geoffrey R. (2018). Immune regulatory cell infusion for graft-versus-host disease prevention and therapy. Blood, 131 (24), 2651-2660. doi: 10.1182/blood-2017-11-785865

Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease

Takahashi, Shuichiro, Hashimoto, Daigo, Hayase, Eiko, Ogasawara, Reiki, Ohigashi, Hiroyuki, Ara, Takahide, Yokoyama, Emi, Ebata, Ko, Matsuoka, Satomi, Hill, Geoffrey R., Sugita, Junichi, Onozawa, Masahiro and Teshima, Takanori (2018). Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease. Blood, 131 (18), 2074-2085. doi: 10.1182/blood-2017-06-792614

DISTINCT IL-6 SIGNALING PATHWAYS DRIVE ALTERNATE PATHOGENIC T CELL DIFFERENTIATION AND GVHD AFTER TRANSPLANT IN VIVO

Wilkinson, Andrew N., Kuns, Rachel D., Varelias, Antiopi, Vuckovic, Slavica, Rose-John, Stefan, Gartlan, Kate H. and Hill, Geoffrey R. (2018). DISTINCT IL-6 SIGNALING PATHWAYS DRIVE ALTERNATE PATHOGENIC T CELL DIFFERENTIATION AND GVHD AFTER TRANSPLANT IN VIVO. The Journal of Immunology, 200 (1_Supplement), 55.2-55.2. doi: 10.4049/jimmunol.200.supp.55.2

Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon

Varelias, Antiopi, Bunting, Mark, Ormerod, Kate, Koyama, Motoko, Olver, Stuart, Straube, Jasmin, Kuns, Rachel, Robb, Renee, Henden, Andrea, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate, Lantz, Olivier J., Kjer-Nielsen, Lars, Mak, Jeffrey, Fairlie, David, Clouston, Andrew, McCluskey, James, Rossjohn, Jamie, Lane, Steven, Hugenholtz, Phil and Hill, Geoff (2018). Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon. The Journal of Immunology, 200 (1_Supplement), 55.15-55.15. doi: 10.4049/jimmunol.200.supp.55.15

Syngeneic stem cell transplantation generates antigen-specific T cells that maintain myeloma-immune equilibrium

Minnie, Simone, Vuckovic, Slavica, Smith, David, Gartlan, Kate H., Watkins, Thomas S., Kuns, Rachel D., Guillerey, Camille, Chesi, Marta, Markey, Kate A., Miles, John J., Smyth, Mark J. and Hill, Geoffrey R. (2018). Syngeneic stem cell transplantation generates antigen-specific T cells that maintain myeloma-immune equilibrium. The Journal of Immunology, 200 (1_Supplement), 55.19-55.19. doi: 10.4049/jimmunol.200.supp.55.19

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset

Hülsdünker, Jan, Ottmüller, Katja J., Neeff, Hannes P., Koyama, Motoko, Gao, Zhan, Thomas, Oliver S., Follo, Marie, Al-Ahmad, Ali, Prinz, Gabriele, Duquesne, Sandra, Dierbach, Heide, Kirschnek, Susanne, Lämmermann, Tim, Blaser, Martin J., Fife, Brian T., Blazar, Bruce R., Beilhack, Andreas, Hill, Geoffrey R., Häcker, Georg and Zeiser, Robert (2018). Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. Blood, 131 (16), 1858-1869. doi: 10.1182/blood-2017-10-812891

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Mathew, Nimitha R, Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A, Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L, Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael ... Zeiser, Robert (2018). Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature Medicine, 24 (4), 526-526. doi: 10.1038/nm0418-526c

Recipient mucosal-associated invariant T cells control GVHD within the colon

Varelias, Antiopi, Bunting, Mark D., Ormerod, Kate L., Koyama, Motoko, Olver, Stuart D., Straube, Jasmin, Kuns, Rachel D., Robb, Renee J., Henden, Andrea S., Cooper, Leanne, Lachner, Nancy, Gartlan, Kate H., Lantz, Olivier, Kjer-Nielsen, Lars, Mak, Jeffrey Y. W., Fairlie, David P., Clouston, Andrew D., McCluskey, James, Rossjohn, Jamie, Lane, Steven W., Hugenholtz, Philip and Hill, Geoffrey R. (2018). Recipient mucosal-associated invariant T cells control GVHD within the colon. Journal of Clinical Investigation, 128 (5), 1919-1936. doi: 10.1172/JCI91646

Granulocytes are unresponsive to IL-6 due to an absence of gp130

Wilkinson, Andrew N., Gartlan, Kate H., Kelly, Greg, Samson, Luke D., Olver, Stuart D., Avery, Judy, Zomerdijk, Nienke, Tey, Siok-Keen, Lee, Jason S., Vuckovic, Slavica and Hill, Geoffrey R. (2018). Granulocytes are unresponsive to IL-6 due to an absence of gp130. Journal of Immunology, 200 (9), 3547-3555. doi: 10.4049/jimmunol.1701191

Epigenetic programming of T cells impacts immune reconstitution in hematopoietic stem cell transplant recipients

Hardy, Kristine, Smith, Corey, Tu, Wen Juan, McCuaig, Robert, Panikkar, Archana, Dasari, Vijayendra, Wu, Fan, Tey, Siok-Keen, Hill, Geoffrey R., Khanna, Rajiv and Rao, Sudha (2018). Epigenetic programming of T cells impacts immune reconstitution in hematopoietic stem cell transplant recipients. Blood Advances, 2 (6), 656-668. doi: 10.1182/bloodadvances.2018015909

Conventional dendritic cells are required for the cross-presentation of leukemia-specific antigen in a model of AML relapse post-BMT

Markey, Kate A., Gartlan, Kate H., Kuns, Rachel D., Lane, Steven W. and Hill, Geoffrey R. (2018). Conventional dendritic cells are required for the cross-presentation of leukemia-specific antigen in a model of AML relapse post-BMT. Bone Marrow Transplantation, 53 (6), 800-803. doi: 10.1038/s41409-018-0148-y

The impact of age, NPM1, and FLT3 allelic ratio in patients with acute myeloid leukemia

Straube, Jasmin, Ling, Victoria Y, Hill, Geoffrey R and Lane, Steven W (2018). The impact of age, NPM1, and FLT3 allelic ratio in patients with acute myeloid leukemia. Blood, 131 (10), 1148-1153. doi: 10.1182/blood-2017-09-807438

Early blood stream infection after BMT is associated with cytokine dysregulation and poor overall survival

Catchpoole, Elizabeth M., Thirunavukarasu, Caitlin E., Varelias, Antiopi, Schlebusch, Sanmarié, Olver, Stuart, Zomerdijk, Nienke, Osland, Emma, Kennedy, Glen A., Tey, Siok-Keen, Hill, Geoffrey R. and Markey, Kate A. (2018). Early blood stream infection after BMT is associated with cytokine dysregulation and poor overall survival. Biology of Blood and Marrow Transplantation, 24 (7), 1360-1366. doi: 10.1016/j.bbmt.2018.02.025

Atypical chemokine receptor 4 shapes activated B cell fate

Kara, Ervin E., Bastow, Cameron R., McKenzie, Duncan R., Gregor, Carly E., Fenix, Kevin A., Babb, Rachelle, Norton, Todd S., Zotos, Dimitra, Rodda, Lauren B., Hermes, Jana R., Bourne, Katherine, Gilchrist, Derek S., Nibbs, Robert J., Alsharifi, Mohammed, Vinuesa, Carola G., Tarlinton, David M., Brink, Robert, Hill, Geoffrey R., Cyster, Jason G., Comerford, Iain and McColl, Shaun R. (2018). Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215 (3), 801-813. doi: 10.1084/jem.20171067

Dysregulated IL-18 Is a key driver of immunosuppression and a possible therapeutic target in the multiple myeloma microenvironment

Nakamura, Kyohei, Kassem, Sahar, Cleynen, Alice, Chrétien, Marie-Lorraine, Guillerey, Camille, Putz, Eva Maria, Bald, Tobias, Förster, Irmgard, Vuckovic, Slavica, Hill, Geoffrey R, Masters, Seth L, Chesi, Marta, Bergsagel, P Leif, Avet-Loiseau, Hervé, Martinet, Ludovic and Smyth, Mark J. (2018). Dysregulated IL-18 Is a key driver of immunosuppression and a possible therapeutic target in the multiple myeloma microenvironment. Cancer Cell, 33 (4), 634-648. doi: 10.1016/j.ccell.2018.02.007

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Mathew, Nimitha R., Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A., Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L., Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael ... Zeiser, Robert (2018). Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature Medicine, 24 (3), 282-291. doi: 10.1038/nm.4484

Oncogenic JAK2causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Prestipino, Alessandro, Emhardt, Alica J., Aumann, Konrad, O'Sullivan, David, Gorantla, Sivahari P., Duquesne, Sandra, Melchinger, Wolfgang, Braun, Lukas, Vuckovic, Slavica, Boerries, Melanie, Busch, Hauke, Halbach, Sebastian, Pennisi, Sandra, Poggio, Teresa, Apostolova, Petya, Veratti, Pia, Hettich, Michael, Niedermann, Gabriele, Bartholomä, Mark, Shoumariyeh, Khalid, Jutzi, Jonas S., Wehrle, Julius, Dierks, Christine, Becker, Heiko, Schmitt-Graeff, Annette, Follo, Marie, Pfeifer, Dietmar, Rohr, Jan, Fuchs, Sebastian ... Zeiser, Robert (2018). Oncogenic JAK2causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Science Translational Medicine, 10 (429) eaam7729, eaam7729. doi: 10.1126/scitranslmed.aam7729

IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection

James, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782

Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD

Markey, Kate A., Kuns, Rachel D., Browne, Daniel J., Gartlan, Kate H., Robb, Renee J., Martins, J. Paulo, Henden, Andrea S., Minnie, Simone A., Cheong, Melody, Koyama, Motoko, Smyth, Mark J., Steptoe, Raymond J., Belz, Gabrielle, Brocker, Thomas, Degli-Esposti, Mariapia A., Lane, Steven W. and Hill, Geoffrey R. (2018). Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD. Clinical Cancer Research, 24 (7), 1604-1616. doi: 10.1158/1078-0432.CCR-17-2148

Development of a Multiplexed Microsphere PCR for Culture-Free Detection and Gram-Typing of Bacteria in Human Blood Samples

Liang, Fang, Browne, Daniel J., Gray, Megan J., Gartlan, Kate H., Smith, David D., Barnard, Ross T., Hill, Geoffrey R., Corrie, Simon R. and Markey, Kate A. (2018). Development of a Multiplexed Microsphere PCR for Culture-Free Detection and Gram-Typing of Bacteria in Human Blood Samples. ACS Infectious Diseases, 4 (5), 837-844. doi: 10.1021/acsinfecdis.7b00277

Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion

Lynch, Jason P., Werder, Rhiannon B., Loh, Zhixuan, Sikder, Md Al Amin, Curren, Bodie, Zhang, Vivian, Rogers, Matthew J. , Lane, Katie, Simpson, Jennifer, Mazzone, Stuart B., Spann, Kirsten, Hayball, John, Diener, Kerrilyn, Everard, Mark L., Blyth, Christopher C., Forstner, Christian, Dennis, Paul G., Murtaza, Nida, Morrison, Mark, Ó Cuív, Páraic, Zhang, Ping, Haque, Ashraful, Hill, Geoffrey R., Sly, Peter D., Upham, John W. and Phipps, Simon (2017). Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion. The Journal of Experimental Medicine, 215 (2), 537-557. doi: 10.1084/jem.20170298

Mismatched unrelated donor allogeneic stem cell transplant for high risk haematological malignancy: A single centre experience

Mediwake, Heshani, Curley, Cameron, Butler, Jason, McLean, Angela, Tey, Siok, Hill, Geoffrey R., Morton, Anthony, Misra, Ashish, Subramoniapillai, Elango, Durrant, Simon and Kennedy, Glen A. (2017). Mismatched unrelated donor allogeneic stem cell transplant for high risk haematological malignancy: A single centre experience. Blood Cancer Journal, 7 (12) 55, 1-4. doi: 10.1038/s41408-017-0012-0

