The University of Queensland

Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis

Wen, Sophie C. H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Riaz, Saba, Paterson, David L. and Irwin, Adam D. (2021). Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis. PLoS Medicine, 18 (9) e1003787, 1-20. doi: 10.1371/journal.pmed.1003787

The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children

Channon-Wells, S., Kwok, M., Booth, J., Bamford, A., Konstanty, P., Hatcher, J., Dixon, G., Diggle, P. J., Standing, J. F. and Irwin, A. D. (2021). The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children. Journal of Antimicrobial Chemotherapy, 76 (9), 2464-2471. doi: 10.1093/jac/dkab187

Predicting risk of serious bacterial infections in febrile children in the emergency department

Irwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853, e20162853. doi: 10.1542/peds.2016-2853

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study

Schlapbach, Luregn J., Ganesamoorthy, Devika, Wilson, Clare, Raman, Sainath, George, Shane, Snelling, Peter J., Phillips, Natalie, Irwin, Adam, Sharp, Natalie, Le Marsney, Renate, Chavan, Arjun, Hempenstall, Allison, Bialasiewicz, Seweryn, MacDonald, Anna D., Grimwood, Keith, Cling, Jessica C., McPherson, Stephen J., Blumenthal, Antje, Kaforou, Myrsini, Levin, Michael, Herberg, Jethro A., Gibbons, Kristen S., Coin, Lachlan J. M., EUCLIDS consortium and RAPIDS Study Group (2024). Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study. The Lancet Child and Adolescent Health, 8 (5), 325-338. doi: 10.1016/S2352-4642(24)00017-8

Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis

Khan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Irwin, Adam (RSG member), Phillips, Natalie (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768

High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection

Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Hancock, Steven J., Peters, Kate M., Alvarez-Fraga, Laura, Forde, Brian M., Andersen, Stacey B., Miliya, Thyl, Harris, Patrick N. A., Beatson, Scott A., Schlebusch, Sanmarie, Bergh, Haakon, Turner, Paul, Brauner, Annelie, Westerlund-Wikström, Benita, Irwin, Adam D. and Schembri, Mark A (2024). High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection. eLife, 12 ARTN RP91853. doi: 10.7554/elife.91853.3

Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

Chai, Ming G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., Mcwhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Correction: Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (5), 810-810. doi: 10.1007/s00134-024-07393-9

Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

Chai, Gene G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., McWhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (4), 1-9. doi: 10.1007/s00134-024-07353-3

A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria

Nhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z. and Schembri, Mark A. (2024). A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria. Nature Communications, 15 (1) 1441, 1441. doi: 10.1038/s41467-024-45176-4

Serum levels of vitamin C and thiamin in children with suspected sepsis: a prospective observational cohort study

McWhinney, Brett, Ungerer, Jacobus, LeMarsey, Renate, Phillips, Natalie, Raman, Sainath, Gibbons, Kristen, Schlapbach, Luregn J., on behalf of Rapid Acute Paediatric Infection Diagnosis in Suspected Sepsis (RAPIDS) Study Investigators and Irwin, Adam (RAPIDS member) (2024). Serum levels of vitamin C and thiamin in children with suspected sepsis: a prospective observational cohort study. Pediatric Critical Care Medicine, 25 (2), 171-176. doi: 10.1097/PCC.0000000000003349

Prevalence of extra-pulmonary tuberculosis in Africa: a systematic review and meta-analysis

Hailu, Semira, Hurst, Cameron, Cyphers, Griffin, Thottunkal, Stefan, Harley, David, Viney, Kerri, Irwin, Adam, Dean, Judith and Nourse, Clare (2024). Prevalence of extra-pulmonary tuberculosis in Africa: a systematic review and meta-analysis. Tropical Medicine & International Health, 29 (4), 257-265. doi: 10.1111/tmi.13970

Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis

Harris, Patrick N. A., Bauer, Michelle J., Lüftinger, Lukas, Beisken, Stephan, Forde, Brian M., Balch, Ross, Cotta, Menino, Schlapbach, Luregn, Raman, Sainath, Shekar, Kiran, Kruger, Peter, Lipman, Jeff, Bialasiewicz, Seweryn, Coin, Lachlan, Roberts, Jason A., Paterson, David L. and Irwin, Adam D. (2024). Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis. Microbiology spectrum, 12 (2) e0306523, e0306523. doi: 10.1128/spectrum.03065-23

Implementing paediatric appropriate use criteria for endotracheal suction to reduce complications in mechanically ventilated children with respiratory infections

Schults, Jessica A., Charles, Karina R., Harnischfeger, Jane, Ware, Robert S., Royle, Ruth H., Byrnes, Joshua M., Long, Debbie A., Ullman, Amanda J., Raman, Sainath, Waak, Michaela, Lake, Anna, Cooke, Marie, Irwin, Adam, Tume, Lyvonne and Hall, Lisa (2023). Implementing paediatric appropriate use criteria for endotracheal suction to reduce complications in mechanically ventilated children with respiratory infections. Australian Critical Care, 37 (1), 1-9. doi: 10.1016/j.aucc.2023.09.008

