The University of Queensland

Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells

Shah, Esha T., Molloy, Christopher, Gough, Madeline, Kryza, Thomas, Samuel, Selwin G., Tucker, Amos, Bhatia, Maneet, Ferguson, Genevieve, Heyman, Rebecca, Vora, Shivam, Monkman, James, Bolderson, Emma, Kulasinghe, Arutha, He, Yaowu, Gabrielli, Brian, Hooper, John D., Richard, Derek J., O’Byrne, Kenneth J. and Adams, Mark N. (2024). Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells. British Journal of Cancer, 130 (7), 1196-1205. doi: 10.1038/s41416-024-02584-z

MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier

McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology, 16 (6), 985-1009. doi: 10.1016/j.jcmgh.2023.08.011

Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma

Raninga, Prahlad V., He, Yaowu, Datta, Keshava K., Lu, Xue, Maheshwari, Uma R., Venkat, Pooja, Mayoh, Chelsea, Gowda, Harsha, Kalimutho, Murugan, Hooper, John D. and Khanna, Kum Kum (2023). Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma. Molecular Therapy, 31 (3) ARTN 212011, 729-743. doi: 10.1016/j.ymthe.2022.12.011

Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancer

Lyons, Nicholas, Giri, Rabina, Begun, Jakob, Clark, David A, Proud, David, He, Yaowu, Hooper, John and Kryza, Thomas (2023). Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancer. Antioxidants and Redox Signaling, 39 (1-3), 186-205. doi: 10.1089/ars.2022.0127

CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy

Khan, Tashbib, Lyons, Nicholas J., Gough, Madeline, Kwah, Kayden K.X., Cuda, Tahleesa J., Snell, Cameron E., Tse, Brian W., Sokolowski, Kamil A., Pearce, Lesley A., Adams, Timothy E., Rose, Stephen E., Puttick, Simon, Pajic, Marina, Adams, Mark N., He, Yaowu, Hooper, John D. and Kryza, Thomas (2022). CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy. Theranostics, 12 (16), 6915-6930. doi: 10.7150/thno.78171

Elevating CDCA3 levels enhances tyrosine kinase inhibitor sensitivity in TKI-resistant EGFR mutant non-small-cell lung cancer

Sahin, Katherine B., Shah, Esha T., Ferguson, Genevieve P., Molloy, Christopher, Kalita-de Croft, Priyakshi, Hayes, Sarah A., Hudson, Amanda, Colvin, Emily, Kamitakahara, Hannah, Harvie, Rozelle, Hasovits, Csilla, Khan, Tashbib, Duijf, Pascal H. G., Howell, Viive M., He, Yaowu, Bolderson, Emma, Hooper, John D., Lakhani, Sunil R., Richard, Derek J., O’Byrne, Kenneth J. and Adams, Mark N. (2021). Elevating CDCA3 levels enhances tyrosine kinase inhibitor sensitivity in TKI-resistant EGFR mutant non-small-cell lung cancer. Cancers, 13 (18) 4651, 4651. doi: 10.3390/cancers13184651

Preclinical molecular PET-CT imaging targeting CDCP1 in colorectal cancer

Cuda, Tahleesa J., He, Yaowu, Kryza, Thomas, Khan, Tashbib, Tse, Brian W., Sokolowski, Kamil A., Liu, Cheng, Lyons, Nicholas, Gough, Madeline, Snell, Cameron E., Wyld, David K., Rose, Stephen, Riddell, Andrew D., Stevenson, Andrew R. L., Thomas, Paul A., Clark, David A., Puttick, Simon and Hooper, John D. (2021). Preclinical molecular PET-CT imaging targeting CDCP1 in colorectal cancer. Contrast Media and Molecular Imaging, 2021 3153278, 3153278. doi: 10.1155/2021/3153278

Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer

He, Yaowu, Khan, Tashbib, Kryza, Thomas, Jones, Martina L., Goh, Justin B., Lyons, Nicholas J., Pearce, Lesley A., Lee, Michael D, Gough, Madeline, Rogers, Rebecca, Davies, Claire M,, Gilks, C. Blake, Hodgkinson, Thomas, Lourie, Rohan, Barry, Sinead C., Perrin, Lewis C., Williams, Charlotte C., Puttick, Simon, Adams, Timothy E., Munro, Trent P., Hooper, John D. and Chetty, Naven (2021). Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer. Molecular Pharmaceutics, 18 (9) acs.molpharmaceut.1c00401, 3464-3474. doi: 10.1021/acs.molpharmaceut.1c00401

Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence

Alharbi, Mona, Lai, Andrew, Sharma, Shayna, Kalita-De Croft, Priyakshi, Godbole, Nihar, Campos, America, Guanzon, Dominic, Salas-Burgos, Alexis, Carrion, Flavio, Zuñiga, Felipe A., Perrin, Lewis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Hooper, John D., Rice, Gregory E. and Salomon, Carlos (2021). Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence. Cancers, 13 (14) 3388, 1-26. doi: 10.3390/cancers13143388

Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

Kryza, Thomas, Khan, Tashbib, Lovell, Scott, Harrington, Brittney S., Yin, Julia, Porazinski, Sean, Pajic, Marina, Koistinen, Hannu, Rantala, Juha K., Dreyer, Tobias, Magdolen, Viktor, Reuning, Ute, He, Yaowu, Tate, Edward W. and Hooper, John D. (2021). Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1. Nature Chemical Biology, 17 (7), 776-783. doi: 10.1038/s41589-021-00783-w

The CDCP1 signalling hub: a target for cancer detection and therapeutic intervention

Khan, Tashbib, Kryza, Thomas, Lyons, Nicholas J., He, Yaowu and Hooper, John D. (2021). The CDCP1 signalling hub: a target for cancer detection and therapeutic intervention. Cancer Research, 81 (9) canres.2978.2020, QF1-QF11. doi: 10.1158/0008-5472.can-20-2978

A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy

Sheng, Yong Hua, Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh, Movva, Ramya, He, Yaowu, Wu, Andy, Hooper, John, McWhinney, Brett, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira, Lucke, Andrew J., Fairlie, David P., McGuckin, Michael A., Florin, Timothy H. and Begun, Jakob (2021). A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy. Cellular and Molecular Gastroenterology and Hepatology, 11 (1), 33-53. doi: 10.1016/j.jcmgh.2020.05.012

Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation

Khan, Tashbib, Sullivan, Mitchell A., Gunter, Jennifer H., Kryza, Thomas, Lyons, Nicholas, He, Yaowu and Hooper, John D. (2020). Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation. Frontiers in Oncology, 10 592455, 592455. doi: 10.3389/fonc.2020.592455

HBV induced hepatocellular carcinoma and related potential immunotherapy

Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D. and Yang, Pengyuan (2020). HBV induced hepatocellular carcinoma and related potential immunotherapy. Pharmacological Research, 159 104992, 104992. doi: 10.1016/j.phrs.2020.104992

miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer

Alharbi, Mona, Sharma, Shayna, Guanzon, Dominic, Lai, Andrew, Zuñiga, Felipe, Shiddiky, Muhammad J.A., Yamauchi, Yusuke, Salas-Burgos, Alexis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2020). miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 28 102207, 102207. doi: 10.1016/j.nano.2020.102207

Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma

Khan, Tashbib, He, Yaowu, Kryza, Thomas, Harrington, Brittney S., Gunter, Jennifer H., Sullivan, Mitchell A., Cuda, Tahleesa, Rogers, Rebecca, Davies, Claire M., Broomfield, Amy, Gough, Madeline, Wu, Andy C., McGann, Thomas, Weroha, S. John, Haluska, Paul, Forbes, Josephine M., Armes, Jane E., Barry, Sinead C., Coward, Jermaine I., Jagasia, Nisha, Chetty, Naven, Snell, Cameron E., Lourie, Rohan, Perrin, Lewis C. and Hooper, John D. (2020). Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma. Cancers, 12 (4) 869, 869. doi: 10.3390/cancers12040869

Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer

Harrington, Brittney S., He, Yaowu, Khan, Tashbib, Puttick, Simon, Conroy, Paul J., Kryza, Thomas, Cuda, Tahleesa, Sokolowski, Kamil A., Tse, Brian W.C ., Robbins, Katherine K., Arachchige, Buddhika J., Stehbens, Samantha J., Pollock, Pamela M., Reed, Sarah, Weroha, S. John, Haluska, Paul, Salomon, Carlos, Lourie, Rohan, Perrin, Lewis C., Law, Ruby H. P., Whisstock, James C. and Hooper, John D. (2020). Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics, 10 (5), 2095-2114. doi: 10.7150/thno.30736

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma

Kryza, Thomas, Khan, Tashbib, Puttick, Simon, Li, Chao, Sokolowski, Kamil A., Tse, Brian W.C., Cuda, Tahleesa, Lyons, Nicholas, Gough, Madeline, Yin, Julia, Parkin, Ashleigh, Deryugina, Elena I., Quigley, James P., Law, Ruby H.P., Whisstock, James C., Riddell, Andrew D., Barbour, Andrew P., Wyld, David K., Thomas, Paul A., Rose, Stephen, Snell, Cameron E., Pajic, Marina, He, Yaowu and Hooper, John D. (2020). Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma. Theranostics, 10 (9), 4116-4133. doi: 10.7150/thno.43589

CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin

He, Yaowu, Davies, Claire M., Harrington, Brittney S., Hellmers, Linh, Sheng, Yonghua, Broomfield, Amy, McGann, Thomas, Bastick, Kate, Zhong, Laurie, Wu, Andy, Maresh, Grace, McChesney, Shannon, Yau Wong, Kuan, Adams, Mark N., Sullivan, Ryan C., Palmer, James S., Burke, Lez J., Ewing, Adam D., Zhang, Xin, Margolin, David, Li, Li, Lourie, Rohan, Matsika, Admire, Srinivasan, Bhuvana, McGuckin, Michael A., Lumley, John W. and Hooper, John D. (2019). CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin. Oncogene, 39 (1), 219-233. doi: 10.1038/s41388-019-0983-3

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y

Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells

Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Palma, Carlos, Zuñiga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D and Salomon, Carlos (2019). Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells. Clinical Science, 133 (13), CS20190082-1419. doi: 10.1042/cs20190082

Evidence that cell surface localization of serine protease activity facilitates cleavage of the protease activated receptor CDCP1

He, Yaowu, Reid, Janet C., He, Hui, Harrington, Brittney S., Finlayson, Brittney, Khan, Tashbib and Hooper, John D. (2018). Evidence that cell surface localization of serine protease activity facilitates cleavage of the protease activated receptor CDCP1. Biological Chemistry, 399 (9), 1091-1097. doi: 10.1515/hsz-2017-0308

Expression of CDCA3 is a prognostic biomarker and potential therapeutic target in non–small cell lung cancer

Adams, Mark N., Burgess, Joshua T., He, Yaowu, Gately, Kathy, Snell, Cameron, Zhang, Shu-Dong, Hooper, John D., Richard, Derek J. and O'Byrne, Kenneth J. (2017). Expression of CDCA3 is a prognostic biomarker and potential therapeutic target in non–small cell lung cancer. Journal of Thoracic Oncology, 12 (7), 1071-1084. doi: 10.1016/j.jtho.2017.04.018

Development of an enzyme-linked immunosorbent assay for detection of CDCP1 shed from the cell surface and present in colorectal cancer serum specimens

Chen, Yang, Harrington, Brittney S., Lau, Kevin C. N., Burke, Lez J., He, Yaowu, Iconomou, Mary, Palmer, James S., Meade, Brian, Lumley, John W. and Hooper, John D. (2017). Development of an enzyme-linked immunosorbent assay for detection of CDCP1 shed from the cell surface and present in colorectal cancer serum specimens. Journal of Pharmaceutical and Biomedical Analysis, 139, 65-72. doi: 10.1016/j.jpba.2017.02.047

Mapping transmembrane residues of proteinase activated recpetor 2 (PAR2) that influence ligand-modulated calcium signaling