Interleukin-12 from CD103+ Batf3-dependent dendritic cells required for NK-cell suppression of metastasis

Mittal, Deepak, Vijayan, Dipti, Putz, Eva M., Aguilera, Amelia R., Markey, Kate A., Straube, Jasmin, Kazakoff, Stephen, Nutt, Stephen L., Takeda, Kazuyoshi, Hill, Geoffrey R., Waddell, Nicola and Smyth, Mark J. (2017). Interleukin-12 from CD103+ Batf3-dependent dendritic cells required for NK-cell suppression of metastasis. Cancer Immunology Research, 5 (12), 1098-1108. doi: 10.1158/2326-6066.CIR-17-0341

A critical role for donor-derived IL-22 in cutaneous chronic GVHD

Gartlan, Kate H., Bommiasamy, Hemamalini, Paz, Katelyn, Wilkinson, Andrew N., Owen, Mary, Reichenbach, Dawn K., Banovic, Tatjana, Wehner, Kimberly, Buchanan, Faith, Varelias, Antiopi, Kuns, Rachel D., Chang, Karshing, Fedoriw, Yuri, Shea, Thomas, Coghill, James, Zaiken, Michael, Plank, Maximilian W., Foster, Paul S., Clouston, Andrew D., Blazar, Bruce R., Serody, Jonathan S. and Hill, Geoffrey R. (2017). A critical role for donor-derived IL-22 in cutaneous chronic GVHD. American Journal of Transplantation , 18 (4), 810-820. doi: 10.1111/ajt.14513

IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection

Sebina, I., Fogg, L. G., James, K. R., Soon, M. S. F., Akter, J., Thomas, B. S., Hill, G. R., Engwerda, C. R. and Haque, A. (2017). IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection. Parasite Immunology, 39 (10) e12455, e12455. doi: 10.1111/pim.12455

Acute myeloid leukemia stem cell function is preserved in the absence of autophagy

Porter, Amy H., Leveque-El Mouttie, Lucie, Vu, Therese, Bruedigam, Claudia, Sutton, Joanne, Jacquelin, Sebastien, Hill, Geoffrey R., MacDonald, Kelli P. A. and Lane, Steven W. (2017). Acute myeloid leukemia stem cell function is preserved in the absence of autophagy. Haematologica, 102 (9), E344-E347. doi: 10.3324/haematol.2017.166389

Cytokine mediators of chronic graft-versus-host disease

MacDonald, Kelli P. A., Blazar, Bruce R. and Hill, Geoffrey R. (2017). Cytokine mediators of chronic graft-versus-host disease. Journal of Clinical Investigation, 127 (7), 2452-2463. doi: 10.1172/JCI90593

Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation

AL-Kouba, Jane, Wilkinson, Andrew N., Starkey, Malcolm R., Rudraraju, Rajeev, Werder, Rhiannon B., Liu, Xiao, Law, Soi-Cheng, Horvat, Jay C., Brooks, Jeremy F., Hill, Geoffrey R., Davies, Janet M., Phipps, Simon, Hansbro, Philip M. and Steptoe, Raymond J. (2017). Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation. JCI Insight, 2 (11) e85742. doi: 10.1172/jci.insight.85742

An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition

Forcade, Edouard, Paz, Katelyn, Flynn, Ryan, Griesenauer, Brad, Amet, Tohti, Li, Wei, Liu, Liangyi, Bakoyannis, Giorgos, Jiang, Di, Chu, Hong Wei, Lobera, Mercedes, Yang, Jianfei, Wilkes, David S., Du, Jing, Gartlan, Kate, Hill, Geoffrey R., MacDonald, Kelli P. A., Espada, Eduardo L., Blanco, Patrick, Serody, Jonathan S., Koreth, John, Cutler, Corey S., Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Paczesny, Sophie and Blazar, Bruce R. (2017). An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition. JCI Insight, 2 (12) e92111. doi: 10.1172/jci.insight.92111

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-beta production

Du, Jing, Paz, Katelyn, Flynn, Ryan, Vulic, Ante, Robinson, Tara M., Lineburg, Katie E., Alexander, Kylie A., Meng, Jingjing, Roy, Sabita, Panoskaltsis-Mortari, Angela, Loschi, Michael, Hill, Geoffrey R., Serody, Jonathan S., Maillard, Ivan, Miklos, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, MacDonald, Kelli P., Schacker, Timothy W., Luznik, Leo and Blazar, Bruce R. (2017). Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-beta production. Blood, 129 (18), 2570-2580. doi: 10.1182/blood-2017-01-758854

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Varelias, Antiopi, Ormerod, Kate L, Bunting, Mark D, Koyama, Motoko, Gartlan, Kate H, Kuns, Rachel D, Lachner, Nancy, Locke, Kelly R, Lim, Chun Y, Henden, Andrea S, Zhang, Ping, Clouston, Andrew D, Hasnain, Sumaira Z, McGuckin, Michael A, Blazar, Bruce R, MacDonald, Kelli PA, Hugenholtz, Philip and Hill, Geoff R (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. The Journal of Immunology, 198 (1_Supplement), 82.8-82.8. doi: 10.4049/jimmunol.198.supp.82.8

Conditioning regimens for autologous haematopoietic stem cell transplantation - can natural killer cell therapy help?

Snowden, John A. and Hill, Geoffrey R. (2017). Conditioning regimens for autologous haematopoietic stem cell transplantation - can natural killer cell therapy help?. British Journal of Haematology, 177 (3), 341-342. doi: 10.1111/bjh.14565

Eomesodermin promotes the development of Type-1 Regulatory T (TR1) cells

Zhang, Ping, Lee, Jason S., Gartlan, Kate H., Schuster, Iona S., Comerford, Iain, Varelias, Antiopi, Ullah, Md Ashik, Vuckovic, Slavica, Koyama, Motoko, Kuns, Rachel D., Locke, Kelly R., Beckett, Kirrilee J., Olver, Stuart D., Samson, Luke D., Montes de Oca, Marcela, de Labastida Rivera, Fabian, Clouston, Andrew D., Belz, Gabrielle T., Blazar, Bruce R., MacDonald, Kelli P., McColl, Shaun R., Thomas, Ranjeny, Engwerda, Christian R., Degli-Esposti, Mariapia A., Kallies, Axel, Tey, Siok-Keen and Hill, Geoffrey R. (2017). Eomesodermin promotes the development of Type-1 Regulatory T (TR1) cells. Science Immunology, 2 (10) eaah7152. doi: 10.1126/sciimmunol.aah7152

The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells

Vuckovic, Slavica, Vandyke, Kate, Rickards, David A., Mccauley Winter, Padraig, Brown, Simon H. J., Mitchell, Todd W., Liu, Jun, Lu, Jun, Askenase, Philip W., Yuriev, Elizabeth, Capuano, Ben, Ramsland, Paul A., Hill, Geoffrey R., Zannettino, Andrew C. W. and Hutchinson, Andrew T. (2017). The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells. British Journal of Haematology, 177 (3), 423-440. doi: 10.1111/bjh.14561

Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT

Gartlan, Kate H., Varelias, Antiopi, Koyama, Motoko, Robb, Renee J., Markey, Kate A., Chang, Karshing, Wilkinson, Andrew N., Smith, David, Ullah, Md Ashik, Kuns, Rachel D., Raffelt, Neil C., Olver, Stuart D., Lineburg, Katie E., Teal, Bianca E., Cheong, Melody, Teng, Michele W. L., Smyth, Mark J., Tey, Siok-Keen, MacDonald, Kelli P. A. and Hill, Geoffrey R. (2017). Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT. Blood Advances, 1 (6), 341-351. doi: 10.1182/bloodadvances.2016002980

Bone Marrow Transplantation Under Regulatory T Cell Cover to Induce Donor-Specific Tolerance

Hill, Geoffrey R. (2017). Bone Marrow Transplantation Under Regulatory T Cell Cover to Induce Donor-Specific Tolerance. Transplantation, 101 (2), 232-233. doi: 10.1097/TP.0000000000001550

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity

Bunting, Mark D., Varelias, Antiopi, Souza-Fonseca-Guimaraes, Fernando, Schuster, Iona S., Lineburg, Katie E., Kuns, Rachel D., Fleming, Peter, Locke, Kelly R., Huntington, Nicholas D., Blazar, Bruce R., Lane, Steven W., Tey, Siok-Keen, MacDonald, Kelli P. A., Smyth, Mark J., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2017). GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity. Blood, 129 (5), 630-642. doi: 10.1182/blood-2016-08-734020

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A ., Hugenholtz, Philip and Hill, Geoffrey R. (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Blood, 129 (15), 2172-2185. doi: 10.1182/blood-2016-08-732628

Chronic graft-versus-host disease: biological insights from preclinical and clinical studies

MacDonald, Kelli P. A., Hill, Geoffrey R. and Blazar, Bruce R. (2017). Chronic graft-versus-host disease: biological insights from preclinical and clinical studies. Blood, 129 (1), 13-21. doi: 10.1182/blood-2016-06-686618

Novel platform technology for modular mucosal vaccine that protects against streptococcus

Zaman, Mehfuz, Ozberk, Victoria, Langshaw, Emma L., McPhun, Virginia, Powell, Jessica L., Phillips, Zachary N., Ho, Mei Fong, Calcutt, Ainslie, Batzloff, Michael R., Toth, Istvan, Hill, Geoffrey R., Pandey, Manisha and Good, Michael F. (2016). Novel platform technology for modular mucosal vaccine that protects against streptococcus. Scientific Reports, 6 (1) 39274, 1-11. doi: 10.1038/srep39274

IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection

Sebina, Ismail, James, Kylie R., Soon, Megan S. F., Fogg, Lily G., Best, Shannon E., Labastida Rivera, Fabian de, Montes de Oca, Marcela, Amante, Fiona H., Thomas, Bryce S., Beattie, Lynette, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J., Hertzog, Paul J., Hill, Geoffrey R., Hutloff, Andreas, Engwerda, Christian R. and Haque, Ashraful (2016). IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection. PLoS Pathogens, 12 (11) e1005999, e1005999. doi: 10.1371/journal.ppat.1005999

Agonistic CD40 mAb-driven IL12 reverses resistance to anti-PD1 in a T-cell-rich tumor

Ngiow, Shin Foong, Young, Arabella, Blake, Stephen J., Hill, Geoffrey R., Yagita, Hideo, Teng, Michele W. L., Korman, Alan J. and Smyth, Mark J. (2016). Agonistic CD40 mAb-driven IL12 reverses resistance to anti-PD1 in a T-cell-rich tumor. Cancer Research, 76 (21), 6266-6277. doi: 10.1158/0008-5472.CAN-16-2141

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

Le Texier, Laetitia, Lineburg, Katie E., Cao, Benjamin, McDonald-Hyman, Cameron, Leveque-El Mouttie, Lucie, Nicholls, Jemma, Melino, Michelle, Nalkurthi, Blessy C., Alexander, Kylie A., Teal, Bianca, Blake, Stephen J., Souza-Fonseca-Guimaraes, Fernando, Engwerda, Christian R., Kuns, Rachel D., Lane, Steven W., Teng, Michele, Teh, Charis, Gray, Daniel, Clouston, Andrew D., Nilsson, Susan K., Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2016). Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease. JCI Insight, 1 (15) e86850, e86850. doi: 10.1172/jci.insight.86850

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD

Leveque-El Mouttie, Lucie, Koyama, Motoko, Le Texier, Laetitia, Markey, Kate A., Cheong, Melody, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Alexander, Kylie A., Clouston, Andrew D., Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2016). Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD. Blood, 128 (6), 794-804. doi: 10.1182/blood-2015-11-680876

Coinfection with human cytomegalovirus genetic variants in transplant recipients and its impact on antiviral T cell immune reconstitution

Smith, Corey, Brennan, Rebekah M., Tey, Siok-Keen, Smyth, Mark J., Burrows, Scott R., Miles, John J., Hill, Geoffrey R. and Khanna, Rajiv (2016). Coinfection with human cytomegalovirus genetic variants in transplant recipients and its impact on antiviral T cell immune reconstitution. Journal of Virology, 90 (16), 7497-7507. doi: 10.1128/JVI.00297-16