The opportunities and challenges for artificial intelligence to improve sepsis outcomes in the paediatric intensive care unit

Aslan, Abdullah Tarik, Permana, Budi, Harris, Patrick N. A., Naidoo, Kuban D., Pienaar, Michael A. and Irwin, Adam D. (2023). The opportunities and challenges for artificial intelligence to improve sepsis outcomes in the paediatric intensive care unit. Current Infectious Disease Reports, 25 (11), 243-253. doi: 10.1007/s11908-023-00818-4

Challenges Facing PICUs in Low- and Middle-Income Countries in the Treatment of Emerging Multidrug-Resistant Organisms: a Review and Perspective from a South African PICU

Saggers, Robin T., Mothibi, Lesego M., Irwin, Adam D. and Naidoo, Kuban D. (2023). Challenges Facing PICUs in Low- and Middle-Income Countries in the Treatment of Emerging Multidrug-Resistant Organisms: a Review and Perspective from a South African PICU. Current Infectious Disease Reports, 25 (11), 1-10. doi: 10.1007/s11908-023-00817-5

Application of the ViroKey® SQ FLEX assay for detection of cytomegalovirus antiviral resistance

Hume, Jocelyn, Lowry, Kym, Whiley, David M., Irwin, Adam D., Bletchly, Cheryl and Sweeney, Emma L. (2023). Application of the ViroKey® SQ FLEX assay for detection of cytomegalovirus antiviral resistance. Journal of Clinical Virology, 167 105556, 1-8. doi: 10.1016/j.jcv.2023.105556

Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance

Hume, Jocelyn, Sweeney, Emma L., Lowry, Kym, Fraser, Chris, Clark, Julia E., Whiley, David M. and Irwin, Adam D. (2023). Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance. Frontiers in Pediatrics, 11 1180392, 1180392. doi: 10.3389/fped.2023.1180392

A multicentre, retrospective audit of fosfomycin use for urinary tract infections in Australian children and adolescents

Purcell, Rachael, Yeoh, Daniel, Bowen, Asha, Britton, Philip N., Carr, Jeremy P., Chen, Ming, Cheung, Kaman, Clark, Julia, Irwin, Adam, Lai, Tony, Lorenzen, Ulrik, Steer, Andrew, Wen, Sophie, Williams, Phoebe, Yap, Natalie, Cooper, Celia and Gwee, Amanda (2023). A multicentre, retrospective audit of fosfomycin use for urinary tract infections in Australian children and adolescents. Journal of Antimicrobial Chemotherapy, 78 (7), 1-6. doi: 10.1093/jac/dkad131

Rapid molecular detection of CMY-2, and CTX-M group 1 and 9 variants via recombinase polymerase amplification

Ertl, Nicole G., Irwin, Adam D., Macdonald, Joanne, Bauer, Michelle J., Wang, Claire Y. T., Harris, Patrick N. A., Heney, Claire, Zowawi, Hosam M. and Whiley, David M. (2023). Rapid molecular detection of CMY-2, and CTX-M group 1 and 9 variants via recombinase polymerase amplification. JAC - Antimicrobial Resistance, 5 (2) dlad023, dlad023. doi: 10.1093/jacamr/dlad023

Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA

Davies, Mark R., Keller, Nadia, Brouwer, Stephan, Jespersen, Magnus G., Cork, Amanda J., Hayes, Andrew J., Pitt, Miranda E., De Oliveira, David M. P., Harbison-Price, Nichaela, Bertolla, Olivia M., Mediati, Daniel G., Curren, Bodie F., Taiaroa, George, Lacey, Jake A., Smith, Helen V., Fang, Ning-Xia, Coin, Lachlan J. M., Stevens, Kerrie, Tong, Steven Y. C., Sanderson-Smith, Martina, Tree, Jai J., Irwin, Adam D., Grimwood, Keith, Howden, Benjamin P., Jennison, Amy V. and Walker, Mark J. (2023). Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA. Nature Communications, 14 (1) 1051, 1-12. doi: 10.1038/s41467-023-36717-4

Evolving insights into the epidemiology of Moraxella species bloodstream infection from two decades of surveillance in Queensland, Australia

Schults, Jessica, Edwards, Felicity, Charles, Karina, Irwin, Adam D., Rickard, Claire M., Harris, Patrick N. A., Paterson, David L. and Laupland, Kevin (2023). Evolving insights into the epidemiology of Moraxella species bloodstream infection from two decades of surveillance in Queensland, Australia. European Journal of Clinical Microbiology and Infectious Diseases, 42 (2), 209-216. doi: 10.1007/s10096-022-04540-2