Suen, J.Y., Adams, M. N., Lim, J., Madala, P.K., Xu, W, Cotterell, A., He, Y., Yua, Mei-Kwan, Hooper, J. D. and Fairlie, D.P. (2017). Mapping transmembrane residues of proteinase activated recpetor 2 (PAR2) that influence ligand-modulated calcium signaling. Pharmacological Research, 117, 328-342. doi: 10.1016/j.phrs.2016.12.020

MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance

Sheng, Yonghua, Ng, Choa Ping, Lourie, Rohan, Shah, Esha T., He, Yaowu, Wong, Kuan Yua, Seim, Inge, Oancea, Iulia, Morais, Christudas, Jeffery, Penny L., Hooper, John, Gobe, Glenda C. and Mcguckin, Michael A. (2017). MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance. International Journal of Cancer, 140 (10), 2351-2363. doi: 10.1002/ijc.30651

Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases

Reid, Janet C., Matsika, Admire, Davies, Claire M., He, Yaowu, Broomfield, Amy, Bennett, Nigel C., Magdolen, Viktor, Srinivasan, Bhuvana, Clements, Judith A. and Hooper, John D. (2017). Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases. American Journal of Cancer Research, 7 (11), 2257-2274.

MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target

Sheng, Y. H., He, Y., Hasnain, S. Z., Wang, R., Tong, H., Clarke, D. T., Lourie, R., Oancea, I., Wong, K. Y., Lumley, J. W., Florin, T. H., Sutton, P., Hooper, J. D., McMillan, N. A. and McGuckin, M. A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target. Oncogene, 36 (5), 700-713. doi: 10.1038/onc.2016.241

CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer

Wu, Andy C., He, Yaowu, Broomfield, Amy, Paatan, Nicoll J., Harrington, Brittney S., Tseng, Hsu-Wen, Beaven, Elizabeth A., Kiernan, Deirdre M., Swindle, Peter, Clubb, Adrian B., Levesque, Jean-Pierre, Winkler, Ingrid G., Ling, Ming-Tat, Srinivasan, Bhuvana, Hooper, John D. and Pettit, Allison R. (2016). CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer. Journal of Pathology, 239 (2), 218-230. doi: 10.1002/path.4718

Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer

Harrington, Brittney S., He, Yaowu, Davies, Claire M., Wallace, Sarah J., Adams, Mark N., Beaven, Elizabeth A., Roche, Deborah K., Kennedy, Catherine, Chetty, Naven P., Crandon, Alexander J., Flatley, Christopher, Oliveira, Niara B., Shannon, Catherine M., deFazio, Anna, Tinker, Anna V., Gilks, C. Blake, Gabrielli, Brian, Brennan, Donal J., Coward, Jermaine I., Armes, Jane E., Perrin, Lewis C. and Hooper, John D. (2016). Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer. British Journal of Cancer, 114 (4), 417-426. doi: 10.1038/bjc.2015.471

New crossroads for potential therapeutic intervention in cancer - intersections between CDCP1, EGFR family members and downstream signaling pathways

He, Yaowu, Harrington, Brittney S. and Hooper, John D. (2016). New crossroads for potential therapeutic intervention in cancer - intersections between CDCP1, EGFR family members and downstream signaling pathways. Oncoscience, 3 (1), 5-8. doi: 10.18632/oncoscience.286

Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance

He, Y., Wu, A. C., Harrington, B. S., Davies, C. M., Wallace, S. J., Adams, M. N., Palmer, J. S., Roche, D. K., Hollier, B. G., Westbrook, T. F., Hamidi, H., Konecny, G. E., Winterhoff, B., Chetty, N. P., Crandon, A. J., Oliveira, N. B., Shannon, C. M., Tinker, A. V., Gilks, C. B., Coward, J. I., Lumley, J. W., Perrin, L. C., Armes, J. E. and Hooper, J. D. (2016). Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance. Oncogene, 35 (4), 468-478. doi: 10.1038/onc.2015.101