Pharmacokinetics and immunological outcomes of alemtuzumab-based treatment for steroid-refractory acute GvHD

Tey, S-K., Vuckovic, S., Varelias, A., Martins, J. P., Olver, S., Samson, L., Sturgeon, E., Leach, J., Avery, J., Nakagaki, M., Butler, J. P., Curley, C., Morton, A. J., Durrant, S. T., Kennedy, G. A. and Hill, G. R. (2016). Pharmacokinetics and immunological outcomes of alemtuzumab-based treatment for steroid-refractory acute GvHD. Bone Marrow Transplantation, 51 (8), 1153-1155. doi: 10.1038/bmt.2016.83

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, Cameron, Flynn, Ryan, Panoskaltsis-Mortari, Angela, Peterson, Nicholas, MacDonald, Kelli P. A., Hill, Geoffrey R., Luznik, Leo, Serody, Jonathan S., Murphy, William J., Maillard, Ivan, Munn, David H., Turka, Laurence A., Koreth, John, Cutler, Corey S., Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome and Blazar, Bruce R. (2016). Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner. Blood, 128 (7), 1013-1017. doi: 10.1182/blood-2016-05-715896

Alloantigen presentation and graft-versus-host disease: fuel for the fire

Koyama, Motoko and Hill, Geoffrey R. (2016). Alloantigen presentation and graft-versus-host disease: fuel for the fire. Blood, 127 (24), 2963-2970. doi: 10.1182/blood-2016-02-697250

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, Ryan, Paz, Katelyn, Du, Jing, Reichenbach, Dawn K., Taylor, Patricia A., Panoskaltsis-Mortari, Angela, Vulic, Ante, Luznik, Leo, MacDonald, Kelli K. P., Hill, Geoffrey R., Nyuydzefe, Melanie S., Weiss, Jonathan M., Chen, Wei, Trzeciak, Alissa, Serody, Jon S., Aguilar, Ethan G., Murphy, William J., Maillard, Ivan, Munn, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, Waksal, Samuel D., Zanin-Zhorov, Alexandra and Blazar, Bruce R. (2016). Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism. Blood, 127 (17), 2144-2154. doi: 10.1182/blood-2015-10-678706

Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation

Ullah, Md Ashik, Hill, Geoffrey R. and Tey, Siok-Keen (2016). Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation. Frontiers in Immunology, 7 (APR) 144, 144. doi: 10.3389/fimmu.2016.00144

Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies

Guillerey, Camille, Nakamura, Kyohei, Vuckovic, Slavica, Hill, Geoffrey R. and Smyth, Mark J. (2016). Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies. Cellular and Molecular Life Sciences, 73 (8), 1569-1589. doi: 10.1007/s00018-016-2135-z

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling

Vu, Therese, Austin, Rebecca, Kuhn, Catherine Paine, Bruedigam, Claudia, Song, Axia, Guignes, Solene, Jacquelin, Sebastien, Ramshaw, Hayley S., Hill, Geoffrey R., Lopez, Angel F. and Lane, Steven W. (2016). Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling. Haematologica, 101 (3), E77-E80. doi: 10.3324/haematol.2015.136705

Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model

Melino, Michelle, Gadd, Victoria L., Alexander, Kylie A., Beattie, Lynette, Lineburg, Katie E., Martinez, Michelle, Teal, Bianca, Le Texier, Laetitia, Irvine, Katharine M., Miller, Gregory C., Boyle, Glen M., Hill, Geoffrey R., Clouston, Andrew D., Powel, Elizabeth E. and MacDonald, Kelli P. A. (2016). Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model. American Journal of Pathology, 186 (3), 524-538. doi: 10.1016/j.ajpath.2015.10.029

Erratum: Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated Tissue pathology (PLoS Pathogens (2016) 12:1 (e1005398) DOI: 10.1371/journal.ppat.1005398)

De Oca, Marcela Montes, Kumar, Rajiv, De Labastida Rivera, Fabian, Amante, Fiona H., Sheel, Meru, Faleiro, Rebecca J., Bunn, Patrick T., Best, Shannon E., Beattie, Lynette, Ng, Susanna S., Edwards, Chelsea L., Muller, Werner, Cretney, Erika, Nutt, Stephen L., Smyth, Mark J., Haque, Ashraful, Hill, Geoffrey R., Sundar, Shyam, Kallies, Axel and Engwerda, Christian R. (2016). Erratum: Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated Tissue pathology (PLoS Pathogens (2016) 12:1 (e1005398) DOI: 10.1371/journal.ppat.1005398). PLoS Pathogens, 12 (2) e1005460. doi: 10.1371/journal.ppat.1005460

Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated tissue pathology

Montes de Oca, Marcela, Kumar, Rajiv, de Labastida Rivera, Fabian, Amante, Fiona H., Sheel, Meru, Faleiro, Rebecca J., Bunn, Patrick T., Best, S.E., Beattie, Lynette, Ng, Susanna S., Edwards, Chelsea L., Muller, Werner, Cretney, Erika, Nutt, Stephen L., Smyth, Mark J., Haque, Ashraful, Hill, Geoffrey R., Sundar, Shyam, Kallies, Axel and Engwerda, Christian R. (2016). Blimp-1-dependent IL-10 production by Tr1 cells regulates TNF-mediated tissue pathology. PLoS Pathogens, 12 (1) e1005398, 1-21. doi: 10.1371/journal.ppat.1005398

IL-17A-Producing gamma delta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver

Sheel, Meru, Beattie, Lynette, Frame, Teija C. M., Rivera, Fabian de Labastida, Faleiro, Rebecca J., Bunn, Patrick T., de Oca, Marcela Montes, Edwards, Chelsea L., Ng, Susanna S., Kumar, Rajiv, Amante, Fiona H., Best, Shannon E., McColl, Shaun R., Varelias, Antiopi, Kuns, Rachel D., MacDonald, Kelli P. A., Smyth, Mark J., Haque, Ashraful, Hill, Geoff R. and Engwerda, Christian R. (2015). IL-17A-Producing gamma delta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver. Journal of Immunology, 195 (12), 5707-5717. doi: 10.4049/jimmunol.1501046

CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells

Kara, Ervin E., McKenzie, Duncan R., Bastow, Cameron R., Gregor, Carly E., Fenix, Kevin A., Ogunniyi, Abiodim D., Paton, James C., Mack, Matthias, Pombal, Diana R., Seillet, Cyrill, Dubois, Benedocte, Liston, Adrian, Macdonald, Kelli P. A., Belz, Gabrielle T., Smyth, Mark J., Hill, Geoffrey R., Comerford, Iain and McColl, Shaun R. (2015). CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nature Communications, 6 (1) 8644, 8644. doi: 10.1038/ncomms9644

Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8⁺ T cells that induce GVHD without antileukemic effects

Gartlan, Kate H., Markey, Kate A., Varelias, Antiopi, Bunting, Mark D., Koyama, Motoko, Kuns, Rachel D., Raffelt, Neil C., Olver, Stuart D., Lineburg, Katie E., Cheong, Melody, Teal, Bianca E., Lor, Mary, Comerford, Iain, Teng, Michele W. L., Smyth, Mark J., McCluskey, James, Rossjohn, Jamie, Stockinger, Brigitta, Boyle, Glen M., Lane, Steven W., Clouston, Andrew D., McColl, Shaun R., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015). Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects. Blood, 126 (13), 1609-1620. doi: 10.1182/blood-2015-01-622662

Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice

Wikstrom, Matthew E., Fleming, Peter, Kuns, Rachel D., Schuster, Iona S., Voigt, Valentina, Miller, Gregory, Clouston, Andrew D., Tey, Siok-Keen, Andoniou, Christopher E., Hill, Geoffrey R. and Degli-Esposti, Mariapia A. (2015). Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice. Blood, 126 (12), 1503-1514. doi: 10.1182/blood-2015-01-622837

Imaging the immunological synapse between dendritic cells and T cells

Markey, Kate A., Gartlan, Kate H., Kuns, Rachel D., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015). Imaging the immunological synapse between dendritic cells and T cells. Journal of Immunological Methods, 423, 40-44. doi: 10.1016/j.jim.2015.04.029

Donor colonic CD103(+) dendritic cells determine the severity of acute graft-versus-host disease

Koyama, Motoko, Cheong, Melody, Markey, Kate A., Gartlan, Kate H., Kuns, Rachel D., Locke, Kelly R., Lineburg, Katie E., Teal, Bianca E., Leveque-El Mouttie, Lucie, Bunting, Mark D., Vuckovic, Slavica, Zhang, Ping, Teng, Michele W. L., Varelias, Antiopi, Tey, Siok-Keen, Wockner, Leesa F., Engwerda, Christian R., Smyth, Mark J., Belz, Gabrielle T., McColl, Shaun R., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015). Donor colonic CD103(+) dendritic cells determine the severity of acute graft-versus-host disease. Journal of Experimental Medicine, 212 (8), 1303-1321. doi: 10.1084/jem.20150329

Erratum: Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Guillerey, Camille, de Andrade, Lucas Ferrari, Vuckovic, Slavica, Miles, Kim, Ngiow, Shin Foong, Yong, Michelle C. R., Teng, Michele W. L., Colonna, Marco, Ritchie, David S., Chesi, Marta, Bergsagel, P. Leif, Hill, Geoffrey R., Smyth, Mark J. and Martinet, Ludovic (2015). Erratum: Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Journal of Clinical Investigation, 125 (7), 2904-2904. doi: 10.1172/JCI82646

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease

Flynn, Ryan, Allen, Jessica L., Luznik, Leo, MacDonald, Kelli P., Paz, Katelyn, Alexander, Kylie A., Vulic, Ante, Du, Jing, Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Poe, Jonathan C., Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Maillard, Ivan, Koreth, John, Cutler, Corey S., Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Chao, Nelson J., Clynes, Raphael A., Sarantopoulos, Stefanie and Blazar, Bruce R. (2015). Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease. Blood, 125 (26), 4085-4094. doi: 10.1182/blood-2014-08-595470

Cytokines in graft-versus-host disease

Henden, Andrea S. and Hill, Geoffrey R. (2015). Cytokines in graft-versus-host disease. Journal of Immunology, 194 (10), 4604-4612. doi: 10.4049/jimmunol.1500117

Autophagy is required for stem cell mobilization by G-CSF

Leveque-El Mouttie, Lucie, Vu, Therese, Lineburg, Katie E., Kuns, Rachel D., Bagger, Frederik O., Teal, Bianca E., Lor, Mary, Boyle, Glen M., Bruedigam, Claudia, Mintern, Justine D., Hill, Geoffrey R., MacDonald, Kelli P. A. and Lane, Steven W. (2015). Autophagy is required for stem cell mobilization by G-CSF. Blood, 125 (19), 2933-2936. doi: 10.1182/blood-2014-03-562660

NK cells require IL-28R for optimal in vivo activity

Souza-Fonseca-Guimaraes, Fernando, Young, Arabella, Mittal, Deepak, Martinet, Ludovic, Bruedigam, Claudia, Takeda, Kazuyoshi, Andoniou, Christopher E., Degli-Esposti, Mariapia A., Hill, Geoffrey R. and Smyth, Mark J. (2015). NK cells require IL-28R for optimal in vivo activity. Proceedings of the National Academy of Sciences of the United States of America, 112 (18), E2376-E2384. doi: 10.1073/pnas.1424241112

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Guillerey, Camille, de Andrade, Lucas Ferrari, Vuckovic, Slavica, Miles, Kim, Ngiow, Shin Foong, Yong, Michelle C. R., Teng, Michele W. L., Colonna, Marco, Ritchie, David S., Chesi, Martha, Bergsagel, P. Leif, Hill, Geoffrey R., Smyth, Mark J. and Martinet, Ludovic (2015). Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Journal of Clinical Investigation, 125 (5), 2077-2089. doi: 10.1172/JCI77181