Validation of a paediatric sepsis screening tool to identify children with sepsis in the emergency department: a statewide prospective cohort study in Queensland, Australia

Gilholm, Patricia, Gibbons, Kristen, Lister, Paula, Harley, Amanda, Irwin, Adam, Raman, Sainath, Rice, Michael, Schlapbach, Luregn J. and Queensland Statewide Sepsis Collaborative (2023). Validation of a paediatric sepsis screening tool to identify children with sepsis in the emergency department: a statewide prospective cohort study in Queensland, Australia. BMJ Open, 13 (1) e061431, 1-25. doi: 10.1136/bmjopen-2022-061431

Nystatin is commonly prescribed as prophylaxis in children beyond the neonatal age

Jayawardena-Thabrew, Harshani, Warris, Adilia, PASOAP Group , Irwin, Adam and Ferreras-Antolin, Laura (2023). Nystatin is commonly prescribed as prophylaxis in children beyond the neonatal age. Medical Mycology, 61 (1) myac097. doi: 10.1093/mmy/myac097

Improving paediatric antimicrobial stewardship in remote and regional Queensland hospitals: development and qualitative evaluation of a tailored intervention for intravenous-to-oral antibiotic switching

Sharman, Leah S., Avent, Minyon L., Lyall, Vivian, Fejzic, Jasmina, Clark, Julia E., Irwin, Adam, Graham, Nicolette and van Driel, Mieke L. (2022). Improving paediatric antimicrobial stewardship in remote and regional Queensland hospitals: development and qualitative evaluation of a tailored intervention for intravenous-to-oral antibiotic switching. BMJ Open, 12 (12) e064888, 1-10. doi: 10.1136/bmjopen-2022-064888

Proof-of-concept, rapid, instrument-free molecular detection of Neisseria gonorrhoeae and ciprofloxacin susceptibility

Ayfan, Abdulrahman K. S., Macdonald, Joanne, Irwin, Adam D., Zowawi, Hosam M., Forde, Brian M., Paterson, David L., Lahra, Monica M. and Whiley, David M. (2022). Proof-of-concept, rapid, instrument-free molecular detection of Neisseria gonorrhoeae and ciprofloxacin susceptibility. Journal of Antimicrobial Chemotherapy, 77 (11), 2933-2936. doi: 10.1093/jac/dkac242

Patient and economic impact of implementing a paediatric sepsis pathway in emergency departments in Queensland, Australia

Blythe, Robin, Lister, Paula, Seaton, Robert, Harley, Amanda, Schlapbach, Luregn J., McPhail, Steven, Venkatesh, Bala, Irwin, Adam, Raman, Sainath, Schlapbach, Luregn, Harley, Amanda, Irwin, Adam, Graham, Nicolette, Thomson, Fiona, Owen, Kieran, Garrish, Kirsten, Sampson, Emma, Long, Debbie, George, Shane, Grimwood, Keith, Bell, Christa, Semple, Bethany, Adams, Claire, Brown, Josea, Maloney, Louise, Lister, Paula, Schofield, Scott, Thomas, Clare, Dejong, Liam ... the Queensland State-wide Sepsis Collaborative (2022). Patient and economic impact of implementing a paediatric sepsis pathway in emergency departments in Queensland, Australia. Scientific Reports, 12 (1) 10113, 10113. doi: 10.1038/s41598-022-14226-6

An innovative Antimicrobial Stewardship Program for children in remote and regional areas in Queensland, Australia: optimizing antibiotic use through timely intravenous-to-oral conversion

Avent, M.L., Lee, X.J., Irwin, A.D., Graham, N., Brain, D., Fejzic, J., van Driel, M. and Clark, J.E. (2022). An innovative Antimicrobial Stewardship Program for children in remote and regional areas in Queensland, Australia: optimizing antibiotic use through timely intravenous-to-oral conversion. Journal of Global Antimicrobial Resistance, 28, 53-58. doi: 10.1016/j.jgar.2021.11.014

Neonatal vascular access practice and complications : An observational study of 1,375 catheter days

McIntyre, Colette, August, Deanne, Cobbald, Linda, Lack, Gill, Takashima, Mari, Foxcroft, Katie, Marsh, Nicole, Smith, Patricia, New, Karen, Koorts, Pieter, Irwin, Adam and Ullman, Amanda (2022). Neonatal vascular access practice and complications : An observational study of 1,375 catheter days. Journal of Perinatal and Neonatal Nursing, 37 (4), 332-339. doi: 10.1097/jpn.0000000000000589

Innovation in microsampling for therapeutic drug monitoring of gentamicin in neonates: a proof-of-concept study