Potent small agonists of protease activated receptor 2

Yau, Mei-Kwan, Suen, Jacky Y., Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark N., He, Yaowu, Hooper, John D., Reid, Robert C. and Fairlie, David P. (2016). Potent small agonists of protease activated receptor 2. ACS Medicinal Chemistry Letters, 7 (1), 105-110. doi: 10.1021/acsmedchemlett.5b00429

EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface

Adams, M. N., Harrington, B. S., He, Y., Davies, C. M., Wallace, S. J., Chetty, N. P., Crandon, A. J., Oliveira, N. B., Shannon, C. M., Coward, J. I., Lumley, J. W., Perrin, L. C., Armes, J. E. and Hooper, J. D. (2015). EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface. Oncogene, 34 (11), 1375-1383. doi: 10.1038/onc.2014.88

Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells

Casar, B., He, Y., Iconomou, M., Hooper, J. D., Quigley, J. P. and Deryugina, E. I. (2012). Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene, 31 (35), 3924-3938. doi: 10.1038/onc.2011.555

The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration

Dong, Ying, He, Yaowu, de Boer, Leonore, Stack, M. Sharon, Lumley, John W., Clements, Judith A. and Hooper, John D. (2012). The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration. Journal of Biological Chemistry, 287 (13), 9792-9803. doi: 10.1074/jbc.M111.335448

Cellular settings mediating Src substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734

Wortmann, Andreas, He, Yaowu, Christensen, Melinda E., Linn, Mayla, Lumley, John W., Pollock, Pamela M., Waterhouse, Nigel J. and Hooper, John D. (2011). Cellular settings mediating Src substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734. Journal of Biological Chemistry, 206 (49), 42303-42315. doi: 10.1074/jbc.M111.227462

The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2

Adams, Mark N., Christensen, Melinda E., He, Yaowu, Waterhouse, Nigel J. and Hooper, John D. (2011). The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2. PLoS One, 6 (11) e28018, 1-14. doi: 10.1371/journal.pone.0028018

Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKC delta

He, Yaowu, Wortmann, Andreas, Burke, Les J., Reid, Janet C., Adams, Mark N., Abdul-Jabbar, Ibtissam, Quigley, James P., Leduc, Richard, Kirchhofer, Daniel and Hooper, John D. (2010). Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKC delta. Journal of Biological Chemistry, 285 (34), 26162-26173. doi: 10.1074/jbc.M109.096453

Downstream targets of heterogeneous nuclear ribonucleoprotein A2 mediate cell proliferation

He, Yaowu, Rothnagel, Joseph A., Epis, Michael R., Leedman, Peter J. and Smith, Ross (2009). Downstream targets of heterogeneous nuclear ribonucleoprotein A2 mediate cell proliferation. Molecular Carcinogenesis, 48 (2), 167-179. doi: 10.1002/mc.20467

Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B

He, Yaowu and Smith, Ross (2009). Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B. Cellular and Molecular Life Sciences, 66 (7), 1239-1256. doi: 10.1007/s00018-008-8532-1

The cell surface glycoprotein CDCP1 in cancer - Insights, opportunities, and challenges

Wortmann, Andreas, He, Yaowu, Deryugina, Elena I., Quigley, James P. and Hooper, John D. (2009). The cell surface glycoprotein CDCP1 in cancer - Insights, opportunities, and challenges. IUBMB Life, 61 (7), 723-730. doi: 10.1002/iub.198

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels

He, Yaowu, Hryciw, Deanne H., Carroll, Melanie L., Myers, Stephen A., Whitbread, Astrid K., Kumar, Sharad, Poronnik, Philip and Hooper, John D. (2008). The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. Journal of Biological Chemistry, 283 (35), 24000-24010. doi: 10.1074/jbc.M803361200

N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)

He, Yaowu, Ramsay, Andrew, Hunt, Melanie, Whitbread, Astrid, Myers, Stephen and Hooper, John (2008). N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). Biochemical Journal, 412 (1), 45-55. doi: 10.1042/BJ20071722

Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation

He, Y. W., Brown, M. A., Rothnagel, J. A., Saunders, N. A. and Smith, R. (2005). Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation. Journal of Cell Science, 118 (14), 3173-3183. doi: 10.1242/jcs.02448

Roles of heterogeneous nuclear ribonucleoproteins A/B in cell growth

He, Y., Brown, M. A., Rothnagel, J. A., Saunders, N. A. and Smith, R. (2004). Roles of heterogeneous nuclear ribonucleoproteins A/B in cell growth. Molecular Biology of The Cell, 15, 252A-253A.