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

Varelias, Antiopi, Gartlan, Kate H., Kreijveld, Ellen, Olver, Stuart D., Lor, Mary, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Raffelt, Neil C., Cheong, Melody, Alexander, Kylie A., Koyama, Motoko, Markey, Kate A., Sturgeon, Elise, Leach, Justine, Reddy, Pavan, Kennedy, Glen A., Yanik, Gregory A., Blazar, Bruce R., Tey, Siok-Keen, Clouston, Andrew D., MacDonald, Kelli P. A., Cooke, Kenneth R. and Hill, Geoffrey R. (2015). Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation. Blood, 125 (15), 2435-2444. doi: 10.1182/blood-2014-07-590232

CD3 bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+T cells

Paget, C., Chow, M. T., Gherardin, N. A., Beavis, P. A., Uldrich, A. P., Duret, H., Hassane, M., Souza-Fonseca-Guimaraes, F., Mogilenko, D. A., Staumont-Salle, D., Escalante, N. K., Hill, G. R., Neeson, P., Ritchie, D. S., Dombrowicz, D., Mallevaey, T., Trottein, F., Belz, G. T., Godfrey, D. I. and Smyth, M. J. (2015). CD3 bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+T cells. Immunology and Cell Biology, 93 (2), 198-212. doi: 10.1038/icb.2014.94

Autophagy and haematopoietic stem cell transplantation

Leveque, Lucie, Le Texier, Laetitia, Lineburg, Katie E., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2015). Autophagy and haematopoietic stem cell transplantation. Immunology and Cell Biology, 93 (1), 43-50. doi: 10.1038/icb.2014.95

Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation

Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015). Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 (4), 1065-1073. doi: 10.1016/j.jaci.2015.02.032

Post transplant CMV-specific T-cell immune reconstitution in the absence of global T-cell immunity is associated with a high risk of subsequent virus reactivation

Tey, S.-K., Davenport, M. P., Hill, G. R., Kennedy, G. A., Durrant, S. T., Khanna, R. and Cromer, D. (2015). Post transplant CMV-specific T-cell immune reconstitution in the absence of global T-cell immunity is associated with a high risk of subsequent virus reactivation. Bone Marrow Transplantation, 50 (2), 315-316. doi: 10.1038/bmt.2014.265

α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice

Uryu, Hidetaka, Hashimoto, Daigo, Kato, Koji, Hayase, Eiko, Matsuoka, Satomi, Ogasawara, Reiki, Takahashi, Shuichiro, Maeda, Yoshinobu, Iwasaki, Hiromi, Miyamoto, Toshihiro, Saijo, Shinobu, Iwakura, Yoichiro, Hill, Geoffrey R., Akashi, Koichi and Teshima, Takanori (2015). α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood, 125 (19), 3014-3023. doi: 10.1182/blood-2014-12-615781

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy

Bruedigam, C., Bagger, F.O., Heidel, F.H., Paine, Kuhn C., Guignes, S., Song, A., Austin, R., Vu, T., Lee, E., Riyat, S., Moore, A.S., Lock, R.B., Bullinger, L., Hill, G.R., Armstrong, S.A., Williams, D.A. and Lane, S.W. (2014). Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell, 15 (6), 775-790. doi: 10.1016/j.stem.2014.11.010

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial

Kennedy, Glen A., Varelias, Antiopi, Vuckovic, Slavica, Le Texier, Laetitia, Gartlan, Kate H., Zhang, Ping, Thomas, Gethin, Anderson, Lisa, Boyle, Glen, Cloonan, Nicole, Leach, Justine, Sturgeon, Elise, Avery, Judy, Olver, Stuart D., Lor, Mary, Misra, Ashish K., Hutchins, Cheryl, Morton, A. James, Durrant, Simon T. S., Subramoniapillai, Elango, Butler, Jason P., Curley, Cameron I., MacDonald, Kelli P. A., Tey, Siok-Keen and Hill, Geoffrey R. (2014). Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial. The Lancet Oncology, 15 (13), 1451-1459. doi: 10.1016/S1470-2045(14)71017-4

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Dubovsky, Jason A., Flynn, Ryan, Du, Jing, Harrington, Bonnie K., Zhong, Yiming, Kaffenberger, Benjamin, Yang, Carrie, Towns, William H., Lehman, Amy, Johnson, Amy J., Muthusamy, Natarajan, Devine, Steven M., Jaglowski, Samantha, Serody, Jonathan S., Murphy, William J., Munn, David H., Luznik, Leo, Hill, Geoffrey R., Wong, Henry K., MacDonald, Kelli K. P., Maillard, Ivan, Koreth, John, Elias, Laurence, Cutler, Corey, Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Panoskaltsis-Mortari, Angela, Byrd, John C. and Blazar, Bruce R. (2014). Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. Journal of Clinical Investigation, 124 (11), 4867-4876. doi: 10.1172/JCI75328

TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity

Schuster, Iona S., Wikstrom, Matthew E., Brizard, Geraldine, Coudert, Jerome D., Estcourt, Marie J., Manzur, Mitali, O'Reilly, Lorraine A., Smyth, Mark J., Trapani, Joseph A., Hill, Geoffrey R., Andoniou, Christopher E. and Degli-Esposti, Mariapia A. (2014). TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity. Immunity, 41 (4), 646-656. doi: 10.1016/j.immuni.2014.09.013

Reduced mucosal associated invariant T-cells are associated with increased disease severity and Pseudomonas aeruginosa infection in cystic fibrosis

Smith, Daniel J., Hill, Geoffrey R., Bell, Scott C. and Reid, David W. (2014). Reduced mucosal associated invariant T-cells are associated with increased disease severity and Pseudomonas aeruginosa infection in cystic fibrosis. PLoS ONE, 9 (10) e109891, 1-8. doi: 10.1371/journal.pone.0109891

CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease

Alexander K.A., Flynn R., Lineburg K.E., Kuns R.D., Teal B.E., Olver S.D., Lor M., Raffelt N.C., Koyama M., Leveque L., Le Texier L., Melino M., Markey K.A., Varelias A., Engwerda C., Serody J.S., Janela B., Ginhoux F., Clouston A.D., Blazar B.R., Hill G.R. and MacDonald K.P.A. (2014). CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease. Journal of Clinical Investigation, 124 (10), 4266-4280. doi: 10.1172/JCI75935

The biology of graft-versus-host disease: experimental systems instructing clinical practice

Markey, Kate A., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2014). The biology of graft-versus-host disease: experimental systems instructing clinical practice. Blood, 124 (3), 354-362. doi: 10.1182/blood-2014-02-514745

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Flynn, Ryan, Du, Jing, Veenstra, Rachelle G., Reichenbach, Dawn K., Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Freeman, Gordon J., Serody, Jonathan S., Murphy, William J., Munn, David H., Sarantopoulos, Stefanie, Luznik, Leo, Maillard, Ivan, Koreth, John, Cutler, Corey, Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Dubovsky, Jason A., Byrd, John C., MacDonald, Kelli P., Hill, Geoff R. and Blazar, Bruce R. (2014). Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. Blood, 123 (25), 3988-3998. doi: 10.1182/blood-2014-03-562231

Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity

Haque, Ashraful, Best, Shannon E., De Oca, Marcela Montes, James, Kylie R., Ammerdorffer, Anne, Edwards, Chelsea L., De Labastida Rivera, Fabian, Amante, Fiona H., Bunn, Patrick T., Sheel, Meru, Sebina, Ismail, Koyama, Motoko, Varelias, Antiopi, Hertzog, Paul J., Kalinke, Ulrich, Gun, Sin Yee, Renia, Laurent, Ruedl, Christiane, MacDonald, Kelli P.A., Hill, Geoffrey R. and Engwerda, Christian R. (2014). Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity. Journal of Clinical Investigation, 124 (6), 2483-2496. doi: 10.1172/JCI70698

Cross-dressing by donor dendritic cells after allogeneic bone marrow transplantation contributes to formation of the immunological synapse and maximizes responses to indirectly presented antigen

Markey, Kate A., Koyama, Motoko, Gartlan, Kate H., Leveque, Lucie, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2014). Cross-dressing by donor dendritic cells after allogeneic bone marrow transplantation contributes to formation of the immunological synapse and maximizes responses to indirectly presented antigen. Journal of Immunology, 192 (11), 5426-5433. doi: 10.4049/jimmunol.1302490

Immunotherapy following relapse of acute leukaemia after T-cell-replete allogeneic peripheral blood progenitor cell transplantation: importance of new onset chronic graft-versus-host disease

Curley, C., Hill, G. R., McLean, A. and Kennedy, G. A. (2014). Immunotherapy following relapse of acute leukaemia after T-cell-replete allogeneic peripheral blood progenitor cell transplantation: importance of new onset chronic graft-versus-host disease. International Journal of Laboratory Hematology, 36 (2), 197-204. doi: 10.1111/ijlh.12153

Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10

MacDonald, Kelli P. A., Le Texier, Laetitia, Zhang, Ping, Morris, Helen, Kuns, Rachel D., Lineburg, Katie E., Leveque, Lucie, Don, Alistair L., Markey, Kate A., Vuckovic, Slavica, Bagger, Frederik O., Boyle, Glen M., Blazar, Bruce R. and Hill, Geoffrey R. (2014). Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10. Journal of Immunology, 192 (7), 3180-3189. doi: 10.4049/jimmunol.1302315

Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

Koyama, M., Hashimoto, D., Nagafuji, K., Eto, T., Ohno, Y., Aoyama, K., Iwasaki, H., Miyamoto, T., Hill, G.R., Akashi, K. and Teshima, T. (2014). Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning. Bone Marrow Transplantation, 49 (1), 110-115. doi: 10.1038/bmt.2013.134

The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals

Wikstrom, Matthew E., Khong, Andrea, Fleming, Peter, Kuns, Rachel, Hertzog, Paul J., Frazer, Ian H., Andoniou, Christopher E., Hill, Geoffrey R. and Degli-Esposti, Mariapia A. (2014). The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals. European Journal of Immunology, 44 (2), 409-419. doi: 10.1002/eji.201243109

PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria

Horne-Debets, Joshua M., Faleiro, Rebecca, Karunarathne, Deshapriya S., Liu, Xue Q., Lineburg, Katie E., Poh, Chek Meng, Grotenbreg, Gijsbert M., Hill, Geoffrey R., MacDonald, Kelli P. A., Good, Michael F., Renia, Laurent, Ahmed, Rafi, Sharpe, Arlene H. and Wykes, Michelle N. (2013). PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria. Cell Reports, 5 (5), 1204-1213. doi: 10.1016/j.celrep.2013.11.002

Origin of Langerhans cells in normal skin and chronic GVHD after hematopoietic stem cell transplantation

Andani, Rafiq, Robertson, Ivan, MacDonald, Kelli P. A., Durrant, Simon, Hill, Geoffrey R. and Khosrotehrani, Kiarash (2013). Origin of Langerhans cells in normal skin and chronic GVHD after hematopoietic stem cell transplantation. Experimental Dermatology, Accepted Article (1), 1-11. doi: 10.1111/exd.12301

Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo

Zhang, Ping, Tey, Siok-Keen, Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Raju, Jyothy, Leveque, Lucie, Markey, Kate A., Varelias, Antiopi, Clouston, Andrew D., Lane, Steven W., Macdonald, Kelli P. A. and Hill, Geoffrey R. (2013). Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo. Journal of Immunology, 191 (10), 5291-5303. doi: 10.4049/jimmunol.1301181

Clinical Assessment of Anti-Viral CD8+ T Cell Immune Monitoring Using QuantiFERON-CMV® Assay to Identify High Risk Allogeneic Hematopoietic Stem Cell Transplant Patients with CMV Infection Complications

Tey, Siok-Keen, Kennedy, Glen A., Cromer, Deborah, Davenport, Miles P., Walker, Susan, Jones, Linda I., Crough, Tania, Durrant, Simon T., Morton, James A., Butler, Jason P., Misra, Ashish K., Hill, Geoffrey R. and Khanna, Rajiv (2013). Clinical Assessment of Anti-Viral CD8+ T Cell Immune Monitoring Using QuantiFERON-CMV® Assay to Identify High Risk Allogeneic Hematopoietic Stem Cell Transplant Patients with CMV Infection Complications. PLoS ONE, 8 (10) e74744, e74744. doi: 10.1371/journal.pone.0074744

CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus.