Parker, Suzanne L., Irwin, Adam D., Hosking, Francine, August, Deanne, Schoenmaker, Brittany, Pandey, Saurabh, Wallis, Steven C., Lipman, Jeffrey, Roberts, Jason A. and Davies, Mark W. (2022). Innovation in microsampling for therapeutic drug monitoring of gentamicin in neonates: a proof-of-concept study. International Journal of Antimicrobial Agents, 59 (2) 106513, 1-2. doi: 10.1016/j.ijantimicag.2021.106513

Treatment of cutaneous leishmaniasis in a nonendemic country: a case series of children in Australia

Hill, Nicholas, Irwin, Adam, Graham, Nicolette, Leung, Clare, Francis, Joshua R, Wall, Nerilee and Nourse, Clare (2021). Treatment of cutaneous leishmaniasis in a nonendemic country: a case series of children in Australia. The Pediatric Infectious Disease Journal, Publish Ahead of Print (4), e177-e181. doi: 10.1097/inf.0000000000003445

The Paediatric AirWay Suction (PAWS) appropriateness guide for endotracheal suction interventions

Schults, Jessica, Charles, Karina, Long, Debbie, Brown, Georgia, Copnell, Beverley, Dargaville, Peter, Davies, Kylie, Erikson, Simon, Forrest, Kate, Harnischfeger, Jane, Irwin, Adam, Kendrik, Tina, Lake, Anna, Ntoumenopoulos, George, Waak, Michaela, Woodard, Mark, Tume, Lyvonne, Cooke, Marie, Mitchell, Marion, Hall, Lisa and Ullman, Amanda (2021). The Paediatric AirWay Suction (PAWS) appropriateness guide for endotracheal suction interventions. Australian Critical Care, 35 (6), 651-660. doi: 10.1016/j.aucc.2021.10.005

Designing support structures post sepsis in children: perspectives of the Queensland Paediatric Sepsis Program

Raman, Sainath, English, Alana, O'Keefe, Meagan, Harley, Amanda, Steele, Mary, Minogue, Jess, Weller, Kate, Long, Debbie, Irwin, Adam and Lister, Paula (2021). Designing support structures post sepsis in children: perspectives of the Queensland Paediatric Sepsis Program. Frontiers in Pediatrics, 9 759234, 759234. doi: 10.3389/fped.2021.759234

Pediatric antifungal prescribing patterns identify significant opportunities to rationalize antifungal use in children

Ferreras-Antolín, Laura, Irwin, Adam, Atra, Ayad, Chapelle, Faye, Drysdale, Simon B., Emonts, Marieke, McMaster, Paddy, Paulus, Stephane, Patel, Sanjay, Rompola, Menie, Vergnano, Stefania, Whittaker, Elizabeth and Warris, Adilia (2021). Pediatric antifungal prescribing patterns identify significant opportunities to rationalize antifungal use in children. The Pediatric Infectious Disease Journal, Publish Ahead of Print (3), e69-e74. doi: 10.1097/INF.0000000000003402

Impact of 1-hour and 3-hour sepsis time bundles on patient outcomes and antimicrobial use: a before and after cohort study

Venkatesh, Balasubramanian, Schlapbach, Luregn, Mason, Donna, Wilks, Kathryn, Seaton, Robert, Lister, Paula, Irwin, Adam, Lane, Paul, Redpath, Lyndell, Gibbons, Kristen, Ergetu, Endrias and Rice, Michael (2021). Impact of 1-hour and 3-hour sepsis time bundles on patient outcomes and antimicrobial use: a before and after cohort study. The Lancet Regional Health - Western Pacific, 18 100305, 100305. doi: 10.1016/j.lanwpc.2021.100305

Queensland Pediatric Sepsis Breakthrough Collaborative: Multicenter Observational Study to Evaluate the Implementation of a Pediatric Sepsis Pathway Within the Emergency Department

Harley, Amanda, Lister, Paula, Gilholm, Patricia, Rice, Michael, Venkatesh, Bala, Johnston, Amy N.B., Massey, Debbie, Irwin, Adam, Gibbons, Kristen and Schlapbach, Luregn J. (2021). Queensland Pediatric Sepsis Breakthrough Collaborative: Multicenter Observational Study to Evaluate the Implementation of a Pediatric Sepsis Pathway Within the Emergency Department. Critical Care Explorations, 3 (11) e0573, 1-14. doi: 10.1097/cce.0000000000000573

Paediatric Active Enhanced Disease Surveillance (PAEDS) 2019: Prospective hospital-based surveillance for serious paediatric conditions

Dinsmore, Nicole, McRae, Jocelynne E., Quinn, Helen E., Glover, Catherine, Dougherty, Sonia, McMinn, Allissa, Crawford, Nigel, Marshall, Helen, Carlson, Samantha J, Blyth, Christopher, Lucas, Ryan, Irwin, Adam, Macartney, Kristine, Britton, Philip N, Wood, Nicholas and The Paediatric Active Enhanced Disease Surveillance network (2021). Paediatric Active Enhanced Disease Surveillance (PAEDS) 2019: Prospective hospital-based surveillance for serious paediatric conditions. Communicable Diseases Intelligence, 45, 1-24. doi: 10.33321/cdi.2021.45.53

Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis

Wen, Sophie C. H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Riaz, Saba, Paterson, David L. and Irwin, Adam D. (2021). Gram-negative neonatal sepsis in low- and lower-middle-income countries and WHO empirical antibiotic recommendations: A systematic review and meta-analysis. PLoS Medicine, 18 (9) e1003787, 1-20. doi: 10.1371/journal.pmed.1003787

MicroPIPE: validating an end-to-end workflow for high-quality complete bacterial genome construction

Murigneux, Valentine, Roberts, Leah W., Forde, Brian M., Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Irwin, Adam D., Harris, Patrick N. A., Paterson, David L., Schembri, Mark A., Whiley, David M. and Beatson, Scott A. (2021). MicroPIPE: validating an end-to-end workflow for high-quality complete bacterial genome construction. BMC Genomics, 22 (1) 474, 474. doi: 10.1186/s12864-021-07767-z

Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT)

Irwin, Adam D., Coin, Lachlan J. M., Harris, Patrick N. A., Cotta, Menino Osbert, Bauer, Michelle J., Buckley, Cameron, Balch, Ross, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Beatson, Scott A., Forde, Brian M., Paterson, David, Clark, Julia, Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Schlapbach, Luregn J. and Roberts, Jason A. (2021). Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT). Frontiers in Cellular and Infection Microbiology, 11 667680, 1-8. doi: 10.3389/fcimb.2021.667680

New microbiological techniques for the diagnosis of bacterial infections and sepsis in ICU including point of care

Peri, Anna Maria, Stewart, Adam, Hume, Anna, Irwin, Adam and Harris, Patrick N A (2021). New microbiological techniques for the diagnosis of bacterial infections and sepsis in ICU including point of care. Current Infectious Disease Reports, 23 (8) 12, 12. doi: 10.1007/s11908-021-00755-0

Role of C reactive protein and procalcitonin in the diagnosis of lower respiratory tract infection in children in the outpatient setting

Pérez-López, Andrés, Irwin, Adam, Rodrigo, Carlos and Prat-Aymerich, Cristina (2021). Role of C reactive protein and procalcitonin in the diagnosis of lower respiratory tract infection in children in the outpatient setting. BMJ, 373 (11) n1409, n1409. doi: 10.1136/bmj.n1409

The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children

Channon-Wells, S., Kwok, M., Booth, J., Bamford, A., Konstanty, P., Hatcher, J., Dixon, G., Diggle, P. J., Standing, J. F. and Irwin, A. D. (2021). The use of continuous electronic prescribing data to infer trends in antimicrobial consumption and estimate the impact of stewardship interventions in hospitalized children. Journal of Antimicrobial Chemotherapy, 76 (9), 2464-2471. doi: 10.1093/jac/dkab187

Normal saline and lung recruitment with paediatric endotracheal suction (NARES): a pilot, factorial, randomised controlled trial

Schults, Jessica A., Cooke, Marie, Long, Debbie, Schibler, Andreas, Ware, Robert S., Charles, Karina, Irwin, Adam and Mitchell, Marion L. (2021). Normal saline and lung recruitment with paediatric endotracheal suction (NARES): a pilot, factorial, randomised controlled trial. Australian Critical Care, 34 (6), 530-538. doi: 10.1016/j.aucc.2021.01.006

Rapid detection of NDM and VIM carbapenemase encoding genes by recombinase polymerase amplification and lateral flow–based detection

Ayfan, Abdulrahman K. S., Macdonald, Joanne, Harris, Patrick N. A., Heney, Claire, Paterson, David L., Trembizki, Ella, Wang, Claire Y. T., Whiley, David M., Zowawi, Hosam M. and Irwin, Adam D. (2021). Rapid detection of NDM and VIM carbapenemase encoding genes by recombinase polymerase amplification and lateral flow–based detection. European Journal of Clinical Microbiology & Infectious Diseases, 40 (11), 2447-2453. doi: 10.1007/s10096-021-04267-6

Gram-Negative Neonatal Sepsis in Low- and Middle- Income Countries: How Appropriate are the WHO Recommended Empirical Sepsis Antibiotic Regimens? A Systematic Review and Meta-Analysis

Wen, Sophie C.H., Ezure, Yukiko, Rolley, Lauren, Spurling, Geoff, Lau, Colleen L., Paterson, David L. and Irwin, Adam D. (2021). Gram-Negative Neonatal Sepsis in Low- and Middle- Income Countries: How Appropriate are the WHO Recommended Empirical Sepsis Antibiotic Regimens? A Systematic Review and Meta-Analysis. SSRN Electronic Journal. doi: 10.2139/ssrn.3777180

