The University of Queensland

Quantifying Cell Death Induced by the NLRC4 Inflammasome

Emming, Stefan, Monteleone, Mercedes M., Kambara, Hiroto, Starchenko, Alina, Alley, Jennifer, Nolan, Michael A., Li, Wei, Kilty, Iain and Schroder, Kate (2023). Quantifying Cell Death Induced by the NLRC4 Inflammasome. NLR Proteins: Methods and Protocols. (pp. 199-210) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-3350-2_13

Measuring non-canonical inflammasome activation in neutrophils

Monteleone, Mercedes and Boucher, Dave (2022). Measuring non-canonical inflammasome activation in neutrophils. The inflammasome: methods and protocols. (pp. 29-37) edited by Ali A. Abdul-Sater. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-2144-8_3

The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis

Holley, Caroline L., Emming, Stefan, Monteleone, Mercedes M., Mellacheruvu, Manasa, Kenney, Kirsten M., Lawrence, Grace M.E.P., Coombs, Jared R., Burgener, Sabrina S. and Schroder, Kate (2024). The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis. Cell Chemical Biology, 31 (5), 962-972.e4. doi: 10.1016/j.chembiol.2024.04.012

Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages

Thygesen, Sara J, Burgener, Sabrina S, Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515, e2350515. doi: 10.1002/eji.202350515

Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection

Richter, Johanna, Monteleone, Mercedes M, Cork, Amanda J., Barnett, Timothy C., Nizet, Victor, Brouwer, Stephan, Schroder, Kate and Walker, Mark J. (2021). Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology and Cell Biology, 99 (10), 1-13. doi: 10.1111/imcb.12499

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452

Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism

Serafini, Agnese, Tan, Lendl, Horswell, Stuart, Howell, Steven, Greenwood, Daniel J., Hunt, Deborah M., Phan, Minh-Duy, Schembri, Mark, Monteleone, Mercedes, Montague, Christine R., Britton, Warwick, Garza-Garcia, Acely, Snijders, Ambrosius P., VanderVen, Brian, Gutierrez, Maximiliano G., West, Nicholas P. and de Carvalho, Luiz Pedro S. (2019). Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism. Molecular Microbiology, 112 (4) mmi.14362, 1284-1307. doi: 10.1111/mmi.14362

The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses

Bierschenk, Damien, Monteleone, Mercedes, Moghaddas, Fiona, Baker, Paul J., Masters, Seth L., Boucher, Dave and Schroder, Kate (2019). The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses. Journal of Leukocyte Biology, 105 (2), 401-410. doi: 10.1002/JLB.MA0318-112RR

Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

Chen, Kaiwen W., Monteleone, Mercedes, Boucher, Dave, Sollberger, Gabriel, Ramnath, Divya, Condon, Nicholas D., von Pein, Jessica B., Broz, Petr, Sweet, Matthew J. and Schroder, Kate (2018). Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps. Science Immunology, 3 (26) eaar6676, eaar6676. doi: 10.1126/sciimmunol.aar6676

Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion

Monteleone, Mercedes, Stanley, Amanda C., Chen, Kaiwen W., Brown, Darren L., Bezbradica, Jelena S., von Pein, Jessica B., Holley, Caroline L., Boucher, Dave, Shakespear, Melanie R., Kapetanovic, Ronan, Rolfes, Verena, Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2018). Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion. Cell Reports, 24 (6), 1425-1433. doi: 10.1016/j.celrep.2018.07.027

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C., Chen, Kaiwen W., Ross, Connie M., Teo, Jessica L., Gomez, Guillermo A., Holley, Caroline L., Bierschenk, Damien, Stacey, Katryn J., Yap, Alpha S., Bezbradica, Jelena S. and Schroder, Kate (2018). Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. The Journal of Experimental Medicine, 215 (3), 827-840. doi: 10.1084/jem.20172222

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B, Tanzer, Marco J., Monteleone, Mercedes, Robertson, Avril A.B., Cooper, Matthew A., Alvarez-Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate and Masters, Seth L. (2015). NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology, 45 (10), 2918-2926. doi: 10.1002/eji.201545655

Mechanisms of unconventional secretion of IL-1 family cytokines

Monteleone, Mercedes, Stow, Jennifer L. and Schroder, Kate (2015). Mechanisms of unconventional secretion of IL-1 family cytokines. Cytokine, 74 (2), 213-218. doi: 10.1016/j.cyto.2015.03.022

Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing

Ly, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

Kim, Jee-Hyun, O'Brien, Kathryn M., Sharma, Ritu, Boshoff, Helena I. M., Rehren, German, Chakraborty, Sumit, Wallach, Joshua B., Monteleone, Mercedes, Wilson, Daniel J., Aldrich, Courtney C., Barry, Clifton E., III, Rhee, Kyu Y., Ehrt, Sabine and Schnappinger, Dirk (2013). A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence. Proceedings of the National Academy of Sciences of the United States of America, 110 (47), 19095-19100. doi: 10.1073/pnas.1315860110

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

Gandotra, Sheetal, Schnappinger, Dirk, Monteleone, Mercedes, Hillen, Wolfgang and Ehrt, Sabine (2007). In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature Medicine, 13 (12), 1515-1520. doi: 10.1038/nm1683

Silencing essential protein secretion in Mycobacterium smegmatis by using tetracycline repressors

Guo, Xinzheng V., Monteleone, Mercedes, Klotzsche, Marcus, Kamionka, Annette, Hillen, Wolfgang, Braunstein, Miriam, Ehrt, Sabine and Schnappinger, Dirk (2007). Silencing essential protein secretion in Mycobacterium smegmatis by using tetracycline repressors. Journal of Bacteriology, 189 (13), 4614-4623. doi: 10.1128/JB.00216-07

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

Ehrt, S, Guo, XZV, Hickey, CM, Ryou, M, Monteleone, M, Riley, LW and Schnappinger, D (2005). Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Research, 33 (2). doi: 10.1093/nar/gni013