Ong, Monique L., Wikstrom, Matthew E., Fleming, Peter, Estcourt, Marie J., Hertzog, Paul J., Hill, Geoffrey R., Andoniou, Christopher E. and Degli-Esposti, Mariapia A. (2013). CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus.. Blood, 122 (1), 55-60. doi: 10.1182/blood-2012-12-471227

UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages

Handoko, Herlina Y., Rodero, Mathieu P., Boyle, Glen M., Ferguson, Blake, Engwerda, Christian, Hill, Geoff, Muller, H. Konrad, Khosrotehrani, Kiarash and Walker, Graeme J. (2013). UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages. Journal of Investigative Dermatology, 133 (7), 1803-1812. doi: 10.1038/jid.2013.9

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-alpha in a murine model of polycythemia vera

Mullally, Ann, Bruedigam, Claudia, Poveromo, Luke, Heidel, Florian H., Purdon, Amy, Vu, Therese, Austin, Rebecca, Heckl, Dirk, Breyfogle, Lawrence J., Kuhn, Catherine Paine, Kalaitzidis, Demetrios, Armstrong, Scott A., Williams, David A., Hill, Geoff R., Ebert, Benjamin L. and Lane, Steven W. (2013). Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-alpha in a murine model of polycythemia vera. Blood, 121 (18), 3692-3702. doi: 10.1182/blood-2012-05-432989

Promoting regulation via the inhibition of DNAM-1 after transplantation

Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Leveque, Lucie, Chan, Christopher J., Robb, Renee J., Markey, Kate A., Alexander, Kylie A., Varelias, Antiopi, Clouston, Andrew D., Smyth, Mark J., MacDonald, Kelli P.A. and Hill, Geoffrey R. (2013). Promoting regulation via the inhibition of DNAM-1 after transplantation. Blood, 121 (17), 3511-3520. doi: 10.1182/blood-2012-07-444026

CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3

Seillet, Cyril, Jackson, Jacob T., Markey, Kate A., Brady, Hugh J. M., Hill, Geoffrey R., MacDonald, Kelli P. A., Nutt, Stephen L. and Belz, Gabrielle T. (2013). CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood, 121 (9), 1574-1583. doi: 10.1182/blood-2012-07-445650

Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy

Coleman, Miranda A., Bridge, Jennifer A., Lane, Steven W., Dixon, Chantelle M., Hill, Geoffrey R., Wells, James W., Thomas, Ranjeny and Steptoe, Raymond J. (2013). Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood, 121 (6), 1049-1058. doi: 10.1182/blood-2012-06-434100

Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection

Zinkernagel, M.S., Chinnery, H.R., Ong, M.L., Petitjean, C., Voigt, V., McLenachan, S., McMenamin, P.G., Hill, G.R., Forrester, J.V., Wikstrom, M.E. and Degli-Esposti, M.A. (2013). Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection. American Journal of Pathology, 182 (3), 875-885. doi: 10.1016/j.ajpath.2012.11.031

Identification and expansion of highly suppressive CD8 +FoxP3 + regulatory T cells after experimental allogeneic bone marrow transplantation

Robb, R.J., Lineburg, K.E., Kuns, R.D., Wilson, Y.A., Raffelt, N.C., Olver, S.D., Varelias, A., Alexander, K.A., Teal, B.E., Sparwasser, T., Hammerling, G.J., Markey, K.A., Koyama, M., Clouston, A.D., Engwerda, C.R., Hill, G.R. and MacDonald, K.P.A. (2012). Identification and expansion of highly suppressive CD8 +FoxP3 + regulatory T cells after experimental allogeneic bone marrow transplantation. Blood, 119 (24), 5898-5908. doi: 10.1182/blood-2011-12-396119

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets

Markey, Kate A., Koyama, Motoko, Kuns, Rachel D., Lineburg, Katie E., Wilson, Yana A., Olver, Stuart D., Raffelt, Neil C., Don, Alistair L. J., Varelias, Antiopi, Robb, Renee J., Cheong, Melody, Engwerda, Christian R., Steptoe, Raymond J., Ramshaw, Hayley S., Lopez, Angel F., Vega-Ramos, Javier, Lew, Andrew M., Villadangos, Jose A., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2012). Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets. Blood, 119 (24), 5918-5930. doi: 10.1182/blood-2011-12-398164

The interferon-dependent orchestration of innate and adaptive immunity after transplantation

Robb, R.J. and Hill, G.R. (2012). The interferon-dependent orchestration of innate and adaptive immunity after transplantation. Blood, 119 (23), 5351-5358. doi: 10.1182/blood-2012-02-368076

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Raffelt, Neil C., Wilson, Yana A., Don, Alistair L. J., Lineburg, Katie E., Cheong, Melody, Robb, Renee J., Markey, Kate A., Varelias, Antiopi, Malissen, Bernard, Hammerling, Gunter J., Clouston, Andrew D., Engwerda, Christian R., Bhat, Purnima, MacDonald, Kelli P. A. and Hill, Geoffrey R. (2012). Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease. Nature Medicine, 18 (1), 135-142. doi: 10.1038/nm.2597

The IL-17 Differentiation Pathway and Its Role in Transplant Outcome

Serody, J.S. and Hill, G.R. (2012). The IL-17 Differentiation Pathway and Its Role in Transplant Outcome. Biology of Blood and Marrow Transplantation, 18 (1 SUPPL.), S56-S61. doi: 10.1016/j.bbmt.2011.10.001

Disseminated varicella infection caused by varicella vaccine strain in a child with low invariant natural killer T cells and diminished CD1d expression

Banovic, Tatjana, Yanilla, Mayonelo, Simmons, Russell, Robertson, Ian, Schroder, Wayne A., Raffelt, Neil. C., Wilson, Yana A., Hill, Geoffrey R., Hogan, Patrick and Nourse, Clare B. (2011). Disseminated varicella infection caused by varicella vaccine strain in a child with low invariant natural killer T cells and diminished CD1d expression. Journal of Infectious Diseases, 204 (12), 1893-1901. doi: 10.1093/infdis/jir660

Vaccinating donors to improve GVL

Hill, Geoffrey R. (2011). Vaccinating donors to improve GVL. Blood, 118 (22), 5720-5721. doi: 10.1182/blood-2011-10-381160

Critical roles for LIGHT and its Receptors in Generating T cell-mediated immunity during Leishmania donovani infection

Stanley, Amanda C., Rivera, Fabian de Labastida, Haque, Ashraful, Sheel, Meru, Zhou, Yonghong, Amante, Fiona H., Bunn, Patrick T., Randall, Louise M., Pfeffer, Klaus, Scheu, Stefanie, Hickey, Michael J., Saunders, Bernadette M., Ware, Carl, Hill, Geoff R., Tamada, Koji, Kaye, Paul M. and Engwerda, Christian R. (2011). Critical roles for LIGHT and its Receptors in Generating T cell-mediated immunity during Leishmania donovani infection. PLoS Pathogens, 7 (10) e1002279, 1-15. doi: 10.1371/journal.ppat.1002279

Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation

O'Sullivan, Brendan J., Pai, Saparna, Street, Shayna, An, Xiayou, Macdonald, Kelli P. A., Wong, Michelle, Strutton, Geoffrey, Gerondakis, Steve, Steptoe, Raymond J., Fazekas de St Groth, Barbara, Hill, Geoffrey R. and Thomas, Ranjeny (2011). Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation. Journal of Immunology, 187 (7), 4018-4030. doi: 10.4049/jimmunol.1101727

Type I-IFNs control GVHD and GVL responses after transplantation

Robb, Renee J., Kreijveld, Ellen, Kuns, Rachel D., Wilson, Yana A., Olver, Stuart D., Don, Alistair L. J., Raffelt, Neil C., De Weerd, Nicole A., Lineburg, Katie E., Varelias, Antiopi, Markey, Kate A., Koyama, Motoko, Clouston, Andrew D., Hertzog, Paul J., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2011). Type I-IFNs control GVHD and GVL responses after transplantation. Blood, 118 (12), 3399-3409. doi: 10.1182/blood-2010-12-325746

Type I interferons suppress CD4+ T-cell-dependent parasite control during blood-stage Plasmodium infection

Haque, Ashraful, Best, Shannon E., Ammerdorffer, Anne, Desbarrieres, Laure, de Oca, Marcela Montes, Amante, Fiona H., Rivera, Fabian de Labastida, Hertzog, Paul, Boyle, Glen M., Hill, Geoffrey R. and Engwerda, Christian R. (2011). Type I interferons suppress CD4+ T-cell-dependent parasite control during blood-stage Plasmodium infection. European Journal of Immunology, 41 (9), 2688-2698. doi: 10.1002/eji.201141539

CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis

McNally, Alice, Hill, Geoffrey R., Sparwasser, Tim, Thomas, Ranjeny and Steptoe, Raymond J. (2011). CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 108 (18), 7529-7534. doi: 10.1073/pnas.1103782108

Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation

Tawara, Isao, Koyama, Motoko, Liu, Chen, Toubai, Tomomi, Thomas, Dafydd, Evers, Rebecca, Chockley, Peter, Nieves, Evelyn, Sun, Yaping, Lowler, Kathleen P., Malter, Chelsea, Nishimoto, Norihiro, Hill, Geoffrey R. and Reddy, Pavan (2011). Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation. Clinical Cancer Research, 17 (1), 77-88. doi: 10.1158/1078-0432.CCR-10-1198

CD4+ natural regulatory T Cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo

Haque, Ashraful, Best, Shannon E., Amante, Fiona H., Mustafah, Seri, Desbarrieres, Laure, de Labastida, Fabian, Sparwasser, Tim, Hill, Geoffrey R. and Engwerda, Christian R. (2010). CD4+ natural regulatory T Cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PLoS Pathogens, 6 (12) e1001221, 1 - e1001221-14 - e1001221. doi: 10.1371/journal.ppat.1001221

An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation

MacDonald, Kelli P. A., Palmer, James S., Cronau, Stephen, Seppanen, Elke Jane, Olver, Stuart, Raffelt, Neil C., Kuns, Rachel, Pettit, Allison R., Clouston, Andrew, Wainwright, Brandon J., Branstetter, Dan, Smith, Jeffrey, Paxton, Raymond J., Cerretti, Douglas Pat, Bonham, Lynn, Hill, Geoffrey R. and Hume, David A. (2010). An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation. Blood, 116 (19), 3955-3963. doi: 10.1182/blood-2010-02-266296

Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria

Amante, FH, Haque, A, Stanley, AC, Rivera, FD, Randall, LM, Wilson, YA, Yeo, G, Pieper, C, Crabb, BS, de Koning-Ward, TF, Lundie, RJ, Good, MF, Pinzon-Charry, A, Pearson, MS, Duke, MG, McManus, DP, Loukas, A, Hill, GR and Engwerda, CR (2010). Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria. Journal of Immunology, 185 (6), 3632-3642. doi: 10.4049/jimmunol.1000944

Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma

Hill, Geoffrey R., Olver, Stuart D., Kuns, Rachel D., Varelias, Antiopi, Raffelt, Neil C., Don, Alistair L., Markey, Kate A., Wilson, Yana A., Smyth, Mark J., Iwakura, Yoichiro, Tocker, Joel, Clouston, Andrew D. and MacDonald, Kelli P. A. (2010). Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood, 116 (5), 819-828. doi: 10.1182/blood-2009-11-256495

SOCS3 regulates graft-versus-host disease

Hill, Geoffrey R., Kuns, Rachel D., Raffelt, Neil C., Don, Alistair L. J., Olver, Stuart D., Markey, Kate A., Wilson, Yana A., Tocker, Joel, Alexander, Warren S., Clouston, Andrew D., Roberts, Andrew W. and MacDonald, Kelli P. A. (2010). SOCS3 regulates graft-versus-host disease. Blood, 116 (2), 287-296. doi: 10.1182/blood-2009-12-259598

Innate immunity defines the capacity of antiviral T cells to limit persistent infection

Andrews, Daniel M., Estcourt, Marie J., Andoniou, Christopher E, Wikstrom, Matthew E., Khong, Andrea, Voigt, Valentina, Fleming, Peter, Tabarias, Hyacinth, Hill, Geoffrey R., van der Most, Robbert G., Scalzo, Anthony A., Smyth, Mark J. and Degli-Esposti, Mariapia A. (2010). Innate immunity defines the capacity of antiviral T cells to limit persistent infection. Journal of Experimental Medicine, 207 (6), 1333-1343. doi: 10.1084/jem.20091193