The relevance of probiotics in Caesarean-born neonates

Sidjabat, Hanna E., Alsaggaf, Alaa Mohammed Ali, Gopalakrishna, Akshatha, Nadar, Evelyn, Irwin, Adam and Koorts, Pieter (2020). The relevance of probiotics in Caesarean-born neonates. Microbiology Australia, 41 (2), 75-81. doi: 10.1071/ma20020

Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study

Warris, Adilia, Pana, Zoi-Dorothea, Oletto, Andrea, Lundin, Rebecca, Castagnola, Elio, Lehrnbecher, Thomas, Groll, Andreas H., Roilides, Emmanuel, Andersen, Cecilie T., Arendrup, Maiken C., Arsenijevic, Valentina Arsic, Bianchini, Sonia, von Both, Ulrich, Chmelnik, Martin, Controzzi, Tiziana, Emonts, Marieke, Esposito, Susanna, Ferreras-Antolin, Laura, Henriet, Stefanie, Iosifidis, Elias, Irwin, Adam, Kopsidas, John, Lagrou, Katrien, Lyall, Hermione, Casteleiro, Angela Manzanares, Mesini, Alessio, Olbrich, Peter, Paulus, Stephane, Lausch, Karen Rokkedal ... EUROCANDY Study Group (2019). Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study. The Pediatric Infectious Disease Journal, 39 (2), 1-120. doi: 10.1097/INF.0000000000002530

Neonatal Antifungal Consumption Is Dominated by Prophylactic Use; Outcomes From The Pediatric Antifungal Stewardship: Optimizing Antifungal Prescription Study

Ferreras-Antolín, Laura, Irwin, Adam, Atra, Ayad, Dermirjian, Alicia, Drysdale, Simon B, Emonts, Marieke, McMaster, Paddy, Paulus, Stephane, Patel, Sanjay, Kinsey, Sally, Vergnano, Stefania, Whittaker, Elisabeth and Warris, Adilia (2019). Neonatal Antifungal Consumption Is Dominated by Prophylactic Use; Outcomes From The Pediatric Antifungal Stewardship: Optimizing Antifungal Prescription Study. The Pediatric infectious disease journal, 38 (12), 1-1223. doi: 10.1097/INF.0000000000002463

Case ascertainment in active paediatric surveillance systems: a report from the British Paediatric Surveillance Unit Ascertainment Group

Lynn, Richard M, Reading, Richard, BPSU Ascertainment Group and Irwin, Adam (2019). Case ascertainment in active paediatric surveillance systems: a report from the British Paediatric Surveillance Unit Ascertainment Group. Archives of disease in childhood, 105 (1), 62-68. doi: 10.1136/archdischild-2019-317401

Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries

Hsia, Yingfen, Lee, Brian R., Versporten, Ann, Yang, Yonghong, Bielicki, Julia, Jackson, Charlotte, Newland, Jason, Goossens, Herman, Magrini, Nicola, Sharland, Mike, Teston, L., Cheung, K., Koning, S., Grimwood, K., Cross, J., da Silva, A., Benadof, D., Zhang, W. S., Zhao, W., Liu, G., Shen, K. L., Yao, K. H., Zheng, Y. J., Deng, J. K., Zhang, J. S., Wang, Y., Jiang, X. Y., Tian, D. Y., Jing, C. M. ... Gawrys, G. (2019). Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): an analysis of paediatric survey data from 56 countries. The Lancet Global Health, 7 (7), E861-E871. doi: 10.1016/S2214-109X(19)30071-3

Revising paediatric vancomycin dosing accounting for nephrotoxicity in a pharmacokinetic-pharmacodynamic model

Kloprogge, Frank, Hill, Louise, Booth, John, Klein, Nigel, Irwin, Adam, Dixon, Garth and Standing, Joseph F (2019). Revising paediatric vancomycin dosing accounting for nephrotoxicity in a pharmacokinetic-pharmacodynamic model. Antimicrobial Agents and Chemotherapy, 63 (5) e00067-19. doi: 10.1128/aac.00067-19

Detection of epidemic scarlet fever group A Streptococcus in Australia

Walker, Mark J., Brouwer, Stephan, Forde, Brian M., Worthing, Kate A., McIntyre, Liam, Sundac, Lana, Maloney, Sam, Roberts, Leah W., Barnett, Timothy C., Richter, Johanna, Cork, Amanda J., Irwin, Adam D., You, Yuanhai, Zhang, Jianzhong, Dougan, Gordon, Yuen, K. Y., Nizet, Victor, Beatson, Scott A., Grimwood, Keith and Davies, Mark R. (2019). Detection of epidemic scarlet fever group A Streptococcus in Australia. Clinical Infectious Diseases, 69 (7), 1232-1234. doi: 10.1093/cid/ciz099

A case for reduced frequency of CD4 count monitoring for children on combination antiretroviral therapy with consistently undetectable HIV viral load