Bioremediation of PAHs contaminated soil using bio-slurry reactor process

Li, Peijun, Gong, Zongqiang, Jing, Xin, Xu, Huaxia, Zhang, Chungui, Ma, Xuejun and He, Yaowu (2002). Bioremediation of PAHs contaminated soil using bio-slurry reactor process. Chinese Journal of Applied Ecology, 13 (3), 327-330.

Greenhouse gas emissions from a constructed wetland for municipal sewage treatment

Tai, P.D., Li, P.J., Sun, T.H., He, Y.W., Zhou, Q.X., Gong, Z.Q., Mizuochi, M. and Inamori, Y.H. (2002). Greenhouse gas emissions from a constructed wetland for municipal sewage treatment. Journal of Environmental Sciences, 14 (1), 27-33.

Nitrous oxide emissions from aerated composting of organic waste

He, Y. W., Inamori, Y., Mizuochi, M., Kong, H. N., Iwami, N. and Sun, T. H. (2001). Nitrous oxide emissions from aerated composting of organic waste. Environmental Science & Technology, 35 (11), 2347-2351. doi: 10.1021/es0011616

Measurements of N2O and CH4 from the aerated composting of food waste

He, Yaowu, Inamori, Yuhei, Mizuochi, Motoyuki, Kong, Hainan, Iwami, Norio and Sun, Tieheng (2000). Measurements of N2O and CH4 from the aerated composting of food waste. Science of the Total Environment, 254 (1), 65-74. doi: 10.1016/S0048-9697(00)00439-3

Fate of 1,2,4-trichlorobenzene (1,2,4-TCB) in soil-rice paddy system

He, Y.W., Sun, T.H., Ou, Z.Q., Yediler, A. and Kettrup, A. (1996). Fate of 1,2,4-trichlorobenzene (1,2,4-TCB) in soil-rice paddy system. Chemosphere, 32 (7), 1381-1389. doi: 10.1016/0045-6535(96)00047-1

Adsorption of linear alkylbenzene sulfonate (LAS) on soils

Ou, Ziqing, Yediler, Ayfer, He, Yaowu, Jia, Liangqing, Kettrup, Antonius and Sun, Tieheng (1996). Adsorption of linear alkylbenzene sulfonate (LAS) on soils. Chemosphere, 32 (5), 827-839. doi: 10.1016/0045-6535(95)00350-9

Adsorption of fluoranthene on soil and lava: Effects of the organic carbon contents of adsorbents and temperature

He, Yaowu, Yediler, Ayfer, Sun, Tieheng and Kettrup, Antonius (1995). Adsorption of fluoranthene on soil and lava: Effects of the organic carbon contents of adsorbents and temperature. Chemosphere, 30 (1), 141-150. doi: 10.1016/0045-6535(94)00396-c

Effects of linear alkylbenzene sulfonate (LAS) on the adsorption behaviour of phenanthrene on soils

Ou, Ziqing, Yediler, Ayfer, He, Yaowu, Kettrup, Antonius and Sun, Tieheng (1995). Effects of linear alkylbenzene sulfonate (LAS) on the adsorption behaviour of phenanthrene on soils. Chemosphere, 30 (2), 313-325. doi: 10.1016/0045-6535(94)00398-e

Structural basis of an anti-cancer biological warhead bound to its target CDCP1 for the diagnosis and treatment of epithelial cancers

Kwah, Kayden, Gu, Weixi, Arachchige, Kasun S. A., He, Yaowu, Landsberg, Michael, Kobe, Bostjan and Hooper, John (2023). Structural basis of an anti-cancer biological warhead bound to its target CDCP1 for the diagnosis and treatment of epithelial cancers. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323084449

Development of a CUB domain-containing protein 1 (CDCP1)-targeting antibody-drug conjugate for triple-negative and metastatic breast cancer