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis

Teng, Michele W. L., Andrews, Daniel M., McLaughlin, Nicole, von Scheidt, Bianca, Ngiow, Shin Foong, Moeller, Andreas, Hill, Geoffrey R., Iwakura, Yoichiro, Oft, Martin and Smyth, Mark J. (2010). IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis. Proceedings of the National Academy of Sciences of USA, 107 (18), 8328-8333. doi: 10.1073/pnas.1003251107

Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity

Haque, Ashraful, Stanley, Amanda C., Amante, Fiona H., de Labastida Rivera, Fabian, Zhou, YongHong, Kuns, Rachel D., Yardley, Vanessa, Sakaguchi, Shimon, Hill, Geoffrey R. and Engwerda, Christian R. (2010). Therapeutic glucocorticoid-induced TNF receptor-mediated amplification of CD4+ T cell responses enhances antiparasitic immunity. Journal of Immunology, 184 (5), 2583-2592. doi: 10.4049/jimmunol.0903080

Soluble lymphotoxin is an important effector molecule in GVHD and GVL

Markey, KA, Burman, AC, Banovic, T, Kuns, RD, Raffelt, NC, Rowe, V, Olver, SD, Don, ALJ, Morris, ES, Pettit, AR, Wilson, YA, Robb, RJ, Randall, LM, Korner, H, Engwerda, CR, Clouston, AD, MacDonald, KPA and Hill, GR (2010). Soluble lymphotoxin is an important effector molecule in GVHD and GVL. Blood, 115 (1), 122-132. doi: 10.1182/blood-2009-01-199927

Successful immunotherapy of HCMV disease using virus-specific T cells expanded from an allogeneic stem cell transplant recipient

Hill, G. R., Tey, S-K., Beagley, L., Crough, T., Morton, J.A., Clouston, A.D., Whiting, P. and Khanna, R. (2010). Successful immunotherapy of HCMV disease using virus-specific T cells expanded from an allogeneic stem cell transplant recipient. American Journal of Transplantation, 10 (1), 173-179. doi: 10.1111/j.1600-6143.2009.02872.x

Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration

Kuns, Rachel D., Morris, Edward S., MacDonald, Kelli P.A., Markey, Kate A., Morris, Helen M., Raffelt, Neil C., Banovic, Tatjana, Don, Alistair L.J., Rowe, Vanessa, Burman, Angela C., Clouston, Andrew D., Farah, Camile, Besra, Gurdyal S., Illarionov, Petr A., Smyth, Mark J., Porcelli, Steven A. and Hill, Geoffrey R. (2009). Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration. Blood, 113 (23), 5999-6010. doi: 10.1182/blood-2008-10-183335

Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation

Markey, KA, Banovic, T, Kuns, RD, Olver, SD, Don, ALJ, Raffelt, NC, Wilson, YA, Raggatt, LJ, Pettit, AR, Bromberg, JS, Hill, GR and MacDonald, KPA (2009). Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation. BLOOD, 113 (22), 5644-5649. doi: 10.1182/blood-2008-12-191833

Induction of natural killer T cell–dependent alloreactivity by administration of granulocyte colony–stimulating factor after bone marrow transplantation

Edward S Morris, Kelli P A MacDonald, Rachel D Kuns, Helen M Morris, Tatjana Banovic, Alistair L J Don, Vanessa Rowe, Yana A Wilson, Neil C Raffelt, Christian R Engwerda, Angela C Burman, Kate A Markey, Dale I Godfrey, Mark J Smyth and Geoffrey R Hill (2009). Induction of natural killer T cell–dependent alloreactivity by administration of granulocyte colony–stimulating factor after bone marrow transplantation. Nature Medicine, 15 (4), 436-441. doi: 10.1038/nm.1948

Erratum

Markey, K. A., MacDonald, K. P. and Hill, G. R. (2009). Erratum. Tissue Antigens, 73 (2), 192-192. doi: 10.1111/j.1399-0039.2008.01203.x

Graft-versus-Host Disease Prevents the Maturation of Plasmacytoid Dendritic Cells

Tatjana Banovic, Kate A. Markey, Rachel D. Kuns, Stuart D. Olver, Neil C. Raffelt, Alistair L. Don, Mariapia A. Degli-Esposti, Christian R. Engwerda, Kelli P. A. MacDonald and Geoffrey R. Hill (2009). Graft-versus-Host Disease Prevents the Maturation of Plasmacytoid Dendritic Cells. Journal of Immunology, 182 (2), 912-920. doi: 10.4049/jimmunol.182.2.912

Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects

Banovic, Tatjana, MacDonald , Kelli P. A., Markey, Kate A., Morris, Edward S., Kuns, Rachel D., Varelias, Antiopi and Hill, Geofffrey R. (2009). Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects. Biology of Blood and Marrow Transplantation, 15 (1), 126-130. doi: 10.1016/j.bbmt.2008.11.019

Inflammation and bone marrow transplantation

Hill, Geoffrey R. (2009). Inflammation and bone marrow transplantation. Biology of Blood and Marrow Transplantation, 15 (1 SUPPL.), 139-141. doi: 10.1016/j.bbmt.2008.11.008

Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT

Markey, Kate A., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2009). Recipient plasmacytoid DCs are not required to prime allogeneic T-cell responses after BMT. Blood, 113 (23), 6038-6039. doi: 10.1182/blood-2009-03-212944

Cutting edge: Selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA

Randall, Louise M., Amante, Fiona H., Zhou, Yonghong, Stanley, Amanda C., Haque, Ashraful, Rivera, Fabian, Pfeffer, Klaus, Scheu, Stefanie, Hill, Geoff R., Tamada, Koji and Engwerda, Christian R. (2008). Cutting edge: Selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA. Journal of Immunology, 181 (11), 7458-7460. doi: 10.4049/jimmunol.181.11.7458

Impact of cytokine gene polymorphisms on graft-vs-host disease

Markey, K. A., MacDonald, K. P. A. and Hill, G. R. (2008). Impact of cytokine gene polymorphisms on graft-vs-host disease. Tissue Antigens, 72 (6), 507-516. doi: 10.1111/j.1399-0039.2008.01139.x

VCAM-1 and VLA-4 modulate dendritic cell IL-12p40 production in experimental visceral leishmaniasis

Stanley, Amanda C., Dalton, Jane E., Rossotti, Susanna H., MacDonald, Kelli P., Zhou, Yonghong, Rivera, Fabian, Schroder, Wayne A., Maroof, Asher, Hill, Geoff R., Kaye, Paul M. and Engwerda, Christian R. (2008). VCAM-1 and VLA-4 modulate dendritic cell IL-12p40 production in experimental visceral leishmaniasis. PLoS Pathogens, 4 (9) e1000158, e1000158-1-e1000158-11. doi: 10.1371/journal.ppat.1000158

Common strategies to prevent and modulate experimental cerebral malaria in different susceptible mouse strains

Randall, Louise M., Amante, Fiona H., McSweeney, Karli A., Zhou, Yonghong, Stanley, Amanda C., Haque, Ashraful, Jones, Malcolm K., Hill, Geoff R., Boyle, Glen M. and Engwerda, Christian R. (2008). Common strategies to prevent and modulate experimental cerebral malaria in different susceptible mouse strains. Infection and Immunity, 76 (7), 3312-3320. doi: 10.1128/IAI.01475-07

Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis

Amante, Fiona H., Engwerda, Christian R., Godfrey, Dale I., Haque, Ashraful, Hill, Geoff R., Pellicci, Daniel G., Randall, Louise M., Smyth, Mark J., Stanley, Amanda C. and Zhou, Yonghong (2008). Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis. PLoS Pathogens, 4 (2), e1000028-1-e1000028-13. doi: 10.1371/journal.ppat.1000028

Mouse models of bone marrow transplantation

Reddy, Pavan, Negrin, Robert and Hill, Geoffrey R. (2008). Mouse models of bone marrow transplantation. Biology of Blood and Marrow Transplantation, 14 (1, Supplement), 129-135. doi: 10.1016/j.bbmt.2007.10.021

A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria

Amante, Fiona H., Stanley, Amanda C., Randall, Louise M., Zhou, Yonghong, Haque, Ashraful, McSweeney, Karli, Waters, Andrew P., Janse, Chris J., Good, Michael F., Hill, Geoff R. and Engwerda, Christian R. (2007). A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria. American Journal of Pathology, 171 (2), 548-559. doi: 10.2353/ajpath.2007.061033

IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract

Burman, Angela C., Banovic, Tatjana, Kuns, Rachel D., Clouston, Andrew D., Stanley, Amanda C., Morris, Edward S., Rowe, Vanessa, Bofinger, Helen, Skoczylas, Renae, Raffelt, Neil, Fahy, Olivier, McColl, Shaun R., Engwerda, Christian R., McDonald, Kelli P. A. and Hill, Geoffrey R. (2007). IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood, 110 (3), 1064-1072. doi: 10.1182/blood-2006-12-063982

Effector and regulatory T cell function is differentially regulated by RelB within antigen presenting cells during GVHD

MacDonald, Kelli P. A., Kuns, Rachel D., Rowe, Vanessa, Morris, Edward S., Banovic, Tatjana, Bofinger, Helen, O'Sullivan, Brendan, Markey, Kate A., Don, Alistair L., Thomas, Ranjeny and Hill, Geoffrey R. (2007). Effector and regulatory T cell function is differentially regulated by RelB within antigen presenting cells during GVHD. Blood, 109 (11), 5049-5057. doi: 10.1182/blood-2007-01-067249

Cutting Edge: Conventional Dendritic Cells are the Critical APC Required for the Induction of Experimental Cerebral Malaria

deWalick, Saskia, Amante, Fiona H., McSweeney, Karli A., Randall, Louise M., Stanley, Amanda C., Haque, Ashraful, Kuns, Rachel D., MacDonald, Kelli P. A., Hill, Geoff R. and Engwerda, Christian R. (2007). Cutting Edge: Conventional Dendritic Cells are the Critical APC Required for the Induction of Experimental Cerebral Malaria. Journal of Immunology, 178 (10), 6033-6037. doi: 10.4049/jimmunol.178.10.6033

Advances in the understanding of acute graft-versus-host disease

Morris, Edward S. and Hill, Geoffrey R. (2007). Advances in the understanding of acute graft-versus-host disease. British Journal of Haematology, 137 (1), 3-19. doi: 10.1111/j.1365-2141.2007.06510.x

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

McAuley, Julie L., Linden, Sara K., Png, Chin Wen, King, Rebecca M., Pennington, Helen L., Gendler, Sandra J., Florin, Timothy H., Hill, Geoff R., Korolik, Victoria and McGuckin, Michael A. (2007). MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. Journal of Clinical Investigation, 117 (8), 2313-2324. doi: 10.1172/JCI26705

Allogeneic stem cell transplantation with peripheral blood stem cells mobilized by pegylated G-CSF

Hill, Geoffrey R., Morris, Edward S., Fuery, Madonna, Hutchins, Cheryl, Butler, Jason, Grigg, Andrew, Roberts, Andrew, Bradstock, Ken, Szer, Jeffrey, Kennedy, Glen, Morton, James and Durrant, Simon (2006). Allogeneic stem cell transplantation with peripheral blood stem cells mobilized by pegylated G-CSF. Biology of Blood and Marrow Transplantation, 12 (6), 603-607. doi: 10.1016/j.bbmt.2006.03.001

Combination antithymocyte globulin and soluble TNF alpha inhibitor (etanercept) +/- mycophenolate mofetil for treatment of steroid refractory acute graft-versus-host disease

Kennedy, GA, Butler, J, Western, R, Morton, J, Durrant, S and Hill, GR (2006). Combination antithymocyte globulin and soluble TNF alpha inhibitor (etanercept) +/- mycophenolate mofetil for treatment of steroid refractory acute graft-versus-host disease. Bone Marrow Transplantation, 37 (12), 1143-1147. doi: 10.1038/sj.bmt.1705380

Myeloablative allogeneic stem cell transplantation for advanced stage multiple myeloma: very long-term follow up of a single center experience

Kennedy, GA, Butler, J, Morton, J, Hill, G, Western, R, Cummings, J, Allison, R and Durrant, S (2006). Myeloablative allogeneic stem cell transplantation for advanced stage multiple myeloma: very long-term follow up of a single center experience. Clinical and Laboratory Haematology, 28 (3), 189-197. doi: 10.1111/j.1365-2257.2006.00773.x

Stem cell mobilization with G-CSF analogs: A rational approach to separate GVHD and GVL?