Johnson, S. M., Standing, J. F., Klein, N., Irwin, A. D., Shingadia, D., Lonsdale, D. O., Gilmour, K. C., Flynn, J., Manns, C., Clapson, M. and Bamford, A. (2019). A case for reduced frequency of CD4 count monitoring for children on combination antiretroviral therapy with consistently undetectable HIV viral load. HIV Medicine, 20 (4), e8-e9. doi: 10.1111/hiv.12706

Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children (vol 58, pg 53, 2019)

Boonsathorn, Sophida, Cheng, Iek, Kloprogge, Frank, Alonso, Carlos, Lee, Charmion, Doncheva, Bilyana, Booth, John, Chiesa, Robert, Irwin, Adam and Standing, Joseph F. (2019). Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children (vol 58, pg 53, 2019). Clinical Pharmacokinetics, 58 (1), 141-141. doi: 10.1007/s40262-018-0722-x

Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children

Boonsathorn, Sophida, Cheng, Iek, Kloprogge, Frank, Alonso, Carlos, Lee, Charmion, Doncheva, Bilyana, Booth, John, Chiesa, Robert, Irwin, Adam and Standing, Joseph F. (2018). Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children. Clinical Pharmacokinetics, 58 (1), 1-9. doi: 10.1007/s40262-018-0658-1

Question 2: are three malaria tests necessary in children returning from the tropics with fever?

Wilson, Isabel Emily, Shingadia, Delane, Yeung, Shunmay, Riordan, Andrew and Irwin, Adam David (2018). Question 2: are three malaria tests necessary in children returning from the tropics with fever?. Archives of Disease in Childhood, 103 (1), 109-112. doi: 10.1136/archdischild-2017-313843

Predicting risk of serious bacterial infections in febrile children in the emergency department

Irwin, Adam D, Grant, Alison, Williams, Rhian, Kolamunnage-Dona, Ruwanthi, Drew, Richard J, Paulus, Stephane, Jeffers, Graham, Williams, Kim, Breen, Rachel, Preston, Jennifer, Appelbe, Duncan, Chesters, Christine, Newland, Paul, Marzouk, Omnia, McNamara, Paul S, Diggle, Peter J and Carrol, Enitan D (2017). Predicting risk of serious bacterial infections in febrile children in the emergency department. Pediatrics, 140 (2) e20162853, e20162853. doi: 10.1542/peds.2016-2853

Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study

Braccio, Serena, Irwin, Adam, Riordan, Andrew, Shingadia, Delane, Kelly, Deirdre A., Bansal, Sanjay, Ramsay, Mary and Ladhani, Shamez N. (2017). Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study. Archives of Disease in Childhood, 102 (7), 624-628. doi: 10.1136/archdischild-2016-311916

Predictors of fever-related admissions to a paediatric assessment unit, ward and reattendances in a South London emergency department: the CABIN 2 study

Bustinduy, Amaya L., Chis Ster, Irina, Shaw, Rebecca, Irwin, Adam, Thiagarajan, Jaiganesh, Beynon, Rhys, Ladhani, Shamez, Sharland, Mike and CABIN network (2017). Predictors of fever-related admissions to a paediatric assessment unit, ward and reattendances in a South London emergency department: the CABIN 2 study. Archives of Disease in Childhood, 102 (1), 22-28. doi: 10.1136/archdischild-2016-310494

Supporting decisions to increase the safe discharge of children with febrile illness from the emergency department: a systematic review and meta-analysis

Irwin, A. D., Wickenden, J., Le Doare, K., Ladhani, S. and Sharland, M. (2016). Supporting decisions to increase the safe discharge of children with febrile illness from the emergency department: a systematic review and meta-analysis. e ADC, 101 (3), 259-66. doi: 10.1136/archdischild-2015-309056

Targeted empiric antibiotic therapy for children with non-oncological comorbidities and community-onset invasive bacterial infections

Wells, Rosy, Le Doare, Kirsty, Sharland, Mike, Heath, Paul, Ladhani, Shamez N, CABIN Network and Irwin, Adam (2015). Targeted empiric antibiotic therapy for children with non-oncological comorbidities and community-onset invasive bacterial infections. The Journal of Infection, 71 (3), 294-301. doi: 10.1016/j.jinf.2015.05.002

Etiology of childhood bacteremia and timely antibiotics administration in the emergency department

Irwin, Adam D., Drew, Richard J., Marshall, Philippa, Nguyen, Kha, Hoyle, Emily, Macfarlane, Kate A., Wong, Hoying F., Mekonnen, Ellen, Hicks, Matthew, Steele, Tom, Gerrard, Christine, Hardiman, Fiona, McNamara, Paul S., Diggle, Peter J. and Carrol, Enitan D. (2015). Etiology of childhood bacteremia and timely antibiotics administration in the emergency department. Pediatrics, 135 (4), 635-642. doi: 10.1542/peds.2014-2061