Gough, Madeline, Kwah, Kayden, He, Yaowu, Snell, Cameron Edward, Hooper, John D. and Kryza, Thomas (2023). Development of a CUB domain-containing protein 1 (CDCP1)-targeting antibody-drug conjugate for triple-negative and metastatic breast cancer. 2023 ASCO Annual Meeting, Chicago, IL United States, 2-6 June 2023. Alexandria, VA United States: American Society of Clinical Oncology (ASCO). doi: 10.1200/jco.2023.41.16_suppl.e15012

Development of antibody-drug conjugates targeting the CDCP1 receptor for the treatment of Triple negative and metastatic breast cancer

Gough, M., Kwah, K., Khan, T., He, Y., Pyke, C., Ratnayake, G., Snell, C., Hooper, J. and Kryza, T. (2022). Development of antibody-drug conjugates targeting the CDCP1 receptor for the treatment of Triple negative and metastatic breast cancer. 13th European Breast Cancer Conference (EBCC-13), Barcelona, Spain, 16-18 November 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/s0959-8049(22)01571-4

"Theranostics": radioimmunodetection and radioimmunotherapy for metastatic colorectal cancer

Cuda, T., Hooper, J., Puttick, S., He, Y., Kryza, T. and Khan, T. (2019). "Theranostics": radioimmunodetection and radioimmunotherapy for metastatic colorectal cancer. Australian and New Zealand Society of Nuclear Medicine (ANZSNM) 49th ASM, Adelaide, Australia, 26-28 April 2019. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.

Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo

Alharbi, Mona G., Lai, Andrew, Zuniga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D. and Salomon, Carlos (2019). Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079

Granulocyte Colony Stimulating Factor impacts on osteomacs and bone marrow macrophages - implications for prostate cancer osteoblastic lesion formation

Millard, Susan, Wu, Andy, Kaur, Simran, He, Yaowu, Batoon, Lena, Hooper, John and Pettit, Allison (2018). Granulocyte Colony Stimulating Factor impacts on osteomacs and bone marrow macrophages - implications for prostate cancer osteoblastic lesion formation. Annual Meeting of the American Society for Bone and Mineral Research, Montréal, Quebéc, Canada, Sep 28-Oct 01, 2018. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1002/jbmr.3621

MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target

Sheng, Yong H., He, Yaowu, Hasnain, Sumaira Z., Wang, Ran, Tong, Hui, Clarke, Daniel T., Lourie, Rohan, Oancea, Lulia, Wong, Kuanyau, Lumley, John W., Florin, Timothy H., Sutton, Philip, Hooper, John. D., Mcmillan, Nigel A. and Mcguckin, Michael A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target. AACR 107th Annual Meeting on Bioinformatics and Systems Biology, New Orleans, Los Angeles, 16-20 April 2016 . Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2016-3564

Targeting Apoptosis as a Novel Therapy for Myc-Driven Medulloblastoma

Ji, Pengxiang, Genovesi, Laura, He, Yaowu, Hooper, John and Wainwright, Brandon (2016). Targeting Apoptosis as a Novel Therapy for Myc-Driven Medulloblastoma. 17th International Symposium on Pediatric Neuro-Oncology (ISPNO), Liverpool England, 12-15 June 2016. United States: Oxford University Press.

The role of cancer stem cells in colorectal cancer metastasis

Kemp, M. C., Pummer, J., He, Y., Hooper, J., Reuter, B., Borgovan, T., Zhang, X., Sullivan, R., Maresh, G., Green, H., Del Valle, L., Margolin, D. and Li, L. (2016). The role of cancer stem cells in colorectal cancer metastasis. Southern Regional Meeting of the American Federation for Medical Research (AFMR), New Orleans, LA, United States, Feb 18-20, 2016. London, United Kingdom: BMJ Group. doi: 10.1136/jim-2015-000035.415