Morris, Edward S., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2006). Stem cell mobilization with G-CSF analogs: A rational approach to separate GVHD and GVL?. Blood, 107 (9), 3430-3435. doi: 10.1182/blood-2005-10-4299

NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs

Morris, Edward S., MacDonald, Kelli P. A., Rowe, Vanessa, Banovic, Tatjana, Kuns, Rachel D., Don, Alistair L. J., Bofinger, Helen M., Burman, Angela C., Olver, Stuart D., Kienzle, Norbert, Porcelli, Steven A., Pellicci, Daniel G., Godfrey, Dale I., Smyth, Mark J. and Hill, Geoffrey R. (2005). NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs. Journal of Clinical Investigation, 115 (11), 3093-3103. doi: 10.1172/JCI25249

A prognostic model for prolonged event-free survival after autologous or allogeneic blood or marrow transplantation for relapsed and refractory Hodgkin's disease

Tey, S ., Butler, J ., Durrant, S., Hill, G., Morton, J., Kennedy, G. and Kennedy, G. (2005). A prognostic model for prolonged event-free survival after autologous or allogeneic blood or marrow transplantation for relapsed and refractory Hodgkin's disease. Bone Marrow Transplantation, 36 (6), 553-554. doi: 10.1038/sj.bmt.1705044

TGF-beta in allogeneic stem cell transplantation: friend or foe?

Banovic, T, MacDonald, KPA, Morris, ES, Rowe, V, Kuns, R, Don, A, Kelly, J, Ledbetter, S, Clouston, AD and Hill, GR (2005). TGF-beta in allogeneic stem cell transplantation: friend or foe?. Blood, 106 (6), 2206-2214. doi: 10.1182/blood-2005-01-0062.

The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion

MacDonald, Kelli P. A., Rowe, Vanessa, Bofinger, Helen. M., Thomas, Ranjeny, Sasmono, Tedjo, Hume, David A. and Hill, Geoffrey R. (2005). The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. Journal of Immunology, 175 (3), 1399-1405. doi: 10.4049/jimmunol.175.3.1399

Host gamma delta T cells: an innate bridge to the epithelial targets of GVHD?

Hill, GR (2005). Host gamma delta T cells: an innate bridge to the epithelial targets of GVHD?. Blood, 106 (2), 393-394. doi: 10.1182/blood-2005-04-1616

Twenty-four hour continuous infusion of amphotericin B for the treatment of suspected or proven fungal infection in haematology patients

Hall, P, Kennedy, G, Morton, J, Hill, GR and Durrant, S (2005). Twenty-four hour continuous infusion of amphotericin B for the treatment of suspected or proven fungal infection in haematology patients. Internal Medicine Journal, 35 (6), 374-374. doi: 10.1111/j.1445-5994.2005.00847.x

Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production

Johnson, BJ, Le, TTT, Dobbin, CA, Banovic, T, Howard, CB, Flores, FDL, Vanags, D, Naylor, DJ, Hill, GR and Suhrbier, A (2005). Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. Journal of Biological Chemistry, 280 (6), 4037-4047. doi: 10.1074/jbc.M411569200

Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells

MacDonald, Kelli P. A., Rowe, Vanessa, Clouston, Andrew D., Welply, Joseph K., Kuns, Rachel D., Ferrara, James L. M., Thomas, Ranjeny and Hill, Geoffrey R. (2005). Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells. Journal of Immunology, 174 (4), 1841-1850. doi: 10.4049/jimmunol.174.4.1841

Predicting survival for myeloid leukemia after HLA-identical sibling donor allogeneic stem cell transplantation

Kennedy, GA, Butler, J, Western, R, Morton, J, Hill, G and Durrant, S (2005). Predicting survival for myeloid leukemia after HLA-identical sibling donor allogeneic stem cell transplantation. Leukemia, 19 (2), 317-318. doi: 10.1038/sj.leu.2403549

Chronic graft-versus-host disease after granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation: The role of donor T-cell dose and differentiation

MacDonald, Kelli P. A., Rowe, Vanessa, Filippich, Cheryl, Johnson, Diana, Morris, Edward S., Clouston, Andrew D., Ferrara, James L. M. and Hill, Geoffrey R. (2004). Chronic graft-versus-host disease after granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation: The role of donor T-cell dose and differentiation. Biology of Blood And Marrow Transplantation, 10 (6), 373-385. doi: 10.1016/j.bbmt.2004.02.002

Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance

Morris, ES, MacDonald, KPA, Rowe, V, Johnson, DH, Banovic, T, Clouston, AD and Hill, GR (2004). Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance. Blood, 103 (9), 3573-3581. doi: 10.1182/blood-2003-08-2864

Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression

Vuckovic, S., Kim, M., Turtle, C. J., Khalil, D., Crosbie, G.V., Williams, K., Williams, N., Brown, L., Kelly, C., Stravos, P., Rodwell, R., Hill, G., Wright, S. J., Taylor, K., Gill, D., Marlton, P., Bradstock, K. and Hart, D. N. J. (2003). Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression. Blood, 101 (6), 2314-2317. doi: 10.1182/blood-2002-03-0973

Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation

MacDonald, Kelli P. A., Rowe, Vanessa, Filippich, Cheryl, Thomas, Ranjeny, Clouston, Andrew D., Welply, Joseph K., Hart, Derek N. J., Ferrara, James L. M. and Hill, Geoffrey R. (2003). Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation. Blood, 101 (5), 2033-2042. doi: 10.1182/blood-2002-05-1529

Relapsed plasma cell leukaemia presenting with aggressive extramedullary plasmacytomas in the meninges and testis - A missed opportunity for induction CNS prophylaxis

Wellwood, J, Taylor, K, Wright, S, Bentley, M, Hill, G, Phan, H, Norris, D and Livsey, R (2002). Relapsed plasma cell leukaemia presenting with aggressive extramedullary plasmacytomas in the meninges and testis - A missed opportunity for induction CNS prophylaxis. Leukemia & Lymphoma, 43 (4), 893-896. doi: 10.1080/10428190290017060

Keratinocyte Growth factor (KGF) in hematology and oncology

MacDonald, KPA and Hill, GR (2002). Keratinocyte Growth factor (KGF) in hematology and oncology. Current Pharmaceutical Design, 8 (5), 395-403. doi: 10.2174/1381612023396104

LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation

Cooke, KR, Gerbitz, A, Crawford, JM, Teshima, T, Hill, GR, Tesolin, A, Rossignol, DP and Ferrara, JLM (2001). LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation. Journal of Clinical Investigation, 107 (12), 1581-1589. doi: 10.1172/JCI12156

Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation

Teshima, T, Mach, N, Hill, GR, Pan, LY, Gillessen, S, Dranoff, G and Ferrara, JLM (2001). Tumor cell vaccine elicits potent antitumor immunity after allogeneic T-cell-depleted bone marrow transplantation. Cancer Research, 61 (1), 162-171.

Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: Potential role for a gut-lung axis of inflammation

Cooke, KR, Hill, GR, Gerbitz, A, Kobzik, L, Martin, TR, Crawford, JM, Brewer, JP and Ferrara, JLM (2000). Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: Potential role for a gut-lung axis of inflammation. Journal of Immunology, 165 (11), 6612-6619. doi: 10.4049/jimmunol.165.11.6612

Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation

Cooke, KR, Hill, GR, Gerbitz, A, Kobzik, L, Martin, TR, Crawford, JM, Brewer, JP and Ferrara, JLM (2000). Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation. Transplantation, 70 (2), 272-279. doi: 10.1097/00007890-200007270-00006

The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation

Hill, GR and Ferrara, JLM (2000). The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood, 95 (9), 2754-2759.

G-CSF modulates cytokine profile of dendritic cells and decreases acute graft-versus-host disease through effects on the donor rather than the recipient

Reddy, , Hill, GR, Pan, LY, Gerbitz, A, Teshima, T, Brinson, Y and Ferrara, JLM (2000). G-CSF modulates cytokine profile of dendritic cells and decreases acute graft-versus-host disease through effects on the donor rather than the recipient. Transplantation, 69 (4), 691-693. doi: 10.1097/00007890-200002270-00041

The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity

Hill, GR, Teshima, T, Rebel, , Krijanovski, OI, Cooke, KR, Brinson, YS and Ferrara, JLM (2000). The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity. Journal of Immunology, 164 (2), 656-663. doi: 10.4049/jimmunol.164.2.656

Assessment of cardiotoxicity during haemopoietic stem cell transplantation with plasma brain natriuretic peptide

Snowden, JA, Hill, GR, Hunt, P, Carnoutsos, S, Spearing, RL, Espiner, E and Hart, DNJ (2000). Assessment of cardiotoxicity during haemopoietic stem cell transplantation with plasma brain natriuretic peptide. Bone Marrow Transplantation, 26 (3), 309-313. doi: 10.1038/sj.bmt.1702507

Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level

Rebel, , Hartnett, S, Hill, GR, Lazo-Kallanian, SB, Ferrara, JLM and Sieff, CA (1999). Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level. Journal of Experimental Medicine, 190 (10), 1493-1503. doi: 10.1084/jem.190.10.1493

Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia

Hill, GR, Teshima, T, Gerbitz, A, Pan, LY, Cooke, KR, Brinson, YS, Crawford, JM and Ferrara, JLM (1999). Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. Journal of Clinical Investigation, 104 (4), 459-467. doi: 10.1172/JCI6896

IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation

Teshima, T, Hill, GR, Pan, LY, Brinson, YS, van den Brink, MRM, Cooke, KR and Ferrara, JLM (1999). IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation. Journal of Clinical Investigation, 104 (3), 317-325. doi: 10.1172/JCI7111

Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease

Krijanovski, OI, Hill, GR, Cooke, KR, Teshima, T, Crawford, JM, Brinson, YS and Ferrara, JLM (1999). Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease. Blood, 94 (2), 825-831.

Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease

Pan, LP, Teshima, T, Hill, GR, Bungard, D, Brinson, YS, Reddy, VS, Cooke, KR and Ferrara, LM (1999). Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease. Blood, 93 (12), 4071-4078.

Pretransplant chemotherapy reduces inflammatory cytokine production and acute graft-versus-host disease after allogeneic bone marrow transplantation

Hill, GR, Cooke, KR, Brinson, YS, Bungard, D and Ferrara, JLM (1999). Pretransplant chemotherapy reduces inflammatory cytokine production and acute graft-versus-host disease after allogeneic bone marrow transplantation. Transplantation, 67 (11), 1478-1480. doi: 10.1097/00007890-199906150-00015

Dendritic cell immunotherapy for cancer: Application to low-grade lymphoma and multiple myeloma

Hart, D. N. J. and Hill, G. R. (1999). Dendritic cell immunotherapy for cancer: Application to low-grade lymphoma and multiple myeloma. Immunology and Cell Biology, 77 (5), 451-459. doi: 10.1046/j.1440-1711.1999.00859.x

Congenital dyserythropoiesis with intererythroblastic chromatin bridges and ultrastructurally-normal erythroblast heterochromatin: a new disorder

Wickramashinghe, SN, Spearing, RL and Hill, GR (1998). Congenital dyserythropoiesis with intererythroblastic chromatin bridges and ultrastructurally-normal erythroblast heterochromatin: a new disorder. British Journal of Haematology, 103 (3), 831-834.

Tumor necrosis factor-alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease

Cooke, KR, Hill, GR, Crawford, JM, Bungard, D, Brinson, YS, Delmonte, J and Ferrara, JLM (1998). Tumor necrosis factor-alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease. Journal of Clinical Investigation, 102 (10), 1882-1891. doi: 10.1172/JCI4285

Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation

Hill, GR, Cooke, KR, Teshima, T, Crawford, JM, Keith, JC, Brinson, YS, Bungard, D and Ferrara, JLM (1998). Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. Journal of Clinical Investigation, 102 (1), 115-123. doi: 10.1172/JCI3132

The role of cytokines in acute graft-versus-host disease

Hill, GR, Krenger, W and Ferrara, JLM (1997). The role of cytokines in acute graft-versus-host disease. Cytokines Cellular & Molecular Therapy, 3 (4), 257-265.

Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines

Hill, GR, Crawford, JM, Cooke, KR, Brinson, YS, Pan, LY and Ferrara, JLM (1997). Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines. Blood, 90 (8), 3204-3213.

Cytokine cascades in acute graft-versus-host disease

Krenger, W, Hill, GR and Ferrara, JLM (1997). Cytokine cascades in acute graft-versus-host disease. Transplantation, 64 (4), 553-558. doi: 10.1097/00007890-199708270-00001

The use of low dose Orgaran in heparin-induced thrombocytopenia associated with in vitro platelet aggregation at higher Orgaran concentrations

Hill, GR, Hickton, C, Henderson, S and Patton, WN (1997). The use of low dose Orgaran in heparin-induced thrombocytopenia associated with in vitro platelet aggregation at higher Orgaran concentrations. Clinical and Laboratory Haematology, 19 (2), 155-157. doi: 10.1046/j.1365-2257.1997.00052.x

Acquired heparin-like anticoagulants: A second case in metastatic breast carcinoma and literature review

Hill, GR, Hickton, CM, Brennan, SO, Atkinson, CH and Heaton, DC (1996). Acquired heparin-like anticoagulants: A second case in metastatic breast carcinoma and literature review. Clinical and Laboratory Haematology, 18 (4), 291-295.

Pulmonary hypertension as a consequence of alveolar capillary plugging by malignant megakaryocytes in essential thrombocythaemia

Hill, G, McClean, D, Fraser, R, Hart, D, Crozier, , Snowden, J and Gibbons, S (1996). Pulmonary hypertension as a consequence of alveolar capillary plugging by malignant megakaryocytes in essential thrombocythaemia. Australian and New Zealand Journal of Medicine, 26 (6), 852-853. doi: 10.1111/j.1445-5994.1996.tb00642.x

High dose therapy and autologous bone marrow versus blood cell rescue

Hill, GR, Inder, A and Patton, WN (1996). High dose therapy and autologous bone marrow versus blood cell rescue. New Zealand Medical Journal, 109 (1016), 45-48.

Donor leukocyte infusions in the treatment of chronic myeloid leukemia in relapse post bone marrow transplantation

Hill, GR, Hart, DNJ, Moore, AF and Morris, CM (1996). Donor leukocyte infusions in the treatment of chronic myeloid leukemia in relapse post bone marrow transplantation. Pathology, 28 (1), 51-53. doi: 10.1080/00313029600169523

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice

Adams, Rachael C., Carter-Cusack, Dylan, Llanes, Genesis T., Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R., Furlan, Scott N., Zeiser, Robert and MacDonald, Kelli P. A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice. 65th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, United States, 9-12 December 2023. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2023-184841

Type-1 regulatory T cells are critical for curative immunotherapy outcomes

Zhang, Ping, Gartlan, Kate H., Minnie, Simone A., Yeh, Albert, Takahashi, Shuichiro, Atilla, Erden, Nemychenkov, Nicole S., Boiko, Julie R., Schmidt, Christine R., Legg, Samuel R.W., Sekiguchi, Tomoko, Ensbey, Kathleen S., Koyama, Motoko, Furlan, Scott N. and Hill, Geoffrey R. (2023). Type-1 regulatory T cells are critical for curative immunotherapy outcomes. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.173.11

Pilot Trial of Interferon-γ and Donor Lymphocyte Infusion to Treat Relapsed Myeloblastic Malignancies after Allogeneic Hematopoietic Stem Cell Transplantation

Geramita, Emily, Ventura, Kedwin, Bhise, Shruti, Moore, Erika, Krakow, Elizabeth F., Hill, Geoffrey R., Furlan, Scott N., Shlomchik, Warren D. and Ito, Sawa (2023). Pilot Trial of Interferon-γ and Donor Lymphocyte Infusion to Treat Relapsed Myeloblastic Malignancies after Allogeneic Hematopoietic Stem Cell Transplantation. 2023 Tandem Meetings of ASTCT and CIBMTR, Orlando, FL United States, 15-19 February 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/s2666-6367(23)00122-7

Single Cell RNA Sequencing Identifies IL-17- and CSF-1-Associated Pathologic Gene Expression Signatures in Blood during Chronic Graft-Versus-Host Disease

Boiko, Julie R., Ensbey, Kathleen S., Schmidt, Christine R., Waltner, Olivia G., Minnie, Simone A., Furlan, Scott N. and Hill, Geoffrey R. (2023). Single Cell RNA Sequencing Identifies IL-17- and CSF-1-Associated Pathologic Gene Expression Signatures in Blood during Chronic Graft-Versus-Host Disease. 2023 Tandem Meetings of ASTCT and CIBMTR, Orlando, FL United States, 15-19 February 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/s2666-6367(23)00389-5

A prospective multicenter study of HHV-6B genomic DNA and gene transcription in paired bronchoalveolar lavage fluid and blood from HCT recipients

Hill, Joshua A., Lee, Yeon Joo, Vande Vusse, Lisa K., Xie, Hu, Lisa Chung, E., Keane-Candib, Jacob, Waghmare, Alpana, Cheng, Guang-Shing, Zhu, Haiying, Huang, Meei-Li, Hill, Geoffrey, Jerome, Keith R., Gharib, Sina A, Leisenring, Wendy M., Zerr, Danielle M., Dadwal, Sanjeet S. and Boeckh, Michael J. (2022). A prospective multicenter study of HHV-6B genomic DNA and gene transcription in paired bronchoalveolar lavage fluid and blood from HCT recipients. IDWeek 2022, Washington, DC United States, 19-23 October 2022. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ofid/ofac492.1716

CMV Reactivation in Hematopoietic Cell Transplant Candidates: A Novel Risk Factor for Post-transplant Reactivation

Zamora, Danniel, Xie, Hu, Hill, Joshua A., Duke, Elizabeth, Green, Margaret, Kimball, Louise E., Holmberg, Leona, Waghmare, Alpana, Greninger, Alexander L., Jerome, Keith R., Flowers, Mary, Hill, Geoffrey, Leisenring, Wendy M. and Boeckh, Michael J. (2022). CMV Reactivation in Hematopoietic Cell Transplant Candidates: A Novel Risk Factor for Post-transplant Reactivation. IDWeek 2022, Washington, DC United States, 19-23 October 2022. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ofid/ofac492.683

Characterizing the Association of Pre-Existing Cytomegalovirus (CMV)-specific Humoral Immunity with CMV Reactivation Risk after Hematopoietic Cell Transplantation (HCT)

Zamora, Danniel, Krantz, Elizabeth M., Joncas-Schronce, Laurel, Akoto, Brenda, Stevens-Ayers, Terry L., Bender Ignacio, Rachel A., Hill, Joshua A., Degli-Esposti, Mariapia, Hill, Geoffrey and Boeckh, Michael J. (2022). Characterizing the Association of Pre-Existing Cytomegalovirus (CMV)-specific Humoral Immunity with CMV Reactivation Risk after Hematopoietic Cell Transplantation (HCT). IDWeek 2022, Washington, DC United States, 19-23 October 2022. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ofid/ofac492.549

Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd

Henden, Andrea S., Robb, Renee, Forero, Adriana, Kuns, Rachel D., Ensbey, Kathleen S., Chang, Karshing, Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nic, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey (2021). Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd. 2021 TCT Meetings of ASTCT and CIBMTR, Online, 8-12 February 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s2666-6367(21)00107-x

Being a Stem Cell Donor for a Chronically-ill Family Member: Results from an Australian Multicenter Study

Zomerdijk, Nienke, Turner, Jane, Hill, Geoffrey and Gottlieb, David (2018). Being a Stem Cell Donor for a Chronically-ill Family Member: Results from an Australian Multicenter Study. 20th World Congress of Psycho‐Oncology, Hong Kong, 29 October-2 November 2018. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/pon.4878

Predictors of Negative Psychosocial Outcomes Among Adult Related Stem Cell Donors - An Australian Multicenter Study

Zomerdijk, Nienke, Turner, Jane, Hill, Geoffrey and Gottlieb, David (2018). Predictors of Negative Psychosocial Outcomes Among Adult Related Stem Cell Donors - An Australian Multicenter Study. 20th World Congress of Psycho‐Oncology, Hong Kong, 29 October-2 November 2018. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/pon.4878

Autophagy-dependent TIGIT+ Treg are critical for the maintenance of tolerance

MacDonald, Kelli P. A., Le Texier, Laetitia, Leveque-ElMouttie, Lucie, Lineburg, Katie, Nicholls, Jemma, Guimaraes, Fernando Souza-Fonseca, Alexander, Kylie, Clouston, Andrew, Blazar, Bruce R. and Hill, Geoff R. (2016). Autophagy-dependent TIGIT+ Treg are critical for the maintenance of tolerance. Immunology 2016 Meeting, Seattle, WA United States, 13-17 May 2016. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.196.supp.125.14

Alloantigen presentation by recipient non-professional antigen presenting cells induces lethal acute Gvhd

Koyama, M., Kuns, R. D., Olver, S. D., Raffelt, N. C., Wilson, YA, Don, A. L. J., Lineburg, K. E., Robb, R. J., Markey, K. A., Varelias, A., Malissen, B., Hammerling, G. J., Bhat, P., Clouston, A. D., Engwerda, C. R., MacDonald, K. P. A. and Hill, G. R. (2012). Alloantigen presentation by recipient non-professional antigen presenting cells induces lethal acute Gvhd. BMT Tandem Meeting, San Diego, CA, United States, 01-05 Feburary 2012. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.bbmt.2011.12.422

Nuclear translocation of ROB within host and donor antigen presenting cells is critical for the initiation and maintenance of acute graft-versus-host disease

MacDonald, Kelli, Kuns, Rachel, Rowe, Vanessa, Don, Alistair, Morris, Edward, Thomas, Ranjeny and Hill, Geoffrey (2005). Nuclear translocation of ROB within host and donor antigen presenting cells is critical for the initiation and maintenance of acute graft-versus-host disease. 47th Annual Meeting of the American Society of Hematology, Atlanta, GA, United States, 10 -13 December 2005. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V106.11.455.455

The mechanism of inflammation in RelB deficient mice

Pai, S., O'Sullivan, B. J., MacDonald, K. P., Duggan, E., Gerondakis, S., Hill, G. and Thomas, R. (2005). The mechanism of inflammation in RelB deficient mice. 35th Annual Scentific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, Australia, 29 November - 2 December 2005. OXFORD: Australasian Society of Immunology.

Cytokine expanded myeloid precursors function as regulatory antigen presenting cells and induce tolerance through IL-10 producing regulatory T cells

MacDonald, K. P. A., Rowe, V., Thomas, R., Ferrera, J. L. M. and Hill, G. R. (2004). Cytokine expanded myeloid precursors function as regulatory antigen presenting cells and induce tolerance through IL-10 producing regulatory T cells. 22nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand, Canberra, Australia, 31st March - 2nd April, 2004. Basingstoke, U.K.: Nature Publishing Group. doi: 10.1111/j.1440-1711.2004.1259_2.x

Progenipoietin-1 and G-CSF expand a novel CD40(neg) APC that induces transplant tolerance through IL-10 producing regulatory T cells

MacDonald, K. P. A., Rowe, V., Thomas, R., Welply, J. K., Woulfe, S., Ferrara, J. L. M. and Hill, G. R. (2003). Progenipoietin-1 and G-CSF expand a novel CD40(neg) APC that induces transplant tolerance through IL-10 producing regulatory T cells. 45th Annual Meeting of the American Society of Hematology, San Diego, CA, United States, 6 - 9 December 2003. Washington, DC, United States: American Society of Hematology.