Improving antibiotic prescribing for children in the resource-poor setting

Le Doare, Kirsty, Barker, Charlotte I. S., Irwin, Adam and Sharland, Mike (2015). Improving antibiotic prescribing for children in the resource-poor setting. British Journal of Clinical Pharmacology, 79 (3), 446-455. doi: 10.1111/bcp.12320

Commentaries on ‘Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections’ with a response from the review authors

Sabhaney, Vikram, Enarson, Paul, Irwin, Adam D., Carrol, Enitan D., Schuetz, Philipp, Briel, Matthias, Bucher, Heiner C. and Mueller, Beat (2013). Commentaries on ‘Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections’ with a response from the review authors. Evidence-Based Child Health, 8 (4), 1372-1375. doi: 10.1002/ebch.1928

Measuring antibiotic prescribing in hospitalised children in resource-poor countries: a systematic review

Irwin, Adam and Sharland, Mike (2013). Measuring antibiotic prescribing in hospitalised children in resource-poor countries: a systematic review. Journal of Paediatrics and Child Health, 49 (3), 185-192. doi: 10.1111/j.1440-1754.2011.02126.x

Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children

Irwin, Adam D., Marriage, Fiona, Mankhambo, Limangeni A., Jeffers, Graham, Kolamunnage-Dona, Ruwanthi, Guiver, Malcolm, Denis, Brigitte, Molyneux, Elizabeth M., Molyneux, Malcolm E., Day, Philip J. and Carrol, Enitan D. (2012). Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children. BMC Medical Genomics, 5 (1) 13. doi: 10.1186/1755-8794-5-13

Procalcitonin

Irwin, Adam D. and Carrol, Enitan D. (2011). Procalcitonin. Archives of Disease in Childhood-Education and Practice Edition, 96 (6), 228-233. doi: 10.1136/archdischild-2011-300178

Predicting a patient's choice of dialysis modality: experience in a United Kingdom renal department

Little, Jane, Irwin, Adam, Marshall, Tim, Rayner, Hugh and Smith, Stephen (2001). Predicting a patient's choice of dialysis modality: experience in a United Kingdom renal department. American Journal of Kidney Diseases, 37 (5), 981-986. doi: 10.1016/S0272-6386(05)80014-9

Identifying clinical symptom profiles for sepsis in children screened for sepsis on admission to the emergency department

Gilholm, P., Irwin, A., Lister, P., Harley, A., Raman, S., Schlapbach, L. J. and Gibbons, K. (2022). Identifying clinical symptom profiles for sepsis in children screened for sepsis on admission to the emergency department. 11th Congress of the World Federation of Pediatric Intensive & Critical Care Societies, Online, 12-16 July 2022. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.pcc.0000899876.46317.ec

Recommendations for endotracheal suction interventions in children with highly infectious respiratory disease: results from a RAND/UCLA binational appropriateness panel

Schults, Jessica, Charles, Karina, Long, Debbie, Erikson, Simon, Irwin, Adam, Waak, Michaela, Hall, Lisa and Ullman, Amanda (2021). Recommendations for endotracheal suction interventions in children with highly infectious respiratory disease: results from a RAND/UCLA binational appropriateness panel. 9th International Australasian College for Infection Prevention and Control (ACIPC) online conference, Online, 7-10 November 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.idh.2021.09.031

Rapid and sensitive molecular detection of antimicrobial resistance (AMR); towards point-of-care testing in low resource settings

Ayfan, A., Ertl, N., Whiley, D., Paterson, D., Heney, C., Harris, P., Macdonald, J., Irwin, A. and Zowawi, H. (2020). Rapid and sensitive molecular detection of antimicrobial resistance (AMR); towards point-of-care testing in low resource settings. GCCMID 2019, Dubai, United Arab Emirates, 6-9 November 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jiph.2020.01.059

Neonatal observational vascular access (NOVA): an Australian audit

August, Deanne, Ullman, Amanda, New, Karen, McIntyre, Colette, Smith, Patricia, Koorts, Pieter, Irwin, Adam, Cobbald, Linda, Lack, Gill, Takashima, Mari, Foxcroft, Katie and Marsh, Nicole (2019). Neonatal observational vascular access (NOVA): an Australian audit. 3rd Congress of Joint European Neonatal Societies (jENS), Masstricht, Netherlands, 17-21 September 2019. New York, United States: Nature Publishing Group.

A2.1  A comparison of metrics to evaluate trends in antimicrobial consumption in a tertiary children’s hospital

Kwok, M., Booth, J., Konstanty, P., Standing, J.F. and Irwin, A.D. (2017). A2.1  A comparison of metrics to evaluate trends in antimicrobial consumption in a tertiary children’s hospital. Great Ormond Street Hospital Conference, Nottingham, United Kingdom, 21–22 June, 2017. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/archdischild-2017-084620.21