EGF-induced recycling of the cancer promoting protein CDCP1

Adams, Mark N., Harrington, Brittney S., He, Yaowu, Davies, Claire M., Wallace, Sarah J., Chetty, Naven P., Crandon, Alexander J., Oliveira, Niara B., Shannon, Catherine M., Coward, Jermaine I., Lumley, John W., Perrin, Lewis C., Armes, Jane E. and Hooper, John D. (2015). EGF-induced recycling of the cancer promoting protein CDCP1. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

A New Marker of Poor Outcome and Potential Therapeutic Target in Ovarian Clear Cell Carcinoma

Hooper, J., He, Y., Wu, A., Harrington, B., Davies, C., Wallace, S., Gilks, B., Perrin, L. and Armes, J. (2014). A New Marker of Poor Outcome and Potential Therapeutic Target in Ovarian Clear Cell Carcinoma. 15th Biennial Meeting of the International Gynecologic Cancer Society, Melbourne, VIC Australia, 8-11 November 2014. London, United Kingdom: Lippincott Williams and Wilkins. doi: 10.1097/01.IGC.0000457075.08973.89

Targeting the cell surface protein Cdcp1 in a model of advanced ovarian cancer

Harrington, B., Davies, C. M., Wallace, S. J., He, Y., Armes, J. E., Perrin, L. C. and Hooper, J. D. (2014). Targeting the cell surface protein Cdcp1 in a model of advanced ovarian cancer. London, United Kingdom: B M J Group.

The downstream targets of hnRNP A2 proteins in squamous cell carcinoma cells

He, Y., Epis, M. R., Rothnagel, J. A., Leedman, P. J. and Smith, R. W. (2006). The downstream targets of hnRNP A2 proteins in squamous cell carcinoma cells. ComBio 2006, Brisbane, Australia, 25-28 Sept, 2006. Kent Town, S.A., Australia: Australian Society for Biochemistry and Molecular Biology.

hnRNPs A2/B1: A different splice for a different life?

He, Y., Epis, M. R., Rothnagel, J. A., Leedman, P. J. and Smith, R. W. (2006). hnRNPs A2/B1: A different splice for a different life?. ComBio 2006, Brisbane, Australia, 25-28 Sept, 2006. Kent Town, S.A., Australia: Australian Society for Biochemistry and Molecular Biology.

Cell cycle-dependence of expression of the hnRNP A2/B1 proteins and their roles in carcinogenesis

He, Y. and Smith, R. W. (2003). Cell cycle-dependence of expression of the hnRNP A2/B1 proteins and their roles in carcinogenesis. ComBio 2003, Sydney, 28 Sept - 2 Oct, 2003.

Treatment of domestic wastewater by an underground capillary seepage system

Sun, Tieheng, He, Yaowu, Ou, Ziqing, Li, Peijun, Chang, Shijun, Qi, Bing, Ma, Xuejun, Qi, Enshan, Zhang, Hairong, Ren, Liping and Yang, Guifeng (1998). Treatment of domestic wastewater by an underground capillary seepage system. International Conference on Ecological Engineering (ICEE 96), Beijing, Peoples Republic of China, 7-11 October 1996. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s0925-8574(98)00027-5

Substrate-biased activity-based probes identify the urokinase-plasminogen axis as a master regulator of metastatic signaling by orphan membrane receptor CDCP1

Kryza, Thomas, Khan, Tashbib, Lovell, Scott, Harrington, Brittney S., Yin, Julia, Porazinski, Sean, Pajic, Marina, Koistinen, Hannu, Rantala, Juha, Dreyer, Tobias, Magdolen, Viktor, Reuning, Ute, He, Yaowu, Tate, Edward and Hooper, John David (2020). Substrate-biased activity-based probes identify the urokinase-plasminogen axis as a master regulator of metastatic signaling by orphan membrane receptor CDCP1.

Binding proteins to CUB domain-containing protein (CDCP1)

Puttick, S., Kryza, T., Hooper, J. D., He, Y., Harrington, B., Quigley, J. and Deryugina, E. (2020). Binding proteins to CUB domain-containing protein (CDCP1). PCT/AU2020/051216.

Expression of hnRNPs A/B in cancer cells and their roles in carcinogenesis

He, Yaowu (2006). Expression of hnRNPs A/B in cancer cells and their roles in carcinogenesis. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